Knee osteoarthristis

This trial tests whether a smartphone app-guided rehabilitation program (MOKneeTOR) is as effective as traditional hospital-based physiotherapy for people with knee osteoarthritis. Participants will be randomly assigned to either use the app for 24 weeks or attend outpatient phys…

This trial tests whether a new robotic system, KUNWU®, can accurately achieve the planned knee alignment during total knee replacement, regardless of which of two implant types is used. Adults with knee osteoarthritis needing surgery will be randomly assigned to receive either th…

This study tests a program that uses artificial intelligence to guide exercise and continuous glucose monitors to help people with both knee osteoarthritis and obesity. The goal is to see if it can improve blood sugar control, reduce knee pain, and lower the need for knee replace…

This study is a registry that will follow 300 people who receive the Freedom Total Knee System, a new artificial knee implant. The goal is to see how well the device holds up over time and how safe it is. Participants are adults with severe knee arthritis who have not gotten reli…

This study compares two types of knee surgery for people with bow-legged knees and a torn meniscus. One surgery uses a newer bone-cut method, while the other uses a standard bone-cut method. About 20 participants will be randomly assigned to one of the two surgeries. Researchers …

This study tests a 6-week physiotherapy program designed to improve pain, function, and joint awareness in adults with knee osteoarthritis. The program uses sensory modulation and graded weight-bearing exercises, and the trial compares outcomes between male and female participant…

This study tests whether combining blood-flow-restricted exercise (light exercise with a cuff on the leg) and pain education can reduce pain and improve movement in people with knee osteoarthritis. About 90 adults aged 40 and older with knee osteoarthritis will take part. The goa…

This study tests whether improving sleep before total knee replacement surgery can reduce pain after the operation. Adults aged 60 and older with knee osteoarthritis and sleep difficulties will receive either cognitive-behavioral therapy for insomnia, bright light therapy, or a c…

This study compares two ways to restrict blood flow during exercise—using a special floss band or a traditional cuff—to see which better reduces pain and improves movement in people with knee osteoarthritis. 46 adults aged 40-60 with mild to moderate knee OA will do leg exercises…

This study tests two types of leg exercises—closed chain (like mini-squats) and open chain (like leg lifts)—both done with a blood flow restriction cuff on the thigh, in people with mild knee osteoarthritis. Forty participants aged 45-75 will do these exercises plus standard phys…

This study tests a digital rehabilitation program for people with knee osteoarthritis and healthy older adults. It uses a smart knee brace with sensors, electrical stimulation, and AI to guide exercises at home. The goal is to see if this approach improves pain, muscle strength, …

This study tests a powered boot-like device (exoskeleton) to see if it can help people with knee osteoarthritis walk more easily. Nine adults with knee pain who have trouble walking will try the device in a lab. The goal is to see if the device is comfortable and can reduce strai…

This study is tracking 1,200 adults with knee osteoarthritis who have not found relief from standard treatments. They will undergo a procedure called genicular artery embolization, which blocks certain blood vessels to reduce inflammation and pain. Researchers will follow partici…

This study tests a procedure called transarterial microembolization (TAME) for people with knee osteoarthritis and long-lasting pain that hasn't improved with standard treatments. Doctors will inject tiny beads into blood vessels around the knee to block abnormal blood flow, aimi…

Some people hear clicking or popping after knee replacement surgery, which can be bothersome. This study compares two different knee replacement designs to see if one causes less noise. Researchers will ask 170 patients about the sounds they hear and how much it bothers them over…

This study tests whether a type of exercise called diagonal proprioceptive neuromuscular facilitation (PNF) can reduce pain and improve function in people with knee osteoarthritis. Researchers will compare PNF exercises to standard strength training in 150 adults aged 40-60. Both…

This study tests whether frozen platelet-rich plasma (PRP) injections can reduce pain and improve knee function in people with knee osteoarthritis. About 60 adults aged 40-85 with mild to moderate knee arthritis will receive either frozen PRP or fresh PRP injections. The goal is …

This study tests whether a faster rehabilitation program helps people recover better after total knee replacement surgery. Researchers will compare the accelerated program to standard rehab in 32 adults aged 50-80. The goal is to see if the faster approach improves knee function …

This study is testing whether extracorporeal shockwave therapy (ESWT) can reduce pain and improve function in athletes who developed knee osteoarthritis after ACL reconstruction. Researchers will treat 70 participants with a device that delivers pressure waves to the knee. The go…

This study will compare two FDA-approved machines that make platelet-rich plasma (PRP) for people with knee osteoarthritis. PRP is made from a person's own blood and is injected into the knee to help with pain and stiffness. The researchers will check if the two machines produce …

This study checks if a standardized ultrasound scoring system for knee osteoarthritis works well in Turkish patients. Researchers will compare ultrasound findings with pain and function questionnaires in 100 adults aged 45 and older. The goal is to see if this method is reliable …

This pilot study tests two different exercise programs in 20 people with knee osteoarthritis to see how cartilage responds. One group exercises with rest breaks, the other without. The goal is to understand the mechanical and molecular effects of exercise on cartilage, not to tre…

This study aims to find out how many people with knee osteoarthritis also have nerve-related pain, and whether that type of pain makes their symptoms and daily function worse. Researchers will measure pain and physical ability in 102 participants using standard questionnaires. Th…

This observational study looks at hip and knee tissue from 1000 adults with osteoarthritis who are scheduled for joint replacement surgery. Researchers want to measure levels of rare metals and immune markers in the joint tissue and blood. The goal is to find imbalances that coul…

This study adds a return-to-sports test to an existing knee replacement recovery study. The test uses a stepwise approach to assess athletic readiness, starting with low-level sports and progressing only if safe. Researchers hope to provide an objective way to guide patients back…