New approach uses blood test to guide targeted treatment for advanced lung cancer

NCT ID NCT05429320

First seen Feb 02, 2026 · Last updated May 05, 2026 · Updated 9 times

Summary

This study tested whether using local ablative therapy (LAT) — treatments like radiation or heat to destroy tumors — can control metastatic non-small cell lung cancer when a blood test shows rising cancer DNA (MRD). 37 participants received LAT instead of switching to stronger drugs. The goal was to reduce cancer DNA levels and delay disease progression. Results help guide future use of LAT in managing advanced lung cancer.

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Contacts and locations

Locations

  • BAPTIST ALLIANCE - MCI (Data collection only)

    Miami, Florida, 33143, United States

  • Hartford Healthcare ALLIANCE (Data collection only)

    Hartford, Connecticut, 06102, United States

  • Memorial Sloan Kettering Bergen (Limited Protocol Activities)

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center (All Protocol Activities)

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau (Limited Protocol Activities)

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities)

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Westchester (Limited Protocol Activities)

    Harrison, New York, 10604, United States

  • Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)

    Basking Ridge, New Jersey, 07920, United States

Conditions

Explore the condition pages connected to this study.