Glucose metabolism disease

Researchers are testing two experimental gene therapies, VV-14299 and VV-14300, in adults with long-standing type 1 diabetes whose blood sugar remains poorly controlled despite using an automated insulin pump. The therapies are injected into muscle and are designed to work togeth…

Researchers are testing a gene therapy called VV-14300 in adults with long-standing type 1 diabetes whose blood sugar remains poorly controlled despite using an automated insulin delivery system. The therapy uses a harmless virus to deliver the glucokinase gene into muscle, where…

This phase 1 trial tests whether injecting RGB-5088 islet cells under the abdominal muscle can safely help people with type 2 diabetes. The study enrolls 10 adults aged 18 to 65 who have had diabetes for at least 5 years and currently use insulin. Researchers will monitor safety …

Researchers are testing whether a carbohydrate drink before gastrointestinal surgery can reduce insulin resistance and improve blood sugar stability in adults with type 2 diabetes. Participants are randomly assigned to one of three groups: standard fasting without a carb drink, a…

Researchers are testing UrDiaCare, an Urdu-language app that gives diabetes self-management education and support through WhatsApp or Android. The trial includes 406 adults aged 30 to 70 in Pakistan who have type 2 diabetes and higher-than-recommended blood sugar levels. Particip…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

Researchers are testing whether waiting until 41 weeks to induce labor leads to fewer cesarean deliveries than inducing at 40 weeks in first-time mothers with diet-controlled gestational diabetes. The trial enrolls 1,500 women who manage their blood sugar through diet and exercis…

This study tests a combination of four drugs (epalrestat, HAIC, donafenib, and tislelizumab) as a first treatment for people with advanced liver cancer that cannot be removed by surgery and who also have diabetes. The goal is to see if this approach can control the cancer for at …

This study tests an experimental pill (cadisegliatin) taken alongside insulin in people with type 1 diabetes who already use a hybrid closed-loop insulin pump. The goal is to see if the pill helps keep blood sugar in a healthy range more consistently. About 40 adults will receive…

Researchers are testing whether seltoplasmid, a gene therapy injected into the calf muscle, can improve outcomes for people with type 2 diabetes who have poor blood flow to the foot and a non-healing ulcer. All participants first undergo a standard procedure to restore blood flow…

This study looks at the safety and effectiveness of Rybelsus, a pill for type 2 diabetes, in everyday medical practice in Korea. About 600 adults will take the medicine as their doctor prescribes, and researchers will track side effects and blood sugar control for 26 weeks. The g…

This study tests whether a continuous glucose monitor (CGM) is better than standard finger-prick tests for managing blood sugar in 100 pregnant women with gestational diabetes. Participants will either wear a small sensor or continue finger-pricking. The goal is to see if CGM is …

Researchers test whether coconut oil pulling or a moringa mouthwash can reduce gingivitis in children with diabetes, compared with chlorhexidine. Thirty children aged 6 to 12 with mild to moderate gingivitis use one of the three rinses. The team measures gum inflammation and leve…

This trial is testing whether a combination of drugs—inavolisib plus fulvestrant, with or without palbociclib—is safe for people with a specific type of advanced breast cancer (HR+, HER2-negative) that has a PIK3CA mutation, and who also have type 2 diabetes. The main focus is on…

Researchers are testing whether a combination of four experimental oral drugs, AD-233A, AD-233B, AD-233C and AD-233D, can improve blood sugar control in adults with type 2 diabetes. The Phase III trial enrolls about 354 participants and compares the drug combination against an ac…

This study will enroll 20 severely obese adults scheduled for metabolic surgery. Half will use a continuous glucose monitor (CGM) and half will use standard finger-stick testing to track blood sugar. Researchers want to see if the CGM leads to steadier blood sugar levels and fewe…

Researchers are testing whether limiting all meals and snacks to a 9-hour window each day improves blood sugar control, insulin levels, and daily metabolic rhythms in adults with obesity and prediabetes. The trial enrolls 26 people aged 35 to 75 who usually eat over 13 hours a da…

The HARVEST study is testing whether eating a special low-glycemic, high-protein rice instead of regular white rice can improve blood sugar control in people with prediabetes or type 2 diabetes. Over 16 weeks, 225 adults in Singapore will replace their usual rice with one of thre…

This trial tests whether eating almonds as an evening snack improves overnight blood sugar in pregnant women with gestational diabetes. About 156 women will either eat 43 grams of whole almonds daily or a nut-free snack for 28 days. Researchers will measure blood sugar levels ove…

Many people live with heart disease, kidney disease, and type 2 diabetes at the same time, but care often focuses on each condition separately. This trial tests a primary care model that brings these conditions together under one coordinated plan. Primary care centers receive tra…

This trial investigates whether adding a once-weekly injection of tirzepatide to standard diabetes pills can improve blood sugar control and promote weight loss in obese adults with type 2 diabetes. Over six months, researchers will compare changes in HbA1c and body weight betwee…

Researchers are testing whether a digital behavioral therapy app, added to standard diabetes care, can improve blood sugar control and lower the risk of liver fibrosis in adults with type 2 diabetes. The trial enrolls 180 adults with type 2 diabetes who are at low to moderate ris…

Researchers are testing how safely and comfortably people with type 2 diabetes can switch from semaglutide to CagriSema, a weekly injection that combines cagrilintide and semaglutide. About 210 adults who have taken a stable dose of branded semaglutide for at least three months w…

This study tests whether a smartphone app that shows real-time blood sugar and activity data can help adolescents and young adults with type 2 diabetes improve their glucose control. Participants use a continuous glucose monitor and Fitbit, and some receive prompts to reflect on …

Researchers at El Katib Hospital are testing a procedure called endoscopic band ligation on the upper part of the small intestine in people with type 2 diabetes. The goal is to reshape the duodenal lining so it may release more gut hormones that help control blood sugar. Ten adul…

Researchers are testing whether a multidisciplinary care model helps people with type 2 diabetes and chronic kidney disease start and adjust five classes of heart and kidney protective medicines within four months. The trial enrolls about 570 adults at high or very high risk of k…

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

Researchers are observing how tirzepatide works in routine care for adults in Pakistan who have obesity, prediabetes, or type 2 diabetes. The study follows 330 people starting the medicine as part of their normal treatment at ten diabetes and endocrinology centres. Doctors decide…

This trial tests whether the GX-01S continuous glucose monitoring system helps adults with type 1 or type 2 diabetes improve their blood sugar control. Participants wear the sensor for about 4.5 months, with the first 15 days blinded to establish a baseline, then full access to r…

Researchers in Oman are testing whether a structured education program that combines diabetes and oral health advice can improve blood sugar control and gum health in adults with type 2 diabetes. The trial enrolls 290 adults aged 35 and older who have had type 2 diabetes for at l…

This 52-week trial tests whether combining a structured lifestyle program with a mushroom-based supplement and the drug bupropion helps overweight adults lose weight and lower cardiometabolic risk. About 250 adults aged 18 to 55 with a BMI between 25 and 35 will be randomly assig…

This trial tests whether individualized nursing care can help adults with diabetes feel more confident and capable in managing their condition. Participants receive structured, personalized sessions that include education, goal-setting, and self-monitoring guidance. The study mea…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This trial tests whether an automated insulin delivery system, the DEKA TWIIST pump with Tidepool Loop software, can safely manage glucose levels in pregnant people with type 1 diabetes. The system adjusts insulin automatically and can be set to pregnancy-specific glucose targets…

This trial tests whether two moderate low-carbohydrate diets, one higher in protein and one higher in fat, improve blood sugar, blood fats, and weight more than a standard diet. Adults with type 2 diabetes, high triglycerides, and overweight or obesity will follow one of the thre…

This study tests two common methods for calculating mealtime insulin doses in hospitalized adults with type 2 diabetes. One method, carbohydrate counting, adjusts the insulin dose based on the grams of carbs a patient actually eats. The other uses a fixed dose that changes only w…

This study tests a 12-week digital program led by a nurse to help young adults (ages 18-45) with type 2 diabetes better manage their condition. Participants use a web or mobile app for education, goal-setting, and direct messaging with a nurse. The goal is to see if this approach…

This early study tests if injecting a person's own stem cells into the upper gut is safe and feasible for treating type 2 diabetes. The stem cells are taken from belly fat and processed before being injected during a scope procedure. Only 15 people will take part, and the main go…

This trial tests whether continuous glucose monitoring (CGM) can improve blood sugar control and reduce complications in hospitalized adults with type 2 diabetes, compared to standard finger-prick testing. Participants are randomly assigned to either CGM with a sensor-guided insu…

This 8-week pilot trial tests whether eating at least 56 grams of almonds daily can raise blood levels of vitamin E and improve overall diet quality in adults taking GLP-1 medications like semaglutide or tirzepatide for obesity or type 2 diabetes. Participants are split into two …

This Phase 2 trial tests an investigational once-weekly injection called SYH2069 in adults with type 2 diabetes whose blood sugar is not well controlled by diet, exercise, or metformin alone. Researchers compare several doses of SYH2069 against a placebo and an existing diabetes …

This trial tests whether a specially designed smartphone app can improve self-management and blood sugar control in adults with type 2 diabetes. Participants use the app for daily tracking, video health lessons, and guidance from a team of doctors, nurses, dietitians, and pharmac…

This phase II trial is testing whether an experimental oral medication, DA-302168S, can help people with type 2 diabetes control their blood sugar. The study will compare the drug against a placebo in about 272 adults who are already taking metformin. Researchers will measure cha…

This trial tests whether adding a second procedure to a standard weight-loss operation leads to greater weight loss and better metabolic health in adults with obesity. The standard procedure, endoscopic sleeve gastroplasty (ESG), uses stitches to make the stomach smaller. The add…

This trial tests whether a daily supplement of calcium-HMB plus vitamin D3 can help adults aged 65 to 85 with type 2 diabetes keep their muscle mass and metabolism while starting semaglutide, a common weight-loss and diabetes medication. Participants take the supplement or a plac…

This trial tests whether adding a nurse-led telehealth education program to usual diabetes care improves blood sugar control, medication habits, and quality of life in adults with type 2 diabetes in Oman. About 160 participants will be randomly assigned to either receive weekly 2…

This study tests a new treatment using clonal fetal mesenchymal stem cells (cfMSCs) for people with type 2 diabetes. The goal is to see if it is safe and can improve blood sugar control. Thirty adults with poorly controlled diabetes will receive the stem cell therapy and be monit…

This study looks at whether playing active video games can help children and young adults (ages 5-21) with obesity and type 2 diabetes lose weight and lower their blood sugar levels. Participants will play active video games at home, and researchers will track changes in weight a…

This study tests whether eating one avocado daily for 12 weeks can improve blood flow to the brain and support heart and blood vessel health in adults with prediabetes and overweight or obesity. Researchers will measure brain blood flow using MRI, along with markers of blood vess…

This study will give 100 adults with prediabetes a continuous glucose monitor (CGM) called Stelo, which tracks blood sugar every few minutes. The goal is to see if seeing real-time sugar levels helps people make better food and activity choices, lowering their A1c and improving h…

This trial is testing whether dorzagliatin, an experimental oral medication, can improve blood sugar control in people with type 2 diabetes who also have moderate to severe chronic kidney disease. Participants will be randomly assigned to receive either dorzagliatin or linaglipti…

This pilot trial tests a personalized AI platform called PIPE-AI, enhanced by DiabetesGPT, to see if it can help adults with prediabetes or type 2 diabetes improve their self-management and knowledge. Participants are randomly assigned to either use the AI platform for three mont…

This trial tests whether online peer education can help people with type 2 diabetes become more physically active. Participants will be placed in groups led by peers who have type 2 diabetes and exercise above recommended levels. The study measures changes in daily step count, al…

This trial is testing whether an investigational drug called AZD6234, given as a weekly injection, can help adults with type 2 diabetes and excess weight lose more weight than a placebo. Participants will receive either AZD6234 or a placebo for 68 weeks, and researchers will meas…

This trial tests whether clazakizumab, an experimental anti-inflammatory drug, can lower a blood marker of inflammation called hsCRP in adults who have elevated levels and are at increased risk for heart problems. Participants must have conditions like established heart disease, …

This trial tests a shared decision-making program for adults with type 2 diabetes. The program helps patients identify their concerns, learn about their condition and treatment options, and work together with doctors, nurses, and family to create a personalized care plan. Researc…

This trial tests whether combining nurse-delivered care with text message check-ins and support can help adults with uncontrolled high blood pressure lower their blood pressure and improve diabetes management. Participants receive either usual care or the enhanced support, which …

This trial tests a 12-week community program for older stroke survivors who also have high blood pressure or type 2 diabetes. Participants take part in physical activities like exercise and nutrition education, plus cognitive games on an AI-enabled large screen. The goal is to se…

This trial tests whether a weight-loss procedure called endoscopic sleeve gastroplasty (ESG) can improve blood sugar control and reduce the need for insulin in adults with obesity and type 2 diabetes. Participants have poorly controlled diabetes despite taking standard medication…

This trial is testing whether adding dapagliflozin to metformin can improve levels of a growth-related hormone (IGF-1) in men with type 2 diabetes and fatty liver disease. The study will include 84 men aged 30-60 who are already taking metformin. Half will continue metformin alon…

This trial aims to find out whether a standard exercise program (Otago) or a specialized balance training that engages multiple senses (multisensory integration) is more effective at improving balance and walking in older adults with type 2 diabetes. Participants, aged 65 to 75, …

This early-stage trial tests a small, soft implant that holds donor insulin-making cells (islets) and protects them from the immune system. The goal is to see if the device is safe and keeps the cells alive and working in adults with type 1 diabetes. Some participants are also on…

This study looks at whether supervised exercise and the diabetes drug semaglutide, alone or together, can improve thinking and brain health in older adults with type 2 diabetes. About 164 people aged 65 and older will take part. They will be assigned to exercise training, a contr…

This study tests a new once-daily oral pill called orforglipron against a weekly injection (dulaglutide) in 170 teens aged 10-18 with type 2 diabetes. The goal is to see if the pill works better at controlling blood sugar and is safe. Participants will be followed for about 61 we…

This trial tests whether drinking galactose, a sugar that breaks down slowly, can help refill muscle energy stores after exercise in people with type 1 diabetes. Participants will consume galactose alone or with glucose, and researchers will use PET scans to see how much galactos…

This trial compares three different negative-pressure wound dressings (NPseal, PICO, and Prevena) applied after total knee replacement surgery. The study enrolls adults at higher risk for wound problems, such as those with diabetes, obesity, or chronic kidney disease. Participant…

This trial tests whether different combinations of rowing and cycling exercise can reduce inflammation and improve blood sugar control in people newly diagnosed with type 2 diabetes. Participants, aged 18-60 and not yet on medication, will be assigned to one of five exercise prog…

This trial is testing an experimental procedure called pulsENDO therapy for adults with type 2 diabetes whose blood sugar is not well controlled with current medications. The procedure uses a thin tube to deliver gentle electric pulses to the lining of the small intestine, aiming…

This trial tests whether adding Hebenrun, a functional food made from natural grain bran, to standard metformin treatment helps people with type 2 diabetes achieve better blood sugar control. About 110 adults with type 2 diabetes will be randomly assigned to take either metformin…

This trial tests whether mazdutide, a weekly injection, can help people with type 2 diabetes achieve normal blood sugar levels—a state called remission. Participants are adults with type 2 diabetes who are not well controlled on diet, exercise, or a single medication. They receiv…

This trial tests a new laparoscopic procedure called SIBS, which combines sleeve gastrectomy with a side-to-side connection between the duodenum and ileum, without cutting the duodenum. The goal is to see if the surgery is safe and technically feasible in adults with obesity and …

This study tests whether a specially developed high-protein, low-glycemic index rice can improve blood sugar control in adults with prediabetes. Participants will eat both this special rice and conventional rice in a crossover design, allowing each person to serve as their own co…

This pilot trial tests whether a 4-week group education program that blends Chinese medicine concepts—like body constitution, dietary therapy, and acupressure—with standard diabetes self-management training is feasible and acceptable for adults with type 2 diabetes in Hong Kong. …

This trial is testing whether taking a daily Ceylon cinnamon supplement, combined with a structured educational program, can improve blood sugar control, cholesterol levels, and nerve pain in adults with type 2 diabetes and painful diabetic peripheral neuropathy. About 900 partic…

This trial tests whether a culturally tailored, Spanish-language onboarding and support program helps Latino youth aged 10–20 with type 1 diabetes adopt and consistently use the Medtronic MiniMed 780G automated insulin delivery system. Participants receive one-on-one nutrition su…

This trial tests whether open-source automated insulin delivery (AID) systems can control blood sugar as well as commercial systems in adults with type 1 diabetes, even when meals are not announced. Participants will use both types of systems for four weeks each, with a focus on …

This trial tests whether applying a gel containing either metformin or zoledronate under the gums can improve healing of bone defects caused by periodontitis in people with well-controlled type 2 diabetes. Participants receive standard deep-cleaning treatment, and some also get o…

This trial tests whether different intermittent fasting schedules—5:2, alternate-day, and time-restricted eating—can improve blood sugar, cholesterol, inflammation, and body composition in adults with prediabetes. Participants will be randomly assigned to one of three fasting pla…

This study tests NeoMayor, a smartphone app that gives personalized advice on exercise, diet, sleep, and mood to improve heart health. Researchers will enroll 240 adults aged 55 to 75 in Chile who are at risk for heart problems. Participants use the app for 4 months, and some als…

This trial tests whether extending a 6-month exercise coaching program to 12 months helps people with type 2 diabetes maintain a healthier activity level. Participants will be randomly assigned to either the standard 6-month program or an extended version with sessions every two …

This trial tests whether taking coenzyme Q10 (CoQ10) for 12 weeks can reduce fat buildup in the liver of people with mitochondrial diabetes, a rare form of diabetes caused by mitochondrial dysfunction. Participants with the m.3243A>G mutation will take 300 mg of CoQ10 daily, and …

This trial tests different ways to start once-weekly insulin icodec in adults with type 2 diabetes who haven't used insulin recently. Participants are randomly assigned to one of three starting-dose methods: a fixed dose, a dose based on their fasting blood sugar, or a dose based…

This study tests whether using ultrasound to push propolis (a natural bee product) into the skin can help heal diabetic foot ulcers faster. Eighty adults with diabetes and foot ulcers will either get propolis plus ultrasound or standard wound care for 4 weeks. The goal is to see …

This study looks at whether a wearable device that tracks both glucose and ketones can help people with type 1 diabetes avoid diabetic ketoacidosis (DKA), a serious complication. About 1,200 adults and children with type 1 diabetes will use the Abbott Continuous Dual Glucose Keto…

This study tests whether putting type 2 diabetes into remission through a 24-week lifestyle program can also slow biological aging. Researchers will measure changes in an epigenetic clock called DunedinPACE, which tracks how fast the body is aging. The trial enrolls 100 Chinese a…

This trial investigates whether adding a PCSK9 inhibitor to a high-intensity statin can reduce liver fat—measured by a non-invasive FibroScan—in diabetic patients who have recently had a heart attack or unstable angina. Half the participants will receive the combination therapy, …

This trial tests whether a one-time dose of fecal microbiota transplantation (FMT) — taking capsules containing processed donor stool — can improve blood sugar control and reduce thyroid antibodies in adults who have both type 2 diabetes and Hashimoto's thyroiditis. All 38 partic…

This trial explores whether starting transdermal estradiol (a skin gel or patch) soon after menopause can protect the heart and brain in women who have hot flashes and at least one cardiovascular risk factor. One hundred women will be randomly assigned to receive the hormone ther…

This pilot study tests whether a voice-activated smart speaker can help adults aged 50 and older with poorly controlled type 2 diabetes improve their blood sugar levels. Participants receive weekly diabetes education and skills training calls through the smart speaker for 12 week…

This trial compares two types of tooth-colored fillings—zirconia-reinforced glass ionomer and injectable giomer—for cavities on the side of the tooth (Class V) in adults with and without type 2 diabetes. Researchers will track how well each filling stays in place, how it looks, a…

This trial compares two simple diet strategies — eating only during early hours or cutting staple foods like rice and bread in half — each combined with an app-guided exercise program, against exercise alone. Researchers want to see which approach helps adults with obesity and pr…

This study looks at whether a wearable insulin patch pump, guided by a continuous glucose monitor, can better control high blood sugar caused by high-dose steroids in people with sudden hearing loss and diabetes or prediabetes. About 44 participants will be randomly assigned to e…

This study tests four nutrition programs—meal kits, ready-to-eat meals, cooking classes, and motivational texts—in 400 adults with overweight or obesity who use food pantries. The goal is to see which approach best improves diet quality and food security, with the aim of reducing…

This study tests whether switching to a new drug called mazdutide can reduce liver fat more effectively than staying on semaglutide in people with type 2 diabetes and moderate-to-severe fatty liver. Participants who have been on semaglutide for at least 16 weeks are randomly assi…

This study tests whether giving teens with obesity and prediabetes a continuous glucose monitor (CGM) — along with nutritional counseling — helps them eat better and keep blood sugar in check. For three months, participants see their glucose levels in real time and learn how diff…

This study looks at whether eating a daily serving of peanut butter at breakfast can improve blood sugar control, thinking skills, and heart health in middle-aged adults with prediabetes. Participants will either add peanut butter to their first meal or stick with their usual die…

This pilot study tests whether a daily dietary supplement called Diaplex can improve how the body handles blood sugar in healthy adults aged 30 to 65 who have mildly elevated glucose levels. Over 16 weeks, participants receive either Diaplex or a placebo, and researchers measure …

This pilot study tests whether a family-based, culturally tailored diabetes management program can help Native Hawaiian and Pacific Islander adults with type 2 diabetes. Participants attend group education sessions with a family member and receive help connecting to social servic…

This two-part study investigates Lembas Edge, a dietary supplement derived from a peptide. Part 1 tests its safety and tolerability in healthy adults. Part 2 evaluates its ability to control blood sugar after meals in overweight or obese adults with prediabetes. Participants take…

This study tests a smart computer system that helps primary care doctors screen for and manage diabetic kidney disease in adults with type 2 diabetes. The tool automatically calculates kidney function, reminds doctors to order urine tests, and gives personalized treatment advice.…

This study tests a program where social workers screen families of youth with type 1 diabetes for social challenges like food insecurity, then connect them to community resources. The goal is to see if this approach is practical and acceptable, and whether it can improve diabetes…

This study tests whether Bletilla formosana (BF), a traditional Chinese herbal medicine from a Taiwanese ground orchid, can safely help control blood sugar and reduce inflammation in adults with prediabetes. Prediabetes is a condition where blood sugar is higher than normal but n…

This study tests whether secukinumab, a drug that blocks inflammation, can reduce the risk of major heart problems and kidney decline in people with cardiorenal metabolic syndrome and hardened arteries. About 100 adults will receive either secukinumab injections plus standard car…

This trial investigates whether tirzepatide, a medication already used for diabetes and weight loss, can help repair nerve damage in people with diabetic peripheral neuropathy. The study includes 40 adults with diabetes and nerve pain or numbness. Researchers will measure nerve h…

This study tests whether a home-based balance and strength program called Otago exercises can improve mobility, balance, and quality of life in adults with type 2 diabetes. Participants do the exercises 5 days a week for 4 weeks, plus walking. The trial measures how quickly they …

This study tests whether a daily 4-gram dose of ajwa seed powder, made from date seeds, can improve blood sugar control (HbA1c) and body composition in overweight and obese adults aged 30–50 with type 2 diabetes. Over 12 weeks, researchers will measure changes in HbA1c, weight, w…

This study tests whether an AI-powered intensive lifestyle program can help people with obesity and newly diagnosed type 2 diabetes lose weight and control blood sugar as well as the drug tirzepatide. Adults aged 18 to 65 with a BMI of 28 to 40 and recent diabetes diagnosis are r…

This study explores whether eating durian daily for two weeks changes the gut microbiome, metabolism, and blood sugar levels in adults with type 2 diabetes. Forty participants will eat fresh durian pulp and undergo blood and stool tests, plus continuous glucose monitoring. The go…

This study tests whether a set of simple treatments—daily blood pressure checks, dietitian visits, hearing and vision tests, and mood screening—can help preserve thinking and memory after a stroke. About 50 adults who recently had a mild stroke will either receive this care bundl…

This study tests whether a 10-week digital mindfulness program, combined with dietary advice, can help people with type 2 diabetes and obesity lose weight and improve blood sugar control. Participants learn mindful eating techniques through videos and home exercises. The trial me…

This study tests whether verapamil, a common blood pressure medication, can help protect insulin-producing cells in people with cystic fibrosis who have early blood sugar problems or diabetes. Participants take verapamil for several weeks, and researchers measure changes in insul…

This study tests a new combination drug called TriGlytza-01 in overweight adults with type 2 diabetes whose blood sugar is not well controlled by metformin alone. The trial compares TriGlytza-01 to standard metformin over 16 weeks, measuring safety, blood sugar levels, and body w…

This study tests whether a mobile app that provides structured diabetes education can help adolescents with type 1 diabetes improve their blood sugar control, confidence, and self-care habits. Participants aged 10 to 19 with type 1 diabetes and an HbA1c of 7% or higher will use t…

This study tests whether an integrated digital health platform—combining a continuous glucose monitor, activity and sleep tracker, and food log—can improve blood sugar control in adults with type 2 diabetes. Some participants also receive weekly feedback from a healthcare provide…

This study investigates whether regular blood tests can detect liver cancer earlier in people with type 2 diabetes who also have significant liver scarring. Participants are randomly assigned to either a surveillance group receiving specialized blood tests every six months or a s…

This study looks at whether combining peer support with remote patient monitoring can help Black adults with uncontrolled type 2 diabetes improve their blood sugar levels. About 200 participants from Alabama will use the program for 6 months. The goal is to see if this approach l…

This study will test whether eating a diet rich in whole fruit (up to 50% of daily calories) for 17 weeks can improve blood sugar control, reduce liver fat, and lower heart disease risk in adults with type 2 diabetes who do not use insulin. Participants will eat fruit prepared in…

This early-stage trial is testing whether injecting placental stem cells into and around non-healing diabetic foot ulcers is safe. The study involves 12 people with Type 2 diabetes who have a foot ulcer that has not healed for at least four weeks despite standard care. Researcher…

This study compares two 20-week exercise programs for adults aged 30-65 with both type 2 diabetes and obesity. One group attends supervised, in-person sessions twice a week, while another follows the same plan through a mobile app. A third group receives standard medical care onl…

This study tests whether montelukast, a common allergy medication, can reduce damage to the kidneys, eyes, and blood vessels in adults with type 2 diabetes and early kidney disease. The drug works by blocking inflammatory chemicals called leukotrienes, which are linked to diabete…

This trial investigates whether a supplement called butyrate (a substance produced by gut bacteria) and an intensive lifestyle program (Mediterranean diet plus exercise) can reduce liver fat in adults with type 1 diabetes who also have fatty liver disease. Participants are random…

This study tests whether adding blood flow restriction (BFR) training to standard exercise helps adults aged 50-60 with type 2 diabetes improve balance, muscle strength, and physical function. Participants wear compression cuffs on their limbs during low-intensity resistance exer…

This study tests whether an artificial intelligence (AI) tool can help doctors choose better diabetes medicines for patients with type 2 diabetes. Many patients are treated by doctors who are not diabetes specialists, so the AI provides real-time suggestions and predictions about…

This study tests whether people with type 2 diabetes can switch from a weekly injection of dulaglutide to a once-monthly shot called PG-102. The trial involves 60 adults whose blood sugar is well-controlled on dulaglutide. Researchers will compare blood sugar levels and safety ov…

This study compares two exercise programs—combined aerobic and resistance training versus seated soleus push-ups—against standard care in people with type 2 diabetes and diabetic peripheral neuropathy. Researchers will measure blood markers of nerve repair (BDNF, NGF, S100B) and …

This Phase 3 study tests SAB-142, an antibody that targets immune cells, in 108 people aged 5 to 40 with type 1 diabetes. The goal is to see if it can preserve the body's ability to produce insulin over 12 months. Participants receive either the drug or a placebo alongside standa…

This early-stage study tests how the body processes HRS9531 tablets under different dosing conditions. It involves 100 healthy adults aged 18-55 with a BMI between 23 and 35. The goal is to measure drug levels and safety, not yet to treat weight or diabetes.

This study tests whether replacing missing back teeth with dental implants can help people with uncontrolled type 2 diabetes improve their blood sugar levels. The idea is that better chewing leads to healthier eating, which may lower HbA1c. 140 adults will either get implants plu…

This study tests whether the drug finerenone can reduce protein in the urine (a sign of kidney damage) in adults with type 2 diabetes and chronic kidney disease. About 148 participants will receive either finerenone or a placebo pill daily for 6 months, on top of their usual medi…

This study tests a new, simpler weight training program called D-STORM for adults with type 2 diabetes. The program uses easier exercises to build muscle and improve blood sugar control. Over 12 weeks, 56 participants will either do the training plus usual care or just usual care…

This study tests whether a personalized online lifestyle program, with or without a virtual AI coach, can help people with type 2 diabetes improve their blood sugar control. 160 adults will use continuous glucose monitors and attend online group sessions over 12 months, with foll…

This pilot study will test whether supplements made from bilberries and olives can reduce inflammation and oxidative stress in people with prediabetes who are overweight. Researchers will collect blood, urine, and stool samples from 60 participants to measure changes in key healt…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This study tests whether a once-weekly injectable drug called mazdutide can help adults with prediabetes achieve normal blood sugar levels. About 150 participants will receive either a low dose, a higher dose, or a placebo for 24 weeks, along with diet and exercise advice. The ma…

This trial investigates whether a diet rich in polyphenols—including daily cocoa and extra fruits and vegetables—can reduce oxidative stress and improve blood vessel function in pregnant women. Researchers will randomly assign 60 pregnant women to receive dietary counseling and c…

This trial compares an automated insulin delivery system (AID) to standard insulin injections for managing blood sugar in hospitalized adults with type 2 diabetes who have an infection. The AID system uses a continuous glucose monitor and a smart pump to automatically adjust insu…

This study tests whether an interactive educational video, added to standard diabetes education, helps children aged 8 to 14 with type 1 diabetes improve their blood sugar control. The video lets kids make decisions in everyday situations and see the results. Researchers will mea…

This pilot study in Colombia will test whether a nursing program that tailors education and counseling to each patient's needs can help people with high blood pressure or type 2 diabetes stick to their medications and achieve better disease control. About 100 to 200 adults alread…

This study tests a new medicine called bofanglutide (GZR18) for adults with type 2 diabetes whose blood sugar is not well controlled with metformin alone. Bofanglutide is given as a shot under the skin every two weeks, and researchers compare it to semaglutide, a weekly injection…

This study tests a modified oral rehydration salts (ORS) drink designed for diabetic pilgrims at risk of heat stress and dehydration during the Hajj. The modified ORS has adjusted electrolytes and carbohydrates to avoid raising blood sugar. Researchers will compare it to standard…

This study tests whether the shingles vaccine Shingrix and the diabetes drug semaglutide, alone or together, can help preserve the body's ability to make insulin in adults recently diagnosed with type 1 diabetes. The goal is to slow the immune attack on insulin-producing cells an…

This study tests whether a daily prebiotic drink (containing inulin) can improve blood sugar control in 30 postmenopausal women with prediabetes. Participants will consume the drink or a placebo for 4 weeks. The goal is to see if this simple dietary supplement can help reduce the…

This early-phase trial tests a three-step immune treatment for people recently diagnosed with Type 1 diabetes (within 6 months). The goal is to preserve the body's remaining insulin production by calming the immune attack and teaching the immune system to tolerate insulin. Sixty …

This study tests a new way to deliver insulin for type 2 diabetes: a spray applied to the skin instead of an injection. Thirty adults who already use insulin will try the spray for 21 days. Researchers will check if it keeps blood sugar in a safe range and causes less skin irrita…

This study will test an automated insulin delivery system (the Medtronic 780G pump with continuous glucose monitoring) in 20 pregnant women with type 2 diabetes. Participants join before 16 weeks of pregnancy and use the device until delivery. The main goal is to see how much tim…

This study tests whether a 3-month support program, led by a nurse and a community health worker and guided by an AI tool called MEDBRIDGE, can help people with type 2 diabetes manage their medications after leaving the hospital. The program aims to reduce confusion about medicat…

This study compares two glucose monitoring methods—continuous glucose monitors (CGM) and traditional finger-prick tests—in adults with type 2 diabetes who are taking the drug dapagliflozin. The 120 participants will be split into two groups and followed for 12 weeks to see which …

This study will test a program based on WHO guidelines to improve diabetes screening and care in 10 primary health centers in Nigeria. About 2,800 adults with or at risk for diabetes will take part. The goal is to see if the program helps more people get diagnosed and treated.

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study tests a community-to-facility care model to help control type 2 diabetes in Bangladesh. Researchers will compare the new integrated approach with usual care in 20 city wards involving 5,000 adults. The goal is to see if linking community health workers with clinics imp…

This pilot study tests whether starting four approved kidney disease medicines quickly (over about 8 weeks) is safe and effective for people with type 2 diabetes and chronic kidney disease. Researchers will compare this rapid approach to usual care, where medicines are started on…

This pilot study tests whether a home-based high-intensity interval training (HIIT) program can help people who have reversed their type 2 diabetes keep it from returning. Twenty adults who completed the NHS Path to Remission programme will either do HIIT three times a week or co…

This study tests a special education program designed to boost confidence in managing type 2 diabetes. About 400 adults will either receive this program or standard care. The goal is to see if the program improves blood sugar monitoring, diabetes knowledge, and quality of life.

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This study tests a new automated insulin delivery system (NMX8) in 230 adults with type 1 diabetes who are not meeting their blood sugar goals. Participants will use either the NMX8 system or another approved system to see which helps keep blood sugar in the target range more oft…

This study looks at whether a 12-week Mediterranean diet can lower oxidative stress and improve blood sugar control in girls aged 10-18 with type 1 diabetes who have high HbA1c levels. Researchers will measure changes in blood markers and glucose levels. The goal is to see if thi…

This study tests whether a 3-month video-based lifestyle program works better when delivered by a patient's own primary care doctor versus an unfamiliar doctor. The program covers healthy eating, physical activity, and behavior change. Researchers will measure blood sugar control…

This study tests whether five virtual sessions with a trained pharmacist can improve blood sugar, diabetes knowledge, medication adherence, and quality of life in adults with uncontrolled type 2 diabetes. Participants are randomly assigned to receive the tele-education program pl…

This study looks at whether a program called HEARTS can help people who have both high blood pressure and diabetes get better care. About 1,440 adults in Guatemala will take part, and clinics will either use the HEARTS program or continue their usual care. The program includes tr…

This study tests a new way of managing care for older adults (ages 60-74) who have both high blood pressure and type 2 diabetes. About 960 people from rural community health centers will either receive the new integrated care package or continue with standard care. The goal is to…

This study looks at whether people with type 1 diabetes can safely start using an advanced hybrid closed-loop insulin pump system at home instead of in the hospital. Researchers will track blood sugar levels, quality of life, and costs over 12 months in 80 adults. Participants re…

This study tests whether a mobile app can help people with diabetes better manage their condition after leaving the hospital. The app provides education, reminders, and monitoring tools for 90 days. Researchers will compare self-care behaviors, blood sugar control, and hospital r…

This study tests whether adding artificial intelligence to an automated insulin delivery system can improve blood sugar control for people with type 1 diabetes. The AI learns each person's meal patterns and automatically gives insulin boluses without requiring them to announce me…

This study looks at whether using a continuous glucose monitor (CGM) can help manage high blood sugar better than standard finger-prick tests in people with type 2 diabetes who have had a stroke. High blood sugar after a stroke can lead to worse outcomes. The study will involve 8…

This study will test whether applying a special heat-reflecting coating to roofs can improve the health and well-being of 800 households in Colima, Mexico. The coating is designed to keep homes cooler indoors, which may help lower heart rate, improve blood sugar control, reduce d…

This Phase 3 trial tests a new once-weekly injection, NNC0487-0111, against the approved drug semaglutide in 1000 adults with overweight or obesity and type 2 diabetes. Participants receive two weekly shots (active drug plus placebo) to see if the new drug is safe and leads to gr…

This study compares two diabetes medications—imeglimin and metformin—in 176 adults newly diagnosed with type 2 diabetes. Participants will take one of the two drugs for 12 weeks. The main goal is to see which drug better improves mitochondrial function, measured by a blood test c…

This study tests whether a 9-month lifestyle coaching program (individual and group sessions with a dietician) helps obese male firefighters lose weight and improve metabolic health. Fifty participants will be randomly assigned to coaching or usual care. The main outcomes are cha…

This study tests a new approach to managing type 2 diabetes that combines an AI smartphone app with support from family doctors. About 1200 adults in China will use the app to track their meals and get personalized feedback, while also receiving regular check-ins from their docto…

This study tests whether a home-based vibrating calf device can help adults with type-2 diabetes improve blood sugar control. 305 participants in Saudi Arabia will be assigned to active vibration, a sham device, or usual care for 12 weeks. The main goal is to see if vibration-ass…

This study tests whether an automated insulin delivery system (the Omnipod 5) can help people with type 2 diabetes who are on dialysis achieve better blood sugar control. Half of the 84 participants will use the automated system, while the other half will continue their usual ins…

This study tests whether domperidone, a drug that speeds up stomach emptying, can help people with type 1 diabetes keep their blood sugar in a healthy range. About 70 adults with type 1 diabetes who have slow stomach emptying but no digestive symptoms will take either domperidone…

This study tests whether a special education plan using continuous ketone monitoring can lower the risk of diabetic ketoacidosis (DKA) in people with type 1 diabetes who also take SGLT2 inhibitors, a drug class that raises DKA risk. About 75 adults with type 1 diabetes will be en…

This study tests a temporary device placed in the upper small intestine to help control type 2 diabetes and obesity. The implant stays for 6 months and is then removed. Researchers will check if it lowers blood sugar (HbA1c), helps with weight loss, and improves liver health in p…

This study tests whether a liquid carob extract can improve blood sugar levels in 70 adults with prediabetes. Participants take the extract or a placebo twice daily for 90 days. Researchers will measure blood glucose and insulin responses to see if the extract helps control blood…

This study will enroll 120 children and teens with type 1 diabetes who use automated insulin pumps. Participants will be randomly assigned to follow either the standard blood sugar target (70-180 mg/dL) or a tighter target (70-140 mg/dL) for 12 months. Researchers want to see if …

This study tests whether taking melatonin daily can help pregnant women with gestational diabetes better control their blood sugar. Researchers will compare melatonin to a placebo in 150 women. Participants take the supplement or placebo from diagnosis until delivery and have reg…

This study compares two different drug combinations for people with type 2 diabetes whose blood sugar is not well controlled with metformin and sitagliptin. About 200 adults will receive either empagliflozin or glimepiride added to their current treatment. The goal is to see whic…

This study looks at two common diabetes pills—henagliflozin and metformin—to see how they affect muscle mass and blood sugar in older adults (ages 60-85) who are newly diagnosed with type 2 diabetes. About 116 participants will take one of the two medicines daily for 24 weeks. Th…

This study tests whether taking a daily supplement made from bitter melon extract and snakehead fish powder can help lower blood sugar in adults with type 2 diabetes. About 80 participants will take either the supplement or a placebo for 4 weeks. The goal is to see if this natura…

This study tests a program that combines online diabetes education videos with help connecting to social services for low-income Chinese and Latino/a immigrants with type 2 diabetes. The goal is to improve blood sugar control and see if people find the program useful and easy to …

This study tests whether an AI-powered app called 'Smart family doctor' can help people who have had heart surgery (bypass or stent) better control their blood pressure, blood sugar, and cholesterol. About 951 participants from 10-20 hospitals will use the app for personalized he…

This study tests a mobile app called Diactive-1 that provides personalized resistance training and education for children and adolescents with type 1 diabetes. Over 12 weeks, participants follow a tailored exercise program (like strength training or high-intensity intervals) and …

This Phase 3 trial will test whether glimepiride, a standard diabetes pill, can reduce the risk of heart-related death, heart transplant, or worsening heart failure in people with type 2 diabetes and chronic heart failure. About 1,484 participants will receive either glimepiride …

This study tests a natural supplement called Berbevis in 90 adults with slightly high blood sugar (100-126 mg/dL) and a BMI between 25 and 35. Participants will take one of three daily doses (500, 750, or 1000 mg) for 2 months to see if it lowers blood sugar and is safe. The goal…

This study tests a 12-week program that uses WhatsApp to teach people with type 2 diabetes and their family members how to manage the disease better. Participants get videos, quizzes, and weekly phone calls to improve self-care and blood sugar levels. The goal is to see if this a…

This study tests whether adding ganagliflozin tablets to standard care can slow kidney disease progression in 1,244 adults with type 2 diabetes and chronic kidney disease. Participants will take either ganagliflozin or a placebo daily for 120 weeks. The main goal is to measure ch…

This study tests whether using a continuous ketone monitor with a lower alarm threshold (1.0 vs 1.5 mmol/L) can reduce the risk of diabetic ketoacidosis in people with type 1 diabetes who take dapagliflozin, a drug typically used for type 2 diabetes. 115 adults will wear a dual g…

This study tests whether a personalized diet, exercise, sleep, and counseling program can help adults with type 2 diabetes achieve remission. 120 participants will follow the program for 6 months, then be monitored for another 12. The goal is to see if blood sugar levels can retu…

This study tests whether adding WhatsApp-based education and counseling to standard care helps stroke patients with type 2 diabetes improve their lifestyle, blood sugar control, and disease knowledge. 84 participants will be split into two groups: one gets routine education, the …

This phase 2 trial tests whether combining dapagliflozin (a diabetes drug) with SC0062 (a blood vessel drug) can better protect kidneys in adults with type 1 diabetes and chronic kidney disease. Thirty-six participants will try each treatment alone and together in a cross-over de…

This study will compare two diabetes medications, cofrogliptin and linagliptin, when added to insulin therapy in Chinese adults with type 2 diabetes. About 594 participants will take either a biweekly or daily pill alongside their usual insulin. Researchers will track blood sugar…

This study looks at whether showing women detailed pictures of their own blood vessels can motivate them to make healthier choices after having pregnancy complications like preeclampsia or gestational diabetes. About 318 women will be split into two groups: one gets the visual fe…

This study tests a new drug called cofrogliptin against an older drug, acarbose, in 200 adults with type 2 diabetes who have never taken diabetes medication. The goal is to see which drug better lowers blood sugar levels and has fewer side effects. Participants will take one of t…

This study compares two types of foot pads—siliconepads and felted foam—to see which one better reduces pressure under the ball of the foot in people with diabetes who are at high risk for foot ulcers. Researchers will measure pressure relief and ask participants about comfort an…

This study tests Mobili®, a portable digital dispenser that automatically gives the right pills at the right time. Researchers will enroll 96 adults with diabetes or heart disease who take at least two daily medications. Participants use the device for a period, and the study mea…

This study tests whether a 12-week virtual health coaching program powered by artificial intelligence can improve blood sugar control in adults with type 2 diabetes. 206 participants in Indonesia will be randomly assigned to use the DIACOACH app or receive standard diabetes educa…

This study tests whether sending SMS reminders and advice to people with type 2 diabetes and gum disease can improve their blood sugar control over two years. 516 adults who recently completed gum disease treatment will be split into two groups: one gets standard follow-up, the o…

This study will test whether using a continuous glucose monitor (isCGM) helps more people with type 2 diabetes achieve remission compared to standard finger-stick testing. Both groups will follow a low-calorie meal replacement plan and receive diabetes education. The trial aims t…

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …

This study tests whether eating four GlucoBites cookies daily for 12 weeks can improve blood sugar control and reduce the risk of diabetic foot ulcers in adults with type 2 diabetes. The cookies contain an herb called Gynura procumbens. Researchers will compare blood sugar, insul…

Many people with diabetes skip regular eye exams, even though early treatment can prevent vision loss. This pilot study tests whether offering retinal photography during routine occupational health visits makes screening easier to access. Workers with diabetes attend one visit wh…

Researchers at Assiut University are studying whether two ultrasound measures of fetal heart function and blood flow can predict poor outcomes in pregnancies complicated by diabetes or preeclampsia. The study enrolls 69 pregnant women, including those with gestational diabetes, p…

Researchers at Gaziantep City Hospital are using bedside ultrasound to measure stomach volume in pregnant women right before a scheduled cesarean section. They compare women who have gestational diabetes with those who do not, to see whether diabetes affects how much food or flui…

Researchers at Assiut University are studying whether two types of routine blood measurements can help predict how quickly kidney disease worsens in people with diabetes. The first is the Triglyceride-Glucose index, a calculation from standard cholesterol and blood sugar tests. T…

This study tests whether using an AI program to screen for diabetic eye disease during regular primary care visits can get more people to follow up with an eye specialist. It will include 4,000 adults with diabetes who have Medicaid and haven't had an eye exam in the past year. T…

This study tests whether community pharmacies can help find undiagnosed type 2 diabetes and prediabetes in adults living in Irbid, Jordan. Participants without a diabetes diagnosis will fill out a risk questionnaire and, if their score is high, receive a quick finger-prick HbA1c …

This trial tests whether measuring glucose in umbilical cord blood, already collected at birth, can screen newborns for congenital hyperinsulinism, a condition that causes dangerously low blood sugar and can lead to brain damage if missed. Researchers will check the test's accura…

This study is testing whether a new saliva-based test can accurately measure a key marker of blood sugar control called 1,5-anhydroglucitol (1,5-AG). The researchers will compare saliva levels with blood levels and continuous glucose monitor data in 180 adults with and without ty…

This study is testing a new device called PropArm-PosiMoF (PropArm) that aims to measure proprioception—your sense of where your arm is and how much force it uses—in the upper limbs. Researchers will first check how reliable and accurate the device is in healthy young adults, the…

This study looks at whether routine blood test markers—like the Systemic Immune-Inflammation Index and platelet ratios—can help identify diabetic kidney disease in people with type 2 diabetes. Researchers will compare these markers across patients with different levels of albumin…

This trial is testing a new implantable sensor called the HALO System in people with type 1 or type 2 diabetes. The sensor is designed to continuously measure glucose, ketones, and lactate in the fluid just beneath the skin, which could give a more complete picture of metabolic h…

This study investigates whether specific proteins found in tiny particles in the blood (called small extracellular vesicles) can help identify obese individuals who are at risk for developing type 2 diabetes. Researchers will measure levels of two proteins, integrin-β2 and ECM1, …

This trial tests whether a finger-prick HbA1c test can detect type 2 diabetes better than the standard random blood glucose test in at-risk adults living in rural Dali, China. Researchers will compare detection rates and costs among 720 permanent rural residents with no known dia…

This study will screen about 2,200 children aged 2-10 for autoantibodies that signal early type 1 diabetes. The goal is to find the disease before symptoms appear and test if educational programs help families. Researchers will also check if this screening is practical and cost-e…

This study will use ultra-high-frequency ultrasound to measure the thickness of artery layers in 1,740 adults with prediabetes. The goal is to detect early signs of blood vessel damage that could lead to heart disease. Researchers also aim to establish normal values for healthy a…

Researchers are testing an AI chatbot that gives personalized, culturally tailored advice on nutrition, physical activity, and goal setting to adults at risk for type 2 diabetes. About 30 adults aged 18 to 55 will use the chatbot for 6 weeks. The study will check whether the chat…

This study tests whether an enhanced version of the Intensive Diabetes Prevention Program (IDPP) works better than the standard program at recruiting and keeping participants in district health centres. Researchers will compare the two approaches in 170 adults with prediabetes, l…

Researchers are testing whether an intensive Mediterranean diet program started in the first trimester of pregnancy lowers the chance of developing gestational diabetes in women at high risk. The trial enrolls about 1,200 pregnant women aged 18 to 50 with a single, unassisted pre…

Researchers in South Savo, Finland, invite residents turning 45, 50 or 55 to take a blood test that measures many small molecules at once. The test estimates each person's 10-year risk of type 2 diabetes, heart attack, stroke, chronic kidney disease and fatty liver disease. Peopl…

Researchers are testing whether adding family health history and family participation to the standard Diabetes Prevention Program helps adults with prediabetes. The trial enrolls 400 adults with prediabetes and a family member who joins them. Participants are assigned to either t…

Researchers at New York University are testing whether a package of online tools can help low-income families with teens at risk for type 2 diabetes buy and eat more fruits, vegetables, and legumes. The trial enrolls 200 households that receive SNAP or have low incomes and includ…

This study tests whether delivering prepared meals or boxes of unprepared food to pregnant people at risk of gestational diabetes is practical and acceptable. Researchers will give participants either ready-to-heat meals from a diabetes-friendly menu or boxes with fresh produce a…

This trial tests whether giving semaglutide (Wegovy) to women shortly after a pregnancy affected by gestational diabetes can reduce their risk of developing metabolic syndrome, a cluster of conditions that raise the chance of heart disease and diabetes. About 226 postpartum women…

This phase 3 trial tests whether orforglipron, a daily oral medication, can help overweight adults reduce their risk of developing obesity-related complications such as type 2 diabetes, high blood pressure, and high cholesterol, as well as progression to class 1 obesity. Particip…

This trial tests whether combining time-restricted eating (eating only within a 10-hour window each day) with moderate-to-high intensity exercise can improve heart and metabolic health in women who recently had gestational diabetes. Participants are randomly assigned to either an…

This trial tests whether a lifestyle program that includes the partner can help women who had gestational diabetes improve their weight and blood sugar control. Participants receive three months of health education on diet, physical activity, and stress management, with one group…

This study works with First Nations communities in Manitoba to design and test ways to prevent type 2 diabetes in children. Pregnant women with or without diabetes are enrolled, and their children are followed from birth. The approach includes breastfeeding support, nutrition and…

This trial investigates whether a nasal spray containing insulin can prevent postoperative delirium—a sudden, temporary state of confusion—in older adults (65+) with type 2 diabetes who are undergoing liver tumor surgery. Participants are randomly assigned to receive one of two d…

This trial tests a family-focused program for women diagnosed with gestational diabetes in northern Vietnam. The program includes nutrition advice, physical activity guidance, breastfeeding support, and digital tools, delivered from pregnancy through two years after birth. The go…

This trial tests whether golimumab, a drug used for arthritis, can delay or prevent type 1 diabetes in people who have early signs of the disease but normal blood sugar. Participants receive monthly injections of golimumab or a placebo for up to 6 years. The study tracks how long…

This study investigates whether drinking kefir, a fermented dairy drink rich in live bacteria and yeasts, from around 14 weeks of pregnancy until routine diabetes screening can improve blood sugar control and reduce the risk of gestational diabetes. Pregnant individuals are rando…

This study tests whether eating all meals within an 8-hour window (between early morning and early afternoon) combined with morning exercise can prevent sarcopenia—age-related muscle loss—in postmenopausal women with obesity and type 2 diabetes. Forty-five women will follow eithe…

This study tests whether two types of fish oil, EPA and DHA, can improve metabolic health in people at high risk for type 2 diabetes. Over 12 weeks, 84 participants will take daily capsules of EPA, DHA, or a placebo (corn oil) and undergo specialized tests to measure insulin func…

This study tests whether combining continuous glucose monitors (CGMs) with group lifestyle sessions can help people with prediabetes lower their blood sugar and prevent type 2 diabetes. Twenty adults with prediabetes will attend regular group meetings on diet, exercise, and stres…

This study tests a 12-session virtual program to help adults with prediabetes in the UAE prevent type 2 diabetes. The program covers diet, physical activity, sleep, and stress management, and is led by a health coach from the same cultural background. Thirty participants will att…

This study tests whether a virtual health community can help people with prediabetes improve blood sugar control and prevent type 2 diabetes. Participants will receive lifestyle support through a digital platform, including education, guidance, and group interaction. The trial wi…

This European study tests a program called B2B&ME+ that uses a smartphone app and personal health coaching to help pregnant women at high risk for gestational diabetes. 3600 women will be enrolled across four countries. The goal is to see if this approach can reduce diabetes and …

Researchers are testing a program that combines mindful eating and yoga-based movement for adults with type 2 diabetes. The trial enrolls 60 people aged 40 and older who have had diabetes for at least six months. Half receive the mindfulness program and half receive standard diet…

Researchers are testing a diabetes education program that combines standard self-management lessons with hands-on activities involving miniature horses. Children and teens ages 8 to 20 with type 1 or type 2 diabetes, along with their caregivers, attend four sessions led by a diab…

Diabetic foot ulcers heal in only about half of patients, even with standard care. Researchers are testing a turmeric-derived nanoparticle hydrogel applied to the wound alongside usual treatment, such as medication, insulin, or surgery. The trial enrolls adults with type 1 or typ…

Researchers at Mayo Clinic are running a pilot study to see whether clearing a blocked pancreatic duct improves how the pancreas makes insulin in people with chronic pancreatitis. Participants are adults with minimally symptomatic chronic pancreatitis and a duct blockage. The stu…

Researchers are testing DiaFootCare, a mobile app that teaches foot self-care, sends medication and care reminders, guides users through taking wound photos, and shares information with pharmacists. The trial enrolls 139 adults aged 40 to 60 with diabetes and an active foot ulcer…

Researchers are testing whether foot care education delivered with digital tools helps people with type 2 diabetes take better care of their feet. Ninety participants are randomly assigned to either a structured education program or standard care. The program includes two face-to…

This study tests whether taking vitamin D supplements can reduce nerve pain, improve sleep, and boost quality of life in people with type 2 diabetes who have nerve damage. Researchers will give vitamin D to 150 adults with low vitamin D levels and track their pain and sleep over …

This trial tests whether a lidocaine gel applied to the feet can ease painful diabetic neuropathy as well as the oral drug duloxetine. Adults with type 2 diabetes and moderate-to-severe nerve pain will be randomly assigned to one of the two treatments for 8 weeks. Researchers wil…

This trial tests whether a virtual reality version of Mindfulness-Based Stress Reduction (MBSR-VR) can be delivered to young adults aged 16 to 20 with type 1 diabetes who report high stress. Participants will attend group sessions that teach meditation, body awareness, and mindfu…

This study tests whether adding moderate-intensity aerobic exercise (like treadmill walking) to standard shoulder rehabilitation can reduce shoulder pain and disability in people with type 2 diabetes who also have a common shoulder tendon problem called supraspinatus tendinopathy…

This trial is testing whether a combination of Bao Yuan Tang, a traditional Chinese medicine extract, and galactooligosaccharides, a type of prebiotic, can improve sleep quality, reduce fatigue, and support better metabolism in female nurses who work night shifts. The study will …

This trial tests whether a structured art therapy program, grounded in positive psychology, can improve self-compassion and hope in children aged 8 to 12 who are staying in a hospital ward. Half of the 80 participants will receive the art therapy sessions alongside standard nursi…

This trial tests whether adding pain neuroscience education and graded motor imagery to standard physiotherapy can improve pain, movement, and fear of movement in people with type 2 diabetes and frozen shoulder. Fifty adults aged 40-65 with diabetic adhesive capsulitis will recei…

This pilot study tests a software tool called NEXT that gives personalized advice on insulin and carbohydrate adjustments before and after exercise for adults with type 1 diabetes. Twenty participants will try three different approaches to managing their blood sugar around exerci…

This trial tests whether inhaling bitter orange oil before bed can improve sleep quality and reduce fatigue in adults with type 2 diabetes. One hundred participants will be randomly assigned to inhale either bitter orange oil or plain water for three nights. On the fourth morning…

This study tests whether a structured cognitive training program can improve memory, attention, and other thinking skills in older adults who have type 2 diabetes and mild cognitive impairment. Participants will be randomly assigned to either the cognitive intervention or a contr…

This early-stage study tests whether the drug sodium phenylbutyrate (NaPB) can improve blood pressure and blood vessel function. It will include 30 healthy volunteers and people with diabetes. The goal is to see if NaPB might help ease vascular problems linked to diabetes.

This study investigates whether a device called FREMS, which delivers rhythmic electrical pulses to the legs, can improve blood flow, reduce nerve pain and numbness, and enhance quality of life in people with type 2 diabetes who have peripheral neuropathy and poor leg circulation…

This study investigates whether the 4-7-8 breathing technique can help reduce pain and anxiety in people with type 2 diabetes and diabetic neuropathy during an electromyography (EMG) procedure. EMG can be uncomfortable and stressful, and this trial compares the breathing techniqu…

This study tests whether an AI-powered educational platform can help parents of children with type 1 diabetes count carbohydrates more accurately and manage diabetes better. About 80 parents will either use the AI platform plus usual care or usual care alone for 12 weeks. The goa…

This study tests whether individualized video consultations can help adults with type 1 diabetes manage exercise and blood sugar more confidently. Sixty participants will receive up to three 30-minute sessions with a doctor or exercise specialist. The goal is to improve self-mana…

This study looks at whether morning or evening exercise is better for controlling blood sugar in men with type 2 diabetes. Sixty men aged 40-60 will do high-intensity interval and resistance training for 12 weeks, either in the morning or evening. Researchers will measure changes…

This study will test a mindfulness-based education program for adults with type 2 diabetes. The goal is to see if it reduces diabetes-related distress and helps people feel more empowered to manage their condition. 70 participants will take part in group sessions that combine min…

This study tests whether light physical activity after meals can improve blood sugar levels in adults with metabolic syndrome and prediabetes. Twenty-five participants will try three routines in random order: sitting, a 15-minute walk, or brief resistance exercises like squats ev…

This pilot study tests an 8-week program called DREAM that uses AI-powered text messages to encourage physical activity in adults with type 2 diabetes. Twenty participants will receive twice-weekly messaging and set weekly activity goals. The study focuses on whether the program …

This study tests whether Anakinra, a drug that reduces inflammation, can prevent dangerous drops in blood sugar after meals in a patient who had his stomach removed. The 52-year-old man also has kidney failure and needs dialysis. Over 10 weeks, he will receive either Anakinra or …

This study will test whether a single dose of beetroot juice can improve blood pressure and heart rate recovery after light cycling in adults with type 2 diabetes. About 20 participants aged 40-65 will receive either beetroot juice or a placebo in random order. The goal is to see…

This study tests if a gentle electrical stimulation on the outer ear can activate the vagus nerve and reduce nausea, vomiting, and stomach discomfort in people with diabetes and gastroparesis. Sixty adults with both conditions will receive the treatment and report symptom changes…

This pilot study tests a virtual program called STRIDE, designed for adults aged 21-44 who have type 2 diabetes and are raising children. The program includes three online sessions focused on self-care, healthy eating, and family activity. Researchers will measure changes in diab…

This study compares pain after root canal therapy done in one visit versus two visits for people with diabetes. 200 patients aged 12-60 with a single-rooted tooth needing root canal will be randomly assigned to either a single session or two sessions. The main goal is to see whic…

This study tests a single injection of CIL001 (Paliroden) into the ear to repair nerve damage that causes hearing problems in people with type 2 diabetes. The trial includes 135 adults aged 45-75 with diabetes for at least 5 years. Researchers will check safety and whether the in…

This study tests a structured psycho-social program (PSP) for adults aged 30-40 with type 2 diabetes who have mild-to-moderate mental health issues. Over 6-8 sessions, participants learn to manage stress, challenge negative thoughts, and improve daily habits. The goal is to reduc…

This study will test if a program combining supervised exercise and perineal massage during pregnancy can help prevent problems like urinary incontinence, depression, and gestational diabetes. About 2000 healthy pregnant women will be randomly assigned to either the program or us…

This pilot study will test whether five weekly sessions of Swedish massage can reduce stress and improve blood sugar control in 20 adults with type 1 diabetes. Researchers will measure stress hormones, inflammation, and glucose levels before and after the massage program. The goa…

This study will test three approaches to reduce painful nerve damage in people with type 2 diabetes. Sixty adults aged 35-85 with moderate to severe neuropathy will receive either a special massage-like therapy (INF), a diet guided by a food sensitivity test (NVIf), or both toget…

This study tests whether teaching parents of children with type 1 diabetes can improve the child's diabetes management and quality of life. About 42 families with children aged 8-12 will take part. Parents will receive special education sessions and motivational interviews. The g…

This study tests a 10-session online program called REDCHiP for parents of young children (up to age 8) with type 1 diabetes. The program uses cognitive behavioral therapy to help parents manage their fear of hypoglycemia (low blood sugar) and reduce diabetes-related distress. Ab…

This study will follow 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or have metabolic issues. Researchers will collect blood, saliva, urine, and stool samples during routine clinic visits, along with questionnaires about diet, sleep, and mood. The goal is …

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

Researchers at the University of California, San Francisco are testing whether short bursts of high-intensity exercise control blood sugar as well as longer, moderate workouts. The study enrolls 12 non-diabetic or pre-diabetic adults who wear a continuous glucose monitor for 11 d…

This pilot study will check if it's possible to collect useful nutrition and health information from 30 adults with diabetic foot ulcers. Researchers want to see if they can recruit enough people and gather complete data. The goal is to learn about patients' diet, body compositio…

This study will test whether combining continuous glucose monitor (CGM) data with information from a smartwatch and a phone app (like meals and activity) can better predict blood sugar levels in people with type 2 diabetes. Thirty-six adults will wear a CGM and smartwatch and log…

This study will test if an AI chatbot can give helpful nutrition advice to pregnant women. About 100 women will either use the chatbot or get standard care. The goal is to see if the chatbot is easy to use and if it helps improve diet and knowledge about conditions like gestation…

Researchers at Assiut University Hospitals are studying whether a simple calculation from two routine blood tests, the leukocyte glucose index, relates to how severe diabetic ketoacidosis becomes in adults with diabetes. The index multiplies white blood cell count by blood sugar …

People with type 2 diabetes often have high lactate levels, which researchers link to heart failure and thinking problems. This early study uses a carbon-13 MRI contrast agent called hyperpolarized pyruvate to watch how the heart and brain process pyruvate, lactate, and bicarbona…

Researchers at Al-Azhar University are studying whether type 2 diabetes is linked to changes in women's hair and scalp. The study compares 130 women aged 20 to 60, half with diabetes for at least a year and half healthy controls matched by age. Participants undergo clinical hair …

Researchers at Kırıkkale University are studying how GLP-1 receptor agonists, drugs prescribed for type 2 diabetes and obesity, affect saliva and oral health. Fifty adults aged 18 to 65 who are newly prescribed these drugs provide saliva samples and undergo dental exams at the st…

This study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…

Researchers are studying whether extracellular vesicles released by pancreatic islets can indicate islet quality and be used to improve their fitness before transplantation. The trial involves adults with type 1 diabetes who are on the waiting list for an islet transplant. The go…

This study looks at children and teenagers with type 1 diabetes to see how many have abnormal liver function tests. Researchers will check blood samples for signs of liver stress and try to find patterns or risk factors. The goal is to understand whether liver issues are common i…

Researchers at Mass General Brigham are testing whether genetic information can help identify people who might benefit from early screening for type 1 diabetes, even before they feel sick. The study involves 150 adults from the MGB Biobank who agreed to be recontacted. Participan…

This phase 1 trial asks whether a single dose of tirzepatide changes how quickly the stomach empties in adults with type 1 diabetes who are overweight or have obesity. Researchers will give participants either tirzepatide or a placebo injection, then measure stomach emptying usin…

Researchers are testing whether standard blood tests can indicate the quality of stem cells taken from the heel bone during foot or ankle surgery. The study includes adults aged 40 to 80, some with type 2 diabetes and diabetic foot ulcers. Before surgery, participants give blood …

Doctors in the ICU often check blood gases through an arterial line, but that carries risks like clots and infection. This study asks whether blood drawn from a central venous line, which is already in place for other care, gives equally useful information. Researchers will compa…

This study investigates how different genetic pathways affect the body's response to food and to a short course of orforglipron, an oral GLP-1 drug used for weight management and blood sugar control. Researchers will enroll about 100 adults, with or without type 2 diabetes, who a…

This study investigates whether the speed at which blood sugar falls after starting a new diabetes medicine affects small blood vessels in the eye. Adults with type 2 diabetes who are beginning a GLP-1 receptor agonist or an SGLT2 inhibitor will undergo advanced eye scans and blo…

This study follows 100 adults with diabetes who are on peritoneal dialysis or about to start it. Researchers use a continuous glucose monitor to track blood sugar levels over time. They will look for links between glucose patterns and health events like hospitalizations, heart pr…

This study looks at how to safely use a type of diabetes drug (SGLT1&2 inhibitor) in people with type 1 diabetes and mild to moderate chronic kidney disease. The goal is to find out what increases the risk of a serious condition called diabetic ketoacidosis (DKA). About 80 adults…

This study explores the real-life experiences of adults with type 2 diabetes who have used a continuous glucose monitoring (CGM) device daily for at least a year. Through in-depth interviews, researchers aim to uncover the benefits and challenges people face with these devices. T…

This study is investigating how GLP-1 receptor agonist drugs, commonly used for type 2 diabetes, affect the movement of the entire digestive tract. Researchers will use a special swallowed capsule to measure gut motility in 20 adults before they start the medication and again aft…

This study looks at how children and teens with type 1 diabetes use the Omnipod 5, a tubeless insulin pump that automatically adjusts insulin based on glucose readings. Researchers will track how quickly families adopt the system, who chooses it, and how it affects blood sugar co…

This study will test how well the Dexcom G7 continuous glucose monitor works in 100 adults undergoing heart surgery with cardiopulmonary bypass. The device's readings will be compared to standard blood glucose checks during and after surgery. The goal is to see if the monitor sta…

This study looks at anonymized health records from about 100,000 people in a Turkish hospital network to see how common cardiometabolic conditions—like obesity, type 2 diabetes, heart disease, fatty liver, and kidney disease—are and how often they occur together. By tracking thes…

This study looks at how the mouth heals after gum surgery in people with and without diabetes. Researchers will measure wound size and track healing over 12 weeks. They will also check bacteria and inflammation levels to see what affects recovery. The goal is to learn why healing…

This study looks at how well the mouth heals after gum surgery in people with diabetes compared to those without. Researchers will track healing, measure gum recession, and check factors like bacteria and inflammation. The goal is to understand what affects recovery in diabetic p…

This study investigates whether targeted electrical stimulation of peripheral nerves can improve blood flow and blood vessel function in the lower limbs of veterans with diabetic peripheral neuropathy. Researchers will measure skin blood flow, vessel density, and oxygen levels us…

This observational study looks at whether two classes of diabetes medications—SGLT2 inhibitors and GLP-1 receptor agonists—help protect the heart in Korean adults with type 2 diabetes. Researchers will analyze health records from multiple hospitals to compare heart attack, stroke…

This study tests whether continuous glucose monitors (CGMs) like the Dexcom G7 can be safely and effectively used in intensive care units. The monitors provide real-time blood sugar readings and alarms for dangerously high or low levels, potentially reducing the need for frequent…

This study tracks blood sugar changes after an epidural steroid injection for back or leg pain. Researchers will compare 36 adults with and without type 2 diabetes using a continuous glucose monitor worn for 15 days. The goal is to see if the injection causes higher or longer-las…

This study looks at how muscle cells send tiny packages called extracellular vesicles to fat cells during exercise, which may affect how the body processes sugar and fat. Researchers will compare 40 adults—some with prediabetes and some healthy—to understand why some people's fat…

This study looks at how anticipated stigma and illness identity affect quality of life in men with hypogonadism (low testosterone). It compares these men to those with other chronic endocrine conditions like diabetes, hypothyroidism, or hypertension. The goal is to see if these p…

This study looks at how common fatty liver disease (MASLD) is in adults with type 1 diabetes. Researchers will check 250 adults with type 1 diabetes for signs of liver fat and scarring, using non-invasive tests. The goal is to understand if type 1 diabetes raises the risk of live…

This study looks at how beta-cells (which make insulin) respond to growth hormone in people with prediabetes. Researchers will measure insulin release in 10 adults with impaired fasting glucose or impaired glucose tolerance. The goal is to better understand what raises the risk o…

This study looks at how the hormone glucagon works with insulin in the liver to manage blood sugar. Researchers want to understand glucagon's multiple, sometimes opposite, roles to create better diabetes medicines. Forty healthy adults aged 18-45 will have two 5-hour sessions whe…

This study will test two new non-invasive devices (HEMI and SPG-NINOX) that measure small blood vessel function in 165 adults. Participants include healthy volunteers and people with high blood pressure, type 2 diabetes, or chronic kidney disease. The goal is to see if these devi…

This observational study looks at whether the total antioxidant capacity of a person's diet is linked to levels of inflammation and nutritional health in adults with type 2 diabetes. Researchers will compare people with well-controlled blood sugar to those with poorly controlled …

This study investigates whether blood levels of irisin, a protein linked to glucose metabolism and nerve protection, differ in people with type 2 diabetes who have diabetic polyneuropathy (nerve damage) compared to those without it and healthy controls. Researchers will measure i…

This study looks at whether levels of a protein called Neuregulin-4 (NRG4) in the blood are linked to obesity, insulin resistance, and different diabetes treatments in people with type 2 diabetes. Researchers will compare NRG4 levels across groups including obese and non-obese pa…

This early-stage trial is testing two experimental oral drugs, AD-236A and AD-236B, in healthy adult volunteers. The goal is to see how the drugs interact when taken together and whether the combination is safe. The study involves 44 participants aged 19 to 55 and will measure dr…

This observational study is investigating whether vitamin D levels are linked to cholesterol and other blood fats in obese adults with type 2 diabetes. Researchers will measure vitamin D status and lipid profiles in 150 participants from a diabetes clinic in Cairo. No treatments …

This study investigates whether psychological well-being and social support influence how well people with diabetic kidney disease manage their own health. Adults with type 2 diabetes and diabetic kidney disease who are not on dialysis will fill out questionnaires about their emo…

This observational study investigates whether cardiac autonomic neuropathy (nerve damage affecting the heart) changes the risk of death and cardiovascular events in people who have diabetes, coronary heart disease, and sleep apnea. Researchers will follow 326 participants, dividi…

This observational registry study follows 2,250 adults with cardiovascular-kidney-metabolic syndrome (CKMS) at five hospitals in India. Researchers aim to understand how the condition progresses over 12 months, how it affects quality of life, and what treatments doctors prescribe…

This study follows 425 adults with type 2 diabetes and chronic kidney disease who are taking finerenone, a standard medication. Researchers collect blood and urine samples over four months to look for biomarkers that predict whether the drug helps reduce kidney damage. The goal i…

This study investigates whether insulin resistance, measured by the TyG index, is linked to the no-reflow phenomenon—where blood flow fails to restore properly—after primary PCI (stenting) for heart attacks in people with type 2 diabetes. Researchers will also examine how insulin…

This study looks at whether taking a combination of GLP-1 receptor agonists and SGLT2 inhibitors before being hospitalized with pneumonia improves early outcomes in adults with type 2 diabetes. Researchers analyzed health records from over 70,000 patients, comparing those on both…

This study follows 7,000 adults with type 2 diabetes and a common form of fatty liver disease (MASLD) to see how liver problems influence the risk of heart attacks, strokes, and heart failure. Researchers will track participants for five years, using advanced models to separate t…

This study investigates whether blocking GLUT1, a protein that helps immune cells use sugar, can reduce the autoimmune attack that destroys insulin-producing cells in type 1 diabetes. Researchers will analyze stored blood samples from adults with type 1 diabetes and test immune c…

This study uses a hidden continuous glucose monitor (CGM) to track blood sugar levels in people with diabetes during vitrectomy eye surgery. The monitor records glucose every 15 minutes but does not show readings to doctors or patients, so it does not affect care. The goal is to …

This study uses advanced MRI and spectroscopy to track how semaglutide therapy changes muscle strength, volume, and quality over six months. Researchers will measure muscle function and fat infiltration in people with type 2 diabetes and obesity. The goal is to understand whether…

This pilot study tests a new continuous glucose monitor (CGM) called SAVA in 20 adults with Type 1 Diabetes. Participants wear three SAVA sensors and one standard sensor for 15 days to check how well the SAVA measures blood sugar compared to lab tests. The study also looks at com…

This global registry study follows 5,000 people with diabetes who use a Dexcom continuous glucose monitor (CGM). Researchers will track changes in HbA1c, a key measure of blood sugar control, over time. The goal is to understand how CGM use affects diabetes management in real-wor…

This study looks at how menopause and poor sleep change heart structure and function in women aged 48-58 with type 2 diabetes. Researchers will use heart ultrasounds to measure early signs of heart strain. No treatment is given; the goal is to better understand these risks.

This study tests whether a large language model (LLM) — a type of AI — can help village doctors make better care plans for patients with type 2 diabetes and high blood pressure. About 20 rural doctors will review standardized patient cases, with half receiving AI-assisted decisio…

This study screens adults aged 18 and older in suburban and peri-urban areas of Faisalabad, Pakistan, for four major noncommunicable diseases: diabetes, hypertension, obesity, and high cholesterol. Participants who are found to have these conditions are referred to doctors for st…

This study follows 3,000 adults in Qatar—both citizens and long-term residents—to track how cardiometabolic conditions like diabetes and heart disease develop over time. Participants are grouped by blood sugar status (normal, pre-diabetes, or diabetes) and monitored for major car…

This study will follow 5,500 first-time pregnant women to see if blood tests and eye scans can predict complications like preeclampsia, fetal growth restriction, and gestational diabetes. Researchers will collect samples and images at different points during pregnancy and compare…

The EXPAND study is a research project that will enroll 440 adults with and without pancreatic conditions to understand why type 2 diabetes varies so much from person to person. Researchers will collect data on metabolism, genetics, and pancreas health to identify distinct diabet…

This early-stage trial will check whether two different ways of making the experimental drug GZR4 produce the same levels in the blood. About 64 healthy men will receive a single shot of one version or the other. The study is not designed to treat diabetes, but to ensure future b…

This study aims to identify newborns with a high genetic risk of developing type 1 diabetes. Researchers will screen 50,000 infants using a simple genetic test to find those with a greater than 10% risk. The goal is not to treat diabetes, but to find eligible babies for future pr…

This study compares two ways of inviting people to screen for type 1 diabetes at home: a simple email or letter versus a personal phone call. Researchers want to see which method leads more people to complete and return a home screening kit. Participants are adults and children a…

This study will test whether a therapeutic patient education program is acceptable and useful for adults living with obesity and related conditions like diabetes or joint problems. About 42 participants will take part in a one-day group session and follow-up workshops, then answe…

This study will follow 200 people with colorectal cancer and healthy controls to explore how genes, blood sugar, and immune responses are connected. Researchers will analyze blood and tissue samples to find shared genetic factors that may influence both cancer and diabetes. The g…

This study follows 500 people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't fill properly. Researchers will use heart ultrasounds, blood tests, and medical history to group patients into different subtypes. The goal is to better understand …

This study tests whether adding health messages to lab reports can reduce serious heart and kidney problems in people with both diabetes and chronic kidney disease. Over 125,000 participants will be randomly assigned to receive either routine care or extra health messages in thei…

This study uses a wearable glucose sensor and artificial intelligence to understand how healthy adults process sugar. Researchers will track blood sugar patterns for 14 days and link them to diet, activity, and health measures. The goal is to develop personalized nutrition tools …

This study looks at how removing part or all of the pancreas changes blood sugar control in adults who already have diabetes and need pancreatic surgery. Researchers will track 408 patients over time to see if diabetes gets worse depending on how much pancreas is removed. The goa…

This study tests whether special amino acid-enriched drinks can help people on GLP-1 weight-loss drugs maintain muscle and prevent weight regain. Eight adults aged 30-65 who recently started GLP-1 medication will drink different supplement beverages, and researchers will measure …

This early-stage trial will test a new tablet that combines two common drugs—one for type 2 diabetes and one for high blood pressure—in healthy volunteers. The goal is to see if the single pill works the same in the body as taking the two drugs separately. Thirty-six healthy adul…

This 5-year study will follow 2,800 overweight or obese Chinese adults aged 18-60 to see how their health changes over time. Participants will use a smartphone app to track their data and get lifestyle support. The goal is to understand who develops diabetes or complications, and…

This observational study will check if diathermy, a tool used during surgery to stop bleeding, affects the accuracy of continuous glucose monitors in people with Type 1 Diabetes. About 126 adults and children will have their glucose readings compared before and after diathermy us…

This study looks at how a diet high in acid-forming foods (like meat, cheese, and grains) affects kidney function and blood sugar in people with type 2 diabetes and chronic kidney disease. Researchers will ask 80 participants to follow either a high- or low-acid diet for 8 weeks …

This study tracks physical activity in 175 pregnant women with type 1 or type 2 diabetes to see how it relates to blood sugar control and mental health. Participants wear an activity monitor for a week each trimester and complete questionnaires. The goal is to understand current …

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study looks for genetic differences that might explain a rare form of diabetes that is not caused by the immune system. Researchers will study 118 adults of African or Indian ancestry in the French West Indies who have this atypical diabetes. The goal is to find gene changes…

This study looks at whether wearing a continuous glucose monitor (CGM) and receiving education can help teenagers with prediabetes improve their blood sugar levels and adopt healthier behaviors. Twenty-five teens aged 13-17 will take part in a 20-week program, first receiving sta…

This study will look at health records of 10,000 patients in Qatar who were hospitalized for heart problems and have diabetes or prediabetes. Researchers will use artificial intelligence to find patterns that predict future heart attacks, strokes, or death. The goal is to create …

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—just observation and data collection over time.

This study looks at whether fear of hypoglycemia (low blood sugar) affects the heart, physical activity, and exercise ability in children and teens with type 1 diabetes. About 67 participants aged 10-18 will answer questionnaires and have their heart rate, blood pressure, and oxy…

This early-stage study tests a new medicine called efsubaglutide alfa (YN-011) in 48 healthy adults in Brazil. The goal is to check the drug's safety, how the body processes it, and its effects. Participants receive a single injection of either the drug or a placebo and are monit…

The SIRENA study will follow 300 children and adults who have tested positive for islet autoantibodies, which are early markers of type 1 diabetes. Over up to 10 years, researchers will track how their blood sugar, immune system, and metabolism change. The goal is to better predi…

This study will test a two-step screening program for advanced liver fibrosis in people with type 2 diabetes. About 1,714 patients will first get a blood test (FIB-4), and if that suggests risk, they will receive a liver stiffness measurement (transient elastography). The goal is…

This study tests a companion mobile app that wirelessly collects real-time glucose readings from Dexcom G7 continuous glucose monitors (CGMs) used by children with diabetes in the hospital. The app sends the data to a central hospital database, making it accessible to care teams …

This study looks at how different temperatures—cold, normal, and hot—affect blood sugar levels and insulin absorption in adults with type 1 diabetes. Thirty participants will sit in a special room at each temperature for two hours while researchers monitor their blood sugar, hear…

This study will check how often fatty liver disease and liver scarring happen in adults with type 1 diabetes or LADA in Quebec. About 100 participants will get a special liver scan (FibroScan) during one visit. The goal is to find hidden liver problems that current checkups might…

This study looks at how the amount of fat in a meal and a woman's menstrual cycle affect blood sugar after eating in people with type 1 diabetes. Fifty adults (25 women, 25 men) will eat standardized low-fat and high-fat meals while wearing continuous glucose monitors. The goal i…

This study will test whether a new e-learning app can help school nurses feel more confident and knowledgeable about diabetes devices like insulin pumps and continuous glucose monitors. About 86 school nurses in Pennsylvania will use the app over 16 weeks and complete surveys bef…

This study will follow 1300 women with type 1 diabetes who had a pregnancy. Researchers want to see if a high risk of preeclampsia (a dangerous pregnancy complication) in the first trimester is linked to hidden heart disease years later. Participants will have an ultrasound to ch…

This observational study looks at how having type 2 diabetes impacts quality of life in cancer patients receiving immunotherapy. Researchers will compare changes in well-being over six months between patients with and without diabetes. About 920 adults with solid tumors will fill…

This study will check if low vitamin D levels are linked to higher insulin resistance in 165 adults with type 2 diabetes. Researchers will use a simple blood test called the triglyceride-glucose index. The goal is to better understand how vitamin D might affect diabetes control.

This study looks at whether using a continuous glucose monitor (CGM) can help find and manage low blood sugar in newborns whose mothers had insulin-treated gestational diabetes. About 120 babies will be monitored for the first 72 hours after birth. The goal is to see if CGM catch…

This study looks at how gut bacteria are linked to obesity and type 2 diabetes in New Caledonia, where these conditions are very common. Researchers will collect blood, urine, and stool samples from 270 adults to analyze their gut microbes and related chemicals. The goal is to be…

This study will look at 3000 young Asians in Singapore who do not have diabetes yet. Researchers will use blood tests, glucose monitors, food diaries, and body measurements to find better ways to detect diabetes early. The goal is to create new risk tools to identify young people…

This study looks at whether it's practical to screen close relatives of people with type 1 diabetes for early signs of the disease. About 1,000 adults in Quebec will have blood tests and answer questionnaires. If they show early markers, they will be monitored either by the resea…

This study looks at whether a moldable silicone toe divider (Otoform) can help people with diabetes who have had a lesser toe amputated. Researchers want to see if it is possible to run a larger trial by testing how well patients accept the device and how it affects walking and f…

This study will analyze medical records of 400 adults with type 2 diabetes or obesity to see how semaglutide affects blood sugar, heart, and kidney health over three years. Researchers will compare those taking semaglutide to those on other diabetes medications. The goal is to un…

This study looks at how healthy people without diabetes respond to sitagliptin, an FDA-approved diabetes medication. Researchers want to understand why some people's bodies process sugar differently after taking the drug. About 400 healthy Amish adults will take part in two clini…

This study will give 10 overweight men a daily pill called ATR-258 for 8 weeks to see how it changes signaling pathways in their muscles. Researchers will take small muscle samples and measure blood sugar control and body composition. The goal is to understand the biology, not to…

This pilot study tests whether fecal microbiota transplantation (FMT) can change the gut microbiome in 30 people with type 2 diabetes and stable coronary artery disease. Participants receive processed stool from healthy donors via colonoscopy. The goal is to see if this alters gu…

This study looks at how well ankle numbing (ankle block) works in people with and without diabetes during foot or ankle surgery. Researchers will measure how fast the numbing starts, how much pain medicine is needed afterward, and if blood sugar control plays a role. The goal is …

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study aims to understand how dry eye disease and diabetic macular edema (a swelling in the back of the eye) are related in people with diabetes. About 50 adults with diabetes for over 8 years will have their eyes tested using questionnaires, tear measurements, and imaging. T…

This study looks at how fasting during Ramadan impacts treatment adherence, emotional well-being, and blood sugar levels in adults with type 2 diabetes. Researchers will compare those who fast and those who do not, using surveys and HbA1c tests before and after Ramadan. The goal …

This study will follow 3000 adults with chronic heart failure to see how often they also have kidney disease, diabetes, fatty liver, or clogged arteries. Researchers want to understand how these conditions interact and affect patient outcomes over two years. No new treatments are…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This early-stage study looks at how three popular statins (atorvastatin, rosuvastatin, simvastatin) affect blood sugar levels in 100 healthy volunteers. Participants will take the medicine for two days, and researchers will measure changes in blood glucose, insulin, and C-peptide…

This study looks at how artificial sweeteners (saccharin, sucralose) and a natural one (erythritol) affect blood sugar control, blood clotting, and heart disease risk in 80 adults with prediabetes. Participants will be randomly assigned to take one sweetener or water for two week…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study will give 50 women who had gestational diabetes a continuous glucose monitor (Stelo) to wear after giving birth. The goal is to learn how their blood sugar levels change during daily life and how well the device works. Participants will use the monitor for up to 6 week…

This study looks at ways to help VA medical centers put proven health programs into practice for women Veterans in midlife. The programs focus on heart health, weight management, diabetes, mental health, and menopause care. Researchers will test two support strategies at 18 VA si…

This study will screen up to 10,000 adults aged 18-75 who are overweight or have metabolic issues like high blood sugar or cholesterol. Researchers will use questionnaires, blood tests, and liver ultrasounds to find out how common fatty liver disease is and what factors increase …

This study compares two ways of making treatment decisions for people with diabetes and severe blockages in all three main heart arteries. One group gets a real-time online discussion among heart specialists during an angiogram, while the other gets usual care. The goal is to see…

This study looks at whether training general practitioners to better monitor and manage kidney health can slow the loss of kidney function in people with type 2 diabetes. About 360 patients aged 50 and older with early kidney problems will take part. Doctors in the intervention g…

This study will use a safe ultrasound test to look for early signs of artery hardening in 96 adults who have both type 2 diabetes and stage 3 chronic kidney disease. Many patients with these conditions develop heart problems without symptoms. The goal is to find out how common th…

This study will use a special eye scan called OCT to look for early signs of retinal damage in people with diabetes who have no vision problems. Researchers want to see if these scans can detect changes before symptoms appear. About 112 participants will get a detailed eye exam, …

This pilot study tests a program that provides education, motivation, and social support to adults with diabetes and early-stage chronic kidney disease (CKD). The goal is to see if the program is practical and helps patients stay motivated, learn about kidney disease, and use sup…

This 10-year observational study will follow 10,000 adults with diabetes, metabolic disorders, and related conditions like high blood pressure and fatty liver disease. Researchers will collect routine medical data to identify markers of disease severity and activity. The goal is …

This study looks at how diabetes affects small blood vessels and nerves in the eyes and brain. Researchers will use advanced imaging to detect damage and test a traditional Chinese herbal medicine called Tangshen'an Granules to see if it can help. 160 adults with diabetes will ta…

This study will follow 100 adults with diabetes and foot ulcers to see how non-vascular factors like nerve damage, infection, and poor blood sugar control affect ulcer severity and healing. Researchers hope to find which risk factors can be changed to prevent ulcers from coming b…

This study looks at a simple blood test called the triglycerides glucose index in people with type 2 diabetes. Researchers want to see if this index can help predict microvascular complications. The study will follow 200 adults aged 18 to 65.

This study will follow 20 adults with type 2 diabetes who are starting on semaglutide or tirzepatide. Researchers will use PET/CT scans and physical tests to track changes in muscle mass, strength, and bone health over one year. The goal is to find early warning signs of muscle o…