Please sign in to follow a disease.
Could a plant hormone help tame prediabetes?
NCT ID NCT04722354
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This small phase 2 trial tested whether taking abscisic acid (ABA), a natural plant hormone, can improve how the body handles sugar in people with prediabetes. Five adults with elevated fasting glucose or HbA1c took ABA and had their insulin sensitivity measured using a precise clamp technique. The study monitored side effects and changes in glucose disposal to see if ABA might help manage blood sugar.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- abscisic acid (ABA)
- What this could lead to
- If it works, this could point toward a natural supplement to help control blood sugar in people with prediabetes.
- What could go wrong
- This is a very small, early-phase trial with only 5 participants, so results may not apply broadly. The intervention is a plant hormone, and its effects on humans are not well established.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
5 people
The number who actually took part.
- Started
-
Mar 2021
- Finished
-
Dec 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. Male or female, aged 18-65 4. In good general health as evidenced by medical history or diagnosed with \<specify condition/disease\> or exhibiting \<specify clinical signs or symptoms or physical/oral examination findings\> 5. Fasting glucose \>5.6 and\<7.0 mmol/L and/or HbA1C \>5.6 and \<6.5 % 6. Ability to take oral medication and be willing to adhere to the \<study intervention\> regimen 7. Females currently on hormone replacement therapy (HRT) can participate in the study if they have been on HRT for at least 6 months and will continue to be on HRT during the study. 8. For males of reproductive potential: use of condoms or other methods to ensure effective contraception with partner 9. Agreement to adhere to Lifestyle Considerations throughout study duration. Exclusion Criteria 1. Treated or untreated diabetes 2. 19\>BMI\<40.0 kg/m2 3. Blood pressure (BP) ≤ 150mmHg systolic and ≤ 95 mmHg diastolic 4. Current use of medications or antioxidant vitamins or supplements that would impact dependent variables, including glucose metabolism. 5. Past or current ischemic heart disease, stroke, respiratory disease, endocrine or metabolic disease, neurological disease, hematological-oncological disease and free of recent infection (prior 2 weeks) 6. Pregnancy or lactation 7. Treatment with another investigational drug or other intervention within 1 year. 8. Current smoker or tobacco use within the past year. 9. Disqualifying findings on physical examination include cardiac murmurs, diminished pulses or the presence of bruits in the lower extremities, lower extremity thrombophlebitis, evidence of peripheral neuropathy, paresis or edema.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Pre diabetes are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
AdventHealth Translational Research Institute
Orlando, Florida, 32803, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can an AI chatbot coach people away from type 2 diabetes?
- A fingernail scan could reveal hidden diabetes risk
- Can diverse tissue samples unlock Obesity's secrets?
- Can mango timing tame blood sugar spikes?
- Grape seed extract put to the test for blood pressure and heart health
- Strawberries as medicine? trial tests whether the fruit can calm inflammation and boost insulin response