Singapore General Hospital

This study looks at whether a genetic test can help decide the best treatment for men with prostate cancer. Instead of treating the whole prostate, doctors may only treat the cancerous spots (focal therapy) to reduce side effects. The trial will check if men with certain genetic …

This study tests whether a special care bundle given at home can help heal pressure injuries (bedsores) and stop new ones from forming in older adults. About 216 people who recently left the hospital with a bedsore will take part, along with their caregivers. Half will get the ne…

This study tests whether a program combining physical activity counseling and a personalized exercise plan can help stroke survivors who live at home become more active. Researchers will compare a group receiving this program plus usual care to a group receiving only usual care. …

This study tests whether a care coach-led program that combines palliative care and rehabilitation can improve quality of life for 770 adults with advanced cancer who are undergoing major surgery. Participants will receive extra support from trained coaches, surgical teams, and r…

This study looks at two different ways to align a new knee joint during robotic-assisted knee replacement surgery. About 240 people with knee osteoarthritis will be randomly assigned to one of two alignment methods. The goal is to see which approach helps patients feel more natur…

This study tests whether cooling cardiac arrest patients right after their heart restarts, using a special vest worn in the ambulance, is practical and safe. About 50 adults in Singapore will take part. The goal is to see if this early cooling can be done smoothly by paramedics, …

This study follows 2200 adults with liver cirrhosis to find early warning signs of liver failure and death. Researchers will review medical records without requiring extra visits or tests. The goal is to help doctors identify high-risk patients sooner and develop better treatment…

This study looks at whether AS01, an ingredient used in some vaccines, can act like a general trainer for the immune system, making it stronger against various infections. Researchers will give AS01 to healthy adults aged 21-59 and measure immune responses over 3 months. The goal…

This study will check how often muscle loss (sarcopenia) happens in 300 adults with obesity. Researchers will measure muscle mass, strength, and physical function, and look at factors like age, diet, and activity. The goal is to help doctors better identify and manage this condit…

This study looks at how body weight and weight-loss surgery change natural chemicals in scalp hair. Researchers will track 60 adults with severe obesity who are scheduled for bariatric surgery, plus healthy-weight controls. They aim to understand hair thinning and muscle loss in …

This study tests whether a multilingual AI chatbot called PEAR helps patients understand anesthesia risks better than the usual face-to-face talk with a doctor. About 120 adults having planned surgery will take part. The goal is to see if the chatbot improves understanding and re…

This study tests whether giving community first responders real-time feedback and video support from dispatchers helps them perform better CPR during out-of-hospital cardiac arrests. About 165 trained volunteers will be randomly assigned to use the current system or an enhanced v…