Memorial Sloan Kettering Cancer Center

This study tested a drug called enasidenib in 4 adults with clonal cytopenia of undetermined significance (CCUS) who have a specific gene change (IDH2). The goal was to see if the drug is safe and can improve low blood cell counts. Enasidenib works by blocking the faulty IDH2 pro…

This early-phase trial tested two drugs, vemurafenib and copanlisib, in 8 people with advanced thyroid cancer that had stopped responding to radioiodine therapy. The goal was to see if the combination could make tumors sensitive to radioiodine again and shrink them. The study als…

This early-phase study tested the safety of combining different doses of external radiation therapy with the chemotherapy drug gemcitabine for people with bladder cancer. Nineteen participants with early-stage bladder cancer that had not spread were enrolled. The main goal was to…

This study tested a new type of radiation therapy for low- and intermediate-risk prostate cancer that delivers a higher dose each day, reducing total treatments from 45-48 to just 5 over 2 weeks. 120 participants received this ultra-hypofractionated, image-guided radiotherapy. Th…

This study tested whether adding the drug pembrolizumab to standard radiation or ablation could help the immune system attack tumors that were not directly treated. It included 34 people with metastatic colorectal cancer who had already tried at least two standard treatments. The…

This early-phase trial tested a combination of three drugs (ibrutinib, rituximab, and lenalidomide) in 25 adults with recurrent or treatment-resistant central nervous system lymphoma. The main goal was to find the safest dose of ibrutinib when given with the other two drugs. Rese…

This study tested the safety and effectiveness of combining two targeted drugs, copanlisib and ibrutinib, in 18 adults with primary CNS lymphoma that had come back or not responded to prior treatment. The goal was to find the best dose and see how many patients' tumors shrank. Th…

This study tested two drugs, amivantamab and lazertinib, in 43 adults with a specific type of lung cancer (EGFR-mutant) that had spread to the brain and was getting worse despite previous treatments. The goal was to see if the combination could shrink or control brain tumors. Bot…

This study tested whether a smaller dose of radiation can still control high-risk neuroblastoma while causing fewer long-term side effects. 78 children with high-risk neuroblastoma received reduced-dose radiation to the main tumor site. Doctors checked scans and clinical signs to…

This study looked at whether switching from the immunotherapy durvalumab to the targeted pill sotorasib could better control locally advanced non-small cell lung cancer in people with a KRAS G12C mutation. The switch was triggered when a blood test showed signs of remaining cance…

This study tested the drug ibrutinib in 93 adults with a rare type of brain cancer called primary or secondary central nervous system lymphoma. The goal was to find the safest dose and see if adding ibrutinib to standard chemotherapy could improve how well the cancer responds. Th…

This early-phase study tested the safety of combining two targeted drugs, dacomitinib and osimertinib, in 22 people with a specific type of advanced lung cancer (EGFR mutant). The goal was to find the highest safe dose and see how well the combination shrinks tumors. Participants…

This study tested whether adding the targeted drug panitumumab to a special chemotherapy given directly into the liver (hepatic arterial infusion) plus standard IV chemo could help keep colorectal cancer from coming back after liver metastases were surgically removed. 75 adults w…

This study tested whether giving anti-testosterone drugs before, during, and after high-dose, targeted radiation can prevent very high-risk prostate cancer from returning. 64 men with aggressive prostate cancer took part. The goal was to see if this combination keeps PSA levels l…

This study tested a combination of two drugs, talazoparib and temozolomide, in 16 men with advanced prostate cancer that had spread and stopped responding to hormone therapy. The goal was to find the safest dose and see if the treatment could shrink tumors. The study was complete…

This study tested proton therapy for people whose head and neck cancer came back after previous radiation. The goal was to see if this precise type of radiation can control the tumor and limit side effects. 87 adults with recurrent or new head and neck cancer that could not be su…

This early study tested a drug called BGJ398 in 4 people with a specific type of bladder cancer that had returned after standard therapy. The goal was to see if the drug could make tumors disappear when viewed with a camera inside the bladder. The study was small and focused on p…

This study tested the drug vemurafenib in 36 people with hairy cell leukemia that had returned or not responded to standard treatments. The goal was to see how well the drug could clear leukemia cells from the blood and what side effects it might cause. Participants took vemurafe…

This study tested a new device that delivers targeted radiation to early-stage basal and squamous cell skin cancers without surgery. 36 people aged 60 or older with small, low-risk tumors received treatment. Researchers measured how well the radiation controlled the cancer, side …

This study looked at whether a targeted treatment called local ablative therapy (LAT) can help control metastatic non-small cell lung cancer (NSCLC) when a blood test shows rising levels of cancer DNA (minimal residual disease or MRD). 37 participants received LAT to all visible …

This study tested whether adding a radioactive drug called radium-223 to standard targeted radiation (SBRT) helps control prostate cancer that has come back in a few places but is still hormone-sensitive. Twelve men participated and were randomly assigned to get either SBRT alone…

This study tested whether combining two immunotherapy drugs, nivolumab and ipilimumab, can shrink or control advanced salivary gland cancer that has come back or spread. 64 adults with different types of salivary cancer took part. The main goal was to see how many patients' tumor…

This study tested whether giving the drug romidepsin after a stem cell transplant can help keep T-cell non-Hodgkin lymphoma from coming back. 47 adults whose lymphoma was in remission received high-dose chemotherapy, a stem cell transplant, then romidepsin as maintenance therapy.…

This study tested a combination of Hu3F8 (an antibody) and GM-CSF (an immune booster) along with isotretinoin in 59 children with high-risk neuroblastoma who had achieved their first remission. The goal was to see if this immunotherapy could prevent the cancer from coming back. W…

This study tested the oral drug regorafenib in 38 people with advanced adenoid cystic carcinoma, a rare cancer that often starts in salivary glands. The goal was to see if the drug could slow or stop tumor growth. Participants started at a lower dose to reduce side effects, with …

This study tested whether combining two drugs, fulvestrant and abemaciclib, can shrink or control a specific type of uterine cancer (hormone-receptor-positive endometrial cancer). 28 adults with this cancer took the drug combination. The main goal was to see how many patients' tu…

This study tested the drug nivolumab in people with primary central nervous system lymphoma (PCNSL) whose spinal fluid still showed signs of tumor DNA after their first round of chemotherapy. The goal was to see if nivolumab could safely prevent the cancer from returning. Fourtee…

This early-phase trial tested the safety of a drug called duvelisib when given with either romidepsin or bortezomib for people with T-cell lymphoma that had come back or stopped responding to treatment. The study involved 114 adults and aimed to find the safest dose. While not a …

This study tested two ways to use the drug pomalidomide in people with multiple myeloma that has come back or stopped responding to treatment. All 23 participants first received a combination of clarithromycin, pomalidomide, and dexamethasone (ClaPD) for 4 cycles. Then, half rece…

This study tested two radiation methods for people with cancer that has spread to the lining of the brain and spinal cord (leptomeningeal metastases). One method, proton craniospinal irradiation, treats the entire fluid-filled space around the brain and spine. The other, partial …

This study tested a combination of two drugs, pembrolizumab and olaparib, in 26 people with endometrial cancer that came back or didn't go away. The goal was to see if the combo could shrink tumors and how safe it was. Participants had specific types of endometrial cancer, includ…

This study tested whether a targeted drug called brentuximab vedotin (SGN-35) could replace the standard ICE chemotherapy as the first step before a stem cell transplant in people with Hodgkin lymphoma that came back or didn't respond to initial treatment. 66 participants receive…

This early-phase study tested whether adding the immunotherapy drugs nivolumab (with or without ipilimumab) to standard chemotherapy could safely treat advanced high-grade serous ovarian, fallopian tube, or primary peritoneal cancer. 27 patients received the combination before an…

This study tested whether giving higher doses of carfilzomib together with lenalidomide and dexamethasone is safe and effective for people newly diagnosed with multiple myeloma. 29 participants took part to find the best tolerated dose and to measure how many cancer cells remain …

This study looked at whether a Medtronic pump and Codman catheter could safely deliver chemotherapy directly to the liver in 35 people with colorectal cancer that spread to the liver or bile duct cancer. The main goal was to check safety, like liver side effects and need for sten…

This study tested whether a device called Nevisense, which measures electrical properties of skin, can provide useful information about atypical moles during routine skin cancer screening. Forty adults with many moles (at least 100) and several large moles took part. The goal was…

This study tested a new imaging technique that combines a special tracer called [18F]PARPi with PET and MRI scans to get clearer pictures of brain tumors. Five adults with new or suspected returning brain tumors took part. The goal was to see how well this method shows tumor acti…

This study tested whether a one-time colonoscopy or yearly stool tests are better at finding early signs of colorectal cancer in healthy people aged 50 to 69. Over 4,900 participants were randomly assigned to one of the two screening methods. The goal was to see which approach de…

This study tested whether placing a special mesh during bladder removal surgery (radical cystectomy) could lower the chance of developing a parastomal hernia, a common complication. A total of 178 patients having surgery for bladder cancer took part. The goal was to compare outco…

This study looked at two ways to help older patients (65+) with head and neck cancer manage side effects during radiation and chemotherapy. Researchers compared geriatric co-management and geriatric guided supportive care to see which approach might reduce hospital stays. The goa…

This study looked at whether family therapy sessions, given while a family member is being treated for advanced cancer, can improve communication and support during and after the loss. 700 families were randomly assigned to standard care, 6 therapy sessions, or 10 therapy session…

This study tested the safety of adding a drug called rucaparib to standard radiation therapy for women with triple negative breast cancer who still had cancer after chemotherapy and surgery. 31 women participated. The goal was to find the best dose that does not cause severe side…

This study tested a therapy called Managing Anxiety from Cancer (MAC) to help reduce anxiety in people aged 65 and older with cancer, and their caregivers. 26 participants were randomly assigned to either MAC or usual care. MAC uses a proven plan that includes the caregiver to he…

This early-stage trial tested a new dye called Illuminare-1 that makes nerves glow during prostate cancer surgery. The goal was to help surgeons avoid damaging nerves, which can cause side effects like incontinence and erectile dysfunction. The study involved 41 men and focused o…

This study tested different nerve block injection sites to see which best reduces the need for pain medication after a double mastectomy with immediate reconstruction. Over 1,500 women participated. The goal was to find the most effective approach for managing post-surgery pain.

This study tested whether colesevelam, a drug used for high cholesterol, can safely improve diarrhea in people with multiple myeloma who take lenalidomide. 25 participants received colesevelam, and researchers measured if their diarrhea improved within 4 weeks. The goal was to fi…

This study tested whether a 30-week walking program is safe for cancer patients who were hospitalized for COVID-19. Only 3 people took part, and the goal was to see if the exercise caused any serious side effects. The walking plan was adjusted to each person's fitness level.

This study tested a special radiation method called multi-beam IMRT in 100 women with breast cancer who had implant reconstruction after mastectomy. The goal was to see if this technique could lower the chance of implant failure and other side effects compared to standard radiati…

This study tested a faster radiation treatment called Quad Shot for people with advanced lung cancer who are also receiving other cancer drugs. The goal was to see if giving radiation in fewer, more intense sessions is safe and less likely to interfere with their regular treatmen…

This study tested whether a special gel (Oleogel-S10) can help heal skin burns caused by radiation therapy in breast cancer patients. The gel was used along with a standard steroid cream. 18 patients with moderate to severe skin reactions took part. The goal was to see if the gel…

This study asked 41 stem cell transplant patients and their caregivers what they thought of the Coping Together manuals, which are self-guided booklets to help manage stress after transplant. The goal was to see if people found them helpful and to get suggestions for making them …

This study looked at whether screening cancer caregivers for distress and providing targeted support (called S+C) is better than usual care. Researchers followed 150 caregivers of cancer patients at Memorial Sloan Kettering. The goal was to see if this approach reduces unmet need…

This study looked at 133 Hodgkin lymphoma survivors who had chest radiation at least 5 years ago. Researchers compared two heart tests—a stress echocardiogram and a cardiac MRI—to see which one finds heart damage earlier. The goal is to improve long-term heart monitoring for thes…

This study tested whether small devices called Calypso beacons can help doctors track lung tumors during radiation treatment. 48 people with lung cancer took part. The beacons were placed near the tumor and sent signals to show its exact location while the patient held their brea…

This study looked at whether a Community Health Worker (CHW) program could help at-risk Chinese community members in New York City make informed decisions about lung cancer screening. About 99 participants, including Chinese immigrants who smoke or used to smoke, took part. The g…

This study looked at how people with a close family history of melanoma make choices about sun protection, like using sunscreen or seeking shade. Researchers interviewed 94 participants to understand the reasons behind these decisions. The goal is to use this knowledge to better …

This study aims to understand why some men feel anxious about using penile injections for erectile dysfunction after pelvic surgery. About 126 men who have had radical pelvic surgery and are starting injection therapy will fill out questionnaires at several points. The goal is to…

This study looked at why some breast cancer treatments stop working over time. Researchers took tumor samples from 269 patients whose cancer had returned or worsened after targeted therapy. By studying genetic and protein changes in the tumors, they hope to understand resistance …

This study looked at whether a low-dose vaginal estrogen tablet (Vagifem) is safe for women who have had breast cancer and are taking hormone-blocking drugs called aromatase inhibitors. 31 postmenopausal women with a history of breast cancer used the tablet for vaginal dryness, a…

This study looked at 73 adults with many moles (50 or more) to find patterns that might predict melanoma risk. Researchers examined mole features using a special camera to see which patterns are linked to skin cancer. The goal is to personalize melanoma screening so people at hig…

This study looked at 111 people who had surgery for early-stage cervical or vulvar cancer to find out how many develop lower leg swelling (lymphedema) after lymph node removal. Participants filled out a questionnaire about their symptoms. No new treatments or tests were given—the…

This study tested if a green dye (ICG) can help surgeons find the first lymph nodes that might show if ovarian cancer has spread. 48 women having surgery for an ovarian mass or to lower their cancer risk took part. Doctors injected the dye in three different ways and used a speci…

This study tested whether a hyperspectral camera can measure blood flow and oxygen levels in the skin of healthy volunteers. Only 8 people took part. The goal was to see if the camera works, not to treat any disease.

This study created a worldwide registry for people with fibrolamellar cancer (FLC), a rare liver cancer. Researchers collected information from 12 participants about their medical history and routine care. The goal was to build a database that can be used for future studies. No t…

This study looked at whether it's possible to set up a nutrition support program for people about to have surgery for ovarian cancer. Researchers enrolled 23 adults scheduled for surgery and measured how many agreed to participate. The goal was simply to see if such a program cou…