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New MRI technique could catch osteoarthritis years earlier

NCT ID NCT04536103

Diagnosis Sponsor: Xiaojuan Li Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aims to develop a faster and more consistent MRI method to detect early signs of osteoarthritis and other joint problems. Researchers will scan 88 healthy volunteers and patients with ACL tears using MRI machines from different manufacturers. The goal is to create a standardized tool that can reliably measure cartilage health, which could lead to earlier diagnosis and better monitoring of joint diseases.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
MRI scan
What this could lead to
If successful, this could provide a reliable, early way to diagnose osteoarthritis before it causes permanent damage, improving treatment timing.
What could go wrong
This is an early observational study focused on developing the imaging method, not testing a treatment. The new MRI technique may not prove accurate enough for widespread use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 88 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2022

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Subjects between the ages of 18-50 years old. And subjects who sustain an acute full ACL tear in one knee with the contralateral knee uninjured.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Group 1 1\. Age \> 18 Group 2 1\. Age 18-50 Group 3 1. Age 18-50 2. Sustain an acute full ACL tear in one knee; the contralateral knee uninjured 3. Undergo ACL reconstructions and standard rehabilitation Group 4 1\. Age 18-50 Exclusion Criteria: Group 1 1. Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc. 2. Pregnancy. Group 2 1. Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc. 2. Pregnancy. 3. History of osteoarthritis and inflammatory arthritis 4. Previous injury and/or surgery on either knee Group 3 1. Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc. 2. Pregnancy. 3. Inability to undergo standard pre- and post-injury/operative rehabilitation Group 4 1. Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc. 2. Pregnancy. 3. History of osteoarthritis and inflammatory arthritis 4. Previous injury and/or surgery on either knee

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries arthropathy Bone Diseases, Infectious musculoskeletal system disorder osteoarthritis osteomyelitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acl tear Bone diseases, infectious Cartilage degeneration Joint diseases Musculoskeletal diseases Osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cleveland Clinic Foundation

    RECRUITING

    Cleveland, Ohio, 44195, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.