Cannabis capsules tested for joint pain relief in new study
NCT ID NCT06878417
First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 2 times
Summary
This study tests whether daily cannabis extracts (CBD or THC) can reduce pain interference in people with hip or knee osteoarthritis. One hundred adults aged 40-80 will take either CBD, THC, or a placebo capsule daily for 8 weeks and track their symptoms remotely. The goal is to see if a larger trial is possible, not to prove the treatment works yet.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2026
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age 40-80 years 2. Diagnosed with hip and/or knee osteoarthritis as per the American College of Rheumatology criteria 3. Experiencing moderate to severe pain interference as indicated by a PROMIS-PI SF-6a T-score ≥ 60 4. Have not initiated any new analgesics or osteoarthritis treatments in the previous 4 weeks 5. Able to self-report, understand and read English or French Exclusion Criteria: 1. Hip or knee surgery planned in the coming 4 months, 2. Injection into the affected joint(s) within the past 3 months (e.g., cortisone, plasma-rich protein, etc.), 3. Planned injection into the affected joint(s) during trial period, 4. Inflammatory arthritis (e.g., rheumatoid arthritis, Psoriatic arthritis, gout, etc.), 5. Contraindications to taking cannabis/cannabinoids, 6. Used nabilone or nabiximols in the last 30 days, 7. Used cannabis (medical or recreational) in the last 30 days (to allow sufficient washout), 8. A history of diagnosed cannabis use disorder or dependence, 9. Active substance use disorder, 10. Current DSM-V diagnosis of bipolar disorder, major depression, or psychosis, 11. An uncontrolled medical or major psychiatric disorder, 12. Currently on warfarin, 13. Known pregnancy or currently breastfeeding, 14. Men and women planning a pregnancy during the study or in the 12 weeks after stopping IPs 15. No fixed address or a plan to change addresses in the coming 4 months, 16. Known or suspected allergy to palm/coconut oil
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
3 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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McGill University Health Centre/Montreal General Hospital
RECRUITINGMontreal, Quebec, H3G 1A4, Canada
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University Health Network
RECRUITINGToronto, Ontario, M5G 2C4, Canada
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Women's College Hospital
RECRUITINGToronto, Ontario, M5S 1B2, Canada
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Other studies related to the condition(s) this trial covers.
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