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Knee pain relief showdown: PRP vs. Cytokine-Rich serum

NCT ID NCT07473232

Symptom relief Sponsor: Pamukkale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 21, 2026 · Updated 2 times

Summary

This study will compare the effects of a single injection of platelet-rich plasma (PRP) versus conditioned serum (CS) in 60 people with knee osteoarthritis. Participants must have had knee pain for at least 6 months and meet specific criteria. The goal is to see which treatment better reduces pain, measured by a visual pain scale.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
platelet-rich plasma (PRP) and conditioned serum (CS)
What this could lead to
If successful, this could show which injection offers better pain relief for knee osteoarthritis, guiding future treatment choices.
What could go wrong
This is a small, early-stage trial with only 60 participants, and results may not apply to all patients. Pain relief may be modest or temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Diagnosis of knee osteoarthritis according to ACR criteria at least 6 months ago. 2. Being between grade 1-2 according to the Kellgren-Lawrence radiological classification. 3. Not having had PRP injection in the last year. 4. Knee pain ≥ 5 according to the visual pain scale. Exclusion Criteria: 1. Those with significant neurological or cardiovascular disorders. 2. Those with active thrombovascular disease. 3. Those with joint or skin infections. 4. Those who have recently had an infectious disease. 5. Those infected with Hepatitis B, C, and HIV. 6. Those who have received intra-articular knee injections (hyaluronic acid, PRP, corticosteroids, and others) within the last year. 7. Those who use oral corticosteroids. 8. Those who have used NSAIDs within the last week. 9. Those who have used anti-platelet or anti-aggregant drugs within the last week. 10. Those with coagulation disorders. 11. Those with hemoglobin \<10 g/dl and platelet count \<100,000 12. Those with cancer. 13. Pregnant or breastfeeding women, drug addicts. 14. Those scheduled for knee surgery or arthroscopy, or those who have undergone knee surgery or arthroscopy. 15. Those with diseases causing secondary osteoarthritis: 1. post-traumatic, 2. congenital or developmental diseases 1. Local diseases (leg length discrepancy, varus, valgus deformities, hypermobility syndromes, scoliosis) 2. Generalized diseases (Bone dysplasias, Metabolic disorders (hemochromatosis, ochronosis, Gaucher disease, hemoglobinopathy, Ehlers-Danlos disease)) 3. Calcium storage diseases (calcium pyrophosphate storage disease, etc.) 4. Other bone and joint diseases (avascular necrosis, rheumatoid arthritis, gouty arthritis, septic arthritis, Paget's disease, osteoporosis, osteochondritis) 5. Other diseases 1. Endocrine diseases (Diabetes mellitus, acromegaly, hypothyroidism, hyperthyroidism) 2. Neuropathic arthropathy (Charcot joint) 3. Other (Frost, Kashin-Beck disease, Caisson disease) -

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Conditions

The condition(s) this trial relates to.

Inflammation osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Conditioned serum Knee arthritis osteoarthritis Platelet rich plasma injection

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Pamukkale University Hospital

    RECRUITING

    Pamukkale, Denizli, 20070, Turkey (Türkiye)

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