Could a plant hormone help tame prediabetes?

NCT ID NCT04722354

Completed Symptom relief Sponsor: AdventHealth Translational Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This small phase 2 trial tested whether taking abscisic acid (ABA), a natural plant hormone, can improve how the body handles sugar in people with prediabetes. Five adults with elevated fasting glucose or HbA1c took ABA and had their insulin sensitivity measured using a precise clamp technique. The study monitored side effects and changes in glucose disposal to see if ABA might help manage blood sugar.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: abscisic acid (ABA)
What this could lead to: If it works, this could point toward a natural supplement to help control blood sugar in people with prediabetes.
What could go wrong: This is a very small, early-phase trial with only 5 participants, so results may not apply broadly. The intervention is a plant hormone, and its effects on humans are not well established.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glucose intolerance prediabetes syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRE-DIABETES

Contacts and locations

Locations

AdventHealth Translational Research Institute

Orlando, Florida, 32803, United States

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