Can a gel under the gums regrow bone in diabetic gum disease?
NCT ID NCT07753317
First seen Aug 07, 2026 · Last updated Aug 12, 2026 · Updated 2 times
Summary
This trial tests whether applying a gel containing either metformin or zoledronate under the gums can improve healing of bone defects caused by periodontitis in people with well-controlled type 2 diabetes. Participants receive standard deep-cleaning treatment, and some also get one of the gels or a placebo. The study measures changes in bone defect depth and gum attachment levels to see if the gels help.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- 1% metformin gel or 0.05% zoledronate gel, applied under the gums as an add-on to minimally invasive nonsurgical treatment
- What this could lead to
- If effective, these gels could offer a simple, targeted way to improve bone healing and gum health in people with diabetes and periodontitis, potentially reducing the need for surgery.
- What could go wrong
- This is a small, early-stage trial, so results may not apply broadly. The gels might not provide extra benefit over standard treatment, and there is a risk of local irritation or other side effects.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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30 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosed with type 2 diabetes mellitus, with HbA1c levels \<7.0% (controlled). * Diagnosis of chronic periodontitis (Stage III/IV, Grade B/C) with at least one intrabony defect of ≥3 mm depth, PPD ≥5 mm, and CAL ≥4 mm measured with a calibrated UNC-15 probe. * Angular bone loss of ≥3 mm measured on digital intraoral periapical radiographs and having three walled intrabony defects without involving furcation confirmed on cone beam computed tomography (CBCT). Exclusion Criteria: 1. Smokers. 2. Pregnant or lactating women. 3. Patients on systemic bisphosphonate therapy or other medications known to affect bone metabolism. 4. Uncontrolled diabetes (HbA1c \>8%) or other systemic diseases that could affect periodontal status. 5. History of radiation therapy to the head and neck
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
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How to take part
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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