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King of fruits takes on diabetes: Durian's effect on gut and glucose

NCT ID NCT07697612

Disease control Sponsor: Singapore General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study explores whether eating durian daily for two weeks changes the gut microbiome, metabolism, and blood sugar levels in adults with type 2 diabetes. Forty participants will eat fresh durian pulp and undergo blood and stool tests, plus continuous glucose monitoring. The goal is to see if this tropical fruit can be part of diabetes management without harming glucose control.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
durian pulp
What this could lead to
If durian proves beneficial, it could offer a tasty dietary option for managing blood sugar and gut health in type 2 diabetes.
What could go wrong
This is a small, early-phase study without a comparison group, so results may not be conclusive. Durian is high in sugar and calories, which could worsen blood sugar control in some participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 21 to 70 years. 2. Diagnosis of type 2 diabetes mellitus. 3. Agrees to consume durian for 2 weeks. 4. Body mass index 25 to 40 kg/m². Exclusion Criteria: 1. Known or suspected intolerance or allergy to durian. 2. Known skin reaction to adhesives used in a continuous glucose sensor. 3. Uncontrolled diabetes (HbA1c greater than 8.5%). 4. Severe hypertriglyceridemia (triglycerides greater than 4.5 mmol/L). 5. Smoking. 6. Previous gastrointestinal surgeries, including cholecystectomy, gastrectomy, bariatric surgery, or colectomy. 7. Inflammatory bowel disease. 8. Glomerular filtration rate less than 30 mL/min. 9. ALT greater than 3 times upper limit of normal. 10. AST greater than 3 times upper limit of normal. 11. Liver cirrhosis. 12. Significant alcohol consumption, defined as more than 20 g/day for women and more than 30 g/day for men. 13. Pregnant, breastfeeding, or intending to conceive during the study. 14. Current hemorrhoids or piles causing rectal bleeding during stool passage. 15. Systemic steroid use. 16. Insulin use. 17. Weight loss medications, including GLP-1 receptor agonists, orlistat, or phentermine. 18. Antibiotic, prebiotic, probiotic, vitamin C, or traditional Chinese medicine use in the last 1 month. 19. Uncontrolled thyroid disease. 20. Any factor likely to limit adherence to study protocol, including dementia, substance abuse, poor appointment adherence, or family concerns regarding participation

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Type 2 diabetes

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Singapore General Hospital

    Singapore, Singapore

More trials for these conditions

Other studies related to the condition(s) this trial covers.