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Can a Blood-Derived injection ease thumb arthritis pain?

NCT ID NCT06193499

Disease control Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial tests whether injecting platelet-rich plasma (PRP) into the thumb joint can reduce pain and improve function in people with thumb base osteoarthritis. Participants are randomly assigned to receive either PRP or a saline placebo injection, and neither they nor the researchers know which they get. The study measures pain during thumb use and hand disability over time to see if PRP offers meaningful relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich plasma (PRP) injected into the thumb joint
What this could lead to
If effective, PRP injections could offer a non-surgical option to reduce pain and improve hand function in people with thumb base osteoarthritis.
What could go wrong
This is a small, early-stage trial, and PRP's benefit over placebo is unproven. Results may not apply to all patients, and injection-related risks like pain or infection exist.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Started

Jan 2024

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Osteoarthritis in the thumb base * Radiological Eaton Littler class 1-3. * Clinical signs of thumb base osteoarthritis )pain at palpation of the CMC-1 joint and pain during provocation/grinding test). Exclusion Criteria: * Rheumatoid arthritis * Ongoing infection in the hand or wrist * History of gout or pseudogout in the hand * Inability to co-operate with the follow-up protocol (language difficulties, severe psychiatric disorder, cognitive impairment, drug addiction). * Chronic pain syndrome / centralized pain. * Intra-articular injection in the affected joint within 6 months. * Eaton Littler class 4 (symptomatic STT joint osteoarthritis).

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Conditions

The condition(s) this trial relates to.

osteoarthritis, hand

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis thumb

Contacts and locations

Locations

  • Department of Hand Surgery Södersjukhuset

    Stockholm, S-11883, Sweden

More trials for these conditions

Other studies related to the condition(s) this trial covers.