New DNA test could beat old method for stubborn UTIs

NCT ID NCT06996301

Completed Diagnosis Sponsor: Doc Lab Inc Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This completed study tested whether a DNA-based PCR test works better than the usual lab culture for diagnosing complicated urinary tract infections (cUTIs) in adults. Over 770 participants across six U.S. sites were randomly assigned to have their treatment guided by either PCR or culture results. The goal was to see which method leads to more patients getting better by day 28, and whether PCR can help reduce unnecessary antibiotic use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PCR diagnostic test (DocLab UTM 2.0)
What this could lead to: If PCR proves more accurate or faster than standard culture, it could help doctors choose the right antibiotic sooner, reducing ineffective treatment and antibiotic resistance.
What could go wrong: The trial is completed but results are not yet reported; PCR may not show a clear advantage over culture, and its higher cost or complexity could limit real-world use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

allergic disease disease Pathologic Complete Response urinary tract infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

URINARY TRACT INFECTION (CUTI) URINARY TRACT INFECTION (DIAGNOSIS) URINARY TRACT INFECTION COMPLICATED

Contacts and locations

Locations

Albany Urology Clinic & Surgery Center

Albany, Georgia, 31707, United States
Augusta Urology Associates

Evans, Georgia, 30809, United States
Colquitt Regional Medical Center

Moultrie, Georgia, 31768, United States
Norman Urology Associates

Norman, Oklahoma, 73071, United States
Phoenix Urology of St Joseph

Saint Joseph, Missouri, 64506, United States
Silicon Valley Medical Development

San Jose, California, 95124, United States

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