Could this treatment stop allergies before they start? new study in infants shows promise

NCT ID NCT05003804

Completed Prevention Sponsor: Siolta Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new treatment called STMC-103H in 283 newborn babies and infants who are at high risk for developing allergies (like eczema or food allergies) because of their family history. The goal was to see if the treatment is safe and can prevent these allergic conditions from starting. Babies received either the treatment or a placebo for up to 336 days, and researchers tracked how many developed eczema or other allergies.

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Conditions

The condition(s) this trial relates to.

Hypersensitivity, Immediate IgE responsiveness, atopic atopic eczema prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATOPIC DERMATITIS TYPE 1 HYPERSENSITIVITY

Contacts and locations

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Locations

Arkansas Children's Research Institute

Little Rock, Arkansas, 72202, United States
Boston Children's Hospital

Boston, Massachusetts, 02215, United States
Centro de Neumologia Pediatrica

Caguas, Puerto Rico, 00725, Puerto Rico
Children's Healthcare of Atlanta

Atlanta, Georgia, 30329, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Cincinnati Children's Hospital

Cincinnati, Ohio, 45229, United States
Coastal Pediatrics Research

Summerville, South Carolina, 29486, United States
Dell Medical School at UT Austin

Austin, Texas, 78723, United States
Fiona Stanley Hospital

Murdoch, Western Australia, 6150, Australia
Johns Hopkins University School of Medicine

Baltimore, MD, Maryland, 21205, United States
Lurie Children's Hospital

Chicago, Illinois, 60611, United States
Monash Children's Hospital

Clayton, Victoria, 3168, Australia
Mt. Sinai Jaffe Allergy Institute

New York, New York, 10029, United States
Murdoch Children's Research Institute

Parkville, Victoria, 3052, Australia
NYU Langone Fink Children's

New York, New York, 10016, United States
Northwell Healthcare

Great Neck, New York, 11021, United States
Queensland Children's Hospital

South Brisbane, Queensland, 4101, Australia
Rady Children's Hospital - San Diego

San Diego, California, 92123, United States
Riley Children's Health at University of Indiana

Indianapolis, Indiana, 46202, United States
Seattle Allergy and Asthma Research Institute

Seattle, Washington, 98115, United States
The Children's Hospital at Westmead

Westmead, New South Wales, 2145, Australia
The Women's and Children's Hospital

Adelaide, South Australia, 5000, Australia
Tribe Clinical Research

Greenville, South Carolina, 29607, United States
UCLA Health

Los Angeles, California, 90095, United States
UCSF Benioff Children's Hospital

San Francisco, California, 94158, United States
UT Southwestern/Children's Health

Dallas, Texas, 75235, United States
Univ. of Wisconsin-Madison/Jackson Research Group

Madison, Wisconsin, 53792, United States
University of Arizona Health Sciences

Tucson, Arizona, 85724, United States
University of Chicago Medicine

Chicago, Illinois, 60637, United States
University of Michigan Health

Ann Arbor, Michigan, 48104, United States
University of Rochester Medical Center

Rochester, New York, 14642, United States