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New weekly shot could shed pounds and ease knee pain

NCT ID NCT07509307

Symptom relief Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 18, 2026 · Updated 4 times

Summary

This Phase 3 study tests a once-weekly injection called NNC0487-0111 in 400 adults who are overweight or obese and have knee osteoarthritis. The goal is to see if it helps with weight loss and reduces knee pain compared to a placebo. Participants receive either the active drug or a placebo injection for several weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
NNC0487-0111 (a weekly injection for weight loss and osteoarthritis symptoms)
What this could lead to
If it works, this could offer a new weekly injection that helps people with obesity and knee osteoarthritis lose weight and reduce pain.
What could go wrong
This is a Phase 3 trial, but results are not yet known. The drug may not provide meaningful pain relief or weight loss, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: * Male or female (sex at birth) * Age 18 years or above at the time of signing the informed consent * Clinical diagnosis of knee osteoarthritis (OA) (American College of Rheumatology criteria) with radiographic changes (Kellgren Lawrence \[KL\] grades 2 to 4 as per central reading) in target knee. Target knee joint is defined as most symptomatic knee at screening. If pain in knees is equal, the target knee joint will be the dominant leg * Symptomatic knee OA with first appearance of pain in the target knee \> 90 days prior to screening and pain in the target knee for \> 15 days over the prior 30 days * Willingness to complete a 72-hour washout period of analgesics before all visits involving WOMAC Osteoarthritis Index NRS 3.1 (24-hour) (WOMAC) questionnaire (acetaminophen 4 grams (g)/day is allowed as rescue medication up until 24 hours before those visits) Key Exclusion Criteria: * Glycated haemoglobin (HbA1c) ≥ 6.5% (48 mmol/mol) as measured by the central laboratory at screening * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records * Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), or amylin analogues before screening * Any joint prosthesis or joint replacement in target knee * Arthroscopy or injections into target knee within the last 90 days prior to screening * Any other joint disease in target knee including gout and pseudogout

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder osteoarthritis, knee Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity Osteoarthritis, knee Overweight

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    81 sites in 11 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • "Zdrowie Osteo-Medic" s.c. Lidia i Artur Racewicz, Agnieszka i Jerzy Supronik

    RECRUITING

    Bialystok, Podlaskie Voivodeship, 15-351, Poland

  • ALPHA Recherche Clinique

    RECRUITING

    Lévis, Quebec, G6V 0C9, Canada

  • ALPHA Recherche Clinique

    RECRUITING

    Québec, Quebec, G3K 2P8, Canada

  • Aarhus Universitetshospital - Klinik for Led og bindevævssygdomme

    RECRUITING

    Aarhus N, 8200, Denmark

  • Adana Şehir Eğitim ve Araştırma Hastanesi-Fizik Tedavi ve Rehabilitasyon

    RECRUITING

    Yuregir/Adana, 01060, Turkey (Türkiye)

  • Advanced Res for Health Improve

    RECRUITING

    Naples, Florida, 34102, United States

  • Ankara Bilkent Şehir Hastanesi- Fizik Tedavi ve Rehabilitasyon

    RECRUITING

    Çankaya/Ankara, 06800, Turkey (Türkiye)

  • Arcturus Healthcare, PLC.

    RECRUITING

    Troy, Michigan, 48098-6368, United States

  • Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit

    RECRUITING

    Marousi, 15125, Greece

  • Athens Medical Center S.A. (Iatriko Psychikou) - Department of Internal Medicine & Metabolic Diseases

    RECRUITING

    Athens, 11525, Greece

  • Auxologico San Luca - Endocrinologia e Malattie del Metabolismo

    RECRUITING

    Milan, Lombardy, 20149, Italy

  • Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Civile Maggiore Borgo Trento - U.O. Reumatologia

    NOT_YET_RECRUITING

    Verona, Veneto, 37126, Italy

  • Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi-Fizik Tedavi ve Rehabilitasyon

    RECRUITING

    Yıldırım/Bursa, 16310, Turkey (Türkiye)

  • Casa della Salute di Ceccano - Ambulatori Campus Biomedico

    RECRUITING

    Rome, Lazio, 00128, Italy

  • CenterMed Kraków Sp. z o.o.

    RECRUITING

    Krakow, 31-530, Poland

  • CenterMed Kraków Sp. z o.o.

    NOT_YET_RECRUITING

    Krakow, 31-530, Poland

  • Centre Medical Acadie

    RECRUITING

    Montreal, Quebec, H4N 2W2, Canada

  • Centre de Recherche du CHUS

    RECRUITING

    Sherbrooke, Quebec, J1H 5N4, Canada

  • Centro Especialidades Hermanos Sangro

    NOT_YET_RECRUITING

    Madrid, 28038, Spain

  • Centrum Medyczne Intercor Sp. z o.o.

    RECRUITING

    Bydgoszcz, 85-605, Poland

  • Centrum Medyczne Intercor Sp. z o.o.

    NOT_YET_RECRUITING

    Bydgoszcz, 85-605, Poland

  • Chase Medical Research LLC

    RECRUITING

    Waterbury, Connecticut, 06708, United States

  • ClinicMed Daniluk, Nowak Spółka Komandytowa

    RECRUITING

    Bialystok, 15-879, Poland

  • Clinical Investigation Spec Gurnee

    RECRUITING

    Gurnee, Illinois, 60031, United States

  • Clinical Neuroscience Solutions, LLC

    RECRUITING

    Jacksonville, Florida, 32256, United States

  • Clinvest Research

    RECRUITING

    Springfield, Missouri, 65807, United States

  • Clínica Nuevas Tecnologías en Diabetes y Endocrinología

    RECRUITING

    Seville, 41003, Spain

  • Coastal Digestive Health

    RECRUITING

    Maroochydore, Queensland, 4558, Australia

  • Desert Oasis Healthcare

    RECRUITING

    Palm Springs, California, 92262, United States

  • Emeritus Research Sydney

    RECRUITING

    Botany, New South Wales, 2019, Australia

  • Evangelismos S.A. - Endocrinology department

    RECRUITING

    Athens, 10676, Greece

  • Evanston Premier Hlthcr Res

    RECRUITING

    Skokie, Illinois, 60077, United States

  • First Valley Medical Group

    RECRUITING

    Lancaster, California, 93534, United States

  • Frederiksberg Hospital - Parker Institutet (Artrose)

    RECRUITING

    Frederiksberg, 2000, Denmark

  • H. Infanta Luisa_Endocrino y Obesidad

    RECRUITING

    Seville, 41010, Spain

  • Health Res of Hampton Roads

    RECRUITING

    Newport News, Virginia, 23606, United States

  • Heart of Australia

    RECRUITING

    Chelmer, Queensland, 4068, Australia

  • Hospital For Special Surgery

    RECRUITING

    New York, New York, 10021, United States

  • Hospital General de Valencia

    RECRUITING

    Valencia, 46014, Spain

  • Hospital Germans Trias i Pujol

    RECRUITING

    Badalona, 08916, Spain

  • Hospital HM La Esperanza

    RECRUITING

    Santiago de Compostela, 15705, Spain

  • Hospital Infanta Sofía

    RECRUITING

    San Sebastián de Los Reyes (Madrid), 28702, Spain

  • Hospital Naval Ferrol

    RECRUITING

    Ferrol, 15405, Spain

  • Hospital Quirónsalud Málaga

    RECRUITING

    Málaga, 29004, Spain

  • Hospital Universitario Marqués de Valdecilla

    RECRUITING

    Santander, 39008, Spain

  • Instituto Medico Quirurgico San Rafael

    RECRUITING

    A Coruña, 15006, Spain

  • Istanbul Üniversitesi- Istanbul Tıp Fakültesi Esnaf Hastanesi Poliklinikleri Fiziksel Tıp Ve Rehabilitasyon Anabilim Dalı

    RECRUITING

    Fatih/İstanbul, 34116, Turkey (Türkiye)

  • Kolling Institute

    RECRUITING

    St Leonards, New South Wales, 2065, Australia

  • Laiko General Hospital Of Athens - 1st department of Internal Medicine

    RECRUITING

    Athens, 115 27, Greece

  • Latin Clinical Trial Center Puerto Rico

    RECRUITING

    San Juan, 00909, Puerto Rico

  • MC Dr. Atanasov EOOD

    RECRUITING

    Sofia, 1231, Bulgaria

  • MC Excelsior OOD

    RECRUITING

    Sofia, 1407, Bulgaria

  • MMA MHAT - Sofia, Rheumatology clinic

    RECRUITING

    Sofia, 1606, Bulgaria

  • Mercy Family Clinic

    RECRUITING

    Dallas, Texas, 75208, United States

  • Momentum Clinical Research Darlinghurst

    RECRUITING

    Darlinghurst, New South Wales, 2010, Australia

  • Monroe Biomedical Research, LLC

    RECRUITING

    Louisville, Kentucky, 40213, United States

  • NYU Langone Orthopedic Center

    NOT_YET_RECRUITING

    New York, New York, 10016, United States

  • Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher

    RECRUITING

    Warsaw, 02-637, Poland

  • Neighborhood Healthcare

    RECRUITING

    Escondido, California, 92025, United States

  • NextHealth S.A. - Department of Endocrinology, Metabolism & Diabetes

    RECRUITING

    Thessaloniki, 54635, Greece

  • Northwest Clinical Research Center

    RECRUITING

    Bellevue, Washington, 98007, United States

  • Northwest Research Center

    RECRUITING

    Portland, Oregon, 97202, United States

  • Ospedale Galeazzi S.p.A. - INCO - Istituto Nazionale per la Cura dell'Obesità

    RECRUITING

    Milan, Lombardy, 20157, Italy

  • Ospedale S. Maria della Misericordia - Reparto Endocrinologia e Malattie del Metabolismo

    RECRUITING

    Udine, Friuli Venezia Giulia, 33100, Italy

  • Piedmont Healthcare/Research

    RECRUITING

    Statesville, North Carolina, 28625, United States

  • Pol. Uni. Campus Biomedico - UOC Endocrinologia e Diabetologia

    RECRUITING

    Rome, Lazio, 00128, Italy

  • Policlinico San Donato di Milano S.p.A - UOS Endocrinologia e del Servizio di Nutrizione Clinica e Prevenzione Cardiometabolica

    RECRUITING

    San Donato Milanese, Lombardy, 20097, Italy

  • SBÜ Ankara Gaziler Fizik Tedavi Ve Rehabilitasyon Eğitim Ve Araştırma Hastanesi

    RECRUITING

    Çankaya/Ankara, 06800, Turkey (Türkiye)

  • Sanos Clinic - Herlev

    RECRUITING

    Herlev, 2730, Denmark

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.

    RECRUITING

    Krakow, 31-826, Poland

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.

    NOT_YET_RECRUITING

    Krakow, 31-826, Poland

  • TLC Diabetes and Endocrinology

    NOT_YET_RECRUITING

    Surrey, British Columbia, V3T 2V6, Canada

  • Thermi Clinic S.A. - Diabetes and Internal Medicine Department

    RECRUITING

    Thessaloniki, 57001, Greece

  • Trakya Üniversitesi Tıp Fakültesi Hastanesi-Fizik Tedavi ve Rehabilitasyon

    RECRUITING

    Edirne, 22030, Turkey (Türkiye)

  • UMHAT Sveti Georgi EAD, Plovdiv

    RECRUITING

    Plovdiv, 4002, Bulgaria

  • UMHAT Sveti Ivan Rilski EAD, Rheumatology

    RECRUITING

    Sofia, 1612, Bulgaria

  • UMHAT Tsaritsa Yoanna - ISUL EAD, Orthopaedics and Traumatology

    RECRUITING

    Sofia, 1527, Bulgaria

  • University General Hospital Attikon General Hospital Of West Attica H Agia Varvara - 2nd dept of Internal medicine

    RECRUITING

    Chaïdári, Attica, 12461, Greece

  • Westside Center For Clinical Research

    RECRUITING

    Jacksonville, Florida, 32205, United States

  • Your Research Network

    RECRUITING

    Niagara Falls, Ontario, L2H 1H5, Canada

  • İstanbul Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi

    RECRUITING

    Bahçelievler/İstanbul, 34186, Turkey (Türkiye)

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