Eczema cream showdown: steroid vs Non-Steroid in kids

NCT ID NCT07537751

Completed Disease control Sponsor: Noura Abdelmoneim Mohammed Elseessy Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two creams for mild to moderate eczema in 40 children aged 1-12. One cream was a steroid (fluticasone), the other a non-steroid (crisaborole). Both were applied twice daily for 6 weeks, then twice weekly for 12 weeks if the skin improved a lot. Both treatments worked well; the steroid worked faster, but the non-steroid showed a trend toward keeping eczema away longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Crisaborole 2% ointment and fluticasone propionate 0.05% cream
What this could lead to: If successful, this could show that crisaborole is a good non-steroid option for children with eczema, possibly with fewer relapses than steroid creams.
What could go wrong: This was a small, completed trial with only 40 children, so results may not apply to all patients. The trend toward fewer relapses with crisaborole needs confirmation in larger studies.

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Conditions

The condition(s) this trial relates to.

atopic eczema Eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATOPIC DERMATITIS ECZEMA

Contacts and locations

Locations

Faculty of Medicine, Kafr Elsheikh University

Kafr ash Shaykh, Kafr el-Sheikh Governorate, Egypt

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