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New weekly shot aims to melt weight and soothe aching knees

NCT ID NCT07481630

Symptom relief Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This Phase 3 trial tests whether a once-weekly injection called NNC0487-0111 can help people with overweight or obesity and knee osteoarthritis lose weight and feel less pain. About 400 adults will receive either the drug or a placebo for several weeks. Researchers will measure changes in body weight and knee symptoms using standard pain and function scores.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
NNC0487-0111 (a once-weekly injection for weight loss and osteoarthritis symptoms)
What this could lead to
If it works, this could provide a new weekly injection that helps people with obesity and knee osteoarthritis lose weight and reduce pain and stiffness.
What could go wrong
This is still experimental. The placebo group may also improve, and side effects from the injection are possible. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key inclusion Criteria: * Male or female (sex at birth). * Age 18 years or above at the time of signing the informed consent. * Clinical diagnosis of knee osteoarthritis (American College of Rheumatology criteria) with radiographic changes (Kellgren Lawrence (KL) grades 2 to 3 as per central reading) in target knee. Target knee joint is defined as most symptomatic knee at screening. If pain in knees is equal, the target knee joint will be the dominant leg. * Symptomatic knee OA with first appearance of pain in the target knee more than (\>) 90 days prior to screening and pain in the target knee for \> 15 days over the prior 30 days. * Willingness to complete a 72-hour washout period of analgesics before all visits involving WOMAC Osteoarthritis Index NRS 3.1 (24-hour) (WOMAC) questionnaire (acetaminophen 4 gram (g)/day is allowed as rescue medication up until 24 hours before those visits). Exclusion Criteria: * Glycated haemoglobin more than or equal to (≥) 6.5% \[(48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening. * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records. * Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), or amylin analogues before screening. * Any joint prosthesis or joint replacement in target knee. * Arthroscopy or injections into target knee within the last 90 days prior to screening. * Any other joint disease in target knee including gout and pseudogout.

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis (OA) Obesity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    82 sites in 10 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • "Zdrowie Osteo-Medic" s.c. Lidia i Artur Racewicz, Agnieszka i Jerzy Supronik

    RECRUITING

    Bialystok, Podlaskie Voivodeship, 15-351, Poland

  • "Zdrowie Osteo-Medic" s.c. Lidia i Artur Racewicz, Agnieszka i Jerzy Supronik

    NOT_YET_RECRUITING

    Bialystok, Podlaskie Voivodeship, 15-351, Poland

  • AOU Federico II Di Napoli - DAI Endocr. Diab. Andro. e Nutr. - UOC Medicina Interna e Nutrizione Clinica

    RECRUITING

    Naples, Campania, 80131, Italy

  • Aarhus Universitetshospital - Klinik for Led og bindevævssygdomme

    RECRUITING

    Aarhus N, 8200, Denmark

  • Accellacare and KDCILM, LLC

    RECRUITING

    Wilmington, North Carolina, 28401, United States

  • Adana Şehir Eğitim ve Araştırma Hastanesi-Fizik Tedavi ve Rehabilitasyon

    RECRUITING

    Yuregir/Adana, 01060, Turkey (Türkiye)

  • Alpha Recherche Clinique - Lebourgneuf

    RECRUITING

    Québec, G2J OC4, Canada

  • Angels Clinical Research Institute

    RECRUITING

    Miami Lakes, Florida, 33016, United States

  • Ankara Bilkent Şehir Hastanesi- Fizik Tedavi ve Rehabilitasyon

    RECRUITING

    Çankaya/Ankara, 06800, Turkey (Türkiye)

  • Ankara Üniversitesi Sağlık Uygulama ve Araştırma Hastaneleri- Fiziksel Tıp ve Rehabilitasyon

    RECRUITING

    Altındağ/Ankara, 06230, Turkey (Türkiye)

  • Arizona Research Center, Inc.

    RECRUITING

    Phoenix, Arizona, 85053, United States

  • Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit

    RECRUITING

    Marousi, 15125, Greece

  • Athens Medical Center S.A. (Iatriko Psychikou) - Department of Internal Medicine & Metabolic Diseases

    RECRUITING

    Athens, 11525, Greece

  • Auxologico San Luca - Endocrinologia e Malattie del Metabolismo

    RECRUITING

    Milan, Lombardy, 20149, Italy

  • Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Civile Maggiore Borgo Trento - U.O. Reumatologia

    RECRUITING

    Verona, Veneto, 37126, Italy

  • CNS Healthcare

    RECRUITING

    Jacksonville, Florida, 32256, United States

  • CenExel iResearch, LLC

    RECRUITING

    Decatur, Georgia, 30030, United States

  • CenterMed Kraków Sp. z o.o.

    RECRUITING

    Krakow, 31-530, Poland

  • CenterMed Kraków Sp. z o.o.

    NOT_YET_RECRUITING

    Krakow, 31-530, Poland

  • Centre de Recherche Musculo

    RECRUITING

    Trois-Rivières, Quebec, G8Z 1Y2, Canada

  • Centro Especialidades Hermanos Sangro

    RECRUITING

    Madrid, 28038, Spain

  • Centrum Medyczne Intercor Sp. z o.o.

    RECRUITING

    Bydgoszcz, 85-605, Poland

  • Centrum Medyczne Intercor Sp. z o.o.

    NOT_YET_RECRUITING

    Bydgoszcz, 85-605, Poland

  • Charlottesville Med Research

    RECRUITING

    Charlottesville, Virginia, 22911, United States

  • Chase Medical Research LLC

    RECRUITING

    Hamden, Connecticut, 06517, United States

  • Chase Medical Research LLC

    RECRUITING

    Waterbury, Connecticut, 06708, United States

  • ClinicMed Daniluk, Nowak Spółka Komandytowa

    RECRUITING

    Bialystok, 15-879, Poland

  • ClinicMed Daniluk, Nowak Spółka Komandytowa

    NOT_YET_RECRUITING

    Bialystok, 15-879, Poland

  • Clínica Nuevas Tecnologías en Diabetes y Endocrinología

    RECRUITING

    Seville, 41003, Spain

  • Coastal Carolina Res Ctr

    RECRUITING

    North Charleston, South Carolina, 29405, United States

  • Coastal Digestive Health

    RECRUITING

    Maroochydore, Queensland, 4558, Australia

  • Dawson Clinical Research

    RECRUITING

    Guelph, Ontario, N1H 1B1, Canada

  • Diablo Clinical Research, Inc.

    RECRUITING

    Walnut Creek, California, 94598, United States

  • Elite Clinical Trials

    RECRUITING

    Blackfoot, Idaho, 83221, United States

  • Emeritus Research Sydney

    RECRUITING

    Botany, New South Wales, 2019, Australia

  • Frederiksberg Hospital - Parker Institutet (Artrose)

    RECRUITING

    Frederiksberg, 2000, Denmark

  • General Hospital Of Athens Alexandra - Clinical Therapeutics

    RECRUITING

    Athens, 11528, Greece

  • Great Lakes Medical Research

    RECRUITING

    Westfield, New York, 14787, United States

  • H. Infanta Luisa_Endocrino y Obesidad

    RECRUITING

    Seville, 41010, Spain

  • Hamilton Medical Rsrch Grp

    NOT_YET_RECRUITING

    Hamilton, Ontario, L8L 5G4, Canada

  • Health Res of Hampton Roads

    RECRUITING

    Newport News, Virginia, 23606, United States

  • Heart of Australia

    RECRUITING

    Chelmer, Queensland, 4068, Australia

  • Hope Clin Res & Wellness

    RECRUITING

    Conyers, Georgia, 30094, United States

  • Hospital General de Valencia

    RECRUITING

    Valencia, 46014, Spain

  • Hospital Germans Trias i Pujol

    NOT_YET_RECRUITING

    Badalona, 08916, Spain

  • Hospital HM La Esperanza

    RECRUITING

    Santiago de Compostela, 15705, Spain

  • Hospital Infanta Sofía

    RECRUITING

    San Sebastián de Los Reyes (Madrid), 28702, Spain

  • Hospital Naval Ferrol

    RECRUITING

    Ferrol, 15405, Spain

  • Hospital Quirónsalud Málaga

    RECRUITING

    Málaga, 29004, Spain

  • Hospital Universitario Marqués de Valdecilla

    RECRUITING

    Santander, 39008, Spain

  • Instituto Medico Quirurgico San Rafael

    RECRUITING

    A Coruña, 15006, Spain

  • Jubilee Clinical Research, Inc.

    RECRUITING

    Las Vegas, Nevada, 89106, United States

  • Karadeniz Teknik Üniversitesi Farabi Hastanesi- Fiziksel Tıp ve Rehabilitasyon

    RECRUITING

    Trabzon Merkez/Ortahisar/Trabzon, 61080, Turkey (Türkiye)

  • Kolling Institute

    RECRUITING

    St Leonards, New South Wales, 2065, Australia

  • Laiko General Hospital Of Athens - 1st department of Internal Medicine

    RECRUITING

    Athens, 115 27, Greece

  • Laser Rejuvenation Clinics Inc.

    RECRUITING

    Calgary, Alberta, T2W 4X9, Canada

  • MC Dr. Atanasov EOOD

    RECRUITING

    Sofia, 1231, Bulgaria

  • MC Excelsior OOD

    RECRUITING

    Sofia, 1407, Bulgaria

  • MMA MHAT - Sofia, Rheumatology clinic

    RECRUITING

    Sofia, 1606, Bulgaria

  • MedVadis Research Watertown

    RECRUITING

    Waltham, Massachusetts, 02451, United States

  • Momentum Clinical Research Darlinghurst

    RECRUITING

    Darlinghurst, New South Wales, 2010, Australia

  • Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher

    RECRUITING

    Warsaw, 02-637, Poland

  • Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher

    NOT_YET_RECRUITING

    Warsaw, 02-637, Poland

  • NextHealth S.A. - Department of Endocrinology, Metabolism & Diabetes

    RECRUITING

    Thessaloniki, 54635, Greece

  • Northwest Clinical Research Center

    RECRUITING

    Bellevue, Washington, 98007, United States

  • Ospedale Civile di Baggiovara - UOC Endocrinologia

    NOT_YET_RECRUITING

    Modena, Emilia-Romagna, 41126, Italy

  • Ospedale S. Maria della Misericordia - Reparto Endocrinologia e Malattie del Metabolismo

    RECRUITING

    Udine, Friuli Venezia Giulia, 33100, Italy

  • Pol. Uni. Campus Biomedico - UOC Endocrinologia e Diabetologia

    RECRUITING

    Rome, Lazio, 00128, Italy

  • Policlinico San Donato di Milano S.p.A - UOS Endocrinologia e del Servizio di Nutrizione Clinica e Prevenzione Cardiometabolica

    RECRUITING

    San Donato Milanese, Lombardy, 20097, Italy

  • Sanos Clinic - Herlev

    RECRUITING

    Herlev, 2730, Denmark

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.

    RECRUITING

    Krakow, 31-826, Poland

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.

    NOT_YET_RECRUITING

    Krakow, 31-826, Poland

  • Thermi Clinic S.A. - Diabetes and Internal Medicine Department

    RECRUITING

    Thessaloniki, 57001, Greece

  • UMHAT Sveti Georgi EAD, Plovdiv

    RECRUITING

    Plovdiv, 4002, Bulgaria

  • UMHAT Sveti Ivan Rilski EAD, Rheumatology

    RECRUITING

    Sofia, 1612, Bulgaria

  • UMHAT Tsaritsa Yoanna - ISUL EAD, Orthopaedics and Traumatology

    RECRUITING

    Sofia, 1527, Bulgaria

  • University General Hospital Attikon General Hospital Of West Attica H Agia Varvara - 2nd dept of Internal medicine

    RECRUITING

    Chaïdári, Attica, 12461, Greece

  • VIP Trials_San Antonio

    RECRUITING

    San Antonio, Texas, 78230, United States

  • Zenith clinical research

    RECRUITING

    Hollywood, Florida, 33021, United States

  • Çanakkale Onsekiz Mart Üniversitesi Sağlık Araştırma ve Uygulama Hastanesi-Fiziksel Tıp ve Rehabilitasyon

    RECRUITING

    Kepez/Çanakkale Merkez/Çanakkale, 17110, Turkey (Türkiye)

  • İnönü Üniversitesi Turgut Özal Tıp Merkezi Hastanesi-Fiziksel Tıp ve Rehabilitasyon

    RECRUITING

    Merkez/Battalgazi/Malatya, 44280, Turkey (Türkiye)

  • İstanbul Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi

    RECRUITING

    Bahçelievler/İstanbul, 34186, Turkey (Türkiye)

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