Arthritic joint disease

This trial compares different surgical and antibiotic approaches to treat infections in artificial hip and knee joints. It tests whether cleaning the joint while keeping the implant in place (DAIR) or replacing the joint entirely leads to better cure rates. It also examines wheth…

This study tests whether the Butantan-Dengue vaccine is safe and works well in people aged 12–59 with autoimmune rheumatic diseases (like rheumatoid arthritis or lupus) who are stable on low or no immune-suppressing drugs. Participants receive one vaccine dose and are monitored f…

This study is testing the meningococcal B vaccine (Bexsero) in children and young adults aged 2 to 25 who have autoimmune rheumatic diseases like juvenile arthritis or lupus. Researchers want to see if the vaccine triggers a strong immune response and if it is safe, especially fo…

This study tests the safety and immune response of the 20-valent pneumococcal vaccine (PCV20) in children, adolescents, and young adults aged 2-25 with autoimmune rheumatic diseases like juvenile arthritis. All 114 participants will receive one dose of PCV20, and researchers will…

This study tests whether an investigational drug called PLG0206 can prevent infections from coming back after knee replacement surgery. About 240 adults who need a special cleaning surgery (DAIR) for an infected knee joint will receive either PLG0206 or a placebo during the proce…

This Phase 1 trial tests surovatamig, a bispecific T-cell engager, in 48 adults with rheumatoid arthritis or systemic lupus erythematosus. The study gives the drug as injections in increasing doses to check safety, side effects, and how the body processes it. It is too early to k…

Researchers at a Korean hospital are following 210 adults who receive a cementless total hip replacement using the collarless Actis femoral stem. The study focuses on Asian patients, who tend to be younger at surgery and more often need the operation because of lost blood supply …

This study is testing the long-term safety and effectiveness of a drug called afimkibart in people with moderate to severe rheumatoid arthritis. Participants have already taken afimkibart in a previous study and will continue taking it. The goal is to see if the drug remains safe…

This trial tests an experimental drug called DDY391 in about 220 adults with moderate to severe psoriatic arthritis, a condition that causes joint pain, swelling, and skin patches. Researchers want to see whether DDY391 can reduce joint symptoms better than a placebo and at what …

This Phase 3 study tests whether the oral drug zasocitinib (TAK-279) can improve symptoms of active psoriatic arthritis in people who have never used biologic treatments. About 1,088 adults will receive either zasocitinib, an active comparator, or a placebo for up to 60 weeks. Th…

Researchers are testing an experimental drug called GenaKumab in children and teens with active systemic juvenile idiopathic arthritis, a condition that causes joint inflammation and recurring fevers. The trial enrolls about 290 participants aged 2 to under 18 who have had sympto…

This Phase 3 trial tests whether a gel made from donated umbilical cord stem cells (CARTISTEM) can reduce pain and improve knee function better than a simple surgical cleanup (debridement) in people with knee cartilage damage and osteoarthritis. About 300 adults aged 18-75 with m…

This trial tests whether nicorandil, a drug currently used for heart conditions, can reduce disease activity and symptoms in people with rheumatoid arthritis. About 70 adults with moderate-to-severe RA will take either nicorandil or a placebo twice daily for three months, while c…

Researchers are testing a new once-weekly injection called NNC0487-0111 in about 400 Japanese adults with overweight or obesity. Half the participants receive the drug and half receive a placebo, assigned by chance. The main goal is to measure how much body weight changes over th…

This study tests whether the drug nerandomilast can slow lung scarring in people with autoimmune diseases like rheumatoid arthritis or scleroderma. About 400 adults whose lung function hasn't improved with standard treatment will take either nerandomilast or a placebo twice daily…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This Phase 1 trial tests the safety and tolerability of a new drug called AZD5492 in 72 adults with lupus, myositis, or rheumatoid arthritis. Participants receive one or two doses under the skin and are monitored for side effects and how the drug moves through the body. The study…

This study tests a new oral medication, upadacitinib, in children aged 1 to 17 with active systemic juvenile idiopathic arthritis (sJIA), a rare and serious form of arthritis that can affect the whole body. About 90 participants will receive either upadacitinib or the standard in…

This study tests a new medicine called tulisokibart for people with active psoriatic arthritis, a condition causing joint pain and skin plaques. Researchers will compare different doses of the drug to a placebo in 140 adults to see if it improves symptoms like joint tenderness an…

This early-stage study tests a single dose of ABBV-519 in 30 adults with moderate lupus or rheumatoid arthritis. Researchers will check how the drug moves through the body, how it affects immune cells, and whether it is safe. Participants will be followed for about a year to moni…

This early study tests a new medicine, MK-1045, in about 21 people with lupus or rheumatoid arthritis. The main goal is to see if it is safe and tolerable at different dose levels. Participants receive the drug through an IV infusion, and researchers monitor for side effects.

This study tests a new drug called sonelokimab for adults with active psoriatic arthritis who have not improved with or cannot take standard TNF-blocker medications. About 600 participants will receive either sonelokimab, a placebo, or an existing drug (risankizumab) for comparis…

This phase II trial tests whether an implant made from a patient's own nasal cartilage can treat patellofemoral osteoarthritis (knee arthritis) better than standard platelet-rich plasma injections. 75 adults aged 18–65 with moderate knee arthritis will be randomly assigned to rec…

This study tests the long-term safety and effectiveness of an oral drug called zasocitinib (TAK-279) in adults with active psoriatic arthritis, a condition causing joint pain and skin patches. About 1,182 participants who completed a one-year parent study will take either a lower…

This study tests a new medicine called MAS825 for people with Still's disease, a rare inflammatory condition causing fever, rash, and joint pain. About 20 children and adults with active disease will receive the drug to see if it safely controls symptoms. The goal is to improve d…

This early-stage study tests a new drug called SAR448501 (DR-0201) in 62 adults with lupus or rheumatoid arthritis. The drug is a bispecific antibody designed to target the immune system. The main goal is to check safety and find the right dose, not yet to prove it works. Partici…

This Phase 3 trial tests whether the experimental drug zasocitinib (TAK-279) can reduce joint swelling and pain in people with active psoriatic arthritis. About 600 adults will receive either the drug or a placebo for up to 60 weeks. The main goal is to see if more people on the …

This study is testing a drug called secukinumab, given as an IV infusion, in 20 children aged 2 to 17 with juvenile psoriatic arthritis. The main goals are to see how the drug moves through the body and to check its safety over up to 6 years. This is an early-stage trial, so it f…

This study looks at whether adding tirzepatide (a weight-loss drug) to standard ixekizumab treatment helps adults with active psoriatic arthritis who are overweight or obese. About 200 participants will receive both medications for up to 12 months. The goal is to see if this comb…

This phase 3 trial tests whether belimumab (Benlysta) can stabilize or improve lung function in adults with interstitial lung disease caused by connective tissue diseases like rheumatoid arthritis or lupus. About 440 participants will receive either belimumab injections or a plac…

This study tests whether wearing a knee sleeve daily for five years can slow the progression of knee arthritis and reduce pain in adults aged 50 to 64 who have had knee pain for at least three months. Participants are randomly assigned to either wear a knee sleeve every day or no…

This early-stage study tests an experimental drug called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check safety and how the body handles the drug. Participants will receive either the drug or a placebo, and the study lasts …

This trial tests whether people with rheumatoid arthritis who have stable disease can stop taking methotrexate or leflunomide while continuing their TNF inhibitor, restarting the drug if needed. Researchers compare this approach to staying on the combination therapy. They track d…

This Phase 3 study tests whether the drug apremilast (Otezla) can safely reduce joint inflammation and pain in children aged 5 to 17 with active juvenile psoriatic arthritis. About 60 participants will receive either apremilast or a placebo pill for 16 weeks. The main goal is to …

This study looks at whether adding a bone marrow injection to standard knee surgery can improve pain and function for people with cartilage or meniscus injuries. Fifty adults aged 18 to 64 will be randomly assigned to get either the bone marrow injection or a placebo saltwater in…

This trial tests an investigational cell therapy called FT839 in people with active autoimmune diseases, including ANCA-associated vasculitis, inflammatory myositis, rheumatoid arthritis, lupus, and systemic sclerosis. Participants receive FT839 as two intravenous infusions, some…

This trial tests whether a smartphone app-guided rehabilitation program (MOKneeTOR) is as effective as traditional hospital-based physiotherapy for people with knee osteoarthritis. Participants will be randomly assigned to either use the app for 24 weeks or attend outpatient phys…

This study tests a new drug called TQH3906 for people with active psoriatic arthritis, a condition causing joint pain and skin patches. About 156 adults will receive either TQH3906, a placebo, or an existing drug (tofacitinib) for 12 weeks. The main goal is to see if TQH3906 impr…

This study is testing a shoulder replacement device in 300 people with shoulder arthritis, bone death, or rotator cuff tears. Participants receive the implant and are followed for 10 years to see how well it works and if it is safe. The goal is to improve pain and shoulder functi…

This study tests whether adding deucravacitinib to standard therapy helps adults with psoriatic arthritis that is not well controlled. About 128 participants will receive the combination and be monitored for 48 weeks. The goal is to reduce skin and joint symptoms and improve qual…

This study tests a drug called risankizumab in children with juvenile psoriatic arthritis, a condition causing joint pain and swelling. About 40 kids will receive either risankizumab or the standard drug adalimumab for 24 weeks, with responders continuing for up to 2 years. The g…

This phase 2 trial tests whether telitacicept, an experimental biologic given as a weekly injection, can improve symptoms in people with difficult-to-treat rheumatoid arthritis. Participants receive either telitacicept plus standard therapy or standard therapy alone for 24 weeks.…

This trial tests a procedure called trans-arterial embolization for people with chronic back pain caused by facet joint arthritis. Doctors inject tiny beads into the blood vessels feeding the painful joints to reduce blood flow and potentially ease pain. The study includes 40 adu…

This study follows 200 adults with psoriatic arthritis who are starting guselkumab as part of their normal care. Researchers will track how many patients continue the treatment after one and two years, and why some stop. The goal is to understand how well the drug works in real-w…

This study tests whether the experimental drug JNJ-88545223 can reduce joint pain, swelling, and skin symptoms in adults with active psoriatic arthritis. About 240 participants will receive either the drug or a placebo to see if it works better than no treatment. The goal is to i…

This trial tests whether a single injection of a patient's own bone marrow concentrate (BMAC) can reduce knee pain and improve function better than the standard corticosteroid injection in people with knee osteoarthritis. Adults aged 18-70 with moderate knee arthritis and persist…

This study tests a 3-month virtual program called Choose to Move Replacement Ready for people on waitlists for hip or knee replacement due to osteoarthritis. The program offers choice-based physical activity and group support to help participants stay active, reduce pain, and imp…

This trial tests whether a new robotic system, KUNWU®, can accurately achieve the planned knee alignment during total knee replacement, regardless of which of two implant types is used. Adults with knee osteoarthritis needing surgery will be randomly assigned to receive either th…

This early-stage trial tests an experimental treatment called QEL-005 for people with two serious autoimmune conditions: diffuse cutaneous systemic sclerosis and difficult-to-treat rheumatoid arthritis. QEL-005 is made from a patient's own white blood cells, which are genetically…

This study tests whether removing a small part of the shoulder bone (coracoid) during reverse total shoulder replacement helps patients rotate their arm inward better after surgery. Sixty adults needing shoulder replacement will be randomly assigned to get the standard surgery or…

This trial tests whether adding metformin, a common diabetes medication, to a program of diet and exercise can reduce knee pain and improve function in overweight or obese adults with knee osteoarthritis. Participants will receive either metformin or a placebo for six months, alo…

This study follows 70 Korean adults with ankylosing spondylitis who have never taken biologic drugs. They will receive secukinumab as part of routine care. Researchers will measure changes in disease activity and inflammation over time to see how effective the treatment is in rea…

This study tests whether adding a Chinese herbal formula (Si Miao Xiao Bi Tang) to standard rheumatoid arthritis medication can improve symptoms. About 132 adults with active RA will receive either the herbal medicine or a placebo for 12 weeks. The main goal is to see if more peo…

This trial tests whether transferring gut bacteria from a healthy donor (fecal microbiota transplantation, or FMT) can reduce disease activity in people with axial spondyloarthritis (axSpA) who haven't fully responded to biologic therapy. Participants receive a single enema with …

This trial tests whether a new type of hip resurfacing implant, called the H1, can be as successful as a standard total hip replacement for people with hip arthritis. Participants will receive either the H1 implant or a traditional replacement, and researchers will compare their …

This trial investigates different types of steroid injections for back, neck, and related pain to see which are most effective and safe. It compares various steroids, doses, and injection sites, including epidural and facet joint injections. The study measures pain relief and fun…

This early-stage study tests a new therapy, HN2301, in 30 adults with lupus, scleroderma, or rheumatoid arthritis. The main goal is to check safety and find the right dose. Researchers will also look for early signs that the treatment helps control the disease by measuring immune…

This study tests whether giving sarilumab (Kevzara) through an IV with longer intervals between doses is safe and works well for adults with moderate-to-severe rheumatoid arthritis. Participants receive the drug intravenously, with or without other standard arthritis medications.…

This study is testing the long-term safety and effectiveness of the drug filgotinib in children and adolescents aged 8 to 17 with juvenile idiopathic arthritis. Participants must have already completed a previous filgotinib study and shown improvement. The goal is to see if the d…

This trial asks whether people with rheumatoid arthritis who have low disease activity can safely reduce their JAK inhibitor dose without losing control of their symptoms. Participants will either follow a step-by-step dose-tapering plan or continue their usual full-dose medicati…

This study looks at the safety and effectiveness of the drug Xeljanz in children aged 2 to 17 with active juvenile idiopathic arthritis or juvenile psoriatic arthritis. It is an observational study in Korean clinics, meaning doctors prescribe the drug as usual and researchers mon…

This study tests a new way to treat infected knee replacements. About 100 adults having surgery for an infected knee will be randomly assigned to receive either standard care or standard care plus an extra treatment. The extra treatment involves injecting antibiotics along with s…

This trial compares three common surgical procedures for thumb basal joint arthritis: trapeziectomy with ligament reconstruction, trapeziectomy with suture suspensionplasty, and arthroscopic trapeziectomy alone. The goal is to see which technique best restores grip and pinch stre…

This study tracks about 678 adults with moderate to severe rheumatoid arthritis in Germany to see how long they stay on either upadacitinib or TNF inhibitors. Doctors choose the treatment before the study starts, based on standard care. The goal is to learn which drug people stic…

This early-stage trial tests a new treatment called AZD0120 for adults with three autoimmune diseases: systemic sclerosis, idiopathic inflammatory myopathies, or difficult-to-treat rheumatoid arthritis. AZD0120 is made from a patient's own immune cells, which are modified in a la…

This early study tests a new treatment called CD19/BCMA CAR-T for people with severe autoimmune diseases like lupus and Sjögren's syndrome that haven't improved with standard care. The treatment involves taking a patient's own immune cells, modifying them to target specific immun…

This study tests whether temporarily stopping methotrexate for 2 weeks after receiving a pneumonia vaccine (PCV20) helps the vaccine work better in adults with autoimmune rheumatic diseases like rheumatoid arthritis or lupus. About 192 participants with stable, low disease activi…

This early-stage trial tested the safety of a new drug called NTR-1011 in 36 healthy adults and people with lupus or rheumatoid arthritis. The study aimed to find a safe dose and see how the drug behaves in the body. It is a first step toward possibly developing a new treatment f…

This study compares two treatment strategies for people with active rheumatoid arthritis (RA) who have already tried a type of biologic called a TNF inhibitor. Participants are randomly assigned to switch to either a different class of biologic (non-TNFi) or a newer oral medicati…

This trial tests a special bone graft that releases the antibiotic tobramycin to treat infected knee replacements. The graft is placed during the first stage of revision surgery, with the goal of clearing the infection and promoting new bone growth. About 200 adults with infected…

This study will follow 100 adults who receive the 5C® MEDic Knee System during knee replacement surgery. Researchers want to see how long the implant lasts without needing another operation and track any complications over 5 years. Participants will also fill out health questionn…

This trial investigates whether adding antibiotics (vancomycin and tobramycin) to bone graft material during hip replacement surgery can reduce the risk of serious joint infections. The study includes adults undergoing hip replacement who need bone graft, comparing those who rece…

This study tests a new implant called KeriFuse for fusing the last joint of fingers damaged by osteoarthritis. The implant is a staple made of a special metal that returns to its original shape after being placed, which may help the bone heal faster. About 50 adults with painful …

This phase 2 trial tests whether a daily, at-home ultrasound device can safely reduce inflammation and joint pain in people with rheumatoid arthritis. About 40 adults with moderate-to-severe RA will use either an active or a sham device for 8 weeks. The study focuses on safety an…

This study tests a new tool called OPTIBIO that uses blood markers and patient data to help doctors decide if it's safe to reduce biological therapy in rheumatoid arthritis patients who are in remission. About 184 adults with RA in stable remission will be randomly assigned to ha…

This study compares two types of partial knee replacements for people with arthritis on the inner side of the knee. One implant has a fixed bearing (the plastic piece stays still), while the other has a mobile bearing (the plastic piece can move slightly). Researchers will track …

This study tests a new medicine called SBT777101 in 24 people with moderate-to-severe rheumatoid arthritis (RA). It is the first time this drug is given to humans, so the main goal is to check safety and side effects. Participants receive a single dose, and the dose is increased …

This study tests whether taking a once-daily JAK inhibitor for rheumatoid arthritis in the evening works better than taking it in the morning. About 90 adults with RA who qualify for this medication will be randomly assigned to morning or evening dosing. Researchers will compare …

This study compares two surgical treatments for thumb base osteoarthritis: total joint replacement with the TOUCH prosthesis and trapeziectomy (removing a bone at the thumb base). Researchers want to see if joint replacement provides better grip strength and fewer complications. …

This study tests an experimental drug called AZD1163 in 320 people with moderate-to-severe rheumatoid arthritis who haven't gotten enough relief from standard treatments. Participants receive either AZD1163 or a placebo as an injection, along with their usual care. The main goal …

This early-stage study tests a new drug (GSK5926371) in people with lupus and similar autoimmune diseases. The drug is designed to target and calm specific immune cells that attack the body. The main goal is to check if the drug is safe and how the body handles it, with 54 adults…

This study compares two types of wrist fusion surgery for people with post-traumatic wrist arthritis. One surgery fuses four wrist bones and removes the scaphoid. The other fuses three or two bones and also removes the triquetrum. The goal is to see which approach gives better gr…

This trial investigates whether adding the antibiotic rifampicin to standard treatment improves outcomes for people with prosthetic joint infections caused by Cutibacterium acnes bacteria. These infections are hard to treat because the bacteria form a protective biofilm. The stud…

This study tests whether a 20-day fasting schedule before hip replacement surgery can reduce complications like infections. 130 adults will either follow the fasting plan or receive standard care. Researchers will measure changes in gut bacteria and immune markers to see if fasti…

This study tests whether nicorandil, a drug usually used for heart conditions, can reduce inflammation and improve symptoms in people with active rheumatoid arthritis. 46 participants will take nicorandil tablets for 3 months. Researchers will measure joint disease activity and p…

This trial investigates whether montelukast, a common asthma medication, can reduce inflammation and prevent cartilage breakdown after anterior cruciate ligament (ACL) reconstruction. The study enrolls adults aged 25 to 50 who also have a meniscus tear, a group at high risk for r…

This study tests whether Mobithron Advance, a daily oral supplement made from undenatured type II collagen, can slow or reverse cartilage loss in people with knee osteoarthritis. Over 12 months, 84 participants will take either the supplement or a placebo. Researchers will use MR…

This study tests a daily pill called filgotinib in children aged 8 to 17 with a type of arthritis that affects multiple joints. The goal is to see if the drug is safe and helps control the disease over 18 weeks. About 65 participants will take the drug and be monitored for side e…

This study is testing a thumb joint replacement called the TOUCH CMC 1 Prosthesis in people with thumb arthritis. The goal is to see if it reduces pain and improves hand function. About 163 adults with moderate thumb arthritis will receive the implant and be followed for safety a…

This study tests whether a new surgical irrigation solution called XPERIENCE can lower the risk of joint infection after hip or knee replacement better than the standard dilute Betadine wash. About 7,600 adults having primary hip or knee replacement will be randomly assigned to r…

This study tests a new drug called CIT-013 in 88 adults with moderately active rheumatoid arthritis. Participants will receive either CIT-013 or a placebo every two weeks for six weeks. The goal is to see if CIT-013 reduces joint swelling and pain better than a placebo, and to ch…

This study compares two approaches for people with knee osteoarthritis who are already scheduled for knee replacement surgery. One group will have the surgery as planned, while the other will receive a comprehensive medical care plan including medications, injections, and lifesty…

This study is for children and teens aged 1 to 17 with systemic juvenile idiopathic arthritis (sJIA), a condition that causes joint swelling and fever. Researchers are testing different doses of the drug sarilumab to find the best amount that works and is safe. The study involves…

This study looks at how well a short, bone-friendly stem works for total hip replacement when done through a front-of-hip incision. Researchers will follow 400 adults with hip arthritis for at least two years to check implant survival, complications, pain, and recovery. The goal …

This study watches children and adults who are already taking or about to start Ilaris for hereditary periodic fever syndromes or systemic juvenile idiopathic arthritis. Researchers will track side effects and how well the drug controls symptoms over 16 weeks. No new medicine is …

This study looks at whether repairing the shoulder capsule during a common stabilization surgery (Latarjet) can lower the chance of developing arthritis later. About 86 adults with shoulder instability will be randomly assigned to get capsule repair or not, then followed for up t…

This study is testing a new knee implant (Univation XF Pro) in 150 people with knee arthritis. The goal is to see how well the implant works and how safe it is over several years. Participants will have their knee function, pain, and quality of life tracked using questionnaires a…

This study looks at whether taking tofacitinib (a rheumatoid arthritis drug) along with a statin (a cholesterol-lowering drug) can lower the chance of serious heart problems in people with rheumatoid arthritis. The study will compare this combination to another standard treatment…

This study tests an experimental oral drug called D-2570 in 222 adults with active psoriatic arthritis. Participants take the drug or a placebo daily for 12 weeks. The main goal is to see if D-2570 reduces joint tenderness and swelling by at least 20% compared to placebo.

This study tests whether a surgical robot (ROSA Knee) can help surgeons adjust their knee replacement plan during the operation based on the condition of the patient's soft tissues. About 80 adults with knee arthritis or rheumatoid arthritis will take part and be followed for 2 y…

This study compares two types of glenoid implants used in total shoulder replacement for patients with shoulder osteoarthritis. Half of the 94 participants will receive a standard cemented plastic implant, while the other half will receive a new hybrid implant with a titanium cen…

This study tests whether upadacitinib (Rinvoq), a daily pill, can reduce inflammation in the spine and joints of people with active psoriatic arthritis. About 100 adults who have not responded well to other treatments will receive either the drug or a placebo for 12 weeks. Resear…

This early-phase trial is testing a new treatment called KN5601, which uses a patient's own immune cells (NK cells) that have been engineered to target and destroy harmful B cells. The goal is to see if it is safe and can help children aged 5 and older with rheumatic diseases lik…

This phase II trial tests whether a graft made from a patient's own nasal cartilage can treat patellofemoral osteoarthritis (knee arthritis). 150 adults with knee pain will receive either the nasal cartilage implant or standard care (a minor procedure or partial knee replacement)…

This study compares two methods of aligning a new knee joint during total knee replacement surgery: kinematic alignment and mechanical alignment. Researchers want to see which method gives better function and movement one year after surgery. The trial will involve 100 adults with…

This study is tracking 10,000 Chinese adults with rheumatoid arthritis who are starting or continuing a drug called subcutaneous methotrexate. Researchers want to see how well it works and how safe it is in everyday medical practice, including in patients with additional lung or …

This study compares a robot-assisted system (CORI) to conventional manual instruments for total knee replacement. About 140 participants will be randomly assigned to one of the two methods. The main goal is to see if the robot helps achieve more precise leg alignment after surger…

This study tests whether a 6-week aerobic exercise program can reduce cardiovascular risk in people with chronic kidney disease or rheumatoid arthritis. About 90 participants will be assigned to either an exercise program, educational phone calls, or no intervention. Researchers …

This study tests a 12-week digital exercise program for people who had ACL knee surgery. The program uses sensors to help correct how the knee moves during walking, with the goal of reducing joint inflammation and preventing osteoarthritis. Researchers will enroll 60 adults aged …

This study tests custom-made, 3D-printed hip implants for 15 adults whose previous hip replacements failed due to severe bone loss or infection. The implants are designed from CT scans to fit each person's unique bone damage. Researchers will track complications, pain, mobility, …

This study tests the safety of injecting a patient's own stem cells (from fat tissue) into the thumb joint to treat painful thumb arthritis when standard treatments have failed. The goal is to see if this injection can control the disease and avoid the need for surgery. The trial…

This study compares two types of knee replacement surgery for people with advanced knee arthritis: a standard total knee replacement and a robotic-assisted partial knee replacement. The goal is to see which one leads to better knee function and is more cost-effective. About 159 a…

This study follows 150 people with knee osteoarthritis and leg misalignment who had a knee osteotomy—a surgery that realigns the bones to take pressure off the damaged part of the knee. Researchers want to see how well the knee works years later and whether this surgery can help …

This Phase 3 trial tests whether injections of amniotic suspension allograft (ASA) can reduce pain and improve function in people with knee osteoarthritis. 160 participants will receive either ASA, hyaluronic acid, or a saline placebo. Researchers will track pain, knee function, …

This study tracks 50 children and adults with non-malignant disorders like immune deficiencies and anemias who receive a stem cell transplant after a reduced-intensity chemotherapy regimen. The goal is to see if this approach improves survival and reduces severe graft-versus-host…

This study looks at whether the antibiotic clindamycin works as well as other drugs for treating Streptococcus infections in artificial joints. Researchers will compare success rates in 260 adults who had surgery for this infection. The goal is to see if clindamycin can be a good…

This study is testing a special silver coating on hip implants to see if it can prevent infections after revision hip replacement surgery. The trial will enroll 268 adults who need a hip revision due to a chronic infection. Participants will receive either the coated implant or a…

This study tests a personalized approach to slowly reduce the dose of the biologic drug adalimumab in people with rheumatoid arthritis who are in remission. The goal is to find the best blood level of the drug before each dose reduction to lower the risk of disease flares. 180 ad…

This study compares a new ceramic-coated hip implant to a standard plastic one in 100 people with hip arthritis. The goal is to see which implant causes fewer metal particles to enter the blood and which one helps patients move better over three years. Participants will be random…

This study is testing a less intense chemotherapy and radiation regimen before a stem cell transplant for children and young adults up to age 55 with non-cancerous blood disorders like immune deficiencies, anemias, and metabolic diseases. The goal is to see if this gentler prepar…

This study tests an experimental drug called BT-114143 to see if it can reduce blood loss during knee replacement surgery better than a standard treatment. About 270 adults with osteoarthritis who need a knee replacement will take part. Participants will receive either a high or …

This study tests a new device called the LIFT Implant for people with kneecap arthritis. The implant lifts the kneecap tendon to reduce pressure on worn-out cartilage. Researchers will compare it to a standard surgery that moves a piece of shinbone. 245 adults aged 22 to 65 with …

This study tests whether fecal microbiota transplants (FMT) given as capsules can safely improve symptoms in people newly diagnosed with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, or ulcerative colitis. Two hundred participants will receiv…

This study compares two types of hip replacement materials in 100 adults aged 18 to 65 who need a total hip replacement. One group gets a ceramic-on-polyethylene implant where the polyethylene is infused with vitamin E to reduce wear. The other group gets a standard ceramic-on-ce…

This study tests whether the experimental drug LNK01001 can reduce pain and stiffness in adults with active ankylosing spondylitis, a type of arthritis that mainly affects the spine. About 352 participants will receive either LNK01001 or a placebo twice daily for 16 weeks, then e…

This study is testing a new computer navigation system (OrthoPilot with pheno4u software) to help surgeons perform knee replacements more accurately. About 120 people who need a total knee replacement will take part. The goal is to see if the new software improves how well the im…

This study looks at whether giving children with bone and joint infections antibiotics only by mouth works just as well as starting with IV antibiotics for a few days and then switching to pills. About 285 children aged 1 to 18 from hospitals in Australia and New Zealand will tak…

This study tests whether extra support from a pharmacist—starting in the hospital and continuing after discharge—can help people with rheumatoid arthritis take their disease-modifying medications more consistently. Two hundred participants will either receive this pharmaceutical …

This study tests whether replacing the arthritic thumb base joint with a dual-mobility implant provides better pain relief during activity than standard non-implant surgeries. 90 participants will receive the implant and be compared to 90 similar patients from an earlier trial. R…

This early study tests whether a device that electrically stimulates the abdominal vagus nerve is safe for people with moderate to severe rheumatoid arthritis that hasn't improved with medication. Five participants will have the device implanted via keyhole surgery and receive da…

This study looks at whether people with rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis who are doing well on a JAK inhibitor can safely reduce their dose. About 200 participants will either lower their dose or stay on the same dose, guided by disease activi…

This study tests a new treatment called OA-SYS, made from cells taken from fat tissue, for people with moderate to severe knee osteoarthritis. The main goal is to see if it is safe and tolerable. 400 adults aged 35-75 with knee arthritis will receive the treatment and be monitore…

This study tests a portable device that sends mild electrical pulses to the vagus nerve through the ear, aiming to calm the immune system and reduce joint inflammation. It involves 128 adults with moderate-to-severe rheumatoid arthritis who have not responded well to standard bio…

This study tests whether using a person's unique biomarkers to choose their biologic treatment works better than the standard approach for psoriasis and psoriatic arthritis. About 50 adults in Taiwan will be randomly assigned to either a personalized selection group or a standard…

This Canadian study tests whether adding two questions about morning stiffness and lower back pain to a standard screening tool (PEST) can help dermatologists identify psoriatic arthritis earlier in people with moderate-to-severe plaque psoriasis. About 502 adults who are candida…

This study is developing an artificial intelligence platform to analyze knee ultrasound images and predict outcomes after ultrasound-guided injections for degenerative knee disorders like osteoarthritis. Researchers will first train the AI to identify normal and abnormal knee str…

This study tests a portable ultrasound system to measure the position of the shoulder blade (scapula) in patients with shoulder arthritis while they stand. The goal is to see if this non-radiation method can give results similar to CT scans taken when lying down. Thirty adults sc…

This study tests whether a quick, non-invasive lung ultrasound can detect interstitial lung disease in people with rheumatoid arthritis. About 280 adults with RA and risk factors for lung disease will get an ultrasound, and results will be compared to standard chest CT scans. If …

This study aims to develop a faster and more consistent MRI method to detect early signs of osteoarthritis and other joint problems. Researchers will scan 88 healthy volunteers and patients with ACL tears using MRI machines from different manufacturers. The goal is to create a st…

This study tests whether a dermatologist's physical exam is better than a patient questionnaire at spotting psoriatic arthritis (PsA) in people with psoriasis. About 500 adults with psoriasis will be checked by both methods, then referred to a rheumatologist for a final diagnosis…

This trial tests whether a 48-month program of dietary weight loss, exercise, and weight maintenance can prevent knee osteoarthritis in women aged 50 and older who have obesity and no or infrequent knee pain. Participants are randomly assigned to the diet-and-exercise program or …

This study tests whether using a carotid ultrasound (a neck scan) to find hidden plaque in arteries can help prevent heart attacks and strokes in people with inflammatory rheumatic diseases like rheumatoid arthritis or lupus. About 1,944 participants aged 50 and older will be spl…

This study tests if using antiseptic washes and placing antibiotics directly into the wound during hip or knee replacement surgery can lower the chance of a serious infection that requires another operation. Over 21,000 adults getting a joint replacement will be randomly assigned…

This study tests whether the drug guselkumab can prevent psoriatic arthritis in people with psoriasis who are at high risk. 176 adults with psoriasis and early signs of joint inflammation will receive either guselkumab or standard care. The goal is to see if the drug can stop art…

This study looks at how well the shingles vaccine works in people with weakened immune systems, such as those with cancer or autoimmune diseases. Researchers will measure immune responses and track side effects in 300 adults. The goal is to see if the vaccine can effectively prev…

This study tests whether virtual lifestyle-focused pain care works as well as in-person care for adults with chronic back, knee, or hip pain living in rural areas. Participants will receive up to 10 sessions over six months, either in-person with a physiotherapist or virtually wi…

This Phase 2 trial is testing four experimental drugs (taken orally or by IV) against placebo in 10,000 people with chronic pain from knee osteoarthritis, diabetic nerve damage, or low-back pain. The goal is to see if any of these drugs can safely reduce pain. The study uses a fl…

This study tests a device that uses focused sound waves to block pain signals in the knee, offering a needle-free option for people with chronic osteoarthritis pain. Ten adults with moderate to severe knee pain will receive a one-hour treatment and be followed for six months. The…

This study tests a new injection called CartiPRO to see if it can safely reduce knee pain in people with osteoarthritis. About 194 adults will receive either CartiPRO or another approved injection, and then get a second shot 24 weeks later. Researchers will measure pain and knee …

This study tests a new, ultrasound-guided acupotomy technique to improve symptoms in people with ankylosing spondylitis, a type of arthritis that causes back pain and stiffness. About 60 adults with active disease will receive the treatment to see if it reduces pain and improves …

This study tests whether adding lavender aromatherapy massage to standard care can reduce pain and improve wrist movement in people with rheumatoid arthritis. About 100 adults with stable medication will be randomly assigned to get the massage or not. Researchers will measure pai…

This study tests a 6-week physiotherapy program designed to improve pain, function, and joint awareness in adults with knee osteoarthritis. The program uses sensory modulation and graded weight-bearing exercises, and the trial compares outcomes between male and female participant…

Researchers are studying the Exactech Vantage Mobile-Bearing Total Ankle System, an implant used to replace a damaged ankle joint. The study enrolls 400 adults with ankle arthritis or related joint failure who are scheduled for total ankle replacement. Participants receive the im…

Researchers are studying the Exactech Vantage Total Ankle System, an implant used to replace a damaged ankle joint in people with arthritis or a failed previous replacement. The study enrolls 370 adults who are candidates for total ankle replacement and follows them for up to 10 …

This study compares two pain relief methods for people undergoing total knee replacement: injecting numbing medicine into the knee area versus blocking several nerves around the knee. The goal is to see which method reduces the need for strong painkillers like opioids in the firs…

This study compares two types of total knee replacement surgery for people with knee osteoarthritis: one done manually and one assisted by a robotic device (VELYS). About 346 participants will be randomly assigned to one of the two surgeries and followed for a year to see which l…

Researchers are testing whether giving the steroid dexamethasone during total knee replacement helps with pain, nausea, and recovery, and whether it matters if the drug goes into a vein or is injected around the knee joint. The trial enrolls 159 adults with knee osteoarthritis ha…

This study tests three different numbing medicine combinations for pain after total knee replacement. 90 adults having knee surgery will get one of three options: a long-acting numbing drug, or a standard numbing drug plus one of two additives. The goal is to see which approach r…

Researchers are testing whether adding gait re-education on an R-Force anti-gravity treadmill to standard physiotherapy helps adults with knee osteoarthritis. The trial enrolls 80 people aged 40 to 70 who have radiologically confirmed knee arthritis and ongoing knee pain. Partici…

This study compares two surgical treatments for rhizarthrosis, a type of arthritis at the base of the thumb. One group gets a new prosthesis (HORUS implant), the other gets the standard trapezectomy. Researchers will measure hand function and pain in 50 patients over the short te…

This study tests whether combining blood-flow-restricted exercise (light exercise with a cuff on the leg) and pain education can reduce pain and improve movement in people with knee osteoarthritis. About 90 adults aged 40 and older with knee osteoarthritis will take part. The goa…

Researchers at the University of Alberta are comparing two virtual physical therapy programs with usual care for rural adults who have hip or knee osteoarthritis and are not waiting for joint replacement surgery. Participants first continue their usual arthritis care for 12 weeks…

Researchers are testing whether an augmented reality guidance system helps surgeons make more accurate bone cuts and align knee implants during total knee replacement. The study enrolls about 50 adults with advanced osteoarthritis who are scheduled for a primary knee replacement …

This study tests whether a single injection of concentrated bone marrow cells can reduce pain and improve function in people with hip osteoarthritis better than a standard steroid injection. One hundred adults with moderate to severe hip arthritis will be randomly assigned to rec…

This study tests whether a program that strengthens the quadriceps and calf muscles can improve walking, reduce pain, and enhance sleep in people with knee osteoarthritis. About 52 adults aged 40-60 with moderate knee arthritis will be randomly assigned to either the exercise pro…

This study will follow 86 adults with knee osteoarthritis to see if injections of sugar-water (dextrose) or local anesthetic around the knee nerves provide better pain relief and function. Participants will be assessed for six months after their routine injection. The goal is to …

This study tests whether giving a steroid (dexamethasone) during shoulder replacement surgery can improve recovery. Researchers will measure pain, nausea, shoulder movement, and how long patients stay in the hospital. The study involves 74 adults with shoulder arthritis who are h…

This study tests a once-daily pill called orforglipron in 800 adults with obesity or overweight who also have painful knee osteoarthritis. The goal is to see if the drug reduces knee pain and improves physical function over about 74 weeks. Participants will be randomly assigned t…

This Phase 3 study tests a once-weekly injection called eloralintide in 900 adults with osteoarthritis of the knee who are also overweight or obese. The goal is to see if it reduces knee pain and helps with weight loss compared to a placebo. Participants will be in the study for …

This trial compares two injection sites for steroid shots in people with moderate-to-severe knee osteoarthritis. Participants get the injection on either the inside or outside of the knee, then report pain and function over 12 weeks. The goal is to see if one spot provides better…

This Phase 2 trial tests an experimental oral drug, LY4065967, for knee pain caused by osteoarthritis. About 150 adults with chronic knee pain and confirmed osteoarthritis will receive either the drug or a placebo. The main goal is to see if the drug safely reduces pain intensity…

This trial tests whether remote tai chi, taught through web-based sessions twice a week for 12 weeks, can reduce knee pain in adults aged 50 and older with knee osteoarthritis. Researchers compare adding remote tai chi to routine care against routine care alone, measuring pain, p…

This phase 2 trial is testing whether daily doses of THC, CBD, or both can reduce pain and improve symptoms in people with knee osteoarthritis. About 200 participants will take one of the study drugs or a placebo for 16 weeks, with regular pain assessments, blood tests, and brain…

This study tests whether injecting a mix of hyaluronic acid and fibrinogen into the knee can reduce pain and improve function in people with knee osteoarthritis. About 31 adults aged 45 to 75 will receive the injection as part of routine care. Researchers will track changes in pa…

This trial tests two common injections for pain in the shoulder, elbow, wrist, or hand caused by arthritis or tendon problems. One injection is triamcinolone, a corticosteroid that reduces inflammation. The other is ketorolac, a non-steroidal anti-inflammatory drug (NSAID). Parti…

This study tests whether hyaluronic acid injections into the knee can reduce pain and improve function in people with knee osteoarthritis. Researchers will also measure changes in inflammation-related substances in blood and joint fluid. 50 adults aged 45-75 with moderate knee os…

This study tests two different nerve block methods to control pain in people with multiple broken ribs. The goal is to see which technique provides better pain relief, helps patients breathe deeper, and shortens hospital stays. Thirty-six adults with at least two rib fractures wi…

This study tests whether low-dose radiotherapy can reduce pain in people with knee osteoarthritis. 128 participants will receive either real radiation or a sham treatment three times a week for two weeks. Researchers will track pain scores and painkiller use for six months to see…

This study follows 270 adults having knee replacement surgery to see if the steroid dexamethasone (given as a pill or through a vein) helps with early recovery. Researchers will measure pain, mobility, nausea, and need for extra painkillers. The study does not assign treatments—p…

This trial tests whether using two probes during radiofrequency ablation eases knee osteoarthritis pain better than the standard one-probe approach. Radiofrequency ablation uses heat to quiet the nerves that send pain signals from the knee. Researchers will enroll 64 adults over …

This phase 3 trial tests whether ecnoglutide, a GLP-1 drug similar to semaglutide, can reduce knee pain and body weight in obese adults with knee osteoarthritis. Participants receive either ecnoglutide injections or a placebo for several months. The study measures changes in pain…

This study tests whether injecting a person's own bone marrow cells or a mix of fat cells and platelet-rich plasma into the knee can reduce pain from osteoarthritis. About 148 adults with moderate knee arthritis will receive either the real treatment or a placebo (salt water) inj…

This trial tests whether a personalized mobile app can improve recovery after reverse shoulder replacement surgery. About 170 adults undergoing this procedure will be randomly assigned to either use the interactive app or receive standard care. The main goal is to see if the app …

This trial tests whether a genicular nerve block given before knee replacement surgery can reduce pain and the need for opioids. About 70 adults with knee osteoarthritis will receive either the nerve block or a placebo injection. Researchers will track pain levels, opioid use, an…

This study will compare the effects of a single injection of platelet-rich plasma (PRP) versus conditioned serum (CS) in 60 people with knee osteoarthritis. Participants must have had knee pain for at least 6 months and meet specific criteria. The goal is to see which treatment b…

This study compares two common shoulder replacement surgeries—anatomic and reverse—for people with shoulder arthritis and an intact rotator cuff. Researchers want to see which surgery leads to better pain relief and function one year after the procedure. About 108 participants wi…

This study tests whether adding a steroid to the standard pain injection during total knee replacement improves pain control and reduces the need for opioid painkillers. 240 adults undergoing knee replacement will be randomly assigned to receive either the standard injection, one…

This study tests whether a simple saline (salt water) injection works as well as a steroid injection for thumb arthritis pain. Forty adults with thumb osteoarthritis will receive one injection, but neither they nor their doctor will know which one. The goal is to see if saline ca…

This Phase 3 study tests a once-weekly injection called NNC0487-0111 in 400 adults who are overweight or obese and have knee osteoarthritis. The goal is to see if it helps with weight loss and reduces knee pain compared to a placebo. Participants receive either the active drug or…

This study investigates whether a low-carbohydrate diet can reduce pain and improve quality of life in adults with knee osteoarthritis, compared to a standard USDA-recommended diet. Participants will follow a 6-week diet plan with all meals provided, and researchers will measure …

This early-stage study tests a new drug called F8IL10, given as an injection directly into the joint, for people with rheumatoid arthritis. The main goal is to find a safe dose and see if it helps reduce joint pain and swelling. About 42 adults with active arthritis in a knee, an…

This study tests whether improving sleep before total knee replacement surgery can reduce pain after the operation. Adults aged 60 and older with knee osteoarthritis and sleep difficulties will receive either cognitive-behavioral therapy for insomnia, bright light therapy, or a c…

This trial tests whether eccentric strengthening exercises or low-load blood flow restriction training can improve muscle function, strength, and daily mobility in people with knee osteoarthritis. Participants aged 40 to 70 with mild to moderate knee arthritis will follow a four-…

This pilot study tests a care model called Patient Priorities Care (PPC) for older African Americans with heart disease plus other chronic conditions like diabetes or COPD. The approach shifts focus from treating each disease separately to aligning care with what matters most to …

This study is testing whether giving a steroid injection to the knee that is not being operated on can help reduce pain and improve function for people undergoing total knee replacement. The study will involve 60 adults with knee osteoarthritis who are scheduled for a single knee…

This study looks at whether a Mediterranean-style diet can improve arthritis symptoms in children by changing the bacteria in their gut. Fifty-four children aged 8-18 with juvenile idiopathic arthritis will follow the diet for 8 weeks, with an option to continue for 4 more weeks.…

This study tests whether auriculotherapy (ear acupuncture) can reduce pain after outpatient surgery for thumb arthritis. Sixty adults undergoing endoscopic thumb surgery will receive either real or sham ear acupuncture. Pain levels will be measured from day 1 to day 3 after surge…

This trial compares two types of nerve blocks for pain control after bilateral total knee replacement. One combines a standard numbing medication with two steroids, the other uses a long-acting liposomal bupivacaine. Researchers want to see if the steroid-enhanced block provides …

This phase 2 trial tests whether a nerve block containing bupivacaine plus two steroids (dexamethasone and methylprednisolone) can provide better pain relief after total knee replacement than the standard combination of bupivacaine and liposomal bupivacaine (Exparel). About 250 a…

This study tests whether daily cannabis extracts (CBD or THC) can reduce pain interference in people with hip or knee osteoarthritis. One hundred adults aged 40-80 will take either CBD, THC, or a placebo capsule daily for 8 weeks and track their symptoms remotely. The goal is to …

This study tests whether colchicine, a drug used for gout, can lower inflammation and pain in people with CPPD disease. About 150 adults will take either colchicine or a placebo daily for 6 months. Researchers will measure blood markers and joint symptoms to see if the drug helps…

This Phase 3 trial tests whether a once-weekly injection called NNC0487-0111 can help people with overweight or obesity and knee osteoarthritis lose weight and feel less pain. About 400 adults will receive either the drug or a placebo for several weeks. Researchers will measure c…

This study tests whether a 30-minute virtual reality session with nature scenes and music can reduce pain, anxiety, and improve comfort in people who just had hip replacement surgery. Participants choose from forest, beach, underwater, or outdoor footage. The goal is to see if VR…

This study compares a structured telerehabilitation program (exercises done at home with remote supervision) to standard in-person physical therapy for people recovering from total knee replacement. 120 participants aged 50-65 will be randomly assigned to either group and followe…

This study tests whether injections of platelet-rich plasma (PRP) work better than hyaluronic acid (HA) for people with advanced knee osteoarthritis (grades III or IV). 150 participants will receive three injections of either PRP or HA and be followed for a year. The goal is to s…

This study tests whether starting an accelerated shoulder rehabilitation program immediately after reverse total shoulder replacement leads to better pain relief and function than the standard rehab approach. About 74 people with shoulder osteoarthritis will be randomly assigned …

This study tests whether taking vitamin C around the time of knee replacement surgery can reduce long-term pain. About 400 adults having knee replacement will be randomly assigned to receive vitamin C or a placebo for 8 weeks. The main goal is to see if a larger study is possible…

This study tests whether an enhanced recovery after surgery (ERAS) protocol helps people recover faster after total knee replacement. About 120 patients aged 50-70 will either get standard care or the ERAS plan, which includes pre-surgery exercise, shorter fasting, and early walk…

This trial compares two injection treatments for knee osteoarthritis: a combination of platelet-rich plasma (PRP) and hyaluronic acid versus hyaluronic acid alone. Researchers want to see if the combined approach provides better pain relief and function after one year. The study …

This study is tracking 1,200 adults with knee osteoarthritis who have not found relief from standard treatments. They will undergo a procedure called genicular artery embolization, which blocks certain blood vessels to reduce inflammation and pain. Researchers will follow partici…

This study looks at whether adding a technique called blood flow restriction (BFR) exercise to standard physical therapy can help people recover more quickly after total knee replacement. BFR uses a cuff to lightly restrict blood flow during low-weight exercises, which may help b…

This study tests a new pain self-management program designed specifically for Black adults aged 50 to 92 who have long-term muscle or joint pain (like arthritis or back pain). The program aims to reduce pain during movement and improve daily life. Researchers will compare pain le…

This study tests whether a new nerve block (quadri-block) helps people recover better after total knee replacement compared to the usual method (adductor canal block plus surgical infiltration). One hundred adults with knee arthritis scheduled for knee replacement will be randoml…

This study tests whether special shoe insoles can reduce pain in people with knee osteoarthritis who also have foot pain. About 31 participants will wear either lateral wedge insoles or insoles with added arch support for at least 5 hours a day over 3 months. Researchers will mea…

This study tests whether an app called Genus, which provides videos, exercises, and quizzes, can help people with knee osteoarthritis learn more about their condition and feel more confident in treatment decisions. About 204 adults over 50 who are waiting for a specialist appoint…

This study tests whether sleeping near a special device that claims to emit 'biophotons' can reduce chronic severe arthritis pain. About 102 adults with long-term arthritis pain will use either the active device or a placebo (inactive) device for 12 weeks. Researchers will measur…

This study compares two approaches to recovery after total knee replacement: a fast track plan designed to speed up recovery versus standard care. Researchers will measure how well patients can move and care for themselves after surgery, as well as how long they stay in the hospi…

This study looks at whether people who have knee replacement surgery can use remote monitoring and video calls instead of scheduled in-person follow-ups. About 140 patients will be split into two groups: one with standard hospital visits at 2 and 12 months, and another that answe…

This study tests whether an AI-assisted web app that personalizes home exercises can reduce pain and improve knee function in people with knee osteoarthritis, compared to a standard paper exercise program. About 84 adults with knee pain will be randomly assigned to either the AI …

This study tests two different ways to numb the back of the knee after total knee replacement surgery. Both methods are combined with a standard front-of-thigh block. The goal is to see which approach leads to better overall recovery, less pain, and less need for strong painkille…

This study tests whether taking nefopam, a non-opioid painkiller, by mouth before and after knee replacement surgery can reduce pain and the need for morphine. About 50 adults having knee replacement will be randomly assigned to receive either nefopam or a placebo. The goal is to…

This study compares high intensity laser therapy to exercise for people with thumb osteoarthritis. The goal is to see which treatment better reduces pain and improves hand function. About 42 adults with thumb arthritis will be assigned to one of the two treatments and followed fo…

This study tests whether extracorporeal shock wave therapy can reduce pain and improve function in people with knee arthritis. 72 adults with persistent knee pain will receive either shock wave therapy or a daily exercise program. Researchers will measure pain levels and joint fu…

This study compares two methods of pain control during knee replacement surgery. One uses numbing medicine injected into the knee area only. The other adds nerve blocks to that injection. The goal is to see which approach provides better pain relief and reduces the need for stron…

This study tests if a procedure called arterial embolization using Lipiodol is safe for people with painful hand osteoarthritis that hasn't improved with standard treatments. Fifteen participants will receive the procedure and be followed for 6 months to track side effects, pain …

This study tests three home-based programs for people with long-term muscle or joint pain (like back pain or arthritis) who also sleep poorly. Participants will be randomly assigned to 12 months of exercise, cognitive behavioural therapy for insomnia (CBT-I), or both. The goal is…

This study tests whether helping people with insomnia sleep better before knee or hip replacement surgery can reduce pain and improve recovery afterward. One hundred adults scheduled for surgery will receive either cognitive behavioral therapy for insomnia or sleep education for …

This study tests whether Multiprofen-CC cream, applied three times daily, reduces pain in adults with hand osteoarthritis. Forty-two participants will use both the active cream and a placebo for two weeks each, in random order. Researchers will measure pain, hand function, and si…

This study will follow 10,000 adults with common joint or tendon problems—like knee arthritis, tennis elbow, or plantar fasciitis—who choose to receive a platelet-rich plasma (PRP) injection. PRP is made from a patient's own blood, spun to concentrate healing factors. Participant…

This study looks at which extra features added to an online exercise program help people who have had a knee replacement become more active. About 336 adults who had knee surgery at least a year ago and currently do little exercise will take part. Researchers will track changes i…

This study compares two ways to manage pain after total knee replacement: a single-shot nerve block versus a continuous nerve block using a small catheter. About 94 adults having knee surgery will be randomly assigned to one method. The goal is to see which approach reduces opioi…

This study tests whether filling the bone gap with a synthetic putty (AttraX Putty) during knee realignment surgery can reduce pain in the first week after surgery. About 40 adults with knee osteoarthritis will be randomly assigned to get the putty or standard surgery without a g…

This study is testing whether giving extra doses of tranexamic acid (TXA) after hip or knee replacement surgery can reduce bleeding, pain, and help people move around sooner. TXA is a drug already used during surgery to prevent blood loss. The trial will compare the standard sing…

This study tests whether high-intensity laser therapy (HILT) plus exercise works better than standard physical therapy plus exercise for knee osteoarthritis. One hundred adults aged 40 to 75 with knee arthritis will be split into two groups to compare pain relief, joint function,…

This study is testing whether using a special sensor device during knee replacement surgery leads to better results for patients. The device helps the surgeon make precise bone cuts. Researchers will follow 40 people for up to 2 years after surgery, measuring pain, function, and …

This study compares two alignment techniques—kinematic and functional—used during robotic-assisted total knee replacement. 240 people with knee osteoarthritis will be randomly assigned to receive one of two types of implant inserts. Researchers will track how well patients forget…

This study tests whether Epidiolex (a CBD medicine) can help control pain after shoulder surgery when added to standard painkillers. About 80 adults having rotator cuff repair will take either CBD or a placebo for two weeks after surgery. They will track their pain and medication…

This study tests whether cannabidiol (CBD) can lower the need for opioid painkillers after knee replacement surgery. 380 adults with knee osteoarthritis will take CBD or a placebo before and after surgery. Researchers will measure total opioid use and pain over 28 days to see if …

This study tests whether a single steroid injection works as well as a three-week course of steroid pills for treating rheumatoid arthritis flares. Researchers will track how patients feel, their ability to function, and their satisfaction with treatment. The goal is to help pati…

This study looks at whether a single dose of the anti-inflammatory drug dexamethasone, given during hip replacement surgery, can help patients feel better and recover faster. About 224 adults aged 60 and older having a hip replacement will receive either a low or moderate dose of…

This study tests a procedure called transarterial microembolization (TAME) for people with knee osteoarthritis and long-lasting pain that hasn't improved with standard treatments. Doctors will inject tiny beads into blood vessels around the knee to block abnormal blood flow, aimi…

This pilot study tests whether wearing a knee extension brace for the first 72 hours after total knee replacement can reduce pain and improve recovery. 106 participants will be randomly assigned to either the brace or standard care with early movement. The main goal is to see if …

This study tests a new knee injection called ALLOHEAL for people with knee osteoarthritis. The injection contains natural substances to reduce friction in the joint and ease pain. About 286 adults aged 40 to 79 with knee pain will receive either ALLOHEAL or a similar approved tre…

This study looks at how three different levels of physical activity—45, 90, or 150 minutes per week—affect arthritis symptoms like pain and mobility. Researchers will enroll 285 adults with arthritis, rheumatoid arthritis, gout, fibromyalgia, osteoarthritis, or lupus. Participant…

This study tests whether a hands-on technique called gastrocnemius myofascial release (a type of calf muscle massage) can reduce pain and improve physical function in women aged 45-55 with knee osteoarthritis. Thirty participants will receive either the real treatment or a sham v…

This study tests whether injecting Botox into the thumb joint can reduce pain and improve hand function in people with base-of-thumb osteoarthritis. 120 adults with moderate to severe thumb pain will receive either two Botox injections, one Botox and one placebo, or two placebo i…

This study compares two types of knee replacement implants designed to work with a newer, more natural surgical technique called kinematic alignment. The goal is to see which implant helps patients feel more like their knee is their own, with less stiffness and pain. About 120 pe…

This study tests whether taking creatine supplements for 12 weeks helps adults aged 65 and older regain muscle mass, strength, and physical function after total knee replacement surgery. Participants will take creatine or a placebo daily alongside standard rehabilitation. The goa…

This study compares two types of computer-assisted knee replacement surgery: one using a navigation system (OrthoPilot) and one using a robotic arm (MAKO). The goal is to see if they provide similar improvements in knee function and pain relief one year after surgery. About 140 a…

This study looks at whether keeping or removing the posterior cruciate ligament during robotic knee replacement helps patients feel more natural after surgery. About 300 adults having their first robotic knee replacement will be randomly assigned to one of the two methods. The ma…

This study tests two ways to manage pain after hip replacement surgery. One group gets a nerve block plus a second nerve block; the other gets a nerve block plus wound numbing. The goal is to see which method reduces pain and the need for opioid painkillers. About 102 adults havi…

This study tests a procedure called genicular artery embolization (GAE) to see if it can reduce knee pain and inflammation in adults with knee osteoarthritis. Researchers will compare knee fluid samples and MRI scans before and after the procedure to see if changes in inflammatio…

This pilot study is testing whether a remotely-delivered exercise program is practical and acceptable for people recently diagnosed with rheumatoid arthritis (within 6 months). Fifteen participants will receive intensive aerobic and resistance training via video calls. The main g…

This study compares two treatments for chronic hip pain caused by osteoarthritis: a nerve block alone versus a nerve block plus pulsed radiofrequency. About 84 adults with hip pain lasting at least 3 months will be enrolled. The goal is to see if adding radiofrequency provides be…

This study tests a new program called INSPIRE, designed to support informal caregivers (like family or friends) of older adults with rheumatoid arthritis and frailty. The program involves three sessions with a healthcare professional over 12 weeks, focusing on emotional support, …

This study tests whether adding deep breathing exercises to core stability exercises can improve lung function and physical ability in people with ankylosing spondylitis (AS). AS is a type of arthritis that mainly affects the spine, causing pain, stiffness, and sometimes trouble …

Some people hear clicking or popping after knee replacement surgery, which can be bothersome. This study compares two different knee replacement designs to see if one causes less noise. Researchers will ask 170 patients about the sounds they hear and how much it bothers them over…

This study compares a special cold compression device (cryopressotherapy) to standard ice packs for people recovering from total knee replacement. Researchers will measure pain, mobility, swelling, and patient-reported outcomes 14 days after surgery. The goal is to see if the dev…

This study tests whether Reiki, a gentle energy-based touch therapy, can reduce pain and help patients move better after total knee replacement surgery. 90 adults having planned knee surgery will be randomly assigned to receive either Reiki or standard care. Researchers will meas…

This study tests a walking program for people with painful hip or knee osteoarthritis. Participants take a nonsteroidal anti-inflammatory drug (NSAID) only before planned walks to reduce pain while avoiding long-term side effects. The program also includes proper footwear, educat…

This study tests if freezing the nerves around the knee (cryoneurolysis) one day before total knee replacement surgery can lower pain and help patients move better afterward. About 100 adults with knee arthritis will be randomly assigned to get the freezing procedure plus surgery…

This study tests whether a 6-month mobile program can help 200 older adults (65+) with knee or hip arthritis pain become more active, lose weight, and feel less pain. Participants will join weekly group or individual coaching calls and track their steps. After the program, they w…

This study tests a new exercise program using a flywheel device to improve stair-climbing in people with knee osteoarthritis. The training focuses on the muscle-lengthening phase of movement, which may build better muscle and coordination. Researchers will measure changes in move…

This study compares two common shoulder injections—corticosteroids and platelet-rich plasma (PRP)—to see which provides better pain relief for people with advanced shoulder arthritis. About 200 adults with bone-on-bone arthritis will receive one of the two injections and report t…

This study looks at whether adding a 12-week progressive resistance training program to a patient education class improves daily function and pain in people with hip osteoarthritis. 150 participants will be randomly assigned to either exercise plus education or education alone, a…

This study tests whether taking vitamin E (alpha-tocopherol) supplements for one month can reduce inflammation and disease activity in people with rheumatoid arthritis. Researchers will compare vitamin E to a placebo in 46 women with early RA. Participants take two capsules daily…

This study tests whether a structured preparation program before hip or knee replacement surgery can help people recover faster. The program includes personalized exercise, nutritional advice, stress and pain support, and medication review. Researchers will compare recovery in 18…

This study looks at three ways to ease pain from thumb arthritis: steroid injections, saltwater (placebo) injections, and hand therapy exercises. About 354 adults with thumb joint inflammation and pain will take part. The goal is to see which approach works best for reducing pain…

This study tests whether doing supervised exercise and learning about recovery before total knee replacement helps patients feel better and function better one year after surgery. About 110 adults with knee osteoarthritis awaiting surgery will be randomly assigned to either the p…

This study tests two different methods of a nerve block (iPACK) to manage pain after total knee replacement. The goal is to find which approach provides better pain relief and reduces the need for strong painkillers. 120 adults having knee replacement will be randomly assigned to…

This study compares a special cold-and-compression device to regular ice packs for managing pain after total knee replacement. About 138 adults having knee surgery will be randomly assigned to one of the two treatments. The main goal is to see if the device reduces pain more than…

This study compares two methods of using radiofrequency to treat chronic neck pain caused by arthritis in the small joints of the neck. About 72 adults with moderate to severe neck pain for at least 3 months will be randomly assigned to one of two needle techniques. The goal is t…

This study tests two approaches to help people with knee osteoarthritis stay active after physical therapy: a game-like reward system with social support, and health coaching. About 254 veterans will use a Fitbit and smartphone app to track their progress. The goal is to see if t…

This study tests whether supplements made from agar-agar (a seaweed extract) and undenatured type II collagen can reduce knee pain in people with osteoarthritis. Eighty adults aged 40 to 70 with mild to moderate knee pain will take capsules daily for several weeks. The goal is to…

This study looks at whether giving the painkiller nalbuphine at different times during knee replacement surgery can better control pain and keep the heart stable in patients aged 65 and older. About 162 participants will receive nalbuphine either during anesthesia or after cement…

This study is testing whether extracorporeal shockwave therapy (ESWT) can reduce pain and improve function in athletes who developed knee osteoarthritis after ACL reconstruction. Researchers will treat 70 participants with a device that delivers pressure waves to the knee. The go…

This study compares a new procedure called genicular artery embolization (GAE) using Nexsphere-F microspheres against standard steroid injections for knee osteoarthritis. About 126 people with knee pain will be randomly assigned to one of the two treatments. The goal is to see if…

This study tests whether combining the Bowen technique (a gentle hands-on therapy) with walking backward can improve hamstring flexibility, reduce pain, and boost mobility in people with knee osteoarthritis. Researchers will enroll 36 adults aged 40-60 with mild to moderate knee …

This study compares myofascial release (a type of massage) and cupping therapy to see which better improves quality of life in people with restless leg syndrome and knee osteoarthritis. 54 adults aged 40-70 with moderate to severe knee arthritis will receive 12 sessions over 4 we…

This study tests whether high-intensity pulsed electromagnetic field (HI-PEMF) therapy can reduce pain and improve strength in older adults with knee osteoarthritis. 64 participants will receive HI-PEMF on the knee alone or on both the knee and thigh muscle, plus a home exercise …

This study compares yoga therapy to standard physiotherapy for people with moderate axial spondyloarthritis, a type of inflammatory arthritis affecting the spine and pelvis. Seventy-two participants will attend group sessions twice a week for ten weeks. The goal is to see if yoga…

This study looks at whether adding physiotherapy to a hip injection (corticosteroid plus hyaluronic acid) helps reduce pain and improve function more than the injection alone. It includes 100 adults aged 40-60 with mild hip arthritis, labral tears, or hip impingement. Participant…

This study compares two ways to perform total knee replacement: the standard manual technique versus one guided by computer-assisted navigation. Researchers will enroll 160 patients and measure pain, function, blood loss, and costs. The goal is to see if the computer-assisted met…

This study tests whether taking cannabidiol (CBD) extract under the tongue three times a day can safely ease knee osteoarthritis pain and reduce the need for NSAID painkillers. Thirty adults with moderate to severe knee pain will receive either CBD or a placebo for several weeks.…

This study tests whether a 12-week digital exercise program, with or without personal coaching, can help adults aged 65 and older become more physically active after total hip replacement. Participants will be randomly assigned to one of three groups: the digital program with coa…

This study aims to uncover genetic changes that cause autoimmune diseases in people native to Peru. Researchers will collect blood, urine, and stool samples from 300 participants, including patients with conditions like lupus and rheumatoid arthritis, their family members, and he…

This study looks at how much of the drug bimekizumab passes into breast milk. Researchers will collect milk samples from 20 breastfeeding mothers with conditions like psoriasis or arthritis over several weeks. The goal is to understand potential exposure for nursing infants, not …

This study is tracking 20,000 people who have had or will have shoulder replacement surgery to see how well the implants work over at least 10 years. Researchers will measure pain, daily function, and strength using standard shoulder scores. The goal is to better understand the l…

This study looks at thumb osteoarthritis, a common cause of pain and weakness at the base of the thumb. Researchers will assess 93 people using a broad approach that includes physical, psychological, and social factors. They will also test whether artificial intelligence can pred…

This study is for people with certain autoinflammatory diseases (like NOMID, DIRA, CANDLE, SAVI, and others) and their healthy relatives. Researchers want to learn more about what causes these diseases and how they affect the body over time. Participants will have medical tests a…

This study looks at whether certain genes make some people more likely to develop eye damage from the drug Plaquenil, which is used for autoimmune diseases like lupus and rheumatoid arthritis. Researchers will compare people who have had eye damage from Plaquenil with those who h…

This study looks at whether analyzing synovial tissue can help doctors better manage pigmented villonodular synovitis (PVNS), a rare joint disease that causes pain and joint damage. Researchers will collect tissue samples from 30 patients through biopsy or surgery to assess quali…

This study follows up to 2,000 people with spondyloarthritis (a group of inflammatory joint and spine conditions) and their healthy relatives. Researchers aim to identify symptoms, genetic factors, and medical tests that predict who will develop more severe forms of the disease. …

Researchers in Moscow are studying patients who have knee or hip replacement surgery to learn why some develop serious infections around the implant. The study will follow 750 adults aged 45 and older, checking their immune status, mineral metabolism, and tissue samples before an…

This study aims to understand why some adults develop secondary hemophagocytic lymphohistiocytosis (sHLH), a serious immune condition causing fevers and organ damage. Researchers will follow 300 participants for up to 3 years, collecting blood samples and medical data to identify…

This study at Montpellier University Hospital will look at whether low muscle mass and strength before hip replacement surgery affects how well people aged 75 and older regain their independence. About 20 volunteers will have blood tests, scans, and a tiny muscle sample taken dur…

This study collects and stores medical information from people treated for orthopaedic conditions like osteoarthritis, scoliosis, and cerebral palsy. Researchers at the University of Florida will gather data during routine clinical care to create a resource for future research. T…

Researchers at University Hospital Bonn are following 300 adults who undergo knee or hip replacement surgery to understand how their recovery unfolds. The study measures quality of life, hand grip strength, and bone density before and after the procedure. The goal is to identify …

This observational study looks at whether oral health and the bacteria in saliva are linked to disease activity in children with juvenile idiopathic arthritis (JIA). Researchers will compare children with active disease to those in remission, examining their teeth, gums, oral hyg…

This study aims to learn more about alkaptonuria, a rare genetic disease that causes a pigment to build up in bones and tissues, leading to arthritis and other problems. Researchers will evaluate 300 patients over several years using advanced medical tests. The goal is to better …

This study looks at whether malnutrition changes how well older adults recover after shoulder surgery when they use virtual reality (VR) for rehabilitation. Researchers will track 60 frail adults aged 60+ to see if poor nutrition limits the benefits of VR therapy. The goal is to …

This study aims to learn more about the causes of rheumatic diseases—conditions that cause joint pain, stiffness, and swelling—and why they often affect minority groups more severely. Researchers will observe up to 7,500 adults with known or suspected rheumatic disease, providing…

This study aims to understand the causes and progression of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD) by observing up to 2,000 participants over time. Researchers will collect medical history, blood samples, and genetic data to identify …

This study looks at 40 adults with psoriasis—some with joint pain (psoriatic arthritis) and some without—to compare immune signals in their blood and skin. Researchers want to understand why some people develop joint problems. Participants give blood and skin samples for lab anal…

This study looks at how the antibiotic rifampicin is processed by the body in people with staphylococcal bone and joint infections, such as prosthetic joint infections and chronic osteomyelitis. Researchers will take blood samples from 40 participants to measure drug levels and b…

This observational study looks at how physical activity, sedentary time, and sleep relate to early signs of heart and blood vessel disease in adults with rheumatoid arthritis. Participants will wear activity monitors for a week, answer health questionnaires, and undergo heart and…

This observational study aims to understand why some people with rheumatoid arthritis (RA) continue to experience chronic pain even when their inflammation is well-controlled. Researchers will compare two groups of RA patients—those with active disease and those in remission with…

This study will compare two FDA-approved machines that make platelet-rich plasma (PRP) for people with knee osteoarthritis. PRP is made from a person's own blood and is injected into the knee to help with pain and stiffness. The researchers will check if the two machines produce …

This study looks at whether ultrasound measurements of thigh muscle and fat can predict how well patients with knee osteoarthritis respond to a genicular nerve block. Researchers will measure muscle thickness and fat under the skin before the procedure and check pain levels one m…

This study aims to understand why bones weaken with age, leading to conditions like osteoporosis and osteoarthritis. Researchers will collect bone waste and blood samples from 2,000 people undergoing orthopedic surgery, including those with and without bone disease. By analyzing …

This registry is following 3,000 adults with idiopathic pulmonary fibrosis (IPF) or other chronic fibrosing interstitial lung diseases (ILDs) to understand how these conditions progress over time. Researchers collect information on symptoms, treatments, quality of life, and store…

This study looks at whether certain markers of oxidative stress in the blood are linked to early signs of heart disease in people with rheumatoid arthritis. Researchers will measure these markers and check for thickening or stiffness in the carotid arteries. The goal is to better…

This study compares the prevalence of the HLA B leader gene in 658 people with psoriatic arthritis and a healthy control group. Researchers will also look at the related HLA B27 gene. The goal is to see whether this genetic marker, already known to affect outcomes in bone marrow …

People with rheumatoid arthritis have double the risk of heart attack. This study is testing whether a blood test for troponin, along with a heart scan, can catch heart disease early. Researchers will enroll 120 adults aged 40-79 with RA and at least one heart risk factor. The go…

This study will follow 200 people who have had a complex or revision hip replacement at University Hospitals Leuven. The goal is to track how many need another surgery and why, and to improve care by learning from real-world results. No new treatment is being tested—this is an ob…

This study will use advanced CT and MRI scans to see how knee realignment treatments (surgery or braces) affect bone structure and cartilage in 30 people with early knee osteoarthritis. Researchers want to understand why some treatments fail, so they can improve care for younger …

This study investigates knee osteoarthritis and cartilage degeneration by combining MRI scans with gait analysis. Researchers aim to better understand how the disease affects both the structure and function of the knee joint. The study involves 25 participants with knee pain or c…

This study is creating a large collection of medical data and blood samples from 450 adults with autoimmune diseases (rheumatoid arthritis, lupus, or scleroderma) and 50 healthy volunteers. Researchers will use advanced lab techniques to find unique biological markers that could …

This study looks at two types of fat tissue in people with knee osteoarthritis: one inside the knee joint (Hoffa's fat pad) and one inside the thigh muscle. Researchers want to see if these fat deposits are different in size, fat content, and scar tissue. The goal is to better un…

This study is testing a new device called BloodTrackR that lets people with rheumatoid arthritis collect a small blood sample at home using a finger prick and a smartphone app. Twenty participants will try the device and answer questions about how easy it is to use. The goal is t…

This study follows 300 adults with systemic lupus erythematosus (SLE) who are seen by a team of specialists at a hospital in Brest, France. Researchers will collect data on disease patterns, symptoms, and test results over time. The goal is to better understand lupus and improve …

This study will follow 78 people aged 50 to 85 who need a total knee replacement to see how well a newer all-polyethylene (plastic) knee implant holds up over 5 years. Researchers want to know if this design, which may be cheaper and have fewer mechanical problems, works as well …

This study looks at joint tissue from people with early osteoarthritis to find different patterns of inflammation. Researchers will take small samples using a needle under local anesthetic, along with blood tests. The goal is to better understand how the disease starts and progre…

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study is observing 200 patients who received a large leg implant (megaprosthesis) between 2020 and 2023. Researchers want to learn how many get infections, what puts them at risk, and how those infections turn out. The goal is to gather information, not to test a new treatme…

This study collects information from 10,000 adults who have had hip or knee replacement surgery at Heidelberg University Hospital. Researchers will follow participants during routine check-ups to see how long the artificial joints last, how well they function, and what problems m…

This study aims to create better custom insoles for people with rheumatoid arthritis who have foot pain. Researchers will use CT scans and motion analysis to build a digital model of how feet move and apply pressure. The goal is to design insoles that reduce pain and improve comf…

This study aims to develop a better way to locate painful inflammation in the knee joint for people with patellofemoral osteoarthritis. Researchers will use a special PET/MRI scan to see how inflammation changes when the knee is under pressure. About 50 adults, including both pat…

This study aims to learn how well heart scans (MRI, ultrasound, PET) can detect and predict outcomes in people with suspected or known inflammatory heart diseases. Researchers will follow 5,000 adults for one year to see how often heart involvement is confirmed and how it affects…

This study looks at how the alignment of the knee joint, seen on X-rays, relates to pain, daily function, quality of life, and fear of movement in people with knee osteoarthritis. Researchers will measure alignment and joint space width in 100 adults with knee osteoarthritis and …

This study compares two ways of tracking recovery after knee replacement surgery: traditional paper questionnaires filled out at the clinic versus digital surveys sent to a patient's smartphone. Researchers will enroll 50 adults aged 18-78 who own a smartphone, tablet, or compute…

This study looks at 600 teens and young adults (ages 14-26) with conditions like juvenile arthritis, fibromyalgia, or past surgeries to understand why some develop long-lasting pain while others don't. Researchers will examine pain sensitivity, immune markers, and social factors …

This study tests whether using a smartphone app (Google Forms) to fill out recovery questionnaires after hip replacement is as good as the traditional paper method. Researchers will compare how many patients complete the digital survey on time versus the paper one. The goal is to…

This study compares three types of hip replacement surgery—traditional total hip arthroplasty, a neck-preserving Minihip, and hip resurfacing—to see which one best restores the hip's natural biomechanics. Researchers will use CT scans and X-rays before and after surgery to measur…

This study is creating a registry to track how well a procedure called genicular artery embolization (GAE) works for knee osteoarthritis pain over time. Up to 100 adults with mild to moderate knee arthritis that hasn't improved with standard treatments will be enrolled. The goal …

This study compares two advanced technologies used in total knee replacement: computer-assisted navigation and robotic-arm assistance. Both aim to place the new knee joint more precisely. The trial will follow 140 patients for two years to see if one method helps them forget they…

This study follows 200 adults with rheumatoid arthritis who are already in stable remission from standard medications. Researchers will track their health over up to 5 years using exams, ultrasound, and X-rays to see who stays well and who has a flare. The goal is to learn how to…

This study looks at how weight loss (using tirzepatide) and a biologic drug (ixekizumab) affect the body in people with psoriatic arthritis who are overweight or obese. About 45 adults will receive one or both treatments. Researchers will take samples of skin, joint tissue, and f…

This study is building a large database and biobank from 2200 people with chronic inflammatory diseases like lupus, multiple sclerosis, severe asthma, and psoriasis. Researchers will collect blood samples and track disease activity over time using standard medical scores. The goa…

This study looks at how to make it easier for people with axial spondyloarthritis to start using the Axia app. Two groups of 200 participants will get different onboarding brochures: one with standard instructions and one with a 14-day free trial. Researchers will track how many …

This study looks at 750 people with rheumatoid arthritis (RA) who are 45 or older to find early signs of interstitial lung disease (ILD), a serious lung complication. Researchers will use CT scans and track changes over 3-5 years to identify risk factors. The goal is to better un…

This study is testing whether a mathematical model using blood markers can predict how well rheumatoid arthritis patients will respond to a lower dose of the drug rituximab. Thirty adults with RA who already do well on standard-dose rituximab will switch to a lower dose. Research…

This study aims to find out if brain-based tests can predict who will get pain relief from common knee osteoarthritis treatments. About 180 adults with knee pain will be randomly assigned to take duloxetine, celecoxib, or a placebo for 20 weeks. Researchers will use brain MRIs, k…

This pilot study is testing whether increasing daily steps can improve knee cartilage health in people who have had ACL reconstruction. Fifty-six participants will wear a Fitbit and receive daily step goals via text for 16 weeks. Researchers will use MRI scans to measure changes …

This study follows 425 adults with recent psoriatic arthritis (PsA) for up to 10 years to see how many develop joint damage and what factors predict it. Researchers will use X-rays and other data to identify early signs of aggressive disease. The goal is to help doctors decide wh…

This study looks at 200 adults with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis to see if certain blood markers (related to oxidative stress) can help doctors monitor how the disease changes over a year. Participants give blood samples at the start, 6 mon…

This study looks at young adults with chronic inflammatory rheumatic diseases who are moving from pediatric to adult healthcare. Researchers want to see if a structured program that includes education workshops and joint doctor visits helps patients manage their own care better. …

This study aims to find better ways to detect lung scarring (interstitial lung disease) early in people with connective tissue diseases like scleroderma or rheumatoid arthritis. Researchers will analyze tiny particles in the blood called extracellular vesicles and use AI to exami…

This study is a long-term check on the safety and performance of the MADISON total knee replacement system. It will follow 1,000 adults in France who need knee replacement surgery for up to 15 years. The goal is to track how often the implant needs to be revised or causes problem…

This study uses small wearable sensors to measure how people with severe knee osteoarthritis move before and after total knee replacement surgery. Researchers will track 20 patients over age 60 to see if these sensors can detect changes in knee motion and pain. The goal is to fin…

This study follows 2250 Chinese adults with axial spondyloarthritis (a type of inflammatory arthritis affecting the spine) to see how their condition changes over time. Researchers will measure physical function, spinal damage on X-rays, and episodes of eye inflammation. The goal…

This study aims to better understand why people with inflammatory arthritis experience chronic pain. Researchers will look at how the brain processes pain and how it affects daily life. 350 adults starting or switching arthritis medications will be followed over time. The goal is…

This study looks at two different methods of placing a total knee prosthesis: mechanical alignment (standard, fixed angles) and kinematic alignment (customized to each patient's anatomy). Researchers want to see which technique leads to better knee movement and function during ac…

This study aims to better understand rare forms of inflammatory arthritis, including those linked to other autoimmune diseases or cancer immunotherapy. Researchers will analyze joint tissue samples from 100 adults to compare the immune cells and molecules involved. The goal is to…

This study looks at how the bones in the shoulder joint touch each other in people with shoulder arthritis, both before and after they get a shoulder replacement. The goal is to find out why some shoulder implants loosen over time. Researchers will use special X-rays and CT scans…

This study looks at different types of low back pain in people with ankylosing spondylitis, a type of arthritis that mainly affects the spine. Researchers want to see how these pain types relate to daily function and quality of life. The study will involve 200 adults with ankylos…

This study follows 450 adults with gout, CPPD (a crystal-related joint disease), or osteoarthritis to see how crystal deposits in joints and blood vessels change over time. Participants receive routine care and undergo ultrasound and lab tests every six months for up to 10 years.…

This study looks at how bone density changes around two types of knee replacement implants over two years. About 50 people getting a cemented total knee replacement will join. Researchers will use special X-rays to measure bone loss and track how well the knee works. The goal is …

This study looks at whether palliative and supportive care, usually given to people near the end of life, could also help those with long-term inflammatory arthritis like rheumatoid arthritis. Researchers will interview patients and survey healthcare professionals to understand u…

This study is creating a biobank of blood and tissue samples from 2,000 people with rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, or osteoporosis. Researchers will analyze these samples to find biomarkers that predict how well a patient responds to treatment. The …

This study follows 50 adults with infected hip replacements treated at University Hospitals Leuven. Researchers will track which treatments (antibiotics or surgery) work best and note complications. The goal is to gather real-world data to help doctors and patients make better de…

This study follows 329 adults who need surgery for an infection after a hip, knee, or other joint replacement. Researchers will track which treatments—surgery and antibiotics—lead to the best outcomes. The goal is to find patterns that help cure infections more reliably and impro…

This study looks at whether a 3-month virtual program called Choose to Move Replacement Ready is feasible for people waiting for hip or knee replacement surgery due to osteoarthritis. About 60 participants will answer surveys and some will be interviewed. The goal is to see if th…

This study looks at whether brain scans can predict if someone will be satisfied after knee replacement surgery. Up to 1 in 5 patients still have pain or trouble moving after surgery, and doctors can't currently predict who. Researchers will scan the brains of 50 adults before an…

This study aims to improve total knee replacement surgery for people with severe knee arthritis and a bow-legged (varus) deformity. Researchers will use advanced CT scans to compare the angle of the affected leg with the healthy leg, helping surgeons decide how much to correct th…

This study is testing whether giving the COVID-19 booster and flu vaccine at the same time is as good as giving them a month apart for people with weakened immune systems. It also compares getting a COVID-19 booster every 3 months versus every 6 months. The trial involves 660 adu…

This study aims to see if artificial intelligence can use a patient's genetics, biomechanics, and psychology to predict how well they will recover after total knee replacement. Researchers will enroll 197 adults with severe knee osteoarthritis and follow them for a year. The goal…

This study uses two special scanners (HR-pQCT and pQCT) to take detailed pictures of bone and muscle in 1,000 people with conditions that raise the risk of bone loss, like osteoporosis, arthritis, or kidney disease. The goal is to see if these scanners can spot tiny changes in bo…

This study looks at how well the Triathlon Hinge Knee System works in people who need knee replacement surgery, either for the first time or to fix a previous one. Researchers will follow about 200 patients for up to 10 years to see how long the implant lasts and how well patient…

This pilot study will enroll 600 people getting total knee replacements to test a data platform called Pheno4U. Participants will use a sensor and a smartphone app to track their recovery. The goal is to identify unknown risks or side effects and improve personalized care. The st…

This study looks at whether muscle power and control can predict falls better than muscle strength in people aged 65-80 with knee osteoarthritis. Fifty participants will undergo muscle tests, walking analysis, and MRI scans. The goal is to develop a fall-risk assessment tool for …

This study follows 600 people with hip or knee osteoarthritis for one year to understand how their symptoms and daily function change over time. Participants fill out online questionnaires every two weeks and try different self-care programs through a web app called ArtroseCoach.…

This study will follow 500 adults and children with Still disease, a rare inflammatory condition causing fever, joint pain, and rash. Researchers aim to compare how the disease affects different age groups, identify early markers, and improve care. No new treatments are being tes…

This study follows about 70 people who have already received KYV-101, a CAR T-cell therapy, for autoimmune diseases like lupus and multiple sclerosis. Researchers will monitor participants for up to 15 years to track any delayed side effects, new cancers, or other health problems…

This study will follow 300 people with knee osteoarthritis or chronic inflammatory arthritis for up to 10 years. Researchers will collect blood, joint fluid, and platelet-rich plasma samples to look for biomarkers linked to pain, joint damage, and the need for knee replacement. T…

This pilot study tests two different exercise programs in 20 people with knee osteoarthritis to see how cartilage responds. One group exercises with rest breaks, the other without. The goal is to understand the mechanical and molecular effects of exercise on cartilage, not to tre…

This study is for 75 adults with rheumatoid arthritis whose current treatments have stopped working. The goal is to learn how to match each patient to the most effective drug for them, using advanced computer analysis and health data. This is a research study to gather informatio…

This study uses special PET scans to track where an experimental drug called CIT-013 goes in the body of people with rheumatoid arthritis. The drug aims to calm inflammation caused by immune cell traps. About 12 people aged 60-85 will receive a radioactive version of the drug and…

This observational study looks at why some people with knee osteoarthritis have worse pain than others, even when their knee damage looks similar on X-rays. Researchers will study 300 adults aged 45-80 with chronic knee pain. Participants will complete surveys, physical tests, kn…

This study collects blood and optional spinal fluid samples from 350 people with Parkinson's, ALS, glioblastoma, certain cancers, or rheumatoid arthritis. The goal is to find new genetic markers that could lead to better diagnostic tests for autoimmune encephalitis and paraneopla…

This study looks at how often people can return to sports at least three years after total knee replacement. It compares three different types of knee prostheses to see if one type leads to better sports participation. The study will include 660 adults who had their first knee re…

This registry enrolls pregnant women or those planning pregnancy who have autoimmune diseases like lupus or rheumatoid arthritis. Researchers at Duke University will track health data to find ways to improve outcomes for mothers and babies. The goal is to better understand risk f…

This study looks at whether the Iowa Level of Assistance (ILoA) scale is a reliable tool for measuring functional recovery in patients after joint replacement surgery. Researchers will have multiple physiotherapists assess the same patients to see if their scores agree. The goal …

This study is observing 650 people with osteoarthritis who receive cell therapy or other treatments. Researchers aim to assess how well cell therapy works by using a questionnaire. The study is currently recruiting participants.

This study looks at how well a particular type of knee replacement works in 960 adults who had surgery between 2013 and 2024. Researchers will check knee function and X-ray results at least one year after surgery. The goal is to see how the prosthesis performs and compare it to o…

This study looks at how natural cannabis compounds (phytocannabinoids) affect immune cells from 100 people with chronic inflammatory diseases like rheumatoid arthritis, lupus, and Crohn's disease. Researchers will take a blood sample and expose the cells to different cannabis ext…

This study aims to create and test an Italian version of a standard knee questionnaire, the New Knee Society Knee Scoring System. Researchers will translate the English survey into Italian, check its accuracy, and then ask about 300 Italian patients with knee osteoarthritis to fi…

This study uses a technique called microdialysis to measure antibiotic levels directly inside the hip joint after surgery for an infected hip replacement. Researchers want to see how well local antibiotics from a cement spacer work and compare them to levels in the blood. The goa…

This study is not a treatment trial. It aims to collect blood samples from 400 children and their relatives who have rare autoimmune or autoinflammatory diseases (like lupus or juvenile arthritis). Researchers will analyze the samples to find genetic mutations that cause these co…

This study uses a technique called microdialysis to measure antibiotic levels inside the knee joint after surgery for a knee replacement infection. Researchers will place a tiny probe in the joint to collect fluid samples during the hospital stay (about 14 days). They want to see…

This study looks at whether having total knee replacement surgery as an outpatient (going home the same day) leads to better recovery compared to staying in the hospital. Researchers will review medical records of 440 patients who had knee replacement between 2020 and 2023 at a F…

This study aims to understand why the Achilles tendon becomes painful and swollen in people with psoriatic arthritis. Researchers will take small tissue samples from the tendon and look for immune cells and inflammatory markers. The goal is to learn more about the disease, not to…

This study will observe 800 adults with rheumatoid arthritis in Austria to create a standard screening method for lung complications. Researchers will use CT scans, lung function tests, and AI analysis to identify those at high risk. The goal is to detect lung problems earlier an…

This study is testing a French version of a questionnaire that measures how well people with rheumatoid arthritis follow their medication plan. Researchers will enroll 150 adults who have been on a stable dose of methotrexate for at least a month. The goal is to make sure the que…

This study tests a new tool to help surgeons balance knee ligaments during total knee replacement. The goal is to see if the tool makes the procedure more accurate and repeatable. About 40 adults with knee arthritis will take part. The study focuses on measuring how much the liga…

This study looks at how immune cells and inflammatory molecules differ in people with migraine, especially those who also have autoimmune diseases like multiple sclerosis, rheumatoid arthritis, or endometriosis. Researchers will compare blood samples from 396 women to measure reg…

This study is looking at how the gut bacteria (microbiome) change in children with juvenile spondyloarthritis as they receive different treatments. Researchers will collect stool and blood samples from 25 children over several months to see if certain bacteria affect how well the…

This study looks at whether the routine one-year follow-up visit and X-ray after total hip or knee replacement is really needed. Researchers will compare patients who have a check-up only when they have concerns versus those who follow the standard yearly schedule. The goal is to…

This study is testing two different ways to slowly reduce the dose of the steroid prednisone in people with rheumatoid arthritis. One group will taper over 15 days, the other over 150 days. Researchers want to see who develops symptoms or flare-ups during the taper, and why. The …

This study follows 700 people with chronic diseases like arthritis, diabetes, or heart disease for 4 years. Participants wear a small movement sensor for 5 days, three times a year, to track their physical activity and sedentary time. Researchers want to see if a person's unique …