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Thumb arthritis study tests PRP vs steroids – but ends early

NCT ID NCT03196310

Symptom relief Sponsor: Kettering Health Network Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at three treatments for thumb base arthritis: a platelet-rich plasma (PRP) injection, a corticosteroid (Kenalog) injection, or a placebo (saline) injection. The goal was to see which best improved hand function and pain. The trial enrolled 74 people with early-stage thumb arthritis but was terminated early, so results are incomplete.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich plasma (PRP) and corticosteroid (Kenalog)
What this could lead to
If PRP proves effective, it could offer a longer-lasting, natural option for easing thumb arthritis pain without steroids.
What could go wrong
The trial was terminated early, so results are limited. PRP is still experimental for this use, and benefits may not be better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

74 people

The number who actually took part.

Started

Sep 2018

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Stage 1-3 osteoarthritis of the basal joint Exclusion Criteria: * Patients with Stage 4 1st carpometacarpal joint arthritis as described by Eaton * Patients who have received a corticosteroid injection in the last year to the 1st CMC joint on the proposed study side * Patients who have scaphotriquetral, radioscaphoid, or scaphotrapezial osteoarthritis * Patients who have concurrent DeQuervain's tenosynovitis or intersection syndrome or have been treated for either of these in the last 3 months * Patients undergoing evaluation of cervical radiculopathy * Patients with fibromyalgia or inflammatory rheumatic disease * Patients with Pressier disease, Kienbock's, or avascular necrosis of the scaphoid * Patients with any history of primary or secondary bone tumor * Patients that are pregnant or terminally ill

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, hand

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis thumb

Contacts and locations

Locations

  • Orthopedic Associates of Southwest Ohio

    Centerville, Ohio, 45459, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.