New ointment shows promise for eczema sufferers

NCT ID NCT06810050

Completed Symptom relief Sponsor: CAGE Bio Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new ointment called CGB-500, which contains the drug tofacitinib, for treating eczema (atopic dermatitis) in 180 people aged 12 and older. Participants applied the ointment or a placebo daily for 8 weeks. The goal was to see if it safely reduces skin redness, itching, and rash. Results will show whether this ointment could become a new treatment option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CGB-500 ointment with tofacitinib (a drug that calms the immune system)
What this could lead to: If it works, this could offer a new topical treatment option for eczema that reduces skin redness, itching, and rash.
What could go wrong: This is a Phase 2 trial with only 180 people, so results may not apply to everyone. Tofacitinib can have side effects like skin irritation or infection risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atopic eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATOPIC DERMATITIS (AD)

Contacts and locations

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Locations

Ablon Skin Institute and Research Center

Manhattan Beach, California, 90266, United States
Center for Dermatology Clinical Research Inc.

Fremont, California, 94538, United States
Cordova Research Institute

Sweetwater, Florida, 33182, United States
DermResearch

Austin, Texas, 78759, United States
Driven Research

Gables, Florida, 33134, United States
FXM Clinical Research

Fort Lauderdale, Florida, 33308, United States
FXM Clinical Research Miami, LLC

Miami, Florida, 33175, United States
FXM Clinical Research Miramar, LLC

Miramar, Florida, 33027, United States
J&S Studies, Inc.

New Brighton, Minnesota, 55112, United States
JDR Dermatology Research

Las Vegas, Nevada, 89148, United States
Metro Boston Clinical Partners

Brighton, Massachusetts, 02135, United States
Syrentis Clinical Research

Santa Ana, California, 92705, United States
TCR Medical Corporation

San Diego, California, 92123, United States
Tennessee Clinical Research Center

Nashville, Tennessee, 37215, United States
The Indiana Clinical Trials Center, PC

Plainfield, Indiana, 46168, United States
USA and International Research Inc.

Doral, Florida, 33126, United States

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