Full-Dose drug testing could pinpoint surgery allergies
NCT ID NCT06065137
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested whether giving full therapeutic doses of anaesthetics like propofol and ketamine can safely diagnose drug allergies in people who had a suspected allergic reaction during surgery. Fifty adult patients with a history of perioperative hypersensitivity underwent incremental drug provocation testing. The goal was to see how often allergic reactions occur during this direct testing and to compare it with standard skin tests.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- propofol and ketamine
- What this could lead to
- If successful, this could provide a safer, more accurate way to diagnose which anaesthetic drugs cause allergic reactions during surgery.
- What could go wrong
- This is a small, completed study with only 50 participants, so results may not apply to everyone. Drug provocation testing itself carries a risk of triggering an allergic reaction.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Antwerp University Hospital
Edegem, Antwerp, 2650, Belgium
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