Singapore General Hospital

This study tests a new way to choose prostate cancer treatment. Instead of treating the whole prostate, doctors will use genetic tests to decide if a patient can have focal therapy—which targets only the cancer—or needs more aggressive treatment like surgery or radiation. The goa…

This study tests whether a special care plan (called a care bundle) can help heal and prevent bedsores (pressure injuries) in older adults living at home. About 216 people discharged from hospital with a bedsore, along with their family caregivers, will either use the new care pl…

This study tests whether a behavior change program with personalized exercise plans can help stroke survivors become more physically active. Researchers will compare a group that gets up to 6 coaching sessions (in-person and by phone/video) plus a custom activity plan, to a group…

This study tests whether a care coach-led team can improve quality of life for 770 adults with advanced cancer who are undergoing major surgery. The team includes surgical oncology, rehabilitation, and palliative care specialists working together to address physical, emotional, a…

This study looks at two different ways to align a new knee joint during robotic-assisted knee replacement surgery. About 240 people with knee osteoarthritis will be randomly assigned to one of two alignment methods. The goal is to see which approach helps patients feel more natur…

This study tests whether cooling cardiac arrest patients right after their heartbeat returns, using a special vest in the ambulance, is practical and safe. About 50 adults who remain unconscious after cardiac arrest will be cooled by paramedics before reaching the hospital. The g…

This study will check how many adults with obesity also have sarcopenia (loss of muscle mass and strength). Researchers will study 300 people at a specialized obesity center, looking at factors like age, diet, and activity. The goal is to understand how common this problem is and…

This study looks at how the relationship between doctors and patients affects the quality of medical advice. Researchers will interview 300 patients and healthcare workers at Singapore General Hospital to understand how decisions are made together. The goal is to learn what makes…

This study aims to see if giving community first responders real-time video support from emergency dispatchers can improve the quality of CPR they provide. About 165 trained volunteers in Singapore will be randomly assigned to use either the current system or an enhanced version …

This study looks at how body weight and bariatric surgery change natural chemicals in scalp hair. Researchers will also measure hair thinning and muscle loss in the first 6 months after surgery. The study includes 60 adults: some with severe obesity scheduled for surgery, and som…

This study aims to find early warning signs that predict serious liver problems or death in people with liver cirrhosis. Researchers will review medical records from 2,200 participants over time, without requiring any extra tests or visits. The goal is to help doctors identify hi…

This study tests whether AS01, an ingredient in the shingles vaccine, can act like a general trainer for the immune system, making it stronger against various infections. Researchers will give AS01 or a placebo to 40 healthy adults aged 21-59 and measure immune responses over 3 m…

This study tests whether a multilingual AI chatbot called PEAR helps patients understand anesthesia risks better than the usual face-to-face talk with a doctor. About 120 adults having planned surgery will take part. The goal is to see if the chatbot improves understanding and re…