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Knee replacement showdown: surgery vs. intensive medical care

NCT ID NCT06643845

Disease control Sponsor: University Hospital, Brest Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two approaches for people with knee osteoarthritis who are already scheduled for knee replacement surgery. One group will have the surgery as planned, while the other will receive a comprehensive medical care plan including medications, injections, and lifestyle changes. The goal is to see if the medical approach can control pain and function as well as surgery, potentially allowing many to avoid or delay the operation. The trial will enroll 1000 participants across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Multimodal medical and non-medical treatments (medications, injections, physical therapy, lifestyle changes)
What this could lead to
If successful, this could offer a way for many people with knee osteoarthritis to avoid or delay major surgery through a comprehensive medical care plan.
What could go wrong
This is an early-stage study with no phase, and the medical approach may not work as well as surgery for some patients. There is also a risk that delaying surgery could lead to worsening symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Apr 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-90 years old * Femoro-tibial osteoarthritis Kellgren stage stage≥ 2 without laxity in extension; * A proposal of total knee replacement by a surgeon; * No corticosteroid joint injection within 3 months; * Visual analogic score pain (VAS) \>40/100 but \<90/100 or Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index function sub scale \>40/100 at inclusion; * Wish to discuss medical care; * Able to consent and having signed a consent form. Exclusion Criteria: * Contraindication or no indication to surgery or medical care (severe infection for example) * Inflammatory arthritis * Lack of social insurance * Symptomatic (VAS pain \>40) contralateral knee or hip osteoarthritis (with or without replacement) * Pregnant or breastfeeding woman * Patient under court protection, guardianship, curatorship * Patient deprived of liberty

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis, knee

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    21 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AP-HP Cochin

    NOT_YET_RECRUITING

    Paris, France

  • AP-HP La pitié

    NOT_YET_RECRUITING

    Paris, France

  • AP-HP Lariboisière

    NOT_YET_RECRUITING

    Paris, France

  • AP-HP Saint-Antoine

    NOT_YET_RECRUITING

    Paris, France

  • CH Morlaix

    NOT_YET_RECRUITING

    Morlaix, France

  • CHD Vendée

    NOT_YET_RECRUITING

    La Roche-sur-Yon, France

  • CHIC Quimper

    RECRUITING

    Quimper, France

  • CHU Amiens

    NOT_YET_RECRUITING

    Amiens, France

  • CHU Brest

    RECRUITING

    Brest, France

  • CHU Caen

    NOT_YET_RECRUITING

    Caen, France

  • CHU Le Mans

    NOT_YET_RECRUITING

    Le Mans, France

  • CHU Limoges

    NOT_YET_RECRUITING

    Limoges, France

  • CHU Montpellier

    NOT_YET_RECRUITING

    Montpellier, France

  • CHU Nantes

    NOT_YET_RECRUITING

    Nantes, France

  • CHU Nice

    NOT_YET_RECRUITING

    Nice, France

  • CHU Reims

    NOT_YET_RECRUITING

    Reims, France

  • CHU Saint Etienne

    NOT_YET_RECRUITING

    Saint-Etienne, France

  • CHU Strasbourg

    NOT_YET_RECRUITING

    Strasbourg, France

  • CHU Tours

    NOT_YET_RECRUITING

    Tours, France

  • GHICL- Hôpital Saint Philibert

    NOT_YET_RECRUITING

    Lomme, France

  • HCL

    NOT_YET_RECRUITING

    Lyon, France

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