Peanut allergy pill shows promise in early trial

NCT ID NCT05440643

Completed Disease control Sponsor: ALK-Abelló A/S Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a daily tablet placed under the tongue (SLIT) containing peanut protein to help people with peanut allergy tolerate small amounts of peanut. The trial included 209 adults, teens, and children ages 4 to 65. Researchers measured how many participants could safely eat 600 mg of peanut protein after 24 weeks of treatment, and tracked side effects like mouth irritation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Peanut extract sublingual tablet
What this could lead to: If successful, this daily tablet could help people with peanut allergy tolerate small amounts of peanut, reducing the risk of severe reactions from accidental exposure.
What could go wrong: This is an early-phase trial with only 209 participants, so results may not apply to everyone. Side effects like mouth or throat reactions are common, and the tablet does not cure the allergy—daily use is needed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

food allergy Peanut Hypersensitivity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PEANUT ALLERGY

Contacts and locations

Show contact details

Locations

Allergy & Asthma Clinical Research

Walnut Creek, California, 94598, United States
Allergy Partners of NJ

Ocean City, New Jersey, 07712, United States
Ann Robert H. Lurie Childrens Hospital of Chicago

Chicago, Illinois, 60611-2605, United States
Arkansas Children's Hospital

Little Rock, Arkansas, 72202, United States
Asthma, Allergy and Sinus Center

White Marsh, Maryland, 21162, United States
Aventiv research, Inc

Columbus, Ohio, 43212, United States
BC Children's Hospital

Vancouver, British Colombia, V5H 3V4, Canada
Baylor College of Medicine (BCM) Texas Children's Hospital Pediatrics and Immunology

Houston, Texas, 77030, United States
Boston Food Allergy Center

Boston, Massachusetts, 02111, United States
CHU-Saint-Justine

Montreal, Quebec, H3T 1C5, Canada
Center for Advance Pediatrics

Atlanta, Georgia, 30329, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital of Los Angeles - USC School of Medicine

Los Angeles, California, 90027, United States
Children's Hospital of Philadephia

Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Pittsburg of UPMC - Immunology and Rheumatology

Pittsburgh, Pennsylvania, 15224, United States
Clinique Specialisee en Allergie de la Capitale

Québec, G1V 4W2, Canada
Eastern Virginia Medical School - Children's Hospital

San Diego, California, 92123, United States
Family Allergy Asthma Research Institute

Louisville, Kentucky, 40215-1176, United States
Halton Pediatric Allergy

Burlington, Ontario, L7L 6W6, Canada
Hamilton Allergy

Hamilton, Ontario, Canada
Icahn School of Medicine at Mt. Sinai, Pediatric Allergy, Kravis Children Hospital

New York, New York, 10029, United States
Johns Hopkins University School of Medicine

Baltimore, Maryland, 21287-0005, United States
MOORE-PH Dermatology - Clinical Research

Tampa, Florida, 33609, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
McGill University Health Centre (MUHC) - Research Institute (RI-MUHC)

Montreal, Quebec, H3H 2R9, Canada
NYU Langone Health - Fink Children's Ambulatory Care Center

New York, New York, 10016, United States
Northwell Health

Great Neck, New York, 11021, United States
Ottawa Allergy Research Corporation

Ottawa, Ontario, K1H 1E4, Canada
Peninsula Research Associates (PRA)

Rolling Hills Estates, California, 90274, United States
Quality Research of South Florida

Hialeah, Florida, 33016, United States
Rush University

Chicago, Illinois, 60612, United States
Sneeze, Wheeze, & Itch Associates, LLC

Normal, Illinois, 61761, United States
Stanford University - Lucile Packard Children's Hospital

Palo Alto, California, 94304, United States
The Children's Hospital Foundation of Manitoba

Winnipeg, Manitoba, R3A 1M3, Canada
The Hospital for Sick Children, Toronto

Toronto, Ontario, M5G 1E8, Canada
The University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
UCLA - Pediatrics

Los Angeles, California, 90095, United States
USF Asthma Allergy and Immunology Clinical Research Unit

Tampa, Florida, 33609, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of North Carolina

Chapel Hill, North Carolina, 27599, United States
Velocity Clinical Research - Lafayette

Lafayette, Louisiana, 70508, United States
Western Sky Medical Research

El Paso, Texas, 79903, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.