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Can rest during exercise help your knees? new study investigates

NCT ID NCT06857123

Knowledge-focused Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests two different exercise programs in 20 people with knee osteoarthritis to see how cartilage responds. One group exercises with rest breaks, the other without. The goal is to understand the mechanical and molecular effects of exercise on cartilage, not to treat the disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
exercise program with or without rest intervals
What this could lead to
If successful, this could help design better exercise plans for people with knee osteoarthritis to improve joint health.
What could go wrong
This is a very small pilot study (20 people) focused on feasibility, not on proving any treatment works. Results may not apply to everyone with knee OA.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 79 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 45 and 79 yo. * Clinical diagnosis of primary, early to moderate stage knee osteoarthritis. * BMI range \< 35 kg/m2. * Sedentary lifestyle * Knee joint is the most painful joint in the body. * Ability to speak and understand English. * Willingness to comply with all study procedures and be available for the duration of the study. Exclusion Criteria: * Non-OA disease of the knee. * Advanced knee osteoarthritis * Knee injection in the past 3 months. * Major knee trauma/surgery in the past 5 years or previous knee surgery with hardware limiting cartilage assessment.. * Participate in regular exercise or physical activity . * Participation in an intervention study for knee OA. * Currently using a cane, walker or crutches to walk. * History of cardiovascular disease or hypertension not controlled by medication. * Two or more unexplained falls in the past year. * Inflammatory, autoimmune disorders, neurological, systemic, muscular, or connective tissue conditions that affect walking or ability to exercise. * Contraindication to MRI. * Medical condition or characteristic of the participant that could place the individual at increased risk or preclude s/he from complying with study procedures. * Pregnant female. * Acute or terminal illness.

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Conditions

The condition(s) this trial relates to.

Motor Activity osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthristis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Pittsburgh

    RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

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