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New psoriatic arthritis drug shows promise in Mid-Stage trial

NCT ID NCT07321873

Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 4 times

Summary

This study tests whether the experimental drug JNJ-88545223 can reduce joint pain, swelling, and skin symptoms in adults with active psoriatic arthritis. About 240 participants will receive either the drug or a placebo to see if it works better than no treatment. The goal is to improve joint and skin health over 16 weeks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 240 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a diagnosis of psoriatic arthritis (PsA) for at least 3 months before the first administration of study intervention and meet classification criteria for Psoriatic Arthritis (CASPAR) at screening * Have active PsA as defined by: (a) At least 3 swollen joints and at least 3 tender joints at screening and at baseline (Week 0/Day 1) based on the 66/68 joint assessment; AND (b) C-reactive protein (CRP) greater than or equal to (\>=) 0.1 milligrams per deciliter (mg/dL) at screening from the central laboratory * Have \>= 1 of the following PsA subsets: distal interphalangeal joint involvement, polyarticular arthritis with absence of rheumatoid nodules, asymmetric peripheral arthritis, or spondylitis with peripheral arthritis * Have active plaque psoriasis with at least one psoriatic plaque of \>= 2 centimeter (cm) diameter or nail changes consistent with psoriasis * A female participant of childbearing potential must have a negative highly sensitive serum pregnancy test (Beta-hCG) at screening and a negative urine pregnancy test at Week 0 prior to administration of study intervention Exclusion Criteria: * Has a nonplaque form of psoriasis (for example, erythrodermic, guttate, or pustular) * Has a history or current signs or symptoms of severe, progressive, or uncontrolled renal, hepatic, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic (except PsA), psychiatric, genitourinary, or metabolic disturbances * Has suspected or known allergies, hypersensitivity, or intolerance to JNJ-88545223 or excipients used in the investigational medicinal product (IMP), including placebo (JNJ-88545223 investigator's brochure); or has a history of severe allergic reaction, angioedema, or anaphylaxis to drugs or food * Has fibromyalgia or osteoarthritis symptoms that, in the opinion of the investigator, would have potential to interfere with efficacy assessments * Currently has a malignancy or has a history of malignancy within 5 years prior to screening

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Conditions

The condition(s) this trial relates to.

psoriatic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Arthritis, psoriatic

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    73 sites in 8 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Albuquerque Rehabilitation and Rheumatology

    RECRUITING

    Albuquerque, New Mexico, 87102, United States

  • American Research, LLC

    RECRUITING

    Cutler Bay, Florida, 33157, United States

  • Arthritis and Rheumatology Research Institute

    RECRUITING

    Frisco, Texas, 75035, United States

  • Atlanta Research Center for Rheumatology

    RECRUITING

    Marietta, Georgia, 30060, United States

  • Beijing Tsinghua Changgung Hospital

    RECRUITING

    Beijing, 102218, China

  • Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz

    RECRUITING

    Gyula, 5700, Hungary

  • CAIR Heidelberg

    RECRUITING

    Heidelberg, 69121, Germany

  • Centrum Kliniczno Badawcze

    RECRUITING

    Elblag, 82-300, Poland

  • Centrum Medyczne Reuma Park

    RECRUITING

    Warsaw, 02 665, Poland

  • Changzhou No 2 Peoples Hospital

    RECRUITING

    Changzhou, 213003, China

  • Charite Universitaetsmedizin Berlin

    RECRUITING

    Berlin, 10117, Germany

  • Clinical Research Philadelphia

    RECRUITING

    Philadelphia, Pennsylvania, 19114, United States

  • Clinical Research of West Florida

    RECRUITING

    Tampa, Florida, 33606, United States

  • Clintrial s r o

    RECRUITING

    Prague, 100 00, Czechia

  • Complex Rendelo Med Zrt

    RECRUITING

    Székesfehérvár, 8000, Hungary

  • Conquest Research

    RECRUITING

    Winter Park, Florida, 32789, United States

  • ETG Lublin

    RECRUITING

    Lublin, 20 412, Poland

  • Etyka Osrodek Badan Klinicznych Tomasz Pesta S K A

    RECRUITING

    Olsztyn, 10 117, Poland

  • Fachklinik Bad Bentheim

    RECRUITING

    Bad Bentheim, 48455, Germany

  • FutureMeds Targowek

    RECRUITING

    Warsaw, 03 291, Poland

  • Gemeinschaftspraxis Dres. Quist

    RECRUITING

    Mainz, 55128, Germany

  • Hamburger Rheuma Forschungszentrum II

    RECRUITING

    Hamburg, 20095, Germany

  • Hautarztpraxis

    RECRUITING

    Witten, 58453, Germany

  • Hautarztpraxis Mortazawi

    RECRUITING

    Remscheid, 42897, Germany

  • Hosp Univ A Coruna

    RECRUITING

    A Coruña, 15006, Spain

  • Hosp. Clinico Univ. de Santiago

    RECRUITING

    Santiago de Compostela, 15706, Spain

  • Hosp. Infanta Luisa

    RECRUITING

    Seville, 41010, Spain

  • Hosp. Virgen Del Rocio

    RECRUITING

    Seville, 41013, Spain

  • Hosp. Virgen Macarena

    RECRUITING

    Seville, 41009, Spain

  • Hospital of the University of Occupational and Environmental Health

    RECRUITING

    Kitakyushu-shi, 807-8556, Japan

  • Imamura General Hospital

    RECRUITING

    Kagoshima, 890-0064, Japan

  • Innovation Medical Research Center

    RECRUITING

    Palmetto Bay, Florida, 33157, United States

  • Integral Rheumatology And Immunology Specialists

    RECRUITING

    Plantation, Florida, 33324, United States

  • Joint and Muscle Research Institute

    RECRUITING

    Charlotte, North Carolina, 28204, United States

  • L K N Arthrocentrum

    RECRUITING

    Hlučín, 748 01, Czechia

  • MICS Centrum Medyczne Torun

    RECRUITING

    Torun, 87-100, Poland

  • MICS Centrum Medyczne Warszawa

    RECRUITING

    Warsaw, 00 874, Poland

  • MICS Centrum Medyczne Warszawa 1

    RECRUITING

    Warsaw, 00-872, Poland

  • Malopolskie Badania Kliniczne Sp z o o

    RECRUITING

    Krakow, 30-002, Poland

  • Medical Plus Research S R O

    RECRUITING

    Uherské Hradiště, 68601, Czechia

  • NZOZ Lecznica MAK MED S C

    RECRUITING

    Nadarzyn, 05-830, Poland

  • Newport Huntington Medical Group

    RECRUITING

    Huntington Beach, California, 92648, United States

  • Ningbo medical center lihuili hospital

    RECRUITING

    Ningbo, 315041, China

  • Nzoz Osteo Medic

    RECRUITING

    Bialystok, 15 351, Poland

  • Obudai Egeszsegugyi Centrum Kft

    RECRUITING

    Budapest, 1036, Hungary

  • Osaka Metropolitan University Hospital

    RECRUITING

    Osaka, 545 8586, Japan

  • Paramount Medical Research & Consulting

    RECRUITING

    Middleburg Heights, Ohio, 44130, United States

  • Peking University People's Hospital

    RECRUITING

    Beijing, 100044, China

  • Peking University Third Hospital

    RECRUITING

    Beijing, 100191, China

  • Porcika Klinika - Vasarhelyi Sarkanyfu Kft.

    RECRUITING

    Hódmezővásárhely, 6800, Hungary

  • Pratia Czech A S

    RECRUITING

    Pardubice, 53002, Czechia

  • Pratia MCM Krakow

    RECRUITING

    Krakow, 30-727, Poland

  • Praxis Mario Sutowicz

    RECRUITING

    Cottbus, 3042, Germany

  • Qualiclinic Kft

    RECRUITING

    Budapest, 1134, Hungary

  • Qualmedica Research

    RECRUITING

    Evansville, Indiana, 47715, United States

  • RHEUMA s r o

    RECRUITING

    Břeclav, 690 02, Czechia

  • Revmatologicka ambulance

    RECRUITING

    Karvina Frystat, 733 01, Czechia

  • Rheuma Medicus Sp z o o

    RECRUITING

    Warsaw, 02 118, Poland

  • Rheumatologische Schwerpunktpraxis

    RECRUITING

    Berlin, 10777, Germany

  • Rheumatology Center of San Diego

    RECRUITING

    San Diego, California, 92128, United States

  • Sanuki Municipal Hospital

    RECRUITING

    Sanuki, 769-2393, Japan

  • Semmelweis Egyetem Reumatologiai es Immunologiai Klinika

    RECRUITING

    Budapest, 1023, Hungary

  • Shanghai Sixth People's Hospital

    RECRUITING

    Shanghai, 200233, China

  • Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy

    RECRUITING

    Bydgoszcz, 85 168, Poland

  • The First Affiliated Hospital of Chongqing Medical University

    RECRUITING

    Chongqing, 400016, China

  • The Second Affiliated Hospital of Zhejiang University

    RECRUITING

    Hangzhou, 310009, China

  • Tokito Clinic Rheumatology and Orthopaedic Surgery

    RECRUITING

    Shimonoseki, 752 0976, Japan

  • Tokyo Metropolitan Tama Medical Center

    RECRUITING

    Fuchū, 183 8524, Japan

  • Unity Health-White County Medical Center

    RECRUITING

    Searcy, Arkansas, 72143, United States

  • Vital Medical Center Orvosi es Fogaszati Kozpont

    RECRUITING

    Veszprém, 8200, Hungary

  • West China Hospital Sichuan University

    RECRUITING

    Chengdu, 610093, China

  • Willow Rheumatology and Wellness PLLC

    RECRUITING

    Willowbrook, Illinois, 60527, United States

  • Xiangya Hospital Central South University

    RECRUITING

    Changsha, 410008, China

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