Morning eating and exercise may shield older women from muscle loss

NCT ID NCT07075133

Prevention Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether eating all meals within an 8-hour window (between early morning and early afternoon) combined with morning exercise can prevent sarcopenia—age-related muscle loss—in postmenopausal women with obesity and type 2 diabetes. Forty-five women will follow either a standard diabetes diet or the early time-restricted eating plan plus morning workouts for 12 weeks. The goal is to see if this timing-based approach improves muscle strength and blood sugar control better than diet alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: early time-restricted eating (eTRE) and morning physical activity
What this could lead to: If it works, this could point toward a simple lifestyle strategy to prevent muscle weakness in older women with diabetes and obesity.
What could go wrong: This is a small, early-stage trial with only 45 participants, so results may not apply widely. The intervention is demanding and may be hard to stick with long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jul 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Post-menopausal women (amenorrhea for at least 12 months, confirmed by gonadotrophins measures) * Age range 45-70 years * T2DM diagnosed for more than 1 year * Subjects with T2DM treated with lifestyle control alone or associated with metformine ± DPP4 inhibitors * Ability to sign written informed consent before any study-specific procedure * Subject considered as reliable and capable of adhering to protocol * Subjects with Body Mass Index (BMI)≥ 30 kg/m² * Baseline eating period ≥ 14 h per day (as estimated by 95% eating interval) Exclusion Criteria: * Subjects on T2DM injectable medication or drugs able to induce hypoglycemia (glinides, sulfonylurea) * Subjects with HbA1c \> 8% * Subjects with any of the following medical conditions: * Congestive cardiac failure * Stage 4 chronic kidney disease (i.e. eGFR \< 30 ml/min/1.73 m2) * Liver cirrhosis or chronic liver disease * Any medical condition that in the opinion of the investigator could jeopardize or compromise the subject's ability to participate in the study * Subjects with previous or present history of serious eating disorder * Subjects not able to understand the informed consent form or fasting diary instructions * Subjects currently participating or has participated in another study of an investigational medication or an investigational medical device within the last 30 days * Women with menopause hormone replacement therapy

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Circadian clock are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Sarcopenia type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Circadian clock Obesity Post-menopause Sarcopenia Type 2 diabetes

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Morning eating and exercise may shield older women from muscle loss

What the study statuses mean