Which filling holds up better in diabetic teeth? a Head-to-Head trial
NCT ID NCT07731308
First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time
Summary
This trial compares two types of tooth-colored fillings—zirconia-reinforced glass ionomer and injectable giomer—for cavities on the side of the tooth (Class V) in adults with and without type 2 diabetes. Researchers will track how well each filling stays in place, how it looks, and whether it causes sensitivity over 18 months. The goal is to see if one material works better for people with diabetes, who may have different dental needs.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- two dental filling materials: zirconia-reinforced glass ionomer (Zirconomer) and injectable giomer (Beautifil Flow Plus X)
- What this could lead to
- If one material proves more durable, it could lead to better cavity treatments for people with diabetes, who often have higher dental risks.
- What could go wrong
- This is a small, early-stage trial with only 100 restorations, and results may not apply to all patients or cavity types. Both materials could perform similarly.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2027
An estimate. Start dates often move.
- Expected to finish
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Jan 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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22 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or Female participants from 22 to 55 years * Controlled diabetic and non-diabetic patients consulting the outpatient clinic * Patients categorized as moderate or high caries risk * Patients willing to provide informed consent * Co-operative patients agreeing to participate in the trial Inclusion Criteria for teeth * Teeth with class V carious lesion classified according to the International Caries Detection and Assessment System (ICDAS II) as ICDAS code (4) or ICDAS code (5) * Teeth with normal pulp vitality testing; no signs of inflammation or spontaneous pain before treatment Exclusion Criteria: * Patients with spontaneous or elicited pain from caries. * Systemic illnesses other than diabetes. * Severe bruxism/clenching. * Temporomandibular joint disorders. * Inability to return for recall visits/ Refusal to participate in the study. * Pregnancy. * heavy smoking. * Lack of compliance. Exclusion criteria for teeth * Teeth presenting with spontaneous or elicited pain * A lack of normal pulp vitality testing * Visible or clinical signs of pulpal/periapical inflammation before treatment. * Class V carious lesions that are not classified as ICDAS code (4) or ICDAS code (5).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.