Hypersensitivity reaction disease

This early-stage study tests a new vaccine called PollenVax for people with moderate to severe mugwort pollen allergy. The main goal is to see if the vaccine is safe and tolerable in 30 adults aged 18 to 65. Participants receive four shots of either the vaccine or a placebo, and …

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study tests an experimental drug called SHR-1819 in children and adolescents aged 6 to 17 with moderate-to-severe atopic dermatitis (a type of eczema). The main goal is to check the drug's safety and how the body processes it. Researchers will also look at changes in skin-re…

This study tests a new antibody drug called 611 in 124 Chinese children and adolescents aged 6 to 18 with moderate to severe atopic dermatitis (eczema). The drug targets a protein involved in inflammation. The main goals are to check safety and how the drug moves through the body…

This study tests whether a skin test that measures histamine response can help doctors decide if adding an antihistamine (Levocetirizine) to standard asthma treatment improves control in children aged 6-17 with allergic asthma. About 300 African American/Black and Caucasian/White…

This study tests whether a nasal spray containing adelmidrol can reduce inflammation and shrink nasal polyps in people with chronic sinusitis. Participants are adults aged 18 to 70 who are scheduled for sinus surgery. Half receive standard care plus the adelmidrol spray, while th…

This phase 3 study tested a drug called rocatinlimab in 726 adults with moderate-to-severe atopic dermatitis (eczema) that wasn't well controlled by creams. Participants received either the drug or a placebo as a shot under the skin for 24 weeks. The main goals were to see if the…

This early-phase trial tested a new biologic drug called UCB1381 in 109 people, first in healthy volunteers and then in those with moderate to severe atopic dermatitis (eczema). The goal was to check safety and see if it improves eczema symptoms. Participants received either the …

This study tested a drug called nemolizumab in 109 children aged 2 to 11 with moderate-to-severe eczema. The drug is given as a shot under the skin every 4 weeks for a year. Researchers measured how the drug moves through the body, its safety, and whether it improves eczema sympt…

This study tested a new drug called BGB-45035 for the first time in humans. It looked at safety in healthy volunteers and then in people with autoimmune skin diseases like atopic dermatitis (eczema) and prurigo nodularis (a condition causing intensely itchy bumps). The goal was t…

This study tested a daily pill called upadacitinib in 912 teens and adults with moderate to severe eczema (atopic dermatitis) that was not well controlled with creams. Participants received either the study drug or a placebo for 16 weeks. The main goals were to see if the drug co…

This completed trial tested a herbal ointment made from Syzygium formosum leaves in 90 people with mild to moderate atopic dermatitis (eczema). The ointment was compared to standard moisturizers to see if it was safe and effective. The study measured skin severity, water loss, an…

This study tested a new drug, JYB1904, in 69 adults with allergic asthma. Participants received either JYB1904 every 8 weeks or the standard drug omalizumab every 2 to 4 weeks for 24 weeks. The goal was to see how the drug behaves in the body, how safe it is, and how well it cont…

This study looked at whether using a non-invasive ventilation (NIV) mask right after removing a breathing tube can prevent respiratory failure in obese intensive care patients. About 1000 obese adults were randomly assigned to receive either NIV or oxygen therapy. The goal was to…

This study tested a drug called remibrutinib in 76 adults with peanut allergy. Participants took one of three doses or a placebo daily for one month. The main goal was to see if the drug helped them eat more peanut protein without having an allergic reaction. Results showed some …

This study tested whether adding rituximab to standard steroid treatment helps adults with IgA vasculitis (a disease causing inflamed blood vessels) achieve remission without needing steroids long-term. 75 participants with new or relapsing disease were randomly assigned to recei…

This study looks at how safe and effective upadacitinib is for Chinese adolescents and adults with moderate to severe atopic dermatitis (eczema). About 200 participants will take the drug as prescribed by their doctor and be followed for up to 24 months. The goal is to track seri…

This study looked at whether nemolizumab, a drug for moderate-to-severe eczema, interferes with the body's ability to respond to tetanus and meningococcal vaccines. 242 adults and teens with eczema received either nemolizumab or a placebo, plus the vaccines. The goal was to see i…

This study looked at how the drug abrocitinib affects the skin barrier in 20 adults with moderate to severe atopic dermatitis (eczema). Researchers measured water loss from the skin and changes in skin-related genes at 2 and 12 weeks. The goal was to see if the treatment helps re…

This phase 2 study tested the drug Xolair (omalizumab) in 11 people with peanut allergies who had already completed a previous trial. The goal was to see if the drug could reduce serious allergic reactions. Participants received regular injections of Xolair and reported any peanu…

This study tested an oral medication called upadacitinib in 912 teenagers and adults with moderate to severe eczema (atopic dermatitis) who needed stronger treatment. Participants received either the drug or a placebo for 16 weeks. The main goals were to see if the drug could sig…

This study tested whether adding the drugs omalizumab (Xolair) or dupilumab (Dupixent) to oral immunotherapy (OIT) helps people with multiple food allergies tolerate more allergens. 130 participants aged 4 to 55 with allergies to peanut plus one or two other foods were enrolled. …

This phase II trial tested a drug called huMAb OX40L in 29 adults with mild allergic asthma. The drug is an antibody designed to block a protein that triggers allergic reactions in the airways. Researchers measured whether it could prevent breathing problems caused by allergens, …

This study tested the drug dupilumab (Dupixent) in 124 adolescents and adults with darker skin tones who have moderate-to-severe eczema. Participants received injections every two weeks for 24 weeks. The goal was to see if the drug safely improves skin symptoms and quality of lif…

This study looked at 84 people with severe allergic rhinitis (constant sneezing, runny nose, itching, stuffiness) that didn't improve with usual treatments. Researchers compared three procedures that target the nerve in the nose: surgical cutting, radiofrequency, and surface cobl…

This study looked at whether giving a drug called protamine to all patients after a minimally invasive heart valve replacement (TAVI) reduces bleeding complications compared to giving it only when needed. The trial involved 1000 adults with aortic valve stenosis. The goal was to …

This study looked at the long-term safety and effectiveness of lebrikizumab for adults and teens with moderate-to-severe atopic dermatitis (eczema). Participants who completed a previous year-long study could join this 2-year extension. The main goal was to see how many people st…

This study followed 305 Canadian adults and children (ages 6+) with moderate-to-severe eczema who were prescribed Dupixent as part of their routine care. Researchers measured how many patients achieved at least a 75% reduction in eczema severity after 6, 12, and 18 months. The go…

This study tested a drug called tralokinumab in 28 children aged 6 to 12 with moderate-to-severe eczema. The goal was to see how the drug moves through the body and if it is safe. Children received injections over several weeks and used moisturizers daily. The trial is complete, …

This study tested a daily tablet placed under the tongue (SLIT) containing peanut protein to help people with peanut allergy tolerate small amounts of peanut. The trial included 209 adults, teens, and children ages 4 to 65. Researchers measured how many participants could safely …

This study tested a home-based, dietitian-led 'egg ladder' for infants newly diagnosed with egg allergy. Over 12 months, babies gradually ate more cooked egg, starting with baked goods. The goal was to see if this approach is safe and feasible. 109 infants participated, and resea…

This study followed 250 children who received oral immunotherapy (OIT) for severe milk allergy to see how well it works over time. Researchers measured how much milk participants could drink and how their quality of life improved. The goal is to understand the long-term benefits …

This early-stage trial tested whether taking fecal transplants in capsules could help people with peanut allergy tolerate more peanut without a reaction. Fifteen adults aged 18 to 40 received the treatment, and researchers checked for side effects and changes in peanut tolerance.…

This study tested an ointment called RSS0393 in 168 adults with mild to moderate atopic dermatitis (eczema). Participants used different strengths of the ointment or a placebo for a set period. The goal was to see if the ointment could clear or nearly clear the skin rash. Results…

This phase 2 study tested whether the drug omalizumab (Xolair) can make oral immunotherapy safer for people with multiple food allergies. Sixty participants aged 2 to 25 received omalizumab before gradually increasing doses of their problem foods. The goal was to see if this appr…

This study tested a new drug called SHR-1819 in 158 adults with moderate to severe atopic dermatitis (a type of eczema). Participants received one of three doses of the drug or a placebo. The main goal was to see if the drug could reduce eczema severity by at least 75% after 16 w…

This study tested two creams for mild to moderate eczema in 40 children aged 1-12. One cream was a steroid (fluticasone), the other a non-steroid (crisaborole). Both were applied twice daily for 6 weeks, then twice weekly for 12 weeks if the skin improved a lot. Both treatments w…

This study tested whether a moisturizer containing postbiotic Saccharomyces and Lactobacillus can reduce the risk of eczema returning in children aged 0-6 years who are in remission. 98 children used either the special emollient or a standard one for 12 weeks. The goal was to see…

This study tested a drug called interleukin-2 (IL-2) in 10 people with hepatitis C-related vasculitis that did not get better with usual treatments. The goal was to see if IL-2 could boost the body's immune regulation and control the disease. Participants received IL-2 injections…

This study looks at the long-term safety of a drug called CC-93538 (cendakimab) for people with eosinophilic esophagitis, a condition that causes inflammation in the esophagus. It enrolled 367 adults and teens who had already taken part in earlier studies of the same drug. The ma…

This study tested a biologic drug called SIM0718 in 259 adults and teens with moderate to severe atopic dermatitis (eczema) that did not respond well to creams. Participants received either the drug or a placebo every two weeks for 16 weeks. The goal was to see if the drug could …

This completed Phase 2 trial tested a new ointment called CGB-500 (containing tofacitinib) against an approved cream (ruxolitinib) for atopic dermatitis, a type of eczema. Only 3 people aged 12 and older took part, applying both treatments to different skin areas twice daily for …

This study tested whether teenagers and adults with moderate-to-severe eczema (atopic dermatitis) could successfully give themselves injections of the drug rocatinlimab at home using special devices. The main goal was to see how many full doses were self-administered correctly up…

This Phase 3 study tests amlitelimab, an injected drug, in 589 people aged 12 and older with moderate-to-severe atopic dermatitis (eczema) that hasn't responded well to topical treatments. The goal is to see if amlitelimab can clear or nearly clear the skin and reduce eczema seve…

This study tested a new drug, AK120, in 450 adults with moderate to severe atopic dermatitis (eczema). The main goal was to check for side effects and see how well the drug works. Researchers measured changes in eczema severity using standard skin scores.

This study tested an experimental oral drug called ATI-2138 in 14 adults with moderate to severe atopic dermatitis (eczema). Participants took the pill twice daily for 12 weeks. Researchers tracked safety, side effects, and skin improvement using standard eczema scores. The goal …

This study tested a probiotic called INF108F in 20 breastfed infants with a food allergy that causes blood in their stool. The goal was to see if the probiotic could improve the balance of gut bacteria and reduce symptoms like reflux and fussiness. While the treatment aims to con…

This study tested the drug lebrikizumab in 90 adults and teens with moderate-to-severe eczema who have skin of color. The goal was to see if the drug is safe and helps clear skin. Participants received injections over 24 weeks, and doctors measured improvement using a standard ec…

This small pilot study tested whether adding a prebiotic fiber (a type of plant fiber found in grocery stores) to peanut oral immunotherapy could help children aged 4 to 17 with peanut allergy tolerate more peanut protein with fewer side effects. Twenty children participated, and…

This study looked at the long-term safety of the drug SHR-1819 in 79 adults with moderate to severe eczema who had already taken part in earlier studies of the same drug. Researchers tracked side effects and how well the drug controlled the disease over time. The goal was to see …

This study tested the drug upadacitinib in people with moderate to severe atopic dermatitis (eczema) who also have prurigo nodularis, a condition causing intense itching and hard bumps. The goal was to see if the drug reduces itching and improves skin. The study was observational…

This study tested a type of allergy immunotherapy (Clustoid® Max Forte) in 140 people aged 5 to 65 with dust mite allergies. The goal was to see if it reduces allergy and asthma symptoms and the need for medication over one year. Results were measured by symptom scores and medica…

This study tested a drug called lebrikizumab in 86 adults and teens with moderate-to-severe eczema who had already tried dupilumab. The goal was to see if lebrikizumab could safely improve their skin condition. Researchers measured how many participants achieved at least a 75% im…

This study tested a dietary supplement containing immune-supporting nutrients and postbiotics in 40 children aged 5–12 with asthma and/or allergic rhinitis. The goal was to see if the supplement could improve symptom control over 6 months. Researchers also looked at changes in im…

This study tested a new medicine called LEO 138559 (Temtokibart) in 262 adults with moderate-to-severe atopic dermatitis (eczema). Participants received one of four doses or a placebo as injections under the skin for 16 weeks. The goal was to see how well the drug reduces eczema …

This study looked at how safe and effective upadacitinib is for Korean patients with rheumatoid arthritis, atopic dermatitis, ankylosing spondylitis, or psoriatic arthritis. Over 2,300 adults took the drug as prescribed by their doctor and were followed for about 28 weeks. Resear…

This study tested a low-dose oral immunotherapy (OIT) in children aged 18-36 months with allergies to two nuts. Over 18 months, one group received daily tiny doses of the nuts they were allergic to, while the other group avoided them completely. The goal was to see if more childr…

This study tested a daily pill called abrocitinib in 82 adults with moderate to severe chronic hand eczema that did not get better with steroid creams. The goal was to see if the drug could reduce skin redness, scaling, and other symptoms. Researchers also checked for side effect…

This study tested two types of exercise training—high-intensity interval training (HIIT) and moderate continuous training (MICT)—against standard physical activity advice in 188 people who had a heart attack. The goal was to see which approach best improves fitness and reduces he…

This study followed 106 adults with severe eosinophilic asthma in Poland who received mepolizumab injections every 4 weeks for at least a year. Researchers tracked asthma attacks and the need for oral steroids before and during treatment. The goal was to see if the drug helps con…

This study tested the safety and effectiveness of abrocitinib, a daily pill, for people aged 12 and older with moderate to severe eczema. Participants took either 100 mg or 200 mg of abrocitinib for up to 92 weeks, with some continuing until the drug became commercially available…

This study tested a drug called rocatinlimab in 532 teenagers with moderate-to-severe eczema that didn't improve with standard creams. The goal was to see if the drug could clear skin and reduce itching over 24 to 52 weeks. Participants received either the drug or a placebo, and …

This Phase 3 trial tested a new drug called 611 in 519 Chinese adults with moderate-to-severe atopic dermatitis (eczema). 611 is an antibody that blocks a key driver of allergic inflammation. The study compared 611 injections to a placebo over 16 weeks, measuring skin clearance a…

This study tested the drug dupilumab (Dupixent) in 10 people with a chronic skin condition called dermal hypersensitivity reaction. Participants received injections of dupilumab every two weeks for 24 weeks. Researchers looked at changes in immune cells in the skin and how much b…

This study tested a drug called tralokinumab for people with moderate-to-severe atopic hand eczema that hasn't improved with standard treatments. 235 adults received either the drug or a placebo every two weeks for 16 weeks, then everyone got the drug for another 16 weeks. The go…

This study tested whether a cream containing N-acetyl cysteine (NAC) could improve mild-to-moderate eczema better than plain cold cream. One hundred people with eczema used either the NAC cream or a placebo cold cream. Researchers measured changes in skin bacteria (Staph) and ecz…

This Phase 2 trial tested an experimental oral drug called SCD-044 in 250 adults with moderate to severe atopic dermatitis (eczema). Participants received one of three doses of SCD-044 or a placebo for 16 weeks. The main goal was to see if the drug could reduce eczema severity by…

This study looked at the long-term safety of a cream called roflumilast for people with mild to moderate eczema (atopic dermatitis). Over 1,200 participants, ages 2 and up, applied the cream once daily for up to 52 weeks. The main goal was to track any side effects, with secondar…

This study tested whether baricitinib (a newer pill) works better than azathioprine (an older pill) for adults with moderate-to-severe eczema. Both groups also used steroid creams. The goal was to see which combination reduces skin redness, thickness, and itching more effectively…

This study tested a new supplement in 30 children with food allergies who were already avoiding certain foods. The goal was to see if the supplement could improve their growth, vitamin D and DHA levels, and immune system balance. The supplement is not a cure but aims to help chil…

This study tested a drug called rocatinlimab in 187 teenagers aged 12 to 17 with moderate-to-severe eczema that didn't respond well to standard creams. The goal was to see if the drug is safe and tolerable over 52 weeks. Participants received regular injections, and researchers t…

This study tested whether tofacitinib, a drug already approved for arthritis, is safe and helpful for immune-related skin conditions in people with Down syndrome. 47 adolescents and adults with Down syndrome and skin issues like eczema or psoriasis took the drug. Researchers chec…

This study tested whether giving children with peanut allergy a daily dose of peanut protein (either 150 mg or 300 mg) could help them tolerate more peanuts over time. 44 children participated, and researchers measured how much peanut protein they could safely eat after treatment…

This study tested a new drug called amlitelimab, given as a shot under the skin, for people aged 12 and older with moderate-to-severe atopic dermatitis (eczema) that wasn't controlled by creams. The trial included 643 participants and compared amlitelimab to a placebo, while ever…

This completed Phase 3 trial tested a Chinese herbal formula called Xiao-Xian-Gui-Fu-Tang in 19 people aged 6 to 30 with moderate to severe atopic dermatitis (eczema). Participants took the herbal blend or a placebo for several weeks. Researchers measured changes in eczema severi…

This study tested a new medicine called rocatinlimab, given as an injection, for adults with moderate-to-severe eczema that wasn't well controlled with standard creams. About 746 participants received either the study drug or a placebo, along with topical treatments. The goal was…

This study tested a new medicine called amlitelimab, given as a shot under the skin, for people aged 12 and older with moderate-to-severe eczema that didn't get better with creams or other treatments. The goal was to see if it can clear or nearly clear the skin and reduce itching…

This study tested a new medication called rocatinlimab for adults with moderate-to-severe eczema (atopic dermatitis). About 769 people took part to see if the drug can clear skin and reduce itching better than a placebo. The goal is to provide a new treatment option for those who…

This early-stage trial tested a single injection of a new drug called IGNX001 in 32 adults and teens with peanut allergies. The main goal was to check safety and how the body processes the drug. Participants received either the drug or a placebo, and researchers monitored for sid…

This study tested the long-term safety and effectiveness of lebrikizumab, a drug for moderate-to-severe atopic dermatitis (eczema). Over 1,100 participants who had already taken the drug in earlier studies were followed for up to 33 months. The goal was to see how well the drug c…

This Phase 2 trial tested a drug called spesolimab (BI 655130) in 51 adults with moderate to severe atopic dermatitis (eczema). Participants received either the drug or a placebo intravenously. The study measured how much eczema severity changed over 16 weeks using the EASI score…

This study compared an online, team-based care model to standard in-person care for managing atopic dermatitis (eczema). 300 patients were randomly assigned to either online or in-person care for 12 months. The goal was to see if the online approach could match in-person care in …

This study tested an experimental drug called LW402 in 144 adults with moderate-to-severe atopic dermatitis (eczema). The goal was to see if it safely reduces skin redness, thickness, and itching. Participants received either the drug or a placebo, and doctors measured skin impro…

This study tested a new drug called CM310 in 180 teenagers with moderate-to-severe atopic dermatitis (eczema). The drug is a lab-made antibody that blocks a key protein involved in inflammation. The goal was to see if it improves skin clearing and reduces itch compared to a place…

This study tested whether methotrexate, an older drug used for arthritis, works as well as cyclosporine for people with moderate to severe atopic dermatitis (eczema). One hundred adults received either drug for 24 weeks. The main goal was to see if eczema severity dropped by half…

This completed trial tested whether eating specially prepared pancakes daily could help children with egg allergy tolerate eggs. 23 children participated, starting with small doses in the hospital and continuing at home. The goal was to see if they could eat a full serving of coo…

This Phase 2 study tested a new dissolvable film called DESF that delivers epinephrine under the tongue. Thirty-six healthy adults with oral allergy syndrome received DESF and standard epinephrine injections to compare how quickly the drug enters the bloodstream. The goal is to s…

This early-stage trial tests a new drug called CM512 in healthy volunteers and people with moderate to severe atopic dermatitis (eczema). The main goal is to check safety and how the body handles the drug. 110 participants will receive either CM512 or a placebo, and researchers w…

This Phase 3 study tested MH004 ointment in 375 adolescents and adults with mild to moderate atopic dermatitis (eczema). Participants applied the ointment or a placebo twice daily for 4 weeks, followed by a 44-week safety extension. The main goals were to see if the ointment coul…

This study tested whether dupilumab, an injected drug for eczema, improves skin barrier function in 52 people with moderate to severe atopic dermatitis. Researchers measured water loss from the skin after tape stripping to assess barrier repair over 16 weeks. The goal was to see …

This study tested a new drug, camoteskimab, in 62 adults with moderate to severe eczema (atopic dermatitis). Participants received either the drug or a placebo for 16 weeks, followed by an open-label extension where everyone could get the drug. The main goal was to see if camotes…

This study looked at how dupilumab, an injectable biologic drug, affects the skin barrier in 41 children aged 6 to 12 with moderate to severe atopic dermatitis (eczema). Researchers measured water loss through the skin after removing thin layers with tape to assess barrier functi…

This study tested the drug dupilumab (Dupixent) in 44 Chinese patients aged 12 to 65 with moderate to severe atopic dermatitis (eczema). The goal was to see if the drug improves skin barrier function by measuring water loss through the skin over 16 weeks. Participants received du…

This study tested the drug dupilumab (given as a shot) plus steroid creams in 62 Japanese children aged 6 months to 18 years with moderate-to-severe eczema that wasn't controlled by other treatments. The goal was to see if dupilumab could improve skin symptoms and itching over 16…

This study tested whether omalizumab (Xolair), an allergy drug, helps people with peanut and at least two other food allergies eat those foods without severe reactions. Over 470 participants aged 1 to 55 received omalizumab or a placebo, and some also got oral immunotherapy. The …

This study tested a cream called tapinarof in 406 people aged 2 and older with moderate to severe eczema. Participants applied the cream or a placebo once daily for 8 weeks. The main goal was to see if the cream could make skin clear or almost clear. Results are being analyzed to…

This early-stage trial tested an experimental drug called IBI356 in 99 healthy volunteers and people with atopic dermatitis (eczema). The main goal was to check if the drug is safe and how the body processes it. Participants received either a single dose, multiple doses, or a pla…

This study looked at nearly 500 patients who had a paracetamol (acetaminophen) allergy test over 22 years. The goal was to find the smallest dose that triggers a reaction, so future tests can be shorter and safer. By analyzing past data, researchers hope to create a simplified te…

This study tested whether a standard allergy work-up can accurately identify people who were incorrectly labeled as allergic to penicillin. 155 adults with a suspected penicillin allergy went through testing, including a drug challenge to confirm if they were truly allergic. The …

This study tested a non-invasive imaging device called dermal optical coherence tomography (D-OCT) to diagnose basal cell carcinoma (a common skin cancer) around the eye area. Researchers compared its accuracy to standard biopsy results in 210 adults with suspected lesions. The g…

This study tested whether a special lung MRI can replace CT scans for diagnosing idiopathic pulmonary fibrosis (IPF), a scarring lung disease. Researchers compared MRI to standard CT in 60 patients to see if MRI could spot the same key signs of IPF without using radiation. The go…

This study tested whether MRI can accurately detect lung abnormalities caused by allergic bronchopulmonary aspergillosis (ABPA), a fungal allergy. Researchers compared MRI results to standard CT scans in 25 adults with ABPA or severe asthma. If MRI works well, it could provide a …

This study tested a blood test called the Basophil Activation Test (BAT) to see if it can accurately diagnose peanut and egg allergies in children. Currently, the gold standard is an oral food challenge, which can cause severe allergic reactions. The researchers compared BAT resu…

This study looked at whether whole body MRI can accurately diagnose inflammatory myopathies—a group of muscle diseases causing weakness and damage. Researchers compared MRI results with muscle biopsies in 139 people suspected of having these conditions. If MRI proves reliable, it…

This study tested whether an artificial intelligence tool called Legit Health Plus can help doctors track the severity of chronic skin conditions like acne, psoriasis, and eczema from a distance. 160 participants used a smartphone app for 6 months to take photos of their skin and…

This study looked at whether a blood test called flow cytometry can accurately diagnose allergic reactions to muscle relaxants given during anesthesia. Researchers tested 129 adults who had a suspected allergic reaction during a past surgery. The goal was to see if the test could…

This study tested how well cold, heat, and electric pulp tests detect tooth nerve health in 175 adults needing root canals. Researchers compared test results to direct observation of nerve bleeding during treatment. The goal was to find which test is most accurate for diagnosing …

This study looked at three ways to take a small sample of lung tissue (biopsy) in 60 adults with interstitial lung diseases. The goal was to find which method gives the most accurate diagnosis and causes the fewest side effects. The methods tested were forceps biopsy, cryobiopsy …

This study compared three FDA-cleared allergy skin test devices (AllerTest-10, Lincoln Multi-Test II, and Greer Skintestor OMNI) in 30 adults to see which is most accurate and least painful. Participants received histamine and glycerin controls on their skin, and researchers meas…

This study looked at whether the Montreal Cognitive Assessment (MoCA), a short test, can accurately screen for thinking and memory problems in adults with sickle cell disease. Researchers compared MoCA results to a full set of standard cognitive tests in 65 adults. The goal is to…

This study looked at 277 ICU patients on breathing machines to see how well chest X-rays (read by intensive care doctors) agreed with CT scans (read by radiologists) for diagnosing acute respiratory distress syndrome (ARDS). The results showed only fair agreement, meaning X-rays …

This study looked at whether a blood test called the basophil activation test (BAT) can accurately diagnose food allergies in children, potentially replacing the need for oral food challenges (OFCs). Researchers tested 116 children aged 0-18 who were already scheduled for an OFC.…

This study tested a new imaging method called [68Ga]Ga-DOTA-TATE PET/CT to see how well it finds neuroendocrine tumors compared to standard scans. It included 71 adults in Japan, both with and without the disease. The goal was to prove the new scan works well for diagnosis in Jap…

This study tested whether a special scan called [11C]-Methionine PET/MRI can better locate tiny pituitary tumors that cause Cushing's disease. Standard MRI often misses these tumors, leading to risky exploratory surgery. The study involved 33 adults with confirmed Cushing's disea…

This completed study tested whether a DNA-based PCR test works better than the usual lab culture for diagnosing complicated urinary tract infections (cUTIs) in adults. Over 770 participants across six U.S. sites were randomly assigned to have their treatment guided by either PCR …

This study tested whether giving full therapeutic doses of anaesthetics like propofol and ketamine can safely diagnose drug allergies in people who had a suspected allergic reaction during surgery. Fifty adult patients with a history of perioperative hypersensitivity underwent in…

This study tested whether a rapid molecular test using saliva can accurately diagnose strep throat in children aged 3-15. Researchers compared the saliva test to standard throat swab methods in 800 children visiting primary care. If accurate, this could replace uncomfortable thro…

This study looked at ways to reduce breathing problems and allergies in over 1,100 Norwegian salmon industry workers. The goal was to find practical changes in the workplace that lower workers' exposure to dust and other particles that can cause asthma. Researchers measured air q…

This study tested a digital tool called iREACH that helps pediatricians follow national guidelines for introducing peanuts to infants. The tool provides reminders and education during checkups at 4, 6, 9, and 12 months. Researchers measured how well doctors followed the guideline…

This study tested whether a low-protein, extensively hydrolyzed infant formula with added pre- and probiotics can prevent allergies in babies at high risk. Over 1,200 healthy newborns were given either the special formula or a standard formula during their first months of life. R…

This study tested whether giving tree nuts early to infants with peanut allergy could prevent them from developing tree nut allergies. 212 babies aged 4-11 months were split into two groups: one had a supervised hospital challenge with four tree nuts followed by home introduction…

This study tested a new treatment called STMC-103H in 283 newborn babies and infants who are at high risk for developing allergies (like eczema or food allergies) because of their family history. The goal was to see if the treatment is safe and can prevent these allergic conditio…

This study tested whether a supplement containing L-histidine, along with a topical oil or lotion and unscented soap, could improve mild-to-moderate eczema in children. Forty children ages 1 to 12 were split into two groups: one received a powder supplement and the other a gummy …

This early study tested a dexamethasone eye insert placed by a doctor against a standard steroid gel for treating allergy and dry eye symptoms in 36 people with keratoconus who wear gas permeable contact lenses. The goal was to see if the insert improves signs like eyelid bumps a…

This phase 2 trial tested a gel called HY209 on 210 adults with mild to moderate atopic dermatitis (eczema). The study compared different strengths of the gel to a placebo to see if it could reduce skin redness, itching, and rash. Results will show whether the gel is safe and eff…

This study tested whether a topical serum containing Mitopure causes skin irritation or allergic reactions. 112 healthy adults, half with sensitive skin, wore patches with the serum repeatedly. The goal was to see if the product is safe for skin use.

This study tests whether a probiotic gummy containing Weizmannia coagulans BC99 can reduce symptoms of allergic rhinitis (hay fever) in children aged 4 to 14. Over 8 weeks, half the children receive the probiotic gummy and half receive a placebo. Researchers track changes in nasa…

This study tested whether adding thread embedding acupuncture (TEA) to standard steroid nasal spray helps people with allergic rhinitis. 64 adults took part. The goal was to see if the combination reduces symptoms like sneezing and stuffy nose better than the spray alone, and whe…

This study tested three ways of giving the steroid dexamethasone to prevent allergic reactions from the chemotherapy drug paclitaxel in 90 women with breast or gynecologic cancer. One group took oral dexamethasone the night before and morning of treatment, another got it intraven…

This study tested whether a home-use light device (rhinophototherapy) can reduce nasal inflammation and allergy symptoms as well as a standard steroid spray. Thirty-five adults with allergic rhinitis used either the light device for 4.5 minutes three times daily or a steroid spra…

This study tested a cream containing ruxolitinib on 241 adults with moderate atopic dermatitis (eczema) who had not gotten better with standard steroid creams. The goal was to see if the cream could improve skin clearing and reduce itching. The trial is now complete, and results …

This pilot study tested whether adding group psychotherapy to standard care can help adults with moderate-to-severe atopic dermatitis (eczema). Thirty-two participants were assigned to either standard care alone, standard care plus stress management and resilience training, or st…

This study tested whether adding a decongestant nasal spray for the first 5 days to standard steroid spray treatment helps children with persistent allergic rhinitis feel better faster. 76 children aged 4-18 were randomly assigned to receive either steroid spray alone for 4 weeks…

This study tested how comfortable two prescription steroid eye drops feel right after use. Forty adults with eye inflammation or dry eye received one drop of Flarex in one eye and one drop of Lotemax SM in the other. They rated comfort and vision impact at 30 seconds, 5 minutes, …

This study tested an eye drop called reproxalap in 131 adults with moderate-to-severe seasonal eye allergies. Participants were exposed to ragweed pollen in a special chamber to trigger symptoms. The eye drop was compared to a placebo (no active ingredient) to see if it reduced i…

This study tested a special moisturizing cream containing a friendly bacteria called Lactobacillus reuteri to see if it could improve eczema symptoms in children. Forty children aged 6 months to 12 years with mild-to-moderate eczema used the cream for 8 weeks. Researchers measure…

This study looked at whether adding vitamin K2 to standard treatment could improve symptoms in children aged 6–12 with moderate-to-severe atopic dermatitis (eczema). For 12 weeks, 100 children received either vitamin K2 or a placebo alongside their usual care. The main goal was t…

This study tested two experimental drugs, REGN1908 and REGN1909, mixed together to reduce eye allergy signs and symptoms in people with cat allergies. The goal was to see how safe and effective the drug is compared to a placebo. The study included 64 participants with a history o…

This study tested whether a cream made with spruce tree extract can help repair the skin barrier and reduce symptoms like dryness, redness, and itching in people with sensitive, atopy-prone skin. 66 healthy adults used the cream or a placebo for 21 days. Researchers measured skin…

This completed trial tested whether a probiotic called Bifidobacterium longum ES1, or its heat-treated version, could reduce symptoms of allergic rhinitis (hay fever) in 72 adults with moderate-to-severe dust mite allergies. Participants took daily capsules for several weeks and …

This study tested an investigational treatment called PQ Grass 27600 SU in 119 adults with seasonal grass pollen allergies (hay fever). The goal was to see if it could reduce allergy symptoms and the need for relief medications during peak grass pollen season. Participants receiv…

This study tested an experimental nasal spray called INI-2004 in 78 adults with ragweed allergies. Participants received either the spray or a placebo once a week for four weeks, then spent time in a room filled with ragweed pollen to see if symptoms improved. The goal was to che…

This study looked at whether taking a grass pollen tablet (SLIT) together with the drug dupilumab for 2 years can help adults with moderate to severe hay fever tolerate grass pollen better, even after stopping treatment. About 199 participants were involved. The main goal was to …

This study tested an experimental drug called lunsekimig in 150 adults with moderate-to-severe atopic dermatitis (eczema). Participants received one of three doses of the drug or a placebo as a shot under the skin for 24 weeks. The main goal was to see if the drug reduces eczema …

This study tested a nasal spray made from pistacia lentiscus oil (Bactorinol) in 120 adults with vasomotor rhinitis, a chronic condition causing nasal congestion and runny nose. Participants used the spray or a saline placebo for 20 days. The goal was to see if the oil spray impr…

This study tested two experimental drugs, REGN5713 and REGN5715, given together to reduce eye allergy symptoms caused by birch pollen. Fifty-four adults with a history of moderate to severe birch pollen allergy received the drug combo or a placebo. The main goal was to see if the…

This Phase 2 trial tested a cream called VC005 on 118 adults with mild to moderate atopic dermatitis (eczema). The study compared the cream to a placebo to see if it safely reduces eczema symptoms like itching and skin redness. Results will help decide if larger studies are warra…

This early-stage study tested a cream called VC005 in 11 adolescents aged 12 to 18 with mild to moderate eczema. The main goal was to check safety and how the body processes the drug. Researchers measured drug levels in the blood and looked for side effects.

This study tested an experimental oral drug called LNK01001 against a placebo in 356 adults with moderate to severe atopic dermatitis (eczema) who had not responded well to creams or other treatments. The goal was to see if the drug could improve skin clearing and reduce itching …

This study tested a special cream containing a butyrate releaser (a substance that helps the skin barrier) in 100 children aged 6-36 months with eczema. The cream was compared to a standard moisturizer over 12 weeks. The goal was to see if it could reduce eczema severity and impr…

This study looked at whether a therapeutic education program can improve quality of life for children aged 8 to 12 with IgE-mediated food allergies, as well as their families. 46 children and their families took part. The program focused on teaching them how to manage allergies a…

This study tested a new drug called UCB9741 in healthy volunteers and people with moderate-to-severe atopic dermatitis (eczema). The goal was to check its safety and see if it can improve eczema symptoms. The trial involved 107 participants and compared the drug to a placebo.

This study tested a new ointment called CGB-500, which contains the drug tofacitinib, for treating eczema (atopic dermatitis) in 180 people aged 12 and older. Participants applied the ointment or a placebo daily for 8 weeks. The goal was to see if it safely reduces skin redness, …

This early-stage trial tested a new oral drug called ENV-294 in 9 adults with moderate-to-severe atopic dermatitis (eczema). Participants took the drug once daily for 28 days and had weekly checkups. The main goal was to see if the drug is safe and tolerable, while also looking f…

This study tested whether a special toothpaste with 8% arginine (CSPR) can reduce tooth sensitivity better than a regular Colgate toothpaste. 95 adults with sensitive teeth used the toothpaste for 8 weeks. Researchers measured sensitivity using a gentle touch test and a cold air …

This study tested Xolair (omalizumab) in 50 teenagers aged 12 to 17 with severe seasonal allergic rhinitis (hay fever) that standard treatments couldn't control. Researchers tracked side effects and how much symptoms improved. The goal was to see if Xolair is safe and effective i…

This small study tested whether acupuncture can relieve nasal congestion in people with allergic rhinitis. Eleven adults received either acupuncture or a standard nasal spray for 6 weeks. The goal was to see if acupuncture offers a safe, side-effect-free option for stuffy noses.

This early-stage trial tested an experimental drug called soquelitinib in 82 adults with moderate to severe atopic dermatitis (eczema). The main goal was to check safety and tolerability, while also looking for signs of symptom improvement. Participants received either the drug o…

This study tested whether a measles vaccine could help control eczema (atopic dermatitis) in adults. Researchers gave 20 adults with moderate-to-severe eczema either the measles vaccine or a placebo and tracked their symptoms for 45 days. The goal was to see if the vaccine could …

This study tested whether a supplement called M-Gard can help relieve symptoms of seasonal grass pollen allergies (hay fever). Twenty healthy adults with a history of grass allergies took M-Gard or a placebo in a crossover design. Researchers measured symptom severity like nasal …

This study tested the safety and effectiveness of Allegra D (fexofenadine plus pseudoephedrine) in 203 people aged 12 and older with allergic rhinitis. Participants took the medication for up to 13 days, and researchers tracked side effects and symptom improvement using nasal and…

This study tested a new drug called BLU-808 in 21 adults with ragweed allergies. The goal was to see if it is safe and helps reduce sneezing, runny nose, and itchy eyes caused by ragweed pollen. Participants were exposed to ragweed in a special chamber to measure the drug's effec…

This Phase 2 trial tested an injection called TQC2938, a humanized monoclonal antibody, in 136 adults with seasonal allergic rhinitis. All participants also used a standard nasal spray. The study measured how well the injection reduced nasal symptoms like sneezing and congestion …

This study tested whether apple fruit extract, which has antioxidant and anti-inflammatory properties, could improve symptoms of allergic rhinitis (hay fever). Forty adults with persistent allergies received either standard treatment plus apple extract or standard treatment alone…

This study tested whether Ectoin allergy nasal spray and eye drops can relieve symptoms of hay fever (runny nose, sneezing, itchy eyes) better than a placebo. 46 adults with ragweed allergies were exposed to pollen in a special chamber. Researchers measured symptom scores and nas…

This study tested whether an ectoine nasal spray works better than a cromoglycic acid spray for easing allergic rhinitis symptoms like a stuffy nose, runny nose, and sneezing. Fifty adults with proven allergies used one of the two sprays for 14 days. Doctors and patients rated ho…

This early-stage study tested an oral medication called KT-621 in 22 adults with moderate to severe atopic dermatitis (eczema). The main goal was to check safety and how the body processes the drug. Researchers monitored side effects and drug levels in the blood, but did not meas…

This early-stage study tested a new drug called INI-2004 in 68 healthy people and those with ragweed allergies. The goal was to check safety and how well it reduces nasal symptoms like sneezing and congestion. Researchers gave single or multiple doses and monitored side effects a…

This early-stage trial tested the safety and tolerability of a new corticosteroid nasal spray called PA9159 in 36 healthy Chinese adults. Participants received either a single dose or seven daily doses of the spray, or a placebo. The goal was to find the maximum safe dose and see…

This study tested an experimental ointment called LNK01004 in 75 adults with moderate-to-severe atopic dermatitis (eczema). Participants applied the ointment twice daily for 8 weeks. The goal was to see if it reduces skin redness, swelling, and itching better than a placebo ointm…

This study tested whether a daily probiotic called Bifidobacterium longum CCFM1029 can reduce eczema symptoms in infants aged 3 months to 3 years. One hundred children with atopic dermatitis were split into two groups: one received the probiotic and the other a placebo for 3 mont…

This study tested a drug called omalizumab in 337 adults and teens with severe Japanese cedar pollen allergy (hay fever) that standard medicines couldn't control. Participants received either omalizumab or a placebo on top of their usual allergy treatments for 12 weeks. The goal …

This study tested whether the drug TAU-284 (bepotastine besilate) can reduce sneezing, runny nose, and congestion in children aged 7 to 15 with perennial allergic rhinitis (year-round nasal allergies). In a double-blind, placebo-controlled design, 473 children took either the dru…

This study tested whether a new oral medicine called TAU-284 (bepotastine besilate) can reduce itching in children aged 7 to 15 with atopic dermatitis (eczema). Over 300 children took either TAU-284 or an older medicine (ketotifen) twice daily for several weeks. The main goal was…

This study tested a medicine called TAU-284 in 490 children aged 7 to 15 who have year-round nasal allergies. The goal was to see if it reduces sneezing, runny nose, and congestion better than a placebo. The trial was completed and focused on symptom relief, not a cure.

This study tested the long-term safety and effectiveness of TAU-284 (bepotastine besilate) in 58 children aged 7 to 15 with perennial allergic rhinitis (year-round nasal allergies). Over 12 weeks, researchers tracked side effects and changes in sneezing, runny nose, and congestio…

This 56-day study tested a cream containing CBD and cherimoya fruit extract on 42 children and adults with mild-to-moderate atopic dermatitis (eczema). Participants applied the cream twice daily. Researchers measured skin redness, dryness, itching, and sleep quality. The goal was…

This study tested a cream called ARQ-151 on 652 children aged 2 to 5 with eczema (atopic dermatitis). The cream was applied once daily for 4 weeks. The goal was to see if it could clear or nearly clear the skin rash better than a cream with no active ingredient. The study is comp…

This study tested a drug called icatibant (Icanticure) in 5 adults with a rare condition that causes sudden, painful swelling attacks. The goal was to see how quickly the drug relieved symptoms and if it was safe. Participants received the injection for free during an acute attac…

This study tested a new ointment called YR001 in 35 adults with mild to moderate atopic dermatitis (eczema). The main goal was to check if the ointment is safe and how the body processes it. Researchers also looked at whether it improves skin condition. The trial was completed an…

This Phase 1 trial tested the safety and tolerability of a new drug called 9MW1911 in 48 healthy adults. The drug is being developed for asthma, COPD, and atopic dermatitis. Participants received either the drug or a placebo by IV infusion, and researchers monitored side effects …

This study tested a new drug called LP-003 in 180 adults with moderate to severe seasonal allergic rhinitis (hay fever) that wasn't well controlled by usual treatments like antihistamines or nasal sprays. LP-003 is an antibody that blocks IgE, a key driver of allergic reactions, …

This study tested a cream called roflumilast (0.05%) applied once daily for 4 weeks in 101 infants aged 3 months to 2 years with mild-to-moderate eczema. The main goal was to see if the cream is safe and well-tolerated. Researchers tracked side effects, serious side effects, and …

This early-stage study tested a single dose of the investigational drug MT-2990 in 75 adults with seasonal allergic rhinitis triggered by Japanese cedar pollen. The main goals were to check the drug's safety, how the body processes it, and whether it can reduce allergy symptoms w…

This early-stage study tested a new medicine called BMS-986326 in 64 adults with moderate-to-severe atopic dermatitis (eczema) who did not get enough relief from creams or needed stronger treatments. The main goal was to check the drug's safety and how the body processes it. Rese…

This study tested whether a toothpaste containing 8% arginine can reduce tooth sensitivity better than a regular cavity-protection toothpaste. Eighty adults with sensitive teeth used one of the two toothpastes for eight weeks. The main goal was to measure how much their sensitivi…

This study tested an experimental drug, EVO301, in 71 adults with moderate-to-severe atopic dermatitis (eczema). The goal was to see if it safely reduces skin redness, thickness, and itch. Participants received either EVO301 or a placebo, and doctors measured changes in skin seve…

This study tested a medication called STALORAL Birch 300 IR in 553 children aged 5 to 17 with birch pollen allergies. The goal was to see if it safely reduces symptoms like sneezing, runny nose, and itchy eyes during pollen season. Participants received the treatment or a placebo…

This study tested a behavioral therapy called EMD-U in 96 adults with atopic dermatitis or prurigo nodularis who had a strong urge to scratch. The therapy involves focusing on the itchy spot while moving the eyes, repeated until the urge fades. Researchers compared EMD-U plus usu…

This study looked at whether children with year-round allergic rhinitis can use a nasal steroid spray only when symptoms bother them, instead of every day. Sixty-eight children aged 6 to 18 were randomly assigned to either daily use or as-needed use of fluticasone furoate spray. …

This study tested an experimental drug called BSI-045B in 22 adults with moderate to severe atopic dermatitis (eczema). Participants received injections weekly for 4 weeks, then every 2 weeks up to 24 weeks. The main goals were to see if the drug safely reduces eczema severity by…

This completed study tested whether probiotic gummies can relieve allergic rhinitis symptoms in children aged 4 to 14. Over 56 days, 72 kids took either the probiotic or a placebo, and researchers tracked nasal symptoms, quality of life, and gut health. The goal was to see if pro…

This study tested a high-SPF sunscreen on 42 adults with mild to moderate atopic dermatitis (eczema). Over 22 days, doctors checked how well the skin tolerated the sunscreen and if it helped protect the skin barrier. The goal was to see if the product is safe and comfortable for …

This study tested a broad-spectrum SPF50+ sunscreen on 22 children with mild-to-moderate atopic dermatitis (eczema). The goal was to see how well the children's skin tolerated the sunscreen when applied at least twice daily. Doctors rated tolerance as excellent, very good, good, …

This study tested an ointment called MH004 in 160 healthy volunteers and people with mild to moderate atopic dermatitis (eczema). The goal was to check safety and how well it reduces skin symptoms like redness and itching. The ointment was applied to the skin daily for several we…

This early-stage trial tested an experimental antibody injection called BSI-045B in 54 healthy volunteers and people with atopic dermatitis (eczema). The main goal was to check safety and tolerability, with some early looks at how well it might control symptoms. The study is comp…

This study tested whether dupilumab, an injectable drug that reduces inflammation, can improve sleep quality in adults with moderate-to-severe atopic dermatitis (eczema). 188 participants received either dupilumab or a placebo. The main goal was to measure changes in sleep qualit…

This study tested whether a low dose of IL-2 (a protein that helps regulate the immune system) could reduce nasal symptoms in people with birch pollen allergy. Twenty-four adults with a history of seasonal allergies received either the drug or a placebo over several months. The g…

This study tested a nasal spray called AD17002 in 48 adults with house dust mite allergic rhinitis. The goal was to see if it is safe and can reduce symptoms like sneezing, runny nose, and congestion. Participants received either the spray or a placebo, and researchers monitored …

This study tested a new topical gel called PRN473 (SAR444727) in 39 adults with mild to moderate atopic dermatitis (eczema). Each participant had two similar patches of eczema treated: one with the study gel and one with a placebo gel, without knowing which was which. The main go…

This phase 2 trial tested whether VSJ-110 eye drops can reduce itching and redness caused by allergic conjunctivitis (eye allergies). 47 adults received either the active eye drop or a placebo, then were exposed to an allergen. The study measured how much their eyes itched and re…

This study tested a cosmetic cream in 21 women with mild to moderate atopic dermatitis (eczema). Participants applied the cream daily for up to 31 days. Researchers measured skin severity, itching, sleep quality, and skin hydration. The goal was to see if the cream could help eas…

This study tested whether taking the allergy drug fexofenadine for two days before ragweed season can reduce symptoms like sneezing and runny nose. 95 adults with ragweed allergies were randomly given either fexofenadine or a placebo. Researchers measured nasal symptoms over six …

This study tested a cream called tapinarof in 36 children aged 2 to 17 with severe eczema covering large areas of skin. The goal was to see how much of the drug gets into the body and whether it is safe. Children applied the cream once daily, and researchers monitored side effect…

This study tested a cream called tapinarof on 407 people aged 2 and older with moderate to severe eczema (atopic dermatitis). Participants applied the cream or a placebo once daily for 8 weeks. The goal was to see if the cream could clear or nearly clear the skin rash better than…

This phase 3 trial tested a once-daily cream called roflumilast (0.15%) in 354 people aged 6 and older with mild to moderate atopic dermatitis (eczema). Participants applied the cream or a placebo for 4 weeks. The main goal was to see if the cream could make skin clear or almost …

This completed study followed 945 people, mostly children and young adults with severe eczema or related allergic conditions, along with their relatives. Researchers observed how these diseases progress over up to a year, using tests like allergy skin pricks, blood draws, and lun…

This study surveys medical students to understand their attitudes toward tattoos and piercings and measure their awareness of related skin risks, such as infections, allergic reactions, and scarring. Researchers aim to see if students have adequate knowledge and how their views d…

This study looked at 30 adults with Alpha-Gal syndrome, a condition where eating red meat causes allergic reactions. Participants ate cooked ground pork with or without a sugar called alpha-gal, then researchers checked for allergic reactions, gut symptoms, and changes in immune …

This study looked at 107 people with severe food or insect allergies to measure the distance from skin to muscle in their thighs. The goal was to see if the needles on common epinephrine auto-injectors (like EpiPen) are long enough to deliver the medicine into the muscle, as reco…

This study tested whether children under 16 with a history of mild beta-lactam (like penicillin) allergies could safely take the drug again without first having skin tests. Researchers used a questionnaire to identify low-risk kids and then gave them an oral dose. The goal was to…

This study tested a 6-week 'I Love and Protect My Environment' education program in 113 third-graders. Half the students got the program, the other half did not. Researchers measured changes in environmental attitudes and awareness using surveys. The goal is to see if early educa…

This study screened up to 1,000 people with severe allergic conditions—like anaphylaxis, eczema, and asthma—along with their relatives to find genetic causes. Researchers collected blood samples and medical history to link specific gene mutations to these diseases. No treatment w…

This study investigates whether spores from birch rust fungi trigger seasonal allergies in autumn. Researchers will compare 30 people with suspected birch rust allergy to 15 non-allergic controls, tracking symptoms and spore levels. The goal is to understand a possible cause of a…

This study looked at how small differences in the COX-2 gene affect the balance of immune cells that play a role in allergies and asthma. Researchers analyzed blood and urine samples from 117 adults who were part of a larger genetic registry. No treatments were given; the goal wa…

This study looks at how taking VC005 tablets with or without food changes the drug's levels in the blood. It involves 30 healthy adults aged 18 to 45. The goal is to gather information to help design future studies for atopic dermatitis (eczema). Participants will take the drug t…

This study looked at the genes in the skin of 433 people with eczema (atopic dermatitis) to find patterns that separate mild from severe cases. Researchers collected skin samples and tracked how these patterns changed with standard treatments like steroid creams and dupilumab. Th…

This study tested a digital decision support tool for doctors treating hospitalized patients who report a penicillin allergy. Most people who think they are allergic to penicillin are not actually allergic, but they often receive less effective antibiotics. The tool helps doctors…

This study looked at whether certain genes make people who are regularly around pigeons more likely to develop a type of lung disease called hypersensitivity pneumonitis. Researchers analyzed the DNA of 475 pigeon fanciers to find genetic markers linked to lung scarring. The goal…

This completed study looked at how common fish allergy is among people who work with fish, like fishermen and fish-processing factory workers, compared to other workers. Researchers surveyed 486 people in Boulogne-sur-Mer, France, asking about allergic symptoms and exposure to fi…

This study looked at 29 adults with severe bee or wasp sting allergies to understand why a fast, one-day desensitization treatment is safe. Researchers measured changes in immune cells (basophils and T cells) before and after the treatment. The goal was to learn the mechanism, no…

This study looked at how adults with moderate-to-severe atopic dermatitis (eczema) that is controlled by systemic treatments (like pills or injections) use and feel about a cosmetic moisturizer called RV4427C WM0071. The goal was to understand their needs, expectations, and how s…

This study tested a new drug called l-dipivefrin (IN-001) given under the tongue as a spray or drops, compared to standard epinephrine injections, in 32 healthy adults. The goal was to see how the body absorbs the drug and its safety. It is an early-stage study to gather informat…

This study looked at children aged 0-18 who had mild, delayed allergic reactions to beta-lactam antibiotics (like amoxicillin). Researchers compared short (1-4 days) and long (5-8 days) oral drug challenge tests to see if longer testing increased the growth of antibiotic-resistan…

This study looked at 80 adults with moderate-to-severe atopic dermatitis (eczema) whose condition is controlled by systemic treatments. Researchers wanted to understand how these patients use moisturizers and what they expect from them. Participants filled out questionnaires abou…

This study looked at 100 adults with atopic dermatitis (eczema) who were prescribed tralokinumab. Researchers tracked how many developed eye problems like conjunctivitis within 4 months of starting the drug. The goal was to better understand these side effects in real-world use, …

This study looked at how a new drug called amlitelimab affects the way the body processes other medications in adults with moderate-to-severe atopic dermatitis (eczema). 23 participants received amlitelimab and a cocktail of common drugs to measure changes in drug levels. The goa…

This study looked at 185 children aged 0-6 to compare the nutrition and growth of those with food allergies to healthy children. Researchers measured things like arm circumference and height to see if allergies affect development. The goal was to better understand how food allerg…

This completed study followed over 1,100 pregnant women in Guangzhou to see how their diet and nutrition during and after pregnancy relate to blood sugar problems like gestational diabetes. Researchers also tracked the children's growth, brain development, and allergies up to age…

This completed study looked at levels of a specific antibody (IgG4) to cow's milk and egg in 135 children, both with and without allergies. Researchers wanted to see if these levels could help tell which children have outgrown their allergy. The study involved a single blood draw…

This completed study looked at whether substances in nasal fluid can help doctors objectively measure the severity of respiratory conditions like asthma, COPD, hayfever, and sinusitis. Researchers collected samples from 111 adults (including healthy volunteers) using a small nasa…

This study looked at how well vaccines work in adults with moderate-to-severe eczema who are taking amlitelimab, an experimental drug. About 224 participants received either amlitelimab or a placebo along with tetanus and pneumonia vaccines. The goal was to see if the drug change…

This early-stage study tested a single dose of the experimental antibody SM17 in 30 healthy Chinese adults to see if it is safe and how the body processes it. The study did not aim to treat any disease. Results will help plan future trials for conditions like eczema, asthma, and …

This study looked at 145 people who had an allergic or non-allergic reaction during surgery. Researchers wanted to find out which signs, like skin changes or heart rate, could tell the difference between a true allergy and a non-allergic reaction. The goal is to help doctors trea…

This completed Phase 4 trial at Mayo Clinic tested 21 healthy adults to find the highest skin-testing concentrations of midazolam, ketamine, and ondansetron that do not cause irritation. These drugs are commonly used before, during, and after surgery. The goal is to improve aller…

This study looked at skin samples from 170 people with psoriasis, atopic dermatitis (eczema), or healthy skin to understand how a protein called Lyn is involved in inflammation. Researchers measured Lyn activity and related enzymes in both affected and unaffected skin. The goal w…

This study looks at why some people develop hives from physical triggers like cold, pressure, or sunlight. Researchers will test participants' skin reactions and collect blood and genetic samples to understand the role of immune cells and genes. The goal is to uncover the underly…

This study looked at whether it is safe to give another dose of a COVID-19 mRNA vaccine to people who had a bad reaction to a previous dose, or to people with a history of allergies. It also included people with long COVID. A total of 137 adults took part and received either the …

This study looked at gene activity in cells from the nose and lungs of 44 healthy and allergic adults. The goal was to understand how allergies change these cells and why the nose and lungs react differently. Researchers hope this knowledge will lead to better treatments for alle…

This study surveyed 500 parents of children with asthma or allergic rhinitis to see how much they know about air quality and pollution. The goal was to understand their awareness, knowledge, and protective behaviors. The results will help design better education and prevention pr…

This study followed 487 pregnant women in Shanghai to see if key nutrients like folate and vitamin D affect the chance of their baby developing eczema (atopic dermatitis) by 6 months old. Researchers measured nutrient levels in the mothers' blood and checked babies for eczema usi…

This study looked at the types of fungi living on the head and neck skin of 30 adults with eczema (atopic dermatitis) compared to healthy volunteers. The goal was to understand if differences in the fungal community are linked to eczema in these areas. Researchers used advanced l…

This study looked at whether a home visit by an environmental counselor can improve the quality of life for children with asthma or allergic rhinitis. Researchers checked the children's health at the start and again six months after the visit using standard questionnaires. The st…

This study looked at whether the drug dupilumab, used for eczema or asthma, is safe during pregnancy. Researchers compared 581 pregnant women who took dupilumab with those who did not. They tracked birth defects, miscarriages, and infant health up to one year old to see if the dr…

This completed Phase 1 study tested whether two substances in the blood (sST2 and miR-223) can help predict how well patients with dust mite allergies respond to a six-month course of under-the-tongue immunotherapy (SLIT). Fifty-four patients with moderate-to-severe allergic rhin…

This study looked at the safety and effectiveness of the eczema drug upadacitinib in teenagers aged 12 to under 18 in Japan. About 170 teens who were already prescribed the drug by their doctor took part. Researchers collected data from regular clinic visits and questionnaires ov…

This study tested whether an artificial intelligence (AI) tool could help doctors diagnose rare and tricky skin conditions like generalized pustular psoriasis (GPP). Fifteen doctors, including both general practitioners and dermatologists, looked at 100 skin images. They first ga…

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This study looked at a specific immune pathway (PGE2/IL22/IL17) in people with eczema to see if it plays a role in the disease. Researchers collected skin and blood samples from 38 participants, including those with eczema, psoriasis, and healthy volunteers. The goal was to ident…

This study looked at 96 adults with house dust mite allergy to see if they also react to edible insects like crickets or mealworms. Participants had skin prick tests and their allergy history was reviewed. The goal was to understand patterns of insect sensitization, especially in…

This study tested a school program that teaches environmentally friendly habits and includes rhythmic exercise. 64 sixth-grade students took part, with half receiving the program. Researchers measured changes in environmental attitudes, recycling behaviors, and psychological well…

This completed study looked at how well parents of infants with early eczema and parents of healthy infants could use a mobile-friendly platform called OneBiome. The platform gives reports on the baby's gut microbiome and eating patterns. Researchers wanted to see if parents foun…

This completed pilot study collected health and nutrition information from 300 healthy adults living in Northern California. Participants completed an online survey about their stress levels, nut consumption, and bowel habits. The goal was to test and improve study procedures for…

This study looked at how the drug dupilumab changes gene and protein activity in airway cells from adults with asthma and obesity. Researchers compared allergic and non-allergic participants to understand different treatment responses. The goal was to gather knowledge, not to tes…

This study tested how well the body absorbs rocatinlimab, a drug for atopic dermatitis (eczema), when given through an autoinjector pen compared to a traditional vial and syringe. It involved 231 healthy adults aged 18-60. The goal was to see if the autoinjector delivers the drug…

This study looked at how the body naturally stops allergic inflammation after being exposed to grass pollen. Researchers measured specific molecules in the nose that help control and resolve the allergic response. Twenty adults with grass pollen allergies participated. The goal w…

This study tested a new way to collect fluid from the skin using a tiny microneedle patch. Researchers compared samples from 20 healthy volunteers and people with eczema (atopic dermatitis) to see how much fluid could be collected and how well it was tolerated. The goal was to le…

This early-phase study tested a single dose of the experimental drug rocatinlimab in 20 healthy Chinese adults. The main goal was to see how the drug moves through the body and whether it is safe. This is a first step toward possibly using the drug to treat atopic dermatitis (ecz…

This study looked at how staphylococcus bacteria on the skin affect inflammation and immune responses in people with moderate to severe atopic dermatitis (eczema). Researchers took skin biopsies and blood samples from 41 adults to measure bacterial toxins and immune cell activity…

This completed study looked at 147 French children with confirmed peanut or tree nut allergies to see how often they accidentally have allergic reactions in everyday life. Researchers also recorded how severe those reactions were and what factors might increase risk. The goal is …

This study tested how the body absorbs rocatinlimab, a potential eczema treatment, when given through a vial versus a prefilled syringe. 240 healthy adults received a single dose to compare the two methods. The goal was to see if the syringe works as well as the vial, not to trea…

This early-phase study looked at how rocatinlimab, an experimental drug for eczema, affects the way the body processes several common medications (caffeine, metoprolol, midazolam, warfarin, omeprazole). 21 adults with moderate to severe eczema took these drugs with and without ro…

This study examined how the COVID-19 pandemic impacted skin allergy visits among healthcare workers. Researchers analyzed records from 341 healthcare workers who visited skin clinics before and after the pandemic. The goal was to understand if increased use of masks, gloves, and …

This study tested a Turkish version of a questionnaire that measures how drug allergies in children affect their caregivers' quality of life. Researchers worked with 74 parents or guardians to see if the translated questions were reliable and accurate. The goal was to create a to…

This study observed 66 children diagnosed with rheumatoid purpura in three French hospital emergency rooms. Researchers tracked how well doctors followed official care guidelines and surveyed family doctors about their knowledge of the condition. The goal was to identify obstacle…

This study collected blood, saliva, stool, urine, and skin samples from 19 people with unknown or poorly understood immune system problems. The goal was to learn how different parts of the immune system work together. No treatments or drugs were tested. Participants were followed…

This study followed 461 children whose mothers took a special nutritional drink before and during pregnancy. Researchers want to understand how parents' diet, lifestyle, and metabolism influence child growth, thinking skills, and overall well-being. The goal is to identify factor…

This study looked back at the medical records of 67 children treated for anaphylaxis in a Turkish emergency department over 10 years. Researchers wanted to know how long kids were observed and how often a second wave of symptoms (biphasic reaction) occurred. They also looked for …

This study tested whether 6 different skin patches containing Mitopure cause irritation or allergic reactions. A total of 113 healthy adults, half with sensitive skin, wore the patches repeatedly. The goal was to check skin safety, not to treat any disease.

This study examined blood samples from 100 children with Henoch Schönlein Purpura (HSP) and a control group to see if regulatory T cells (Tregs) are missing or not working properly. The goal was to learn more about the disease, not to test a new treatment. Researchers measured Tr…

This study looked at how an experimental medicine called PF-08049820 moves through the body when taken in different forms (fast-release and slow-release tablets) and with or without food. Twelve healthy adults each tried five versions of the medicine, with blood samples taken for…

This study looked at how the eczema drug dupilumab (Dupixent) affects immune cells and genes in the skin. Seventeen adults with moderate-to-severe eczema took the drug, and researchers measured changes in skin samples over 12 weeks. The goal was to understand the biological effec…

This study looked at whether rocatinlimab, a drug for moderate-to-severe eczema, changes how well vaccines work. About 221 adults with eczema received either the drug or a placebo, then got tetanus and meningococcal vaccines. The goal was to see if the drug lowers the body's abil…

This study observed how private pediatricians in France manage allergic rhinitis (hay fever) in children under 18. Over 1,000 children participated, and researchers collected data on current treatment practices, including how many kids might be eligible for allergy immunotherapy.…

This study looked at how two common seasickness drugs (scopolamine and meclizine) change inner ear balance tests in 54 healthy soldiers who get seasick. Researchers measured eye movements before and after taking the drugs to see if these tests could predict which drug works best …

This study aimed to find the right strength of two grass allergen extracts (timothy and orchard grass) to cause a skin reaction similar to histamine. Thirty-one adults with grass pollen allergies received skin prick tests with different concentrations. The goal was to improve all…

This study looked at whether vitamin D levels in the blood are related to early signs of artery hardening (atherosclerosis) in people on dialysis. Researchers measured vitamin D and used ultrasound to check artery thickness in 90 adults with kidney failure. The goal was to see if…

This completed study took blood samples from 4 people with severe asthma or a related condition called ABPA. Researchers used the blood cells to create stem cells and then grew them into tiny models of bronchial tissue. The goal was to see if this lab-grown tissue could mimic rea…

This study looked at 20 years of data from over 1,200 patients to find the safest and most effective doses for drug provocation tests (DPTs) for beta-lactam allergies. Researchers analyzed past positive tests to create a new, simpler testing protocol. They will now test this new …

This study examined 69 children aged 6 to 14 to see if a deviated nasal septum (a crooked wall inside the nose) is linked to allergic rhinitis (hay fever). Researchers compared kids with and without the deviation using allergy tests, nasal samples, and quality-of-life questionnai…

This completed study tested whether a dissolved allergy tablet (Itulazax) can be used as a nasal spray to diagnose birch pollen allergy. 89 participants received either the dissolved tablet or a saltwater spray, and their nasal symptoms and airflow were measured. The goal was to …

This study looked at how dupilumab, an injectable eczema drug, changes nerve fibers in the skin of 54 adults with moderate-to-severe atopic dermatitis and chronic itching. Researchers took skin biopsies to measure nerve density and branching before and after treatment. The goal w…

This study looks at 55 adults with diabetes who are either allergic to insulin or not, to better understand and diagnose insulin allergy. Researchers will test a step-by-step diagnostic approach and study the immune system's role. The goal is to make it easier to identify the exa…

This completed study looked at 143 people with two types of lung scarring diseases (IPF and hypersensitivity pneumonitis). Researchers compared three different scoring systems (GAP, ILD-GAP, and CPI) to see which one best predicts how long patients might live. The goal was to fin…

This completed study looked at how a common skin bacterium, Staphylococcus aureus, might cause eczema flares in people with atopic dermatitis. Researchers applied patches containing the bacteria to the skin of 7 participants (both with and without eczema) and measured immune resp…

This study looked at whether a simple questionnaire called the City Birth Trauma Scale (CityBiTS) can accurately identify post-traumatic stress disorder (PTSD) related to childbirth. Researchers recruited 67 women who had given birth, had them fill out the questionnaire, and then…

This study looked at how many hospital workers had COVID-19 antibodies and how long they lasted. Over 500 staff at a French cancer center gave blood samples and answered questionnaires at the start, 3 months, and 12 months. The goal was to understand immune response in people who…