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Could a plant hormone help tame prediabetes?

NCT ID NCT04722354

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This small phase 2 trial tested whether taking abscisic acid (ABA), a natural plant hormone, can improve how the body handles sugar in people with prediabetes. Five adults with elevated fasting glucose or HbA1c took ABA and had their insulin sensitivity measured using a precise clamp technique. The study monitored side effects and changes in glucose disposal to see if ABA might help manage blood sugar.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
abscisic acid (ABA)
What this could lead to
If it works, this could point toward a natural supplement to help control blood sugar in people with prediabetes.
What could go wrong
This is a very small, early-phase trial with only 5 participants, so results may not apply broadly. The intervention is a plant hormone, and its effects on humans are not well established.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

5 people

The number who actually took part.

Started

Mar 2021

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. Male or female, aged 18-65 4. In good general health as evidenced by medical history or diagnosed with \<specify condition/disease\> or exhibiting \<specify clinical signs or symptoms or physical/oral examination findings\> 5. Fasting glucose \>5.6 and\<7.0 mmol/L and/or HbA1C \>5.6 and \<6.5 % 6. Ability to take oral medication and be willing to adhere to the \<study intervention\> regimen 7. Females currently on hormone replacement therapy (HRT) can participate in the study if they have been on HRT for at least 6 months and will continue to be on HRT during the study. 8. For males of reproductive potential: use of condoms or other methods to ensure effective contraception with partner 9. Agreement to adhere to Lifestyle Considerations throughout study duration. Exclusion Criteria 1. Treated or untreated diabetes 2. 19\>BMI\<40.0 kg/m2 3. Blood pressure (BP) ≤ 150mmHg systolic and ≤ 95 mmHg diastolic 4. Current use of medications or antioxidant vitamins or supplements that would impact dependent variables, including glucose metabolism. 5. Past or current ischemic heart disease, stroke, respiratory disease, endocrine or metabolic disease, neurological disease, hematological-oncological disease and free of recent infection (prior 2 weeks) 6. Pregnancy or lactation 7. Treatment with another investigational drug or other intervention within 1 year. 8. Current smoker or tobacco use within the past year. 9. Disqualifying findings on physical examination include cardiac murmurs, diminished pulses or the presence of bruits in the lower extremities, lower extremity thrombophlebitis, evidence of peripheral neuropathy, paresis or edema.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • AdventHealth Translational Research Institute

    Orlando, Florida, 32803, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.