Could a daily glass of kefir during pregnancy ward off gestational diabetes?
NCT ID NCT07682077
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This study investigates whether drinking kefir, a fermented dairy drink rich in live bacteria and yeasts, from around 14 weeks of pregnancy until routine diabetes screening can improve blood sugar control and reduce the risk of gestational diabetes. Pregnant individuals are randomly assigned to consume 250 mL of kefir daily or continue their usual prenatal care. Researchers measure blood glucose, insulin, gut microbiome changes, and other metabolic markers to see if this simple dietary addition makes a difference.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Kefir (fermented dairy beverage)
- What this could lead to
- If effective, drinking kefir during pregnancy could become a simple, food-based way to help prevent gestational diabetes and improve metabolic health for mothers and babies.
- What could go wrong
- This is a small, early-stage study with 60 participants, so results may not apply to all pregnant people. Kefir may cause digestive discomfort, and its benefits are not yet proven.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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19 years and older
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Pregnant individual with a singleton pregnancy * 19 years and older of age * Gestational age 14,3 weeks or less at enrolment * Able and willing to attend four in-person study visits at the PEADS Laboratory: baseline, 18-20 weeks' gestation, 26-28 weeks' gestation, and 1 month postpartum * Willing and able to comply with study group assignment, including daily consumption of 250 mL of kefir if assigned to the intervention group * Willing to avoid kefir consumption until completion of the 26-28-week study visit if assigned to the control group * Willing to provide required biological and clinical samples, including stool samples and glucose/insulin data, according to the study protocol * No probiotic, prebiotic, synbiotic, or antibiotic use during the first trimester or at enrollment * Not currently consuming probiotic, prebiotic, synbiotic, or antiobiotic supplements * Willing to avoid probiotic, prebiotic, and synbiotic supplements until completion of the 26-28-week study visit. * Does not engage in regular moderate-to-vigorous physical activity * No recent or active infectious illness or significant gastrointestinal symptoms, including diarrhea or constipation in the first trimester of pregnancy. * No history of bariatric surgery * Able to communicate in English or French * Currently living in Fredericton, New Brunswick, and not planning to relocate before the 1-month postpartum visit Exclusion Criteria: * Pre-existing metabolic disease affecting glucose regulation, including type 1 diabetes or type 2 diabetes * Current use or first trimester use of medications known to alter glucose metabolism, such as metformin or semaglutide * Gastrointestinal or inflammatory disease, including Crohn's disease, ulcerative colitis, celiac disease, or diagnosed irritable bowel syndrome * Allergy, intolerance, or other contraindication to dairy or components of kefir
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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