Thumb arthritis sufferers: new study tests simple pain fixes
NCT ID NCT06084364
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at three ways to ease pain from thumb arthritis: steroid injections, saltwater (placebo) injections, and hand therapy exercises. About 354 adults with thumb joint inflammation and pain will take part. The goal is to see which approach works best for reducing pain during daily activities.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 354 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2023
- Expected to finish
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Oct 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: \- Adult (40-85 years of age) men and women In target CMC-1 joint: * OA confirmed by radiographs or ultrasound examination, and * Inflammation by ultrasound (grey scale synovitis grade 1-3), and * Pain of at least 3 on a 0-10 Numeric Rating Scale (NRS) at rest or during activities at both pre-screening and screening. * Patient is assessed as eligible for the proposed use of Kenacort-T Exclusion Criteria: * Use of thumb orthosis on most of the days or structured hand exercises in the last 12 weeks * Intraarticular injections in the target CMC-1 joint in the last 12 weeks * More than 3 previous IACS in the target CMC-1 joint * Use of oral, intramuscular or intravenous steroids in the last 12 weeks * Previous surgery of the target CMC-1 joint * Planned hand surgery in the coming 24 weeks * Do not want to quit using oral or topical NSAIDs on the hands (such as ibuprofen, diclofenac, etoricoxib, naproxen) in the next 12 weeks * Systemic inflammatory joint diseases (such as rheumatoid arthritis (RA), psoriatic arthritis or gout) or other conditions that can better explain the hand pain (such as thoracic outlet syndrome, carpal tunnel disease, diabetic cheiropathy, hand injury in previous six months, or palmar tenosynovitis/trigger finger) * Diagnosis of fibromyalgia * Diagnosis of psoriasis * Infection, skin disease or wounds at joint injection site * Serious comorbidities, cognitive dysfunction, substance/alcohol abuse or any other medical condition that makes adherence to the study protocol difficult * Severe or uncontrolled infections * Known hypersensitivity to Triamcinolone acetonide (Kenacort) or any of the excipients (sodium carboxymethylcellulose, sodium chloride, polysorbate, benzyl alcohol, sodium hydroxide or hydrochloric acid) * Included in another clinical study * Use of digitalis glycosides * Patients vaccinated or immunized with live virus vaccines in the last 2 weeks * Not being able to talk or understand Norwegian * Known pregnancy or planned pregnancy in the next 6 months * Any condition that in the view of the investigator would suggest that the patient is unable to comply with the study protocol and procedures
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
5 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Diakonhjemmet Hospital
RECRUITINGOslo, Norway
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Haugesund Rheumatism Hospital
RECRUITINGHaugesund, Norway
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Martina Hansens Hospital
ACTIVE_NOT_RECRUITINGSandvika, Norway
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Nordlands Hospital
RECRUITINGBodø, Norway
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St Olavs Hospital
RECRUITINGTrondheim, Norway
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Stavanger University Hospital
RECRUITINGStavanger, Norway
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Blood-Derived injection ease thumb arthritis pain?
- Which thumb arthritis surgery works best? a Head-to-Head trial aims to find out
- Shape-Memory staple aims to speed healing of arthritic finger joints
- Opioid-Free pain relief after thumb surgery shows promise in new study
- New cell injection could ease thumb arthritis pain
- Thumb arthritis study tests PRP vs steroids – but ends early