No-Needle epinephrine: could a dissolving film replace the shot?

NCT ID NCT06527937

Completed Disease control Sponsor: Aquestive Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 study tested a new dissolvable film called DESF that delivers epinephrine under the tongue. Thirty-six healthy adults with oral allergy syndrome received DESF and standard epinephrine injections to compare how quickly the drug enters the bloodstream. The goal is to see if this needle-free option can work as a fast and easy treatment for allergic reactions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: DESF (sublingual epinephrine film)
What this could lead to: If successful, DESF could offer a needle-free way to quickly deliver epinephrine during allergic reactions, making treatment easier and faster.
What could go wrong: This is an early Phase 2 study with only 36 healthy adults, not people having severe reactions. It measures drug levels, not real-world outcomes, so results may not translate to emergency use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

allergic disease hypersensitivity reaction disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALLERGIC REACTION

Contacts and locations

Locations

Frontage Clinical Services, Inc.

Secaucus, New Jersey, 07094, United States

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