Simple exercises may boost nerve repair in diabetic neuropathy

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 40-65 years * Diagnosed Type 2 Diabetes Mellitus (T2DM) Confirmed diagnosis of T2DM for at least 5 years. * Confirmed Diabetic Peripheral Neuropathy (DPN) Diagnosis is based on clinical evaluation and scoring tools such as: * Michigan Neuropathy Screening Instrument (MNSI) Cut-off value of ≥4 for Part A (History)(104) Cut-off value of ≥2 from Part B (Examination)(105) * Vibration Pressure Threshold (≥25 Volts)(106) * HbA1c between 6.5% and 9.0% Reflecting moderate glycemic control, patients with extremely poor control were excluded for safety. * Stable medication regimen No changes in antidiabetic, antihypertensive, or neuropathy medications in the past 3 months. * Sedentary or low physical activity level Based on standard questionnaires (International Physical Activity Questionnaire - IPAQ), not currently engaged in structured exercise programs. * Ability to walk independently To ensure safety during aerobic or resistance exercise (for Group A). * Able to understand and follow instructions * Consent to participate and comply with study protocol * Written informed consent, obtained before randomization Exclusion Criteria: * History of recent cardiovascular events Includes myocardial infarction, stroke, or any cardiac intervention within the past 6 months. * Uncontrolled hypertension Blood pressure ≥160/100 mmHg at rest. * Severe musculoskeletal disorders or physical disability Including joint deformities, fractures, or amputation that limit the ability to perform exercise. * Severe diabetic foot ulcers or active lower limb infection Increases risk during lower limb activity or exercise. * End-stage renal disease (CKD stage 4 or higher) Associated systemic complications may confound study outcomes or affect safety. * Severe retinopathy or proliferative diabetic eye disease Exercise may pose risks such as retinal hemorrhage. * Current Smoker, tobacco or alcohol consumer. That may affect the blood biomarkers. * Cognitive impairment or psychiatric disorders That may affect understanding, compliance, or safety during exercise. * Participation in a structured exercise program within the last 3 months To avoid training-induced bias and ensure a sedentary baseline. * Chronic inflammatory or autoimmune conditions Conditions like rheumatoid arthritis or lupus may alter neurotrophic biomarkers. * Use of medications affecting neurogenesis or metabolism Such as corticosteroids, antipsychotics, or immunosuppressants. * Diagnosed sleep disorder * That may affect the outcomes of the intervention. * Pregnancy or lactation Due to altered physiology and ethical concerns.