Eczema drug dupilumab shows promise for better sleep

NCT ID NCT04033367

Completed Symptom relief Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether dupilumab, an injectable drug that reduces inflammation, can improve sleep quality in adults with moderate-to-severe atopic dermatitis (eczema). 188 participants received either dupilumab or a placebo. The main goal was to measure changes in sleep quality over 12 weeks. The trial is already completed, so results are available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dupilumab (an injectable biologic drug that blocks inflammation)
What this could lead to: If successful, this could confirm that dupilumab helps people with eczema sleep better, improving their daily life.
What could go wrong: This is a completed Phase 4 trial, so results are already known. It only tested sleep effects, not a cure, and benefits may not apply to everyone with eczema.

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Conditions

The condition(s) this trial relates to.

atopic eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATOPIC DERMATITIS

Contacts and locations

Locations

Investigational Site Number :0360001

Kogarah, New South Wales, 2217, Australia
Investigational Site Number :0360003

Carlton, Victoria, 3053, Australia
Investigational Site Number :0360006

Phillip, Australian Capital Territory, 2606, Australia
Investigational Site Number :0360007

Woolloongabba, Queensland, 4102, Australia
Investigational Site Number :2500001

Brest, 29200, France
Investigational Site Number :2500002

Paris, 75014, France
Investigational Site Number :2500003

Nantes, 44093, France
Investigational Site Number :2500006

Toulouse, 31059, France
Investigational Site Number :2760001

Göttingen, 37075, Germany
Investigational Site Number :2760002

Frankfurt am Main, 60590, Germany
Investigational Site Number :2760004

Münster, 48149, Germany
Investigational Site Number :2760005

Bad Bentheim, 48455, Germany
Investigational Site Number :2760006

Friedrichshafen, 88045, Germany
Investigational Site Number :3760003

Jerusalem, 91120, Israel
Investigational Site Number :3760005

Afula, 18101, Israel
Investigational Site Number :3800001

Pisa, 56126, Italy
Investigational Site Number :3800002

Roma, 168, Italy
Investigational Site Number :3800003

Siena, 53100, Italy
Investigational Site Number :3800004

Reggio Calabria, 86100, Italy
Investigational Site Number :3800005

Rozzano, Milano, 20089, Italy
Investigational Site Number :3800006

Perugia, 06129, Italy
Investigational Site Number :7240001

Barcelona / Sabadell, Castille and León, 08208, Spain
Investigational Site Number :7240002

Valencia, 46026, Spain
Investigational Site Number :7240003

Manises, Valencia, 46940, Spain
Investigational Site Number :7240004

Granada, Andalusia, 18016, Spain
Investigational Site Number :7240005

Seville, 41013, Spain
Investigational Site Number :7240006

Córdoba, 14004, Spain
Investigational Site Number :7240008

Madrid, 28007, Spain
Investigational Site Number :7240010

Madrid, 28922, Spain
Investigational Site Number :7560001

Bern, 3010, Switzerland
Investigational Site Number :7840001

Dubai, United Arab Emirates
Investigational Site Number :7840002

Abu Dhabi, 46713, United Arab Emirates
Investigational Site Number :8260002

Dudley, Birmingham, DY1 2HQ, United Kingdom
Investigational Site Number :8260004

Edinburgh, Edinburgh, City of, EH16 4SA, United Kingdom
Investigational Site Number :8400001

Rolling Hills Estates, California, 90274, United States
Investigational Site Number :8400002

Redwood City, California, 94063, United States
Investigational Site Number :8400003

Sarasota, Florida, 34239, United States
Investigational Site Number :8400005

Denver, Colorado, 80230, United States
Investigational Site Number :8400007

Medford, Oregon, 97504, United States
Investigational Site Number :8400008

Charleston, South Carolina, 29407, United States
Investigational Site Number :8400012

North Little Rock, Arkansas, 72117, United States
Investigational Site Number :8400013

Colorado Springs, Colorado, 80907, United States

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