Memorial Sloan Kettering Cancer Center

This study tests whether combining the drug pembrolizumab with a precise form of radiation can cure people whose Hodgkin lymphoma has returned or not responded to initial treatment. The trial includes 22 adults with early-stage disease. The goal is to achieve a complete response …

This study tests whether giving an extra-high radiation dose directly to the main tumor, while treating the rest of the prostate with standard doses, can cure intermediate-risk prostate cancer or keep it from coming back longer. About 91 men will receive this MR-guided, ultra-sho…

This study tests whether adding a precise, high-dose radiation treatment (SBRT) can help restart the immune system's fight against cancer when immunotherapy drugs start to lose effect. About 69 adults with metastatic cancers (melanoma, lung, bladder, kidney, or head/neck) will re…

This study tests whether giving palifermin and leuprolide acetate (or degarelix) can help the immune system recover more quickly after a stem cell transplant from a donor. The trial includes 82 adults with blood cancers like leukemia or lymphoma. Researchers will measure CD4+ T c…

This study is for people with a type of lung cancer called malignant pleural mesothelioma that can be removed with surgery. Researchers want to see if giving a combination of the immunotherapy drug nivolumab and chemotherapy before surgery is safe and does not delay the operation…

This study tests whether adding the drug nivolumab to radiation therapy and another drug (bevacizumab) can help people with a returning type of brain cancer called glioblastoma. The trial includes 39 adults whose cancer has come back after standard treatment. The goal is to see i…

This study tested whether adding the targeted drug cetuximab to standard chemotherapy could shrink advanced thymoma or thymic carcinoma tumors before surgery. 18 adults with stage II to IVA disease received the combination, then had surgery to remove any remaining tumor. Research…

This study tests a cream containing ruxolitinib, a drug that blocks certain immune signals, for treating chronic skin graft-versus-host disease (GVHD) after a stem cell transplant. About 24 participants will apply the cream to one side of their body and a standard moisturizer to …

This study tests a new version of the chemotherapy drug melphalan (called Captisol Enabled Melphalan) in people with multiple myeloma or AL amyloidosis who are getting a stem cell transplant. The new formulation is designed to be more stable and possibly cause fewer side effects …

This study tests a new drug called ERAS-601 in people with advanced chordoma, a rare bone cancer. The goal is to see if the drug is safe and can stop or shrink tumors. About 12 adults whose cancer has gotten worse despite prior treatment will take part.

This early-stage study tests a new approach for adults with B-cell acute lymphoblastic leukemia (B-ALL) that has returned or not responded to standard treatment. Doctors take a patient's own T cells (a type of immune cell), add a gene that helps them recognize and attack leukemia…

This study tests whether combining two drugs, rucaparib and nivolumab, can shrink or control advanced leiomyosarcoma (LMS), a rare soft-tissue cancer. About 20 adults with LMS that cannot be removed by surgery or has spread will receive the treatment. The goal is to see if this c…

This early-phase study tests a new, ultra-short radiation treatment for men with intermediate-risk prostate cancer. The approach uses MRI guidance to precisely target the prostate and the main tumor, delivering very high doses in fewer sessions. The main goal is to see if this tr…

This study tests two immunotherapy drugs, durvalumab and tremelimumab, in 30 adults with germ cell tumors that have come back or not responded to standard treatment. The goal is to see if the combination can shrink tumors and control the disease. Participants must have measurable…

This study tests a drug called CPI-613 in people with certain aggressive lymphomas (Burkitt lymphoma or high-grade B-cell lymphoma) that have returned or not responded to prior treatment. About 24 participants aged 12 and older will receive the drug to see if it can shrink or con…

This study tests a drug called pembrolizumab, which helps the immune system fight cancer, in people with advanced adrenocortical carcinoma (a rare adrenal gland cancer) that cannot be removed by surgery. The goal is to see if the drug can shrink or control the tumors. About 39 pa…

This study tests whether the drug niraparib can help control advanced soft tissue sarcoma that has specific DNA repair mutations. Eight adults with tumors that cannot be removed by surgery or have spread will receive niraparib. Researchers will track how long the cancer stays und…

This study looks at whether aerobic exercise can lower ctDNA levels in the blood, which may help prevent cancer from returning. About 33 people who have been treated for high-risk breast, prostate, or colorectal cancer will try different amounts of weekly exercise to find the saf…

This study tests a combination of two drugs—nivolumab and a radioactive antibody called 177Lu-girentuximab—for people with advanced clear cell kidney cancer that has a specific protein (CAIX). The goal is to see if the combination is safe and can shrink tumors. About 9 participan…

This study tests a drug called AG-120 in 6 adults with a rare bone cancer (chondrosarcoma) that has a specific genetic change (IDH1 mutation). The goal is to see if the drug can stop or slow the cancer from growing. Participants have advanced or recurrent disease that cannot be r…

This study looks at how safe and effective glipizide, a standard diabetes drug, is for lowering blood sugar in people with pancreatic cancer. About 29 adults with active pancreatic cancer and high blood sugar will take glipizide and have their glucose levels monitored. The goal i…

This study tests whether combining three drugs—nivolumab (an immunotherapy that unleashes the immune system), FOLFOX (standard chemotherapy), and regorafenib (a targeted therapy)—can safely control HER2-negative metastatic esophagogastric cancer. The trial enrolled 39 adults with…

This study tests whether pembrolizumab, an immunotherapy drug that helps the immune system fight cancer, can shrink or stop the growth of recurrent malignant glioma in 27 patients. The cancer must have returned after prior treatments like radiation and chemotherapy. The goal is t…

This study tests a combination of two drugs, vemurafenib (a pill) and obinutuzumab (given by IV), in 30 people with untreated hairy cell leukemia. The goal is to see how many patients achieve a complete response (no signs of cancer). Participants take vemurafenib for 4 months and…

This study tests if a very low-carb (ketogenic) diet, a low-carb diet, or the diabetes drug canagliflozin can prevent high blood sugar caused by the cancer drug alpelisib. The goal is to see if controlling blood sugar helps alpelisib work better for people with metastatic PIK3CA-…

This study tests whether adding the immunotherapy drug durvalumab to precise radiation therapy (SBRT) can better control early-stage non-small cell lung cancer compared to radiation alone. About 13 adults with stage I to IIIA lung cancer received the combination. The main goal is…

This study looks at whether giving radiation only to the area where the cancer was removed (partial breast irradiation) is safe and effective for women with early-stage breast cancer. Instead of 5-7 weeks of whole-breast radiation, participants receive 2 weeks of daily treatments…

This early-stage study is testing whether giving two cancer drugs (cabozantinib and nivolumab) along with radiation therapy is safe for people with kidney cancer that has spread to the brain. Only 2 participants were enrolled to closely monitor side effects, especially those affe…

This study tests whether the immunotherapy drug pembrolizumab can shrink early-stage NK/T-cell lymphoma in 19 adults who have not yet had chemotherapy. The goal is to see how many patients have their tumors completely disappear. This is a phase 2 pilot study, so results will guid…

This study tests whether combining two drugs, NKTR-214 and nivolumab, can shrink or control advanced sarcoma that has spread. About 88 people aged 12 and older with locally advanced or metastatic sarcoma will receive the combination. The main goal is to see how many patients' tum…

This study compares two ways to give chemotherapy directly into the abdomen after surgery to remove visible cancer in people with appendix or colorectal cancer that has spread to the lining of the belly. One method gives chemotherapy right after surgery through a tube, and the ot…

This study tests whether using special cameras (reflectance confocal microscopy and optical coherence tomography) to guide radiation therapy can effectively treat basal cell carcinoma, a common skin cancer. About 38 adults with early-stage tumors will receive this targeted radiat…

This study tests whether combining T-VEC (a virus that attacks cancer cells) with pembrolizumab (an immunotherapy) can shrink tumors in people with advanced sarcoma that cannot be removed by surgery. About 41 adults with certain sarcoma types will receive both drugs. The main goa…

This study is for people with advanced melanoma that cannot be removed by surgery. It tests a flexible approach to giving two immunotherapy drugs (ipilimumab and nivolumab). Instead of always giving four doses, doctors will check after two doses. If the tumor is shrinking, no mor…

This study tests whether the drug anakinra can prevent or reverse severe side effects from CAR-T cell therapy, a treatment for certain blood cancers. About 62 adults with relapsed B-cell cancers will receive anakinra alongside their CAR-T treatment. The goal is to reduce serious …

This study tests whether combining two drugs, lenvatinib and pembrolizumab, can safely shrink or control advanced soft tissue sarcomas that cannot be surgically removed. About 52 adults with specific sarcoma types will receive the combination. The goal is to see how many patients…

This early-phase study tests whether a personalized cancer vaccine, combined with an immunotherapy drug (atezolizumab) and chemotherapy, is safe for people with pancreatic cancer that has been surgically removed. About 29 participants will receive the vaccine, which is custom-mad…

This study tests whether the chemotherapy drug Ixazomib can help control AL amyloidosis, a rare disease where abnormal proteins build up in organs. Seventeen adults who completed initial therapy receive Ixazomib as maintenance to prevent or delay relapse. The goal is to see if th…

This study tests whether giving a personalized dose of rabbit ATG (a drug that helps prevent transplant rejection) before a stem cell transplant can help the immune system recover faster and reduce side effects. It includes children and adults with acute leukemia or myelodysplast…

This early-stage study tests whether combining the immunotherapy drug pembrolizumab with a special type of radiation (IMPRINT) is safe for people with malignant pleural mesothelioma, a rare cancer of the lung lining. Seven participants who have already tried at least one other tr…

This study tests whether a combination of three drugs—temozolomide, cisplatin, and nivolumab—can shrink tumors in people with advanced colorectal cancer that has not responded to at least two prior treatments. The trial includes 18 adults whose cancer is mismatch repair-proficien…

This study tested a combination of two chemotherapy drugs, irinotecan and carboplatin, as the first treatment for children and adults newly diagnosed with intermediate- or high-risk rhabdomyosarcoma, a type of muscle cancer. The goal was to see if this drug pair could shrink tumo…

This study looks at women having breast reconstruction after mastectomy. It compares two methods: one using a special material called acellular dermal matrix (ADM) and one without it. The goal is to see which method leads to fewer problems like infections or the need for more sur…

This study tests whether a much lower dose of radiation (30 Gy) combined with standard chemotherapy works as well as the usual high dose (70 Gy) for people with HPV-positive throat cancer. About 316 participants with early-stage disease are being enrolled. The goal is to maintain…

This study tests whether combining two immune-boosting drugs, pembrolizumab and BCG, can keep high-risk bladder cancer from coming back. About 45 people with early-stage but aggressive bladder cancer will receive this combination as their first treatment. The goal is to see if th…

This study tests whether combining radiation therapy with the immunotherapy drug cemiplimab can help people with a type of advanced skin cancer called cutaneous squamous cell carcinoma that cannot be removed by surgery. About 34 participants will receive this treatment to see if …

This study tests if people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) can safely stop taking acalabrutinib and obinutuzumab once their cancer responds well, instead of continuing treatment indefinitely. The goal is to reduce side effects and preve…

This early-stage study tests a combination of the immunotherapy drug nivolumab with a procedure called drug-eluting bead chemoembolization (deb-TACE) in 20 adults with advanced liver cancer. The goal is to see if the combination is safe and tolerable. Participants receive both tr…

This study tests whether a higher-than-standard dose of radiation, given with chemotherapy, can shrink pancreatic tumors enough to allow surgery. It involves 47 adults with locally advanced pancreatic cancer that cannot be removed initially. The goal is to see if this approach he…

This study looks at how long doctors should wait after chemoradiation before performing surgery on patients with stage II or III rectal cancer. About 248 people will receive radiation plus chemotherapy (with or without extra drugs) before surgery. The goal is to find the best tim…

This study tests if a shorter course of hormone therapy (ADT) combined with two types of radiation (brachytherapy and external beam) can safely prevent high-risk prostate cancer from returning or spreading. About 50 men with high-risk prostate cancer and a favorable genetic score…

This study tests a combination of two drugs, epacadostat and pembrolizumab, in people with advanced sarcoma that has spread or cannot be removed by surgery. The goal is to see if the combo can shrink tumors or stop them from growing. About 30 adults who have already tried at leas…

This study tests whether combining two drugs, nivolumab and cabozantinib, can shrink tumors in people with advanced or metastatic non-clear cell kidney cancer. About 60 participants who have had little or no prior treatment will receive the drug combination. The goal is to see ho…

This study tests giving two immunotherapy drugs (nivolumab and ipilimumab) before surgery to people with stage III melanoma. The goal is to shrink or kill the tumor and prevent the cancer from coming back. The study also uses an experimental PET scan to see if it can show how wel…

This study tests the safety of adding bumetanide, a common water pill, to a standard procedure that blocks blood flow to liver tumors. About 30 adults with liver cancer that cannot be removed by surgery will receive different doses. The goal is to see if the combination can slow …

This study is for people with advanced Merkel cell carcinoma that has spread or cannot be removed by surgery and has stopped responding to standard immunotherapy. The researchers are testing whether giving a special type of radiation therapy (CART) together with the immunotherapy…

This study tests a combination of two drugs, MEK162 and imatinib, for people with advanced gastrointestinal stromal tumor (GIST). The goal is to find the best dose and see if the combination works better than imatinib alone. The study includes 75 participants who either have not …

This study tests whether giving immunotherapy drugs (nivolumab alone or with ipilimumab) before bladder cancer surgery is safe and does not delay the operation. The goal is to shrink the tumor, making surgery more successful. It involves 52 adults with muscle-invasive bladder can…

This study tests a drug called ado-trastuzumab emtansine (T-DM1) in adults with advanced solid tumors that have a specific HER2 gene change. The goal is to see how well the drug shrinks or controls the cancer. About 131 people with lung, bladder, or other HER2-related cancers are…

This study tests the safety and effectiveness of the drug pembrolizumab in preventing cancer from returning in people who have had a solid tumor surgically removed but still have traces of tumor DNA in their blood. Participants receive pembrolizumab or a placebo for up to 12 mont…

This study tests whether combining the drug durvalumab with radiation therapy can slow down lung cancer growth in people with stage II or III non-small cell lung cancer. Unlike standard treatment, this approach skips chemotherapy. The goal is to see if more patients stay cancer-f…

This pilot study tests meclofenamate, a drug once used for pain, in 30 adults with brain metastases that have come back or worsened. The goal is to see if the drug can slow tumor growth and if a larger study is possible. Participants take the drug and have regular MRI scans to ch…

This study looks at whether giving precise radiation (SBRT) to tumors that have just started to grow can help people with metastatic triple-negative breast cancer or non-small cell lung cancer live longer without their disease getting worse. About 107 adults are taking part. The …

This study compares two different ways of giving the immunotherapy drug atezolizumab together with standard chemotherapy (gemcitabine and cisplatin) for people with advanced bladder cancer that has spread. The goal is to see which schedule works better at shrinking tumors. 32 adu…

This study tests a drug called RP-3500 combined with radiation therapy for people with advanced solid tumors that have spread and have a specific gene change (ATM mutation). The goal is to find a safe dose and see if the combination can control tumor growth for at least 6 months.…

This early-phase study tests if giving the drug Lutathera directly into the liver's main artery is safe and practical for people with neuroendocrine tumors that have spread mostly to the liver. Ten participants will receive two infusions, one into the liver artery and one into a …

This study tests a drug called isatuximab in 12 adults who have low blood cell counts (immune cytopenias) after a stem cell transplant for blood cancer. The goal is to see if the drug can help restore normal blood cell levels. Participants must have their original cancer in remis…

This early-phase study tests the safety of a special type of immune cell, called an "armored" CAR T-cell, in people with certain blood cancers (like CLL) that have not responded to standard treatments. The cells are made from the patient's own blood and are designed to better att…

This early-phase trial tested a second, single dose of highly focused radiation for people with spine tumors that had grown back after previous radiation. Nine adults with solid tumors that spread to the lower spine received one of three radiation doses. The main goal was to chec…

This early-stage study tests whether a drug called AZD1390, given together with a precise type of radiation (SBRT), is safe for people whose solid tumors have spread to other parts of the body. About 54 adults with metastatic cancer will receive increasing doses of the drug along…

This early-stage study tests the safety of a drug called GDC-0084 given together with radiation therapy. It is for people whose cancer has spread to the brain or the lining of the brain and who have a specific genetic change (PIK3CA mutation). The goal is to find the best dose th…

This early-phase trial tests the safety of a new treatment for multiple myeloma, a blood cancer. The therapy uses a patient's own immune cells, modified to target a protein called BCMA on cancer cells. Up to 20 adults whose cancer has not responded to prior treatments will receiv…

This study tests the safety of the drug neratinib in children and teens whose solid tumors, brain tumors, or lymphomas have returned or not responded to standard treatments. Researchers give different dose levels to find the safest dose and watch for side effects. The goal is to …

This early study tests a treatment called lifileucel (LN-144) for people with melanoma that has spread to the brain and stopped responding to standard immunotherapy. The treatment uses a patient's own immune cells, grown in a lab, to attack the cancer. The study aims to see if th…

This study tests a new type of CAR T-cell therapy for adults with B-cell lymphoma that has come back or not responded to treatment. The therapy uses a patient's own immune cells, modified to better target and kill cancer cells. The main goals are to find the safest dose and see i…

This study tests whether N-acetylcysteine, a drug already used for liver protection and lung mucus thinning, can help severe COVID-19 patients by boosting their immune system. About 48 adults with confirmed COVID-19 who are in intensive care or on a ventilator (Arm A) or need ext…

This study tests a treatment that takes a patient's own T cells (a type of immune cell), genetically modifies them in a lab to target a protein called CD19 found on cancer cells, and then gives them back to the patient along with a chemotherapy drug. The goal is to see if this ap…

This early-phase study tests a combination of three drugs (rituximab, bendamustine, and melphalan) followed by a stem cell transplant using the patient's own cells. The goal is to see if this gentler regimen causes fewer severe side effects than standard treatments in older adult…

This study was designed to see if combining three drugs—epcoritamab, lenalidomide, and tafasitamab—could safely and effectively treat people with diffuse large B-cell lymphoma (DLBCL) that had come back or stopped responding to treatment. The trial was withdrawn before enrolling …

This early-stage study tests whether giving a targeted radioactive drug (177Lu-PSMA617) followed by precise radiation (SBRT) is safe for men with hormone-sensitive prostate cancer that has spread to a few places. The goal is to see if this combination can delay or prevent the can…

This study looks at whether people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have no detectable cancer after taking venetoclax can safely stop the drug. Researchers will monitor 81 participants for at least 12 months to see how many remain ca…

This study tests a treatment called ide-cel (a CAR T cell therapy) for people with multiple myeloma that has returned or not responded to treatment. Participants have already had a stem cell transplant. The goal is to see if the quality of the patient's own immune cells affects h…

This study tests whether giving a second, early infusion of the CAR T-cell therapy tisagenlecleucel can keep the immune system's B cells suppressed longer in children and young adults whose B-cell acute lymphoblastic leukemia has returned or not responded to treatment. The goal i…

This study tests whether adding plinabulin to the standard drug pegfilgrastim can shorten the time white blood cells stay dangerously low after a stem cell transplant for multiple myeloma. About 17 adults aged 18-75 who are getting a transplant will receive both drugs. The goal i…

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy (gemcitabine and cisplatin) is safe and effective for people with advanced or muscle-invasive bladder cancer. About 54 adults with good overall health are taking part. The goal is to see …

This study tests whether adding an experimental drug called PEGPH20 to standard chemotherapy can shrink advanced pancreatic tumors. PEGPH20 breaks down a substance called hyaluronan, which is often found in high amounts in these tumors and may help them grow. The study involves 1…

This study adds two chemotherapy drugs, irinotecan and temozolomide, to the standard treatment for people newly diagnosed with Ewing sarcoma. The goal is to see if this stronger combination can improve the chance of staying cancer-free. The trial includes 83 participants aged 1 t…

This study tests whether combining two drugs (etrumadenant and zimberelimab) can shrink tumors or slow the disease in people with advanced dedifferentiated liposarcoma that has returned, spread, or cannot be removed by surgery. About 16 adults with this rare soft-tissue cancer wi…

This study tests the safety of adding the drug durvalumab to standard chemoradiation for people with esophageal or gastroesophageal junction cancer. About 64 participants will receive initial chemotherapy followed by chemoradiation plus durvalumab. The goal is to see if this comb…

This study tests whether a lower dose of radiation aimed at a smaller area after surgery can control soft tissue sarcoma just as well as the standard approach, while causing fewer long-term side effects. About 65 adults who had their tumor removed will receive the experimental ra…

This study tests the safety of combining an experimental drug (neratinib) with a standard chemotherapy (capecitabine) using a different dosing schedule for people with advanced HER2-positive breast cancer. About 34 adults with stage IV disease will receive different dose levels t…

This study tests whether adding a drug called Voraxaze (glucarpidase) to the standard methotrexate and rituximab treatment can safely lower methotrexate levels in the blood of people with central nervous system lymphoma. About 58 adults with B-cell lymphoma in the brain or spinal…

This study compares two maintenance drugs—daratumumab and lenalidomide—for people with newly diagnosed multiple myeloma whose cancer responded well to initial treatment. The main goal is to see which drug provides better quality of life during maintenance therapy. About 95 partic…

This study tests whether adding the immunotherapy drug atezolizumab and targeted radiation (SBRT) to standard hormone therapy can better control metastatic prostate cancer that hasn't been treated yet. About 28 men will receive the combination and be followed for 2 years to see i…

This study tests whether combining two drugs, palbociclib and INCMGA00012, is safe and effective for people with advanced liposarcoma (a type of fat tissue cancer). About 42 participants will receive the combination to find the best dose and see if tumors shrink. The goal is to c…

This study looks at whether the number of stem cells given during a transplant affects recovery for people with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). About 59 adults who have already tried one chemotherapy and are eligible for a stem cell transplant will r…

This early-stage trial tests a new treatment called MCARH109 for people with multiple myeloma that has come back or not responded to at least three prior therapies. The treatment uses specially modified immune cells (CAR T-cells) to target a protein called GPRC5D on myeloma cells…

This early-phase study tests an experimental treatment called HB-200 in 7 people with HPV16-positive head and neck cancer who completed standard therapy but still have HPV DNA in their blood, suggesting possible microscopic cancer. The goal is to see if HB-200 can control or elim…

This study tests whether adding two drugs (lenalidomide and CC-486) to standard radiation therapy is safe and effective for people with plasmacytoma, a rare tumor of plasma cells. About 21 participants will receive the combination treatment. The goal is to see if this approach ca…

This study looks at two methods to help newly diagnosed cancer patients stop smoking before surgery and remain smoke-free afterward. One method involves gradually cutting down on cigarettes before quitting, combined with a nicotine patch, while the other uses standard counseling …

This early-phase study tests whether adding N-acetylcysteine (N-AC) to standard CAR T-cell therapy (Yescarta) is safe for people with lymphoma. The goal is to find the best dose of N-AC that causes few or mild side effects. Only 9 participants are enrolled, and the study is activ…

This study tests whether adding radium-223 to standard chemotherapy (docetaxel) helps men with a tough-to-treat type of advanced prostate cancer live longer. About 732 men will take part. Earlier research showed the combination is safe, but it's not yet known if it works better t…

This study is for men with very high-risk or early-spread prostate cancer. It tests whether giving hormone-lowering medications and other drugs before surgery can shrink the cancer more than surgery alone, possibly lowering the chance it will come back. About 100 participants wil…

This study tests whether adding an experimental drug (BMS-986205) to the immunotherapy nivolumab can shrink tumors or stop them from growing in people with endometrial cancer that has returned or persists. About 24 participants will receive either nivolumab alone or the combinati…

This study tests whether two drugs, lenvatinib and pembrolizumab, can shrink or slow the growth of advanced adenoid cystic carcinoma and other salivary gland cancers that have come back or spread. About 64 adults with these rare cancers will receive the drug combination. Research…

This study looks at whether people with multiple myeloma who have had no signs of cancer for at least 3 years while on maintenance therapy can safely stop that therapy. Instead of continuing medication, they will be closely monitored to see if they remain cancer-free for at least…

This study tests whether adding the drug nivolumab to standard chemotherapy (ABVD) can improve the chance of cure for people with high-risk Hodgkin lymphoma. About 82 participants with untreated stage III or IV disease will receive the combination. The goal is to see if the new a…

This early-phase study tests whether romosozumab, a drug used for osteoporosis, can safely improve bone health in postmenopausal women who also have multiple myeloma. Ten participants receive the drug, and researchers measure changes in bone formation and breakdown markers. The g…

This early study tests if combining two drugs, glofitamab and lenalidomide, can help people with mantle cell lymphoma that returned or didn't respond to prior treatments, including a BTK inhibitor. About 39 adults with this type of blood cancer will take part. The main goal is to…

This study tests a new radiation method (IMRT) for people with malignant pleural mesothelioma, a rare lung cancer. Participants first have surgery to remove the lung lining and then receive chemotherapy, followed by targeted radiation. The main goal is to see if this approach cau…

This study is for people aged 1 to 30 who are newly diagnosed with a rare cancer called desmoplastic small round cell tumor (DSRCT). Researchers are adding three drugs (irinotecan, temozolomide, and bevacizumab) to the usual chemotherapy to see if the combination is safe and tole…

This study tests whether combining two drugs, pembrolizumab and gemcitabine, can shrink tumors in people with advanced mycosis fungoides or Sézary syndrome—rare types of skin lymphoma. The trial enrolled 14 adults who had already tried at least one other treatment. Researchers ar…

This study tests a pill called erdafitinib in people whose bladder cancer has come back after standard treatments like BCG or chemotherapy. Only patients with a specific gene change (FGFR3 mutation) in their tumor can join. The goal is to see if the pill can shrink or eliminate t…

This study tests whether combining two drugs, pembrolizumab (which helps the immune system fight cancer) and olaparib (which stops cancer cells from repairing themselves), can help people with metastatic pancreatic cancer that has a specific genetic feature or has responded well …

This early-phase study tests whether a patient's own immune cells can be genetically modified to recognize and attack prostate cancer cells. Thirteen men with advanced prostate cancer that no longer responds to hormone therapy will receive their own altered T cells. The main goal…

This study tests whether adding daratumumab to three standard drugs (carfilzomib, lenalidomide, and dexamethasone) is safe and effective for people newly diagnosed with multiple myeloma. About 75 participants will receive the four-drug combination. The main goal is to see how man…

This study tests a humanized antibody (Hu3F8) plus a drug called GM-CSF in people with recurrent osteosarcoma, a type of bone cancer. The goal is to see if this treatment can keep the cancer from coming back after surgery. The trial includes 46 participants aged 1 to 40 who are a…

This study tests a new approach for people with cancer that has spread to the bone. Participants receive a precise, high-dose radiation treatment (SBRT) followed by surgery within one week to stabilize the bone. The goal is to see if this combination is safe and helps prevent the…

This study looks at whether a geriatric assessment—checking thinking, mobility, mood, and nutrition—can help doctors choose the best transplant approach for people aged 60 and older with certain blood cancers. The goal is to lower the risk of serious side effects and improve qual…

This study tests whether a chemotherapy plan used for children with acute lymphoblastic leukemia (ALL) is safe and works well for adults aged 18 to 60 with a certain type of ALL (Philadelphia chromosome-negative). The goal is to see if this approach can control the disease and ac…

This study looked at the most effective ways to help smokers quit or cut down when they come in for lung cancer screening. Over 800 patients took part across multiple screening sites. The goal is to make it easier for screening centers to offer tobacco treatment without overloadi…

This study tests whether adding two experimental vaccines (IO102/IO103) to the standard drug combination of nivolumab and relatlimab can safely shrink tumors in people with advanced melanoma that cannot be removed by surgery. About 43 adults who have not had prior treatment for t…

This study tests an experimental drug called ensartinib in people with advanced melanoma that has a specific genetic change (ALK alteration). The goal is to see if the drug can shrink tumors or stop them from growing for at least 24 weeks. Participants must be 18 or older and hav…

This study tests whether adding a chemotherapy drug (doxorubicin) to the targeted therapy sorafenib can help people with advanced liver cancer whose disease got worse on sorafenib alone. About 30 adults with confirmed liver cancer and mild or no cirrhosis will receive the combina…

This study tests a combination of two drugs, venetoclax and obinutuzumab, in people with chronic lymphocytic leukemia (CLL) who have not had any previous treatment. The goal is to see how well this therapy controls the disease and delays its progression. About 100 fit adults with…

This study tests whether giving two drugs, olaparib and pembrolizumab, before standard surgery can shrink breast tumors in people with triple-negative or hormone receptor-positive, HER2-negative breast cancer who have specific gene mutations. The goal is to see if the combination…

This early-phase study tests the safety of combining TTI-622 (a drug that helps the immune system attack cancer cells) with daratumumab (a standard myeloma treatment) in people whose multiple myeloma has returned or stopped responding to prior therapies. Researchers will find the…

This early-phase study tests a new treatment called EGFR-BATs for people with advanced pancreatic cancer that has not responded to standard chemotherapy. The treatment uses the patient's own immune cells, which are trained in a lab to better attack cancer cells. The main goal is …

This study compares a newer imaging method using indocyanine green (ICG) with the standard method to find sentinel lymph nodes in people with early-stage vulvar cancer. About 22 participants will receive both imaging techniques during their planned surgery. The goal is to see if …

This study tests a new dye, called cRGDY-PEG-Cy5.5-C dots, to help surgeons see cancer in lymph nodes during surgery for head and neck melanoma. About 67 people will get the dye injected near their tumor before or during surgery. A special camera then shows which lymph nodes cont…

This study tests a special dye called PARPi-FL that makes cancer cells glow. It is given to people with oral cancer before surgery to help doctors see where the cancer is. The goal is to find the best and safest dose to improve tumor removal. About 23 adults with oral squamous ce…

This study tests the safety of a new drug called PARPi-FL, which is used with a special scan to take pictures of head and neck cancer. The drug has been tested in animals but not yet in people. About 12 adults with head and neck cancer will receive the drug and be monitored for s…

This study tests a new radioactive dye that attaches to cancer cells to make them show up better on PET scans. It involves 10 adults with melanoma or malignant brain tumors. The dye is not a treatment, but the information may help design better detection methods in the future.

This early-phase study tests a new radioactive drug called F-Glutamine, used with PET scans to see if it can find tumors in people with solid cancers or lymphoma. About 67 participants will receive a tiny injection of F-Glutamine, and researchers will measure how long it stays in…

This study was designed to test a new type of PET scan that uses two special substances to find cancer cells with a marker called CA19-9. It was planned for people with pancreatic, bladder, or gastrointestinal cancers. However, the study was withdrawn before any participants were…

This study tests a new, non-invasive imaging technique that uses a special microscope to look at skin lesions in detail without cutting the skin. The goal is to improve early detection of skin cancer and reduce the number of biopsies needed. Over 1,800 people with skin lesions an…

This study tests a new technology called breathprinting (or e-nose) that analyzes breath to detect early-stage lung cancer. About 119 adults with a suspicious lung nodule will provide a breath sample, and the device's results will be compared to standard biopsy or surgery finding…

This early-phase study tests whether a special PET scan (68Ga-PSMA-11) can spot active tumor tissue in people with high-grade glioma or brain metastases. Eleven adults whose tumors are at least 1 cm and who are already scheduled for a biopsy or surgery will receive the scan befor…

This study explores a new imaging technique called Cerenkov luminescence to take pictures of thyroid cancer and tumors that have spread to nearby lymph nodes. About 102 adults with thyroid cancer or other cancers with nodal metastases will be scanned after routine PET or radiatio…

This early-phase study tests whether injecting a radioactive sugar (18F-FDG) into the cervix before a PET/CT scan can more clearly show which pelvic lymph nodes contain cancer in women with stage IB1 cervical cancer or high-grade endometrial cancer. About 42 women scheduled for s…

This early-stage study tests whether a new imaging drug called 89Zr-ss-pertuzumab is safe for people with HER2-positive cancers. About 60 adults with HER2-positive or HER2-low breast or other cancers will receive the agent and be monitored for side effects. The goal is to see if …

This study is testing whether a blood test (NavDx®) can find early signs of HPV-related oropharyngeal cancer by looking for tiny bits of HPV DNA in the bloodstream. Researchers are enrolling 9 people aged 45 and older with multiple sexual partners to see how many cases the test c…

This study tests a new type of MRI scan that is faster and less affected by movement, aiming to produce clearer images of gynecologic tumors. Researchers will compare this new method to traditional MRI in 24 women with gynecologic cancer and healthy volunteers. The goal is to see…

This study tests whether a plant-based diet is practical for overweight people with MGUS or smoldering multiple myeloma, two early blood conditions that can lead to multiple myeloma. Over 12 weeks, 23 participants will follow a whole-food, plant-based diet to see if they can stic…

This study looks at two ways to encourage women who had childhood cancer and chest radiation to get regular mammograms. About 360 women aged 25-49 who haven't had a mammogram in two years will receive either tailored print materials plus a phone chat, or general health informatio…

This study looks at whether training Black men who have already completed a colon cancer screening test (FIT) can help encourage their male friends and family to also get screened. The goal is to see if this peer outreach approach increases screening rates in the community. About…

This study tests whether giving patients their own stool (collected before transplant) after a stem cell transplant can prevent a serious gut infection called C. difficile. About 59 adults receiving a stem cell transplant will be randomly assigned to receive the stool transplant …

This study tested whether a social marketing campaign, with or without text message reminders, could increase HPV vaccination rates among Mexican American children ages 9 to 17. About 181 parents or guardians in New York City took part. The goal was to see if these simple tools h…

This study tests whether adding N-Acetylcysteine (NAC) to the standard drug amiodarone can better prevent atrial fibrillation (a type of irregular heartbeat) in people at high risk after major chest surgery. About 184 adults undergoing lung or esophagus surgery will receive eithe…

This study looks at whether a smartphone app that sends text reminders can help people with breast cancer remember to take their medication, palbociclib, on schedule. About 45 participants will use the app, and researchers will track how accurately they take their pills. The goal…

This study looks at whether adding acupuncture to standard pain care can reduce the need for strong opioid painkillers in people with multiple myeloma, Hodgkin disease, or non-Hodgkin lymphoma who are getting high-dose chemotherapy. About 299 adults will be randomly assigned to r…

This early study tests whether a fecal transplant from a healthy donor can safely ease severe diarrhea caused by immune checkpoint inhibitors (ICIs) in cancer patients. Four adults whose diarrhea did not improve with standard treatments received the transplant during a colonoscop…

This study tests whether taking pancreatic enzyme pills (pancrelipase) can help people with metastatic pancreatic cancer maintain or gain weight. The study includes 17 participants who are starting chemotherapy. Researchers will compare two different dosing schedules and measure …

This study explores whether acupuncture can improve memory, focus, and thinking problems that some people experience after cancer treatment. It includes 48 adults who have finished initial treatment for breast, colorectal, prostate, or gynecologic cancer and report moderate to se…

This study compares acupuncture and massage to see which works better for long-term pain relief in people with advanced cancer. About 300 adults with certain advanced cancers will receive one of the two treatments. The goal is to reduce pain and improve quality of life.

This study tests whether an oral minoxidil pill can safely improve persistent hair loss in children and young adults who had cancer treatment. Ten survivors aged 6-18 who completed cancer therapy at least a year ago will take the drug. Researchers will measure hair density and ch…

This study compares two common surgeries for cancer that has spread to the thigh bone, causing pain or fractures. About 73 people with weakened thigh bones will be randomly assigned to one surgery type. Researchers will track their quality of life, ability to move, pain levels, a…

This study looks at ways to prevent and reduce radiation esophagitis—painful inflammation of the swallowing tube—in people getting chest radiation for cancer. About 142 adults will be enrolled to test if a two-step consent process helps, and if treatments can lower the need for s…

This study looks at whether giving men a deeper level of muscle relaxation during robotic prostate surgery can lower the pressure used in the abdomen during the operation and reduce pain afterward. About 139 men having elective robotic prostatectomy will be randomly assigned to e…

This study tests a new way to calculate the dose of melphalan chemotherapy for lymphoma patients getting a stem cell transplant. Instead of a standard dose based on height and weight, researchers use a model that considers how previous patients processed the drug, aiming for the …

This early-phase trial tests a light-activated drug therapy (VTP) to open up blocked food pipes in 12 people with advanced esophageal or stomach cancer who have trouble swallowing. Doctors will find the safest light dose to shrink tumors blocking the throat. The goal is to ease s…

This study compares two types of support groups for breast cancer survivors: a Meaning-Centered Group that helps find purpose after cancer, and a Discussion Group that offers peer support. About 104 women who have finished treatment (but may still take hormone therapy) will parti…

This study tests whether a smartphone app called AmDTx is practical for helping lung cancer patients manage anxiety before and after surgery. Six participants will use the app, which adjusts to their needs based on doctor prescriptions. Researchers will track how many people stic…

This study tests whether a special type of talk therapy called poetic dignity therapy is practical and helpful for sexual and gender minority (LGBTQ+) patients with cancer who are nearing the end of life. The therapy involves a clinician asking questions to help patients share th…

This study tests a mindfulness program called MORE to see if it can help people with long-term cancer pain. Researchers will enroll 76 adults who have had cancer and still have pain for at least 3 months. The goal is to find out if this approach is practical and helpful for pain …

This study tests whether acupuncture can reduce frequent nighttime urination (nocturia) in prostate cancer survivors. Researchers will enroll 60 survivors who wake up at least twice a night to urinate. Participants will receive 10 acupuncture sessions, and the study will measure …

This study looks at whether flibanserin, a drug for low sexual desire, can be safely taken by breast cancer survivors who are on tamoxifen or similar hormone therapies. About 43 women with a history of breast cancer and no current disease will take flibanserin for 24 weeks. The m…

This study adapts a type of counseling called Meaning-Centered Psychotherapy for Chinese immigrants with advanced cancer. The goal is to help patients maintain a sense of meaning and purpose in life while coping with their illness. Researchers will interview and test the adapted …

This study tests whether a drug called siltuximab can reduce symptoms like fatigue, pain, and nausea after a stem cell transplant. It includes 30 patients aged 60-75 with multiple myeloma or AL amyloidosis. The drug blocks a protein linked to inflammation, which may help patients…

This study compares personalized electro-acupuncture and auricular-acupuncture against usual care for treating chronic pain in 360 adults with musculoskeletal pain or fibromyalgia. Participants either receive acupuncture right away or after 12 weeks of standard care. The goal is …

This study tests whether a telemedicine program, called tele-geriatric oncology, is practical for older adults (70+) with gastrointestinal or gynecological cancer. Participants meet with a nurse via video calls to discuss symptoms and aging-related needs. The goal is to see if th…

This study tests whether an 8-week digital health program called COBRA is safe and practical for older adults with cancer. The program focuses on balance and resistance exercises. Researchers will track how many participants stick with the program to see if it's a feasible option…

This study tests a memory training program for breast cancer survivors who have memory problems after chemotherapy. About 60 women who finished chemo 1-10 years ago will use either a challenging or easier version of the software to see if it improves memory and attention. The goa…

This study looks at whether a ketogenic diet—a very low-carbohydrate diet that forces the body to burn fat for energy—is safe and tolerable for overweight or obese patients with newly diagnosed endometrial cancer. Nineteen participants followed the diet before surgery to see if i…

This study tests whether a type of talk therapy called behavioral activation (BA) can help treat depression in older adults (65+) who have survived cancer. The therapy is delivered remotely by phone or video call. Researchers will compare depression scores between those who recei…

This study looks at whether adding personalized supportive care (like help with symptoms and emotional concerns) to standard cancer treatment in early-phase trials helps patients talk more openly about their health. About 83 adults with advanced solid tumors that have not respond…

This study compares two ways of giving high-dose radiation to people whose cancer has spread to bones, spine, soft tissue, or lymph nodes. One group gets a single large dose in one day, the other gets a slightly higher total dose spread over three days. The goal is to see which s…

This pilot study tested whether a prehabilitation program is practical and helpful for women with advanced ovarian cancer who receive chemotherapy before surgery. The program aims to improve patients' strength and well-being before their operation. 22 women participated, and the …

This study compares two types of radiation therapy for people with head and neck cancer: proton beam therapy and standard photon therapy (IMRT). The goal is to see if proton therapy causes fewer side effects, especially painful mouth sores. About 108 adults with certain cancers (…

This study tests a program that helps cancer patients and their caregivers manage difficult emotions and communicate better about the illness. It includes a version tailored for Latinx participants. The goal is to reduce distress, improve quality of life, and help families discus…

This study tests whether a game-based exercise plan can help childhood cancer survivors (ages 10-16) become more physically active. The plan involves both the child and a parent or caregiver. Researchers will also see if it improves the child's quality of life. About 48 survivors…

This study is developing and testing a mobile app to help breast cancer and rare cancer survivors cope with their fear of the cancer returning. About 252 participants will try different versions of the app to see which is most helpful and easy to use. The goal is to provide a con…

This study looks at the safest amount of aerobic exercise for people about to have surgery for solid tumors like breast, endometrial, or prostate cancer. It tests different exercise doses done at home using apps and devices. The goal is to see if exercise is feasible and what eff…

This study trains home-care nurses to deliver a special type of talk therapy called Meaning-Centered Psychotherapy to people with cancer who are homebound. The goal is to help patients find meaning and ease emotional distress. Researchers will check if the therapy is practical an…

This study tests whether a pelvic floor muscle exercise program, taught by a physical therapist before and after prostate removal surgery, can help reduce or shorten urinary leakage. About 32 men with prostate cancer will participate. The main goal is to see if the program is pra…

This study tests whether benralizumab can safely reduce skin rashes caused by cancer treatments like checkpoint inhibitors. The drug works by lowering eosinophil levels in the blood. About 51 adults with solid tumors or blood cancers who have moderate to severe skin reactions are…

This study collects leftover tissue, blood, and other body fluids from up to 6,000 people with benign or malignant tumors of the soft tissue, gastrointestinal tract, or abdomen. Researchers will use these samples in future lab studies to learn more about what causes these cancers…

This study uses advanced MRI techniques to see if they can predict how well head and neck cancer patients will respond to surgery or chemoradiation. About 272 adults with head and neck cancer will get these special scans before and during treatment. The goal is to find early sign…

This study looks at how the natural bacteria in the gut and diet might influence the risk of colorectal cancer in people with Lynch syndrome or other inherited colon polyp conditions. Researchers collect stool samples, colon tissue, and diet/lifestyle questionnaires from 77 parti…

This study tests a new imaging tool called MSOT that uses light and sound to create pictures of tumors. About 12 people with breast cancer or melanoma will get an MSOT scan before their usual biopsy. The goal is to see if MSOT can find tumors as well as standard methods like ultr…

This study involves 50 healthy volunteers aged 18-80 to learn how a substance called [13C]pyruvate behaves in the body during an MRI scan. The goal is to improve image quality and understand how different organs use energy normally. Participants will receive the substance through…

This study looks at how chemotherapy and other factors affect thinking and memory in older women who survived breast cancer. Researchers compare these women to older women who never had cancer, and also consider genetics and smoking history. About 500 participants take thinking t…

This study aims to understand how normal breast tissue looks on MRI and mammogram, and how that might affect a woman's risk of developing breast cancer. Researchers will compare images and information from questionnaires and medical records from over 2,000 women. The goal is to f…

This study looks at whether telling smokers how tobacco harms their teeth and gums can motivate them to quit. Over 1,000 dental patients who smoke at least 10 cigarettes daily will receive different types of smoking cessation advice. Researchers want to find out which approach wo…

This study looks at how small changes in CT scan settings affect the way tumors are measured in people with colorectal cancer that has spread to the liver. About 169 participants will get an extra CT scan to see if the measurements stay reliable even when scan details vary. The g…

This study tests whether a special computer program can measure liver tumors from ultrasound images as accurately as standard CT scans. About 19 adults with pancreas or gastrointestinal cancer that has spread to the liver will have two research ultrasounds around the time of thei…

This study looks at conversations between lung cancer patients and their healthcare team. Researchers want to learn how these talks affect patient well-being and if training doctors in empathy can improve communication. About 294 patients and their clinicians are taking part.

This study looks at whether a non-invasive brain stimulation technique called tDCS, combined with memory exercises, is practical and well-tolerated by breast cancer survivors who have memory problems after chemotherapy. The main goal is to see if enough people can join and comple…

This study asks 3000 adults who had skin cancer surgery to fill out a one-time online survey about how they feel about their appearance, scars, and quality of life. The goal is to learn what matters most to patients after surgery. No new treatments are being tested.

This study looks at how proton beam radiation therapy (PBRT) changes brain connections in children and young adults (ages 6-25) treated for brain tumors. Researchers use resting-state MRI scans and thinking tests to compare patients with healthy volunteers. The goal is to underst…

This study tests a radioactive antibody called 124I-Hu3F8 to see how it moves through the body and attaches to tumors in people with melanoma, neuroblastoma, or sarcoma. Seven participants received the antibody followed by PET/CT scans at several time points. The goal is to under…

This study looks at whether adding a breath-holding task during fMRI scans can improve the accuracy of mapping essential brain areas in people with brain tumors. Researchers will compare standard fMRI results with those adjusted using breath-hold data. The goal is to reduce false…

This study looks at the experiences of parents who lost a child to cancer between 6 months and 6 years ago. Researchers want to understand what helps these parents find meaning and cope with their loss. The goal is to use this information to create a program that supports grievin…

This study looks at whether a set of online, game-like tests can measure changes in thinking skills (like memory and attention) in breast cancer survivors. About 441 women aged 40-65 will take these tests from home. The goal is to find a better way to detect and understand cognit…

This study looks at whether combining PET/MRI scans with blood and tissue tests can create a detailed profile of high-grade serous ovarian cancer. Researchers hope this will help predict how tumors respond to treatment and allow for more personalized care. The study involves 10 p…

This study looks at how radiation therapy for head and neck cancer might affect thinking skills like memory and focus. Researchers will ask 54 newly diagnosed patients to complete thinking tests and questionnaires three times over one year. The goal is to learn whether patients c…

This study tests a new computer program that reduces blurring in cone-beam CT scans to help doctors better locate lung tumors during radiation therapy. It involves 17 adults with lung cancer who are already scheduled for radiation. The program also tracks small markers placed in …

This study looks at whether hormone therapy (like Lupron or Casodex) changes thinking abilities in men 65 and older with prostate cancer. Researchers will compare thinking and daily function in men starting or already on hormone therapy versus those not on it. The goal is to unde…

This study looks at whether brain scans and spinal fluid tests can find early signs of brain cancer in people with HER2+ breast cancer. About 9 participants will get these tests even if they have no symptoms. The goal is to see if this approach is practical and could lead to earl…

This study looks at how the drug tucatinib enters and works in brain tumors from HER2+ cancers (like breast, lung, and stomach cancers). Researchers will compare genetic differences between tumors that have stopped responding to tucatinib and those being treated for the first tim…

This study aims to develop a digital outreach strategy to inform women about lung cancer screening. Researchers will contact women aged 50–80 who recently had a normal mammogram and have a significant smoking history. The goal is to see if email and a web-based tool can increase …

This study looks at how men with low-risk prostate cancer and their partners decide on treatment. Researchers want to understand how anxiety and difficulty dealing with uncertainty affect those choices. About 541 participants will fill out questionnaires about their feelings and …

This study looks at whether group doctor visits over video (telemedicine) are a practical and acceptable way to follow men with low-risk prostate cancer who are on active surveillance. About 88 men will be randomly assigned to either a group video visit or a one-on-one video visi…

This study looks at how different antibiotics change the helpful bacteria in the gut of people who have had a stem cell transplant. These patients often get fevers and low white blood cell counts, requiring antibiotics. The goal is to see which antibiotics are gentler on the gut'…

This study tests whether it is practical to give women real-time feedback on their recovery after breast surgery. The tool, called BREAST-Q REACT, shows scores from surveys about physical well-being, arm pain, and daily activities. It also provides tips to help patients and docto…

This study looks for brand-new gene changes that appear in a child but not in their parents, which might raise the risk of certain cancers. Researchers will compare DNA from cancer patients and their healthy parents to spot these changes. The goal is to better understand cancer r…

This study follows 600 people with non-muscle invasive bladder cancer to see how lifestyle factors like smoking and body weight influence whether the cancer comes back. Researchers will track recurrences over time. The goal is to understand which habits matter most, not to test a…

This study creates a registry of over 3,500 people, including those with and without urothelial cancer, to better understand the disease. Researchers will look at genetic markers in saliva and risk factors to find links to cancer risk and outcomes. The goal is to improve how we p…

This study tests whether a special dye and camera can help surgeons see blood flow in tissue flaps during gynecologic reconstruction surgery. About 15 women having this surgery will receive the dye, and doctors will check if the images change their surgical plan. The goal is to i…

This study looks at how surviving cancer as a teen or young adult affects a person's sense of self, friendships, and family bonds. Researchers will interview and survey 300 survivors aged 15 to 25 who finished treatment at least 6 months ago. The goal is to learn what these survi…

This study looks at whether a cardiopulmonary exercise test (CPET) can help predict heart and lung function in women with HER2-positive breast cancer who have mild heart problems from their treatment. About 23 women will do a special exercise test to measure oxygen use. The goal …

This early-phase study tests whether a special PET scan tracer called 18F-FAC can measure how much of the standard chemotherapy drug gemcitabine is taken up by pancreatic tumors. About 30 adults with pancreatic ductal adenocarcinoma will receive a PET scan before starting treatme…

This study looks at whether people with Lynch Syndrome, a condition that raises the risk for several cancers, follow recommended screening guidelines after genetic counseling. Researchers will track up to 1,530 participants to see how well they stick to multi-organ screening and …

This study follows 810 women aged 18-45 with early-stage breast cancer to see how treatment affects their menstrual cycles and quality of life. Researchers want to learn what factors lead to early menopause after cancer therapy. The goal is to better understand and predict these …

This study collects DNA samples and medical information from people who have certain gene changes that may be linked to cancer. Researchers want to better understand the risks from less well-studied genes so doctors can give clearer advice to families. About 689 participants, inc…

This study follows 338 adults with two or more ground glass opacities (GGOs) in their lungs. Instead of immediate treatment, participants are actively monitored with regular CT scans. The goal is to collect information about these spots and understand the risk of developing lung …

This study aims to develop new tools that use machine learning to evaluate how well surgeons perform robotic surgery. Researchers will collect data from 1,000 surgeons performing common procedures and analyze their movements, camera use, and instrument handling. The goal is to cr…

This study follows 219 patients who had liver surgery for colorectal cancer that spread to the liver. Researchers track how their quality of life changes over time using surveys. The goal is to help doctors and patients understand what to expect after surgery, so patients can mak…

This early-phase study is testing a tiny amount of a new drug called 124I-PUH71 in 63 people with certain cancers (lymphoma, myeloma, or solid tumors). The goal is not to treat the cancer, but to see how the drug spreads through the body and collects in tumors, and how long it st…

This study collects DNA from over 21,000 New York cancer patients to look for inherited gene changes linked to several cancer types. It is an exploratory project that does not offer treatment but aims to find clues for future research. Participants include people with breast, col…

This study collects blood, tissue, and saliva samples from 7,000 people with and without breast cancer. Researchers will use these samples to study what causes breast cancer and find better ways to prevent, diagnose, and treat it. No direct treatment is given; this is a tissue ba…

This study aims to create a better questionnaire to measure depression in older adults who have or had cancer. Researchers will test this new tool with 329 participants aged 70 and older. The goal is to improve how doctors identify and treat depression in this group.

This study tests a new imaging tracer for PET scans to see if it can help take pictures of brain tumors. Seventeen adults with malignant brain tumors or pituitary adenomas will receive a very small dose of the tracer. The goal is to learn how the tracer spreads and leaves the bod…

This study looks at how prostate cancer changes after radiation treatment using special MRI scans. The goal is to help doctors better understand and manage the disease. About 120 men with newly diagnosed prostate cancer will take part. The study does not test a new treatment but …

This study follows 546 women with early-stage breast cancer to see how chemotherapy or hormone therapy affects their hair, skin, and nails. Researchers want to learn who is more likely to have lasting hair loss or other changes, and how these side effects impact quality of life. …

This study looks at whether it is safe for people with breast tissue expanders to have an MRI scan. The main goal is to see if the MRI causes any heating, burning, or pain near the expander. About 68 people will take part, and if at least 50 scans are completed without problems, …

This study looks back at 300 patients who had hip replacement surgery after a cancer-related hip fracture. Researchers want to see how well patients are able to walk, their pain levels, and survival rates compared to older data. The goal is to find what helps people walk better a…

This study looks at how histiocytosis, a rare group of disorders, may affect memory, thinking, and brain structure. About 13 adults with the disease will take memory tests and have an MRI scan. The goal is to learn more about brain changes, not to test a treatment.

This pilot study looks for better ways to find out if colon cancer might spread to the liver. Researchers are testing new imaging and lab tests in 51 people having surgery for colon cancer or benign colon growths. The goal is to improve early detection and guide future treatment.

This study trains doctors, nurses, and other cancer care providers in a special type of therapy called Meaning-Centered Psychotherapy (MCP). The goal is to help these clinicians better support cancer patients by focusing on meaning and purpose. About 350 providers will take part …

This study looks at whether training doctors to communicate better can help lymphoma patients move from active treatment to survivorship. It involves 314 patients with Hodgkin's or Diffuse Large B-cell Lymphoma and their doctors. The goal is to improve how doctors discuss follow-…

This study looks at how surviving a pediatric brain tumor affects children's thinking, memory, and behavior over time. Researchers will track 42 children who have finished treatment for certain brain tumors to understand these late effects. The goal is to gather information that …

This study aims to create a test that uses circulating tumor cells to predict which chemotherapy regimen will work best for each person with advanced pancreatic cancer. Researchers will analyze tumor cells from 74 participants to see if the test can accurately forecast treatment …

This study looks at how breast cancer treatment might change brain functions like attention, memory, and emotional control. Researchers are testing a new set of evaluations called the SAE Battery on 187 women aged 40-75 with early-stage breast cancer. The goal is to see if this b…

This study looks at why some prostate cancer survivors have trouble with thinking and memory (called cancer-related cognitive dysfunction). Researchers want to see how anxiety, depression, and insomnia play a role, along with social factors and cancer treatments. About 200 surviv…

This study aims to improve how MRI scans work by testing new software and hardware in healthy adults aged 18 and older. Researchers will compare standard images with new ones to see if the new methods provide clearer or more useful pictures. About 662 participants will help deter…

This study aims to improve how doctors estimate survival for people with cancer that has spread to their bones and who need surgery. Researchers will combine the doctor's assessment with the patient's own health report to see if this gives a more accurate survival prediction than…

This study looks at how many women experience lasting pain after mastectomy and breast reconstruction for breast cancer. It also tests whether a surgical technique called regenerative peripheral nerve interface (RPNI) can reduce nerve-related pain. Researchers will follow 274 wom…

This study looks at how the chemotherapy drug cisplatin may damage blood vessels in men with germ cell tumors. Researchers will measure blood vessel function in patients receiving cisplatin and compare it to those who had surgery only. The goal is to understand why cisplatin migh…

This study follows adults who had retinoblastoma (a rare eye cancer) as children, at least five years after treatment ended. Researchers want to understand their long-term health, vision, risk of new cancers, and overall quality of life. The goal is to improve care and follow-up …

This study gathers information from cancer patients and their household members to better understand COVID-19 infections. Participants fill out online questionnaires about their health and lifestyle. The goal is to build a registry that helps researchers see how COVID-19 affects …

This study looks at whether a new training program for nurses, called PACT, helps them better support families of patients with advanced gastrointestinal cancer. The program teaches nurses how to involve family caregivers in care and connect them with resources. Researchers will …

This study looks at how breast cancer treatment affects quality of life in women of different ages. Researchers will ask 650 women with early-stage breast cancer to fill out questionnaires about their health and well-being. The goal is to understand age-related differences in rec…

This study looks at how different treatments for retinoblastoma (a rare eye cancer) affect quality of life years later. Researchers will compare children who had the eye removed versus those who got chemotherapy directly into the eye artery. The goal is to learn which approach le…

This study looks at whether a self-administered geriatric assessment can help predict serious side effects from chemotherapy in people aged 60 and older with Non-Hodgkin lymphoma. About 200 participants will fill out a health questionnaire before starting treatment. The goal is t…

This study checks if a special type of PET scan (PSMA PET) is more accurate than usual scans for seeing prostate cancer and how it responds to treatment. About 58 people with prostate cancer that is new or getting worse will take part. The goal is to see if this scan can better p…

This study looks at how regular exercise might change the biology of breast tumors in women with early-stage breast cancer. Researchers will compare tumor samples from women who exercise regularly with those who do not. The goal is to learn more about exercise's effects on cancer…

This study collects blood or saliva samples from people with cancer and their relatives to build a DNA bank. Researchers will use these samples to study how genes may increase the risk of developing certain cancers. About 992 participants are expected. No treatment or direct bene…

This study looks at whether people with HER2-positive breast cancer can safely have fewer heart check-ups while taking trastuzumab (a targeted therapy). Usually, patients get regular heart scans to watch for side effects. The study will track how many patients develop serious hea…

This study looks at a new approach to genetic testing for people with ovarian, prostate, or pancreas cancer. Instead of always sending patients to a genetic counselor, doctors offer the test and counselors share results by phone. The goal is to see how this affects patient distre…

This study collects tissue, blood, and other fluid samples from men with prostate conditions (including those without cancer) to help researchers understand what causes prostate cancer, why some cancers are more aggressive, and why some respond or resist treatment. The samples ma…

This study is building a registry (a database) of people with BRCA or PALB2 gene mutations who have pancreatic cancer. The goal is to collect information and biological samples to help researchers learn why this cancer develops in some gene carriers. Up to 600 participants, inclu…

This study tests new ways of doing MRI scans to reduce blurring caused by movement. Researchers will try different timing and computer processing methods in 21 children and adults already scheduled for an MRI. The goal is to see if these new techniques produce clearer images than…

This study tests a communication training program for nurses and social workers at Memorial Sloan Kettering Cancer Center. The goal is to help them better support families who are caring for a loved one with cancer. Researchers will see if the training improves the skills and con…

This study gathers information from 49 people with relapsed or hard-to-treat multiple myeloma and their doctors. The goal is to understand why some patients do not receive advanced cell therapies like stem cell transplants or CAR T-cell therapy. No new treatments are given; inste…

This study follows 26 adults with small basal cell carcinomas (a common skin cancer) for up to 3 years. Researchers use special cameras and imaging to measure how the tumors grow, without providing any treatment. The goal is to learn more about these cancers and find better ways …

This study looks at tumor samples from people with bone cancer (osteosarcoma) to understand why some tumors don't respond to chemotherapy. Researchers will test these samples in the lab and also study blood markers. The goal is to learn more about drug resistance, not to test a n…

This study looks at how doctors share information with people who have glioblastoma, a serious brain cancer, and their caregivers. Researchers want to understand how discussions about prognosis and treatment goals happen. The goal is to improve communication so patients and famil…

This study involves 150 people receiving cancer therapy, specifically stem cell transplants. Researchers will securely collect dietary information to see how nutrition relates to treatment response and gut health. The goal is to build a database that can help identify links betwe…

This study looks at whether a pre-treatment biopsy can help predict how well cisplatin and radiation therapy work for people with metastatic or recurrent triple negative breast cancer. About 49 participants will receive the combination treatment and be monitored for tumor respons…

This study looks at how diet, lifestyle, and genetics influence the risk of getting endometrial cancer. Researchers will compare women who have or had the cancer with those who do not. The goal is to identify factors that may lead to the disease. About 1,315 women from New Jersey…

This study looks at how to offer BRCA gene testing to more people, especially those of Ashkenazi Jewish descent, and make it a normal part of medical care. Over 5,400 participants will receive education and then decide if they want testing. Researchers will track who gets tested,…