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Can exercise and diet rewire your cells to fight diabetes?

NCT ID NCT07251504

Knowledge-focused Sponsor: University of Cadiz Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 16, 2026 · Updated 4 times

Summary

This study looked at how different types of aerobic exercise (moderate continuous training vs. high-intensity interval training) and diet counseling affect cell health in people with type 2 diabetes. Researchers measured changes in mitochondria (the cell's power plants) and oxidative stress (cell damage) in 146 participants over 12 weeks. The goal was to find the best combination of exercise and diet for improving cell function and overall health.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

146 people

The number who actually took part.

Started

Mar 2022

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of T2D or prediabetes (glycated hemoglobin ≥ 5.7%) * No history of substance abuse (tobacco, alcohol, or other drugs). * Body mass index ≥25 kg/m², maintaining habitual dietary patterns with stable body weight for at least 6 months * Stable physical activity and medication regimen for at least 6 months * Lack of habitual vigorous-intensity physical activity and the presence of sedentary behavior characterized by prolonged sitting time (screened using the International Physical Activity Questionnaire short form). * Not insulin-dependent * Absence of injury, disease, disability, or other known medical condition which could affect the ability to successfully participate in physical exercise tests * Absence of tumors and cancer disease * Absence of other pathologies that could affect the study outcomes. * Not on a medication regimen that could affect the study outcomes. * Being able to understand communication in Spanish or English. * Not pregnant Exclusion Criteria: * Failure to attend more than 2 consecutive sessions or a total of 4 sessions of nutritional intervention. * Failure to attend more than 4 consecutive or a total of 6 sessions of physical training. * Serious injury * Voluntary withdrawal * Increased dose of diabetes medication

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Conditions

The condition(s) this trial relates to.

metabolic disease type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus type 2

Contacts and locations

Locations

  • Science of Education Faculty

    Puerto Real, Cádiz, 11510, Spain

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