Perceptual disorders

Researchers are testing a gene therapy called rAAV2/4.hRPE65 in people with Leber congenital amaurosis or severe early-onset retinal degeneration caused by mutations in the RPE65 gene. The treatment delivers a working copy of the gene directly into one eye through a single inject…

Researchers are testing a single injection of SKG0106, an experimental gene therapy, in Chinese adults aged 50 and older with wet age-related macular degeneration. The trial aims to find out whether the treatment is safe and how the body responds to it. Participants receive one i…

This trial tests a gene therapy for people with a rare inherited eye disease called Leber congenital amaurosis, caused by mutations in the RPE65 gene. A harmless virus is used to deliver a working copy of the gene into cells under the retina. The goal is to restore vision with a …

Researchers are studying aflibercept (Eylea), an anti-VEGF drug given as an injection into the eye, in adults aged 50 and older with wet age-related macular degeneration. Everyone in the trial receives three monthly loading doses over 12 weeks. The team uses detailed retinal scan…

This study tests an experimental drug called AVD-104, given as an eye injection, for people with geographic atrophy, a late stage of dry age-related macular degeneration that causes blind spots. The trial involves 300 participants and aims to see if the drug is safe and can slow …

Researchers are testing an experimental drug called TAK-935 in children aged 2 to 17 with Dravet syndrome or Lennox-Gastaut syndrome, two severe forms of epilepsy that often resist treatment. The trial compares TAK-935 added to standard anti-seizure medications against a placebo …

This study tests a new drug called zifibancimig for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The drug is given either as an eye injection or through a small implant placed in the eye that releases the drug over time. The trial involv…

This trial compares three painkillers, hydromorphone, fentanyl, and butorphanol, given intravenously to ICU patients who are not on mechanical ventilation. The goal is to find the best dose of hydromorphone that achieves effective pain control while monitoring side effects like l…

This study looks at how well a biosimilar drug called Yesafili works for people with wet age-related macular degeneration (AMD). About 54 participants will switch from the standard drug Eylea to Yesafili. Doctors will check vision and eye health to see if the biosimilar is a safe…

This study tests whether a home eye-scanning device can improve care for people with wet age-related macular degeneration (AMD) who are switching to the medication faricimab. Participants will scan their own retinas at home several times a week, and the images will be sent to the…

This trial tests whether training and employing local community members as ear health facilitators can improve ear care for Aboriginal and Torres Strait Islander children in the Northern Territory. The facilitators would help with ear assessments and management of otitis media, a…

This study compares two regional anesthesia techniques—spinal anesthesia and erector spinae plane block—in critically ill adults over 65 undergoing femur fracture surgery. The goal is to see which method provides better pain control, more stable blood pressure and heart rate duri…

This study tests whether intensive visual retraining at home can help people who have lost part of their vision due to damage to the brain's visual cortex, often from a stroke. Participants will use a computer program to practice detecting motion and orientation of visual stimuli…

This early-stage study tests a new drug called EYE201, given as three eye injections over 12 weeks, to see if it is safe and can help reduce swelling in the back of the eye. It includes people with three different eye conditions that cause vision loss: branch retinal vein occlusi…

This trial tests whether adding vestibular rehabilitation exercises—like gaze stabilization and balance training—to standard physiotherapy can improve balance, walking, and visual clarity in adults aged 38–60 with chronic unilateral vestibular hypofunction, a condition where one …

This trial is testing whether a personalized, place-based pitch map for cochlear implants can improve hearing compared to the standard one-size-fits-all map. The study involves adults with moderate-to-profound hearing loss who are getting a cochlear implant. Participants will be …

This study tested a new cochlear implant (CI632) in 10 adults who have some low-frequency hearing but poor high-frequency hearing. The goal was to see if the implant improves speech understanding and overall hearing. Participants received the implant and were followed to measure …

This study looks at the Bonebridge BCI 602, a bone conduction implant designed to help people with certain types of hearing loss. The trial will measure how well the device improves hearing and speech understanding one year after implantation, compared to not using it. It also tr…

This early feasibility trial tests a new retinal implant called PRIMA in 5 people with advanced dry age-related macular degeneration who have lost central vision. The device is surgically placed in the eye to stimulate remaining retinal cells. Researchers are checking if it is sa…

This trial is testing whether an experimental medication called PRAX-628 can reduce the frequency of focal seizures in adults with epilepsy who are already taking one to three other seizure medications. Participants will receive either PRAX-628 or a placebo for 12 weeks, with the…

This pilot study tests deep brain stimulation (DBS) of the medial pulvinar, a new target in the brain, for people with drug-resistant epilepsy who have not improved with other treatments. Twelve adults aged 18 to 60 will receive the stimulation and track their seizures for 12 mon…

This clinical trial is testing whether an experimental eye injection called ONS-5010 (bevacizumab) can help preserve vision in people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The study will compare ONS-5010 to an existing treatment, ranibiz…

This trial tests whether a daily supplement containing omega-3s, Spirulina, magnesium, and vitamin B6 can help adults with persistent middle ear fluid — a condition that can cause hearing loss and ear fullness. Over 500 adults aged 18 to 70 with confirmed otitis media with effusi…

This study tests whether parents can help improve speech clarity in elementary-aged children who are deaf or hard of hearing. Parents use a technique called Broad Target Speech Recast, where they naturally correct a child's mispronounced words during conversation, without asking …

This trial tests whether an experimental drug called ONS-5010 (a form of bevacizumab) works as well as an approved drug, Lucentis, for treating wet age-related macular degeneration (AMD). Wet AMD causes rapid vision loss due to abnormal blood vessels leaking fluid in the eye. Abo…

This study tested an experimental drug called SPI-1005 (ebselen) in 254 adults with Meniere's disease, a condition causing hearing loss, ringing in the ears, and dizziness. Participants received either the drug or a placebo for a set period, followed by an open-label phase where …

This study tested an experimental drug called tinlarebant in 104 teenagers with Stargardt disease, a genetic condition that causes progressive vision loss. The goal was to see if the drug could slow the growth of damage in the back of the eye. Participants took the drug or a plac…

This study investigates whether a noninvasive brain stimulation technique called transcranial direct current stimulation (tDCS) can enhance recovery from spatial neglect — a condition where stroke survivors ignore one side of their world. Participants who had a stroke 3 to 12 mon…

This early-stage trial tests an experimental drug called Kamuvudine-8 (K8) for people with geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. About 30 participants receive eye injections of K8 and are monitored for 26 weeks to check s…

This study tests the safety of an experimental eye injection called ONS-5010 (bevacizumab) in people with vision loss from wet age-related macular degeneration, diabetic macular edema, or branch retinal vein occlusion. Participants receive the injection and are monitored for side…

This study tests whether SPI-1005, a drug containing ebselen, can prevent hearing loss in people with cystic fibrosis who are receiving IV tobramycin for a lung infection. About 40 participants will receive either a placebo or one of three doses of SPI-1005 for 21 days. Researche…

This study tests whether switching to a higher dose (8mg) of aflibercept can help people with wet age-related macular degeneration (AMD) who have not responded well to standard treatments like faricimab or the usual 2mg dose of aflibercept. Participants receive up to three inject…

This study compares fentanyl and hydromorphone (Dilaudid) for sedating patients on mechanical ventilators in the ICU. About 300 adults will be randomly assigned to one of the two drugs. The main goal is to see if one leads to lower total opioid use. The results could help guide s…

This study tests the safety of a single injection of PST-611, a DNA-based therapy, in people aged 50 and older with dry age-related macular degeneration (AMD). The therapy is designed to make the eye produce a protein that may protect against vision loss. Participants receive one…

This study investigates whether a non-invasive light treatment called photobiomodulation can improve vision and slow vision loss in people with dry age-related macular degeneration (AMD). Participants receive either active light therapy or a sham (inactive) treatment over 12 mont…

This trial tests whether playing a binocular 'Dig Rush' game on an iPad for one hour a day, five days a week, can improve vision in children aged 4 to 13 with amblyopia (lazy eye). Participants wear glasses and are randomly assigned to either play the game or receive glasses alon…

This study tests whether infusing a child's own stored umbilical cord blood stem cells is safe for children with acquired sensorineural hearing loss. The trial enrolls children with moderate to profound hearing loss and aims to see if the infusion can improve inner ear function, …

This study follows people with two inherited eye conditions—choroideremia and X-linked retinitis pigmentosa—who previously received gene therapy. Researchers monitor their safety and vision over several years to see if the treatment remains safe and helps preserve sight. Particip…

This study tests whether cenobamate, an experimental anti-epileptic drug, can safely reduce primary generalized tonic-clonic (PGTC) seizures when added to a person's usual seizure medications. Adults and adolescents aged 12 and older with PGTC seizures are randomly assigned to re…

This study tests whether NPI-001 tablets can safely slow or stop vision loss in people with Usher syndrome, a rare genetic condition that causes blindness and hearing loss. About 49 adults will take either the study drug or a placebo for 24 months. The main goal is to see if the …

This study tests whether a combination of a gentle sedation strategy (called eCASH) and early, personalized exercise can prevent muscle weakness that often develops in ICU patients who need a breathing machine. The trial will include 70 adults on ventilators, with half receiving …

This trial investigates whether bosentan, a drug that blocks endothelin and relaxes blood vessels, can help people who suddenly lose vision from giant cell arteritis (Horton's disease). Standard steroid treatment often fails to restore sight once blindness occurs. The study enrol…

This study tested the long-term safety and effectiveness of pegcetacoplan in 792 people with geographic atrophy, a form of advanced dry age-related macular degeneration that causes vision loss. Participants had previously been in earlier pegcetacoplan trials. The goal was to see …

This study tested whether telehealth can replace in-person clinic visits for older adults who already use hearing aids. 339 participants were randomly assigned to receive hearing care either through telehealth or traditional clinic visits. The goal was to see if telehealth could …

This study tests a smart computer simulation (digital twin) of Saudi streets to train visually impaired people on safe navigation. Participants use 3D audio and a vibrating vest to learn to avoid obstacles. The goal is to see if this high-tech training reduces real-world collisio…

This study tested a drug called cenobamate in 519 adults with partial onset seizures (focal seizures). Participants took cenobamate or a placebo alongside their usual seizure medications. The goal was to see if cenobamate could safely reduce seizure frequency. Results showed a si…

This early-stage study tested a new drug, VP-001, given as an injection into the eye to see if it is safe for people with a rare genetic eye disease caused by a PRPF31 mutation. Seventeen adults took part. The main goal was to check for side effects, not to measure vision improve…

This study checks the long-term safety of an eye injection called avacincaptad pegol for people with geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. About 278 adults who finished a previous study of this drug will receive the injec…

This Phase 3 trial tested a drug called XEN1101 (azetukalner) in 380 adults with focal-onset seizures that were not well-controlled by other medications. Participants took either XEN1101 or a placebo alongside their usual seizure drugs. The study measured whether XEN1101 reduced …

This study tested an eye injection called tarcocimab in 255 people with diabetic retinopathy, a diabetes complication that can damage vision. Participants received either the drug or a sham (fake) injection. The goal was to see if the drug improves the severity of the disease and…

This study looked at whether a cochlear implant is a good value for people who are deaf in one ear or have severe hearing loss in one ear. Participants first tried other hearing devices, and if those didn't work, they were randomly assigned to get a cochlear implant right away or…

This study tested a tiny implant called the PRIMA Bionic Vision System in 5 people with advanced dry age-related macular degeneration who had lost central vision. The implant is placed under the retina and uses electrical stimulation to replace damaged light-sensing cells. The go…

This phase 3 trial tested a small, refillable implant placed in the eye that continuously releases the drug ranibizumab to control diabetic retinopathy. The study enrolled 174 people with moderate-to-severe non-proliferative diabetic retinopathy but without swelling in the center…

This study looked at 9 children under 5 who received the BONEBRIDGE BCI 602 hearing implant. The main goal was to check if the implant is safe within the first year after surgery. Researchers also measured how much the implant improved hearing and quality of life. The implant is …

This early-phase trial tested a combination of two drugs—fluvastatin (a cholesterol-lowering statin) and celecoxib (an arthritis drug)—in 20 children and young adults with certain brain tumors (gliomas) that had come back or not responded to treatment. The goal was to find the sa…

This early-phase trial tested an investigational eye injection called OLN324 in 164 adults with either wet age-related macular degeneration (AMD) or diabetic macular edema (DME). The main goal was to check safety and how the drug moves in the body, with a preliminary look at whet…

This study tested whether injecting a concentrated form of a patient's own blood, called platelet-rich plasma (PRP), into the eye could slow the progression of advanced dry age-related macular degeneration (AMD). Fourteen people with advanced dry AMD received three PRP injections…

This study followed 42 people who received a gene therapy for X-linked retinitis pigmentosa, an inherited eye disease that causes blindness. The goal was to check the treatment's safety over up to 5 years. Researchers also looked at whether patients' vision and ability to move ar…

This study tested whether a traditional Chinese herbal pill called Liuwei Dihuang Pill can improve hearing in older adults with age-related hearing loss. 120 people aged 65-75 took either the pill or a placebo for 48 weeks. Researchers measured changes in speech recognition to se…

This study tested the drug levetiracetam as the first treatment for seizures in 18 full-term newborns who had brain injury from lack of oxygen at birth. The goal was to find the right dose and check if it is safe and effective at reducing seizure activity on brain recordings. The…

This study looked at whether taking ibuprofen for eight days after hip or knee replacement surgery is safe. Over 2,900 adults were randomly given either ibuprofen or a placebo. Researchers tracked serious problems like heart attack, stroke, blood clots, kidney failure, and bleedi…

This study tested a smartphone app called HearCare MED-EL that lets people with cochlear implants adjust their audio processor and check for device problems remotely. 120 adults who already had a MED-EL implant for at least 3 months took part. The goal was to see if the app works…

This study tested whether adding a light-based treatment (photodynamic therapy) to the standard drug ranibizumab could reduce the number of eye injections needed for wet macular degeneration. Sixty adults over age 50 with the condition took part. The goal was to see if the combin…

This study tested a new drug called EYE103, given as an injection into the eye, for people with diabetic macular edema (DME) or wet age-related macular degeneration (NVAMD). The trial had two parts: first, checking safety at increasing doses in about 12 people, then comparing two…

This study tested a new drug called FYB203, which is a biosimilar (a close copy) of the existing medication Eylea, for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The trial involved 434 participants and compared how well FYB203 worked v…

This completed Phase 4 study tested how much of the drug aflibercept gets into the bloodstream when a high dose (8 mg) is injected into both eyes of adults with diabetic macular edema or wet age-related macular degeneration. Fifty-one participants received the injections and had …

This study tests a daily pill called ALK-001, a modified form of vitamin A, to see if it can slow the growth of geographic atrophy—an advanced form of dry age-related macular degeneration that causes blind spots. About 300 people with the condition took either the drug or a place…

This study looked at the long-term safety of faricimab, a drug injected into the eye, for people with wet age-related macular degeneration (AMD). Over 1,000 participants who had completed earlier studies received faricimab at personalized intervals. The main goal was to track sid…

This phase 2 trial tested a new drug called EYP-1901, given as an eye injection, for people with wet age-related macular degeneration (AMD). The goal was to see if it works as well as the standard treatment, aflibercept (Eylea), but with fewer injections. 161 participants receive…

This study tested whether a single dose of naloxone, given right after a generalized tonic-clonic seizure, can help people with epilepsy breathe better and avoid sudden death. Researchers enrolled 485 adults with drug-resistant epilepsy who were already in the hospital for monito…

This study compared two different dosing schedules of brolucizumab (Beovu) in 52 people with wet age-related macular degeneration (AMD) who had not responded well to previous treatment. Participants received the drug as an eye injection either on a fixed schedule or with adjustme…

This trial tested a robotic system (ROSA) to assist with cochlear implant surgery, which restores hearing in people with profound hearing loss. The robot aims to make the surgery safer and less invasive by improving precision. Nine adults eligible for cochlear implants took part,…

This study tests a drug called carbidopa-levodopa (Sinemet), typically used for Parkinson's disease, in people with wet age-related macular degeneration (AMD). It is a 9-month extension for 35 participants who completed an earlier study. The goal is to see if the drug can help ma…

This study tested a robotic stabilizer to help surgeons inject a clot-busting drug (tPA) under the retina in 20 patients with bleeding from age-related macular degeneration. The robot held the needle steady for up to 3 minutes during standard surgery. The main goals were to see i…

This study tests whether a smartphone-based camera can accurately screen for eye diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration. About 550 patients will have photos taken with both the smartphone camera and standard equipment. Ophthalmologis…

This study tests whether using a special hearing-in-noise diagnostic (the ACT test) to fit hearing aids improves speech perception, spatial awareness, and user satisfaction compared to standard fitting. Adults aged 18-50 with moderate to severe hearing loss who use bilateral hear…

This study investigates whether hearing problems are an under-recognized complication of diabetes. Researchers will screen 172 adults with type 1 or type 2 diabetes using hearing tests and a questionnaire. If a hearing issue is found, a more detailed assessment will be done to de…

This trial tests a wearable device called CAVA that records eye and head movements for 30 days in people with dizziness conditions like Meniere's disease and BPPV. The goal is to see if the device can accurately detect episodes of nystagmus, an eye movement linked to dizziness, a…

This study tested a wearable device that tracks eye movements during dizzy spells to help doctors tell apart three common inner-ear conditions: Ménière's disease, vestibular migraine, and BPPV. Four adults wore the device for 30 days to capture data. The goal was to develop a com…

This study tested a new MRI technique to detect endolymphatic hydrops (fluid buildup) in the inner ear of people with Meniere's disease. The new method uses a special 3D FLAIR sequence without contrast dye, compared to the standard method that requires an injection. The goal was …

This study tested whether a special type of MRI that measures sodium levels in the brain can help locate the exact area causing seizures in people with drug-resistant epilepsy. 78 patients who were already scheduled for epilepsy surgery received a sodium MRI scan. Researchers com…

This study looked for a measurable brain signal (biomarker) that could objectively diagnose chronic tinnitus. Researchers used EEG to record brain activity in 560 adults—some with constant tinnitus and some without. The goal is to replace trial-and-error diagnosis with a personal…

This study tested an artificial intelligence (AI) system called Retina4IRD that helps doctors diagnose inherited retinal diseases, which are rare eye conditions that can cause vision loss. The AI looks at eye images and patient information to suggest which gene might be causing t…

This study tested a new device called CochSyn that measures brain waves to detect hearing damage. Researchers compared results from 65 adults with and without hearing difficulties. The goal was to see if the device can accurately identify different types of hearing loss and be ea…

This study tested whether a special eye-tracking device (video-oculography) helps emergency room doctors more accurately diagnose the cause of vertigo or dizziness. About 130 adults with dizziness were randomly assigned to get either the eye-tracking test plus standard care, or s…

This study tested a smartphone app that guides children through deep breathing (hyperventilation) and records their face and sounds to detect absence seizures. 65 children with and without seizure history participated. The app's accuracy was compared to standard EEG monitoring. T…

This study tested whether a simple eye-tracking system can identify children with childhood absence epilepsy and related thinking problems. Researchers compared eye movement recordings from 60 participants (kids with epilepsy and healthy controls) to standard tests. The goal is t…

This study tested whether a device called MAIA, which measures light sensitivity in the retina, can predict when intermediate age-related macular degeneration (AMD) progresses to the advanced stage. Researchers followed 182 people who already had advanced AMD in one eye and inter…

This study tested a new method called CORGEE that uses brain wave recordings (EEG) to measure how well children with hearing loss understand speech. Unlike standard hearing tests that require kids to respond verbally, this approach is objective and does not need active participat…

This study tests whether a basic first aid and accident prevention training program improves awareness and knowledge among parents of children with disabilities. Parents of children enrolled in special education schools are randomly assigned to receive the training or not. Their …

This study tests whether the drug SENS-401 can prevent hearing loss caused by cisplatin, a common chemotherapy. Adults with cancer who are scheduled to receive cisplatin take SENS-401 before, during, and after treatment. Hearing is measured with a standard test to see if the drug…

This study tested whether injections of aflibercept (Eylea) into the eye could prevent the development of wet age-related macular degeneration (AMD) in people at high risk. 128 participants with early signs of AMD in one eye and wet AMD in the other eye received either Eylea or a…

This study tested whether giving the seizure drug levetiracetam right away can prevent seizures in people who had a brain bleed (hemorrhagic stroke). About 50 adults with a recent brain bleed received either the drug or a placebo. The goal was to see if the drug could reduce seiz…

This study tested an oral soft capsule of nalbuphine, a painkiller, for people recovering from hemorrhoid surgery. 106 adults took either the drug or a placebo for up to 2 days. Researchers measured pain levels and how much extra pain relief was needed. The goal was to see if the…

Researchers compare two spinal anesthesia mixtures for pain relief after lower limb surgery. One group receives bupivacaine alone, and the other receives bupivacaine plus tramadol. The trial measures pain scores and how long it takes before patients need additional pain medicine.…

This study tested whether watching calming VR videos or squeezing a stress ball could reduce pain, anxiety, and improve satisfaction during insulin injections in older adults (65+) with type 2 diabetes. 90 participants were split into three groups: VR, stress ball, or usual care.…

Tonsillectomy causes significant pain in children. Researchers are testing whether injecting ropivacaine, a local anesthetic, around the tonsils during surgery reduces postoperative pain. The trial enrolls 60 children aged 3 to 6 who are having their tonsils removed. Doctors comp…

This study compared two types of nerve blocks (supra-inguinal fascia iliaca block and lumbar erector spinae plane block) for pain relief in 84 adults undergoing hip fracture surgery. The goal was to see which block works better for positioning the patient for spinal anesthesia an…

Researchers are studying whether TENS, a device that sends mild electrical pulses through the skin, can lower pain and reduce the need for painkillers after total hip replacement. The trial enrolls 60 adults who have had hip replacement surgery and do not have a pacemaker, heart …

This completed Phase 1 study tested whether olanzapine, an antipsychotic drug, can reduce the discomfort of tinnitus (ringing in the ears). Fifty adults with stable tinnitus for at least 6 months received either olanzapine or a placebo in a crossover design. The main goal was to …

This trial compares three common anesthetic blocks used during knee replacement surgery to see which one controls pain best right after the operation. It also looks at how well patients can move their knee in the first few days, and whether pain and recovery differ by age or sex.…

Researchers at UC Davis are comparing two pain-control plans for women having weight-loss surgery. One group receives standard opioid-based care, while the other gets a mix of non-narcotic medicines with opioids available only if needed. The trial measures pain scores and how muc…

This study is testing a mobile health app designed to help cancer survivors manage pain and other symptoms after treatment. Twenty-five survivors who have finished cancer treatment but still have pain will use the app for one week, receiving helpful messages and completing daily …

Researchers are testing whether a vibrating dolphin-shaped massage device or tablet-based digital storytelling reduces pain and fear in children aged 3 to 6 during blood collection. The trial assigns children to one of these two distraction methods or to a control group. Parents,…

This completed study tested a sound-based therapy for tinnitus (ringing in the ears) in 108 Veterans. Participants used hearing aids that played either notched noise (sound with the tinnitus frequency removed) or broadband white noise. The goal was to see if notched noise could r…

This study tests whether a nerve block called the serratus posterior superior intercostal plane block can reduce pain and the need for strong painkillers after minimally invasive heart surgery. Sixty adults will be randomly assigned to receive either the nerve block plus standard…

This study tests two types of exercises to help people who get dizzy, nauseous, or have blurry vision from using computers for long hours. 46 computer users will do either head-movement or eye-movement exercises for 4 weeks. The goal is to see which exercise better reduces sympto…

This study tests whether 80 sessions of a gentle brain stimulation technique called tDCS, given over 12 months, can improve attention, social skills, and language in 180 children aged 6 to 11 who have autism along with rare diseases, genetic problems, or PANDAS. The treatment is …

This study tests two simple, non-drug methods to reduce pain and fear in children aged 6-9 during blood draws. One group watches a cartoon, the other squeezes a stress ball. Researchers will measure pain and fear levels during the procedure to see which works better.

This study tested three non-drug treatments—cognitive behavioral therapy, a breathing exercise, and psychoeducation—to see which best reduces the distress caused by tinnitus (ringing in the ears). Seventy adults with tinnitus were randomly assigned to one of the three approaches.…

Researchers at MIT are testing whether a smartwatch that vibrates in time with your heartbeat can improve interoceptive awareness, the ability to sense what is happening inside your body. The study enrolls 29 people with high alexithymia scores, a trait linked to difficulty ident…

This trial tests whether meclizine, a drug often used for motion sickness, works as well as dimenhydrinate for controlling acute vertigo symptoms that come from inner-ear problems. Adults aged 18 to 64 with moderate to severe vertigo take one of the two drugs three times a day fo…

This trial tests whether S(+) ibuprofen, a purified form of the common painkiller, can reduce pain in people with knee or hip osteoarthritis better than a standard ibuprofen product. Researchers will compare the two treatments in about 176 adults aged 18 to 75. Participants will …

This phase II trial tests whether S(+) ibuprofen, a modified form of the common painkiller, provides better pain relief than a standard treatment for people with sudden, at least moderate low back pain. Researchers will compare the two approaches in 177 adults whose pain started …

This trial tests two types of nerve blocks for pain after breast cancer surgery. One method targets a deeper layer of muscle, while the other combines both superficial and deep layers. The goal is to see which approach better reduces pain, cuts down on opioid use, and improves co…

This trial asks whether a single piece of nicotine gum can reduce the loudness of tinnitus—the phantom ringing or buzzing in the ears—in non-smoking adults who have had chronic tinnitus for at least six months. Participants will chew either a 4 mg nicotine gum or a flavor-matched…

This trial tests two ultrasound-guided nerve blocks for pain relief after thoracotomy, a surgery that opens the chest. One block targets the paravertebral space, while the other targets a point between the transverse process and the pleura. Researchers will compare how much morph…

This study looks at whether a special pain management plan (called ERAS) helps people recover better after gallbladder removal surgery. It compares patients who got the ERAS plan with those who had standard pain treatment. The goal is to see if the ERAS plan reduces pain, shorten…

This study tested a nerve block called the high-thoracic erector spinae plane block to see if it could reduce pain and improve diaphragm function after posterior cervical spine surgery. 50 adults undergoing this surgery received either the block or standard care. The goal was to …

This trial tests whether communication training helps first-time hearing aid users with mild to moderate hearing loss adapt better. Participants receive training either in a group or one-on-one, and researchers compare their hearing-related quality of life, communication strategi…

This trial tests whether applying cold packs to the wrist after transradial coronary angiography reduces pain, bruising, and discomfort. About 104 adults who had this heart procedure will be randomly assigned to receive either cold packs or standard care. Researchers will measure…

This study looks at whether a combination of over-the-counter pain relievers (like ibuprofen and acetaminophen) can control pain after wisdom tooth removal just as well as, or better than, prescription opioids. About 1,800 people having their wisdom teeth removed will be randomly…

This study tested whether a cochlear implant can help adults aged 65 and older who are deaf in one ear but have normal hearing in the other. Fifteen participants received the implant, and researchers measured how well they understood speech in noisy settings over a year. The goal…

This study compares two types of nerve blocks for pain after repeat lumbar spine surgery. 64 adults aged 40-70 will receive either a caudal epidural block alone or a combined lumbar sympathetic block with caudal epidural. Pain levels will be measured before and after surgery to s…

This study is testing a type of talk therapy, called Brief Cognitive Behavioral Therapy for Suicide Prevention, delivered via video call. The goal is to see if it can reduce suicidal thoughts and attempts in adults with physical disabilities affecting vision, hearing, or mobility…

This study tests whether a smartphone-based mindfulness program is practical and liked by teens and young adults (ages 15-39) with sickle cell disease who have chronic pain or sleep problems. Participants use a guided meditation app for about 8 weeks. The goal is to see if people…

This trial asks whether a smaller 0.2 mL dose of sweet sucrose solution can relieve pain just as well as a larger 0.5 mL dose during routine heel pricks in newborns. Babies up to 28 days old will be randomly assigned to receive one of the two doses before the procedure. Researche…

This study tested a program to help cancer survivors quit smoking and manage pain. Nineteen survivors received counseling and the medication varenicline (Chantix). The goal was to see if the program was practical and helpful, not yet to prove it works.

This trial tests whether hearing a mother's recorded lullaby can reduce pain and improve comfort in children aged 1 to 3 years after minor surgery. Half the children will listen to the lullaby, while the other half hears white noise, for one hour after waking up. Researchers will…

This study looks at whether auto-captioning glasses are easy and helpful for adults with NF2-related schwannomatosis who have hearing loss. Eighteen participants will use the glasses for 12 weeks and report their experience through surveys and interviews. The goal is to see if th…

This study tests whether liquid or pill acetaminophen works better for pain after gastric bypass or sleeve gastrectomy. Surgery changes how the stomach absorbs medication, so the form of the drug could affect pain relief. Adults who had one of these procedures will receive either…

This trial tests whether a combination of expressed breast milk, sucking, and facilitated tucking (gentle holding) reduces pain in healthy newborns during a heel prick, compared with breastfeeding alone. About 128 full-term infants will be randomly assigned to one of the two comf…

This trial tests a new noise-reduction strategy in hearing aids for people with severe hearing loss who already use hearing aids. Participants will try an experimental hearing aid and two currently available models to compare how well they understand speech in a noisy room with m…

This trial tests whether a virtual reality (VR) tour of the operating room can lower anxiety and fear in adults scheduled for arthroscopic orthopedic surgery. Participants in the intervention group watch a 9-minute 360-degree VR video that shows the journey from the ward to the o…

This trial tests two ways to prevent rebound pain—a sudden spike in pain after a nerve block wears off—following ankle fracture surgery. One approach uses a continuous infusion of a local anesthetic, while the other gives a timed dose of a painkiller. The study will compare these…

This study tested an eye drop (POS) in 200 adults who had poor night vision after LASIK or similar eye surgery. The goal was to see if the drops could help them see better in dim light, reducing problems like glare and halos. Participants used the drops for 15 days and had their …

This study investigates whether adding the steroid dexamethasone to a standard ultrasound-guided nerve block (transversalis fascia plane block) can improve pain control after cesarean delivery. Researchers will compare opioid use, pain scores, and recovery quality in women who re…

This study tests whether a virtual reality (VR) mindfulness app can reduce anxiety before surgery and acute pain after surgery. Adults scheduled for surgery will use the VR headset for up to 25 minutes, and researchers will measure changes in anxiety and pain scores, as well as u…

This trial tests whether applying Kinesio tape to the face after bimaxillary jaw surgery can reduce swelling and pain better than standard compression taping. Adults undergoing this surgery will receive either Kinesio tape or regular tape alongside routine cold therapy. Researche…

This study tests whether watching a custom 360-degree virtual reality video during dressing changes can lower pain, anxiety, and the need for opioid painkillers in adults recovering from burn surgery. Eighty participants will wear VR headsets while their bandages are changed and …

This trial tests whether an online support program can help first-time hearing aid users cope with the emotional and social challenges of hearing loss. Participants receive standard hearing rehabilitation plus access to five online chapters offering information, advice, and suppo…

This study tests whether a CT-guided nerve block called celiac plexus neurolysis can relieve severe abdominal pain in people with upper gastrointestinal cancer better than standard pain medication. About 110 adults with biopsy-proven upper GI cancer and severe pain will be random…

This completed study looked at how different amounts of chiropractic care affect chronic low back pain in 766 veterans. In the first phase, participants received either 1-5 or 8-12 visits over 10 weeks. Then, some continued with monthly maintenance visits for 10 months. The goal …

This trial tests whether a newer nerve block, called the Erector Spinae Plane (ESP) block, provides better pain relief after arthroscopic shoulder surgery than the standard periarticular infiltration (PAI) of local anesthetic. Half of the participants will receive the ESP block b…

This study tested a hearing aid feature called AutoFocus360, which automatically points microphones toward whoever is speaking. Thirty adults with mild to moderate hearing loss listened to audio clips and compared AutoFocus360 to standard settings. The goal was to see if it made …

This trial tests two computer-controlled devices that deliver local anesthesia during dental work in children aged 4 to 9. Each child receives anesthesia from both devices on separate visits, and researchers measure pain, behavior, heart rate, and oxygen levels to see which devic…

This trial tests whether virtual reality (VR) can reduce pain and anxiety when surgical drains are removed after bariatric surgery. Sixty adults will be randomly assigned to either watch a 360° nature video with VR goggles during the procedure or receive standard care. Pain and a…

This trial aims to find the optimal dose of bupivacaine, a local anesthetic, for starting epidural pain relief during labor. It will enroll 100 healthy women with a single, full-term pregnancy who request an epidural for pain. The goal is to determine the dose that provides effec…

This pilot study tests whether a technique called conditioning with open-label placebo (COLP) can help patients with spinal cord injuries, polytrauma, or burns reduce their opioid painkiller doses without losing pain relief. Participants receive a sugar pill and an essential oil …

This trial compares two types of nerve blocks for pain relief after open gastric cancer surgery. The blocks are injected near the abdominal wall to numb the area, potentially reducing the need for opioid painkillers, which can cause side effects like drowsiness and constipation. …

This study looks at whether giving a local anesthetic to the abdominal wall at the start of robotic prostate surgery, rather than at the end, can reduce the amount of strong painkillers (opioids) needed during the operation. About 50 adults with prostate cancer or benign prostate…

This trial tests whether virtual reality (VR) distraction can reduce pain in children aged 6-11 during intravenous cannulation or blood sampling in a pediatric emergency department. Half of the participants receive standard care, while the other half wear a VR headset showing age…

This trial tests whether a special skin patch worn behind the ear can reduce the ringing or buzzing of tinnitus. About 90 adults with tinnitus will wear either an active patch or a placebo patch daily for three weeks, and researchers will track changes in tinnitus-related distres…

This study tests two medications, dexmedetomidine and tramadol, given before hemorrhoid surgery to see which one better reduces anxiety and pain. Ninety adults will receive one of the drugs or a placebo before spinal anesthesia. Researchers will measure anxiety levels and pain sc…

This study tests an 8-week program called PhYoMind, which blends physiotherapy, yoga postures, breathing exercises, and mindfulness, against home exercise alone in 40 adults with fibromyalgia. The goal is to see if the combined approach reduces disability, pain, fatigue, and stre…

This study tests a new therapy that uses moving sounds to help stroke survivors with spatial neglect — a condition where they ignore one side of space. 18 participants will either get standard rehab or standard rehab plus dynamic auditory cueing for 4 weeks. The goal is to see if…

This trial tests whether wearing a virtual reality headset during dental anaesthesia and tooth extraction can lower children's pain, anxiety, and stress. Sixty-four children aged 6 to 10 will be randomly assigned to receive either standard behaviour management or VR distraction. …

This trial tests whether an ultrasound-guided nerve block called the mid-transverse process to pleura (MTP) block can improve pain control in children aged 5 to 15 undergoing open chest surgery. Half of the 50 participants will receive the block with bupivacaine before the incisi…

This trial tests whether a device that measures the body's pain signals during surgery can help doctors give just the right amount of pain medicine during C-sections. Sixty women having planned C-sections under general anesthesia will be randomly assigned to either standard monit…

This trial tests whether adding a topical gel containing naproxen and lidocaine to standard intravenous pain medication improves pain relief for adults with isolated rib fractures from blunt chest trauma. Participants receive either the standard IV painkiller alone or the IV pain…

This trial compares two ways of giving the anti-inflammatory drug piroxicam to control pain after root canal treatment: a standard oral pill versus an injection into the ligament around the tooth. Adults with a toothache caused by irreversible pulpitis will receive one of the two…

This trial compares a new painkiller called oliceridine to the standard drug sufentanil for women undergoing hysteroscopy, a procedure to look inside the uterus. The goal is to see if oliceridine provides effective pain control with fewer side effects like nausea or breathing pro…

This pilot study tests a new approach for misophonia, a condition where common sounds like chewing or breathing cause extreme distress. Sixty adults with moderate to severe misophonia will learn emotion regulation skills and receive one of two types of brain stimulation (rTMS) ov…

This phase 2 trial tests whether a single local dose of HTX-011, a long-acting anesthetic, can reduce pain after bunionectomy better than a placebo. About 70 adults undergoing foot surgery receive either the drug or a saline injection, and their pain is tracked over 24 hours. The…

This trial compares two ways to manage pain during hip replacement surgery: an ultrasound-guided nerve block (PENG block) versus injecting anesthetic directly into the joint. The study includes 60 adults scheduled for anterior hip replacement under general anesthesia. The main go…

This trial tests whether a newer nerve block called PENG block provides better pain relief than the standard intra-articular injection for people undergoing hip replacement surgery. Both methods use the anesthetic lidocaine. The study will measure how much morphine patients need …

This study compares two ways of numbing the arm for wrist fracture surgery. One group receives a standard axillary block with a long-lasting anesthetic, while the other gets a short-acting axillary block plus separate long-acting blocks at the elbow for the median and radial nerv…

This study tests whether taking melatonin before a planned C-section can lower pain afterward. Sixty women will receive either 5 mg, 10 mg, or a placebo pill one hour before surgery. Researchers will track pain levels, how soon they need extra pain relief, and any side effects ov…

This study compared two ways to control pain during laser treatment for diabetic retinopathy: a numbing injection around the eye versus standard numbing eye drops. Fifty adults with diabetes were split into two groups to receive either the injection or a sham injection with drops…

This study tests whether a very low dose of LSD (26 micrograms) can improve mood in people with depression compared to a placebo. Researchers measure mood changes, sleep quality, and brain activity using EEG. The trial involves 41 adults with depression and aims to see if this ap…

This study tests a new cochlear implant that slowly releases dexamethasone, a drug that reduces inflammation after surgery. The goal is to see if it works better than a standard implant for adults with severe hearing loss. About 48 adults will be randomly assigned to get either t…

This study compares two different times to give a scalp block—a numbing injection to the scalp—during brain tumor surgery. One group receives the block before the head is pinned in place, the other just before waking up. Researchers will measure recovery quality, pain, and heart …

This study tests whether a ShotBlocker device or a warm gel pack can reduce pain and improve comfort in healthy newborns during routine heel prick blood tests. Babies are randomly assigned to receive one of these two non-drug treatments or standard care. Researchers measure pain …

This study tests whether watching small aquarium fish during a blood draw can reduce pain, stress, and crying in children aged 3 to 6. Half of the children will watch a fish tank while getting blood drawn; the other half will not. Researchers will measure heart rate, oxygen level…

This study tests whether a combination of gabapentin, ketorolac, and a nerve block, along with scheduled Tylenol, can reduce the need for opioid painkillers after head and neck cancer surgery involving free flap reconstruction. Half of the 30 participants will receive the standar…

This trial tests whether a topical ointment containing two numbing agents (lidocaine and tetracaine) can reduce pain after hemorrhoid surgery. Adults scheduled for elective hemorrhoidectomy will apply the ointment or a placebo every 12 hours for 10 days after surgery. Researchers…

This study tests whether using a virtual reality headset during a scheduled cesarean section can help reduce pain and anxiety. Twenty women will be offered the headset at different stages of care, from admission to after birth. Researchers will measure how many accept and use it,…

This trial investigates whether inhaling a 50/50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain when a nasogastric tube is placed in children aged 3 months to 3 years. The study includes children with mild to moderate dehydration from conditions like gastroenterit…

This study tests an experimental drug called SPI-1005 (ebselen) in adults with Meniere's disease, a condition that causes vertigo, tinnitus, and hearing loss. The trial compares three doses of SPI-1005 against a placebo to see if it safely reduces these symptoms. Researchers will…

This study tested three methods to reduce pain and fear in 166 children aged 5-9 during dental numbing injections: a device that cools and vibrates, gentle tapping near the injection site, and a thinner needle. Researchers measured pain scores, heart rate, and cooperation. The go…

This trial compares two types of nerve blocks—femoral nerve block and adductor canal block—for controlling pain after anterior cruciate ligament (ACL) reconstruction. Participants receive one of the two blocks before surgery, and researchers track their pain levels and painkiller…

This phase 3 trial tests whether intravenous arginine, an amino acid, can shorten painful episodes in children with sickle cell disease. Participants aged 3 to 21 receive either arginine or a placebo alongside standard pain treatment. The study measures how quickly the crisis res…

This completed study tested custom in-the-ear hearing aids in 24 adults with mild-to-moderately severe sensorineural hearing loss. Participants were experienced hearing aid users who tried the study device and compared it to their own hearing aids. The goal was to measure speech …

This study tests whether giving magnesium during and after spinal surgery can reduce pain and the need for morphine. Adults undergoing multi-level back surgery are randomly assigned to receive either magnesium or a placebo (saline) infusion for 12 hours after surgery. Pain levels…

This study tested whether Swedish massage with lavender or chamomile oils can help reduce pain, fear, and anxiety during labor. 90 pregnant women were split into three groups: one got massage with chamomile oil, one with lavender oil, and one with plain carrier oil. Researchers m…

This study tested two ways to numb the shoulder during surgery: the standard interscalene block done by anesthesiologists, and a newer shoulder field block done by surgeons. 64 adults having shoulder surgery were randomly assigned to one method. The goal was to see if the field b…

This study tested a new approach that combines a minimally invasive spine-stabilizing procedure (kyphoplasty) with a single dose of targeted radiation given during surgery. The goal was to see if this combination could better control pain from cancer that has spread to the spine.…

This study tested whether a gas called MEOPA (laughing gas) can help elderly people manage pain during physiotherapy for stiff hips or knees. Six patients aged 65 or older received three sessions of physiotherapy with MEOPA or standard care. The goal was to see if the gas improve…

This study tested whether watching an immersive virtual reality (VR) video during IUD insertion can lower pain and anxiety. 90 women took part, with half using VR and half receiving standard care. The goal was to see if VR offers a safe, simple, drug-free way to improve the exper…

This study tested two new features in the MED-EL SONNET 3 audio processor for cochlear implant users: the Focused Beamformer, which improves directional hearing, and the AI Mode Medium, which uses adaptive intelligence to optimize sound processing. Forty experienced cochlear impl…

This study tested two treatments for chronic tailbone pain (coccygodynia) in 100 adults. One group received osteopathic manual therapy—gentle hands-on techniques to mobilize the tailbone and relax muscles—over 6 weeks. The other group got a nerve block injection guided by X-ray. …

This study tests a 10-week visual rehabilitation program for children with autism spectrum disorder who also have vision problems. The program uses games and activities to improve how children use their eyes and process visual information. Researchers want to see if better vision…

This study tested whether a nerve block (PECS II) or local anesthesia works better for pain after breast cancer surgery, without using opioids. 124 women undergoing breast surgery were randomly assigned to receive one of the two methods. Researchers measured pain, nausea, and opi…

This study tested whether listening to music during a daily cleaning procedure can reduce pain in children aged 6 months to 15 years in a pediatric intensive care unit. Each child experienced the cleaning twice—once with music and once without—and pain was measured using a standa…

This pilot study tested whether adding virtual reality (VR) to a standard educational program helps people with chronic pain and central sensitization. 128 participants completed eight weekly sessions that combined pain education, mindfulness, and VR activities. The study measure…

This study tested a speech therapy called ASSIST for children aged 4 to 9 with childhood apraxia of speech, a disorder that makes it hard to plan speech movements. Fifty-one children received 16 hours of individual therapy using repetition and cues. The goal was to see if the the…

This study tested whether a home-based balance therapy program is practical for children aged 4-17 with inner-ear problems that cause dizziness and balance issues. Twenty-one children did balance exercises at home for 8 weeks, with weekly check-ins from a physical therapist. The …

This study tested two different nerve blocks to manage pain after shoulder surgery. 60 adults were randomly assigned to receive either an interscalene block or an infraspinatus-teres minor block. The goal was to see which block reduces the need for strong painkillers and causes f…

This study looked at 82 adults who had hip surgery and received a nerve block (PENG block) for pain. One group got the pain medicine as a manual injection every 4 hours, while the other got it through a pump continuously. Researchers compared pain levels, opioid use, and recovery…

This study tested whether wearing virtual reality goggles showing relaxing nature scenes and music during IUD insertion could reduce pain and anxiety. 70 women were randomly assigned to either VR or standard care. Researchers measured pain, anxiety, comfort, and vital signs. The …

This study compared an oral steroid (prednisolone) to a partial root canal for relieving severe tooth pain from pulpitis. Only 5 adults with a painful lower molar took part. The goal was to see if the pill could reduce pain enough to delay the full root canal by 72 hours, potenti…

This study compared two methods of pain relief after hip replacement surgery: a newer technique called erector spinae plane block (ESPB) and the standard epidural. 60 adults having hip replacement took part. Researchers measured pain levels, opioid use, muscle strength, and walki…

This study tested two numbing methods for a common clubfoot procedure in infants: a needle-free jet injection that works in 1-2 minutes versus a topical cream that takes 30 minutes. Researchers measured pain using a standard scale, heart rate, and oxygen levels in 107 babies. The…

This study looked at whether adding Epidiolex (a CBD-based medicine) to usual treatment can improve seizures, behavior, sleep, and quality of life in people aged 1 to 65 with tuberous sclerosis complex (TSC). 79 participants took the drug and were monitored for changes in symptom…

This study looked at using a heat-based technique called thermocoagulation in 100 children aged 1.5 to 17 years with focal epilepsy that doesn't respond to medication. During a brain monitoring procedure, doctors applied small heat lesions to the area where seizures start, aiming…

This pilot study tested a portable TENS device for reducing menstrual pain in 34 women with primary dysmenorrhea. Participants used the device on their lower abdomen during pain episodes for up to three cycles. The goal was to see if this drug-free approach could ease pain and im…

This study tested whether listening to different types of music can reduce pain and anxiety from a cold water challenge in 40 healthy young adults. Participants immersed their hand in cold water while in silence or while listening to music with different emotional tones and rhyth…

This study tested two ways of giving epidurals to 102 pregnant women in labor: a standard method and a newer one called dural puncture epidural (DPE). The goal was to see which provides faster pain relief and better satisfaction. Results help doctors choose the best option for ma…

This study tested whether a low-immunogenic oat variety called Saul is well-tolerated by adults with celiac disease who are in remission. Forty participants ate 50 grams of gluten-free Saul oat flakes daily for 14 days. Researchers tracked symptoms and blood markers to see if the…

This study tested if freezing the nerves between the ribs (cryoablation) could reduce hospital stay compared to standard epidural pain medicine in 50 young people aged 12-24 having Nuss surgery for pectus excavatum (sunken chest). The goal was to see which method controls pain be…

This study looked at two different nerve blocks to control pain after thigh lift surgery. 42 adults received either a quadratus lumborum block or a lumbar plexus block. Researchers measured pain levels and how long it took for patients to need extra pain medicine.

This study tested whether wearing a virtual reality headset showing a nature video could reduce pain and anxiety in 90 adults undergoing coronary angiography, a heart procedure where patients are awake. One group watched the VR video during the procedure, while the other received…

This study tested whether adding ketoprofen to standard paracetamol (acetaminophen) can better control pain in patients receiving brachytherapy for cervical or upper airway/digestive tract cancers. Sixty-eight adults were randomly assigned to receive either paracetamol alone or p…

This study tested whether using a vibrating device, alone or with a cold gel pack, could reduce pain and anxiety when chest tubes are removed after coronary artery bypass surgery. 93 patients were split into three groups: vibration only, vibration plus cold, or standard care. Res…

This study tested a smartphone app called e-PainSupport for people receiving home hospice care. The app helps patients and their caregivers report pain levels to nurses and learn about pain management. Researchers wanted to see if using the app could reduce pain intensity. The st…

This study tested whether using a stress ball during active labor can reduce pain and improve comfort. 78 pregnant women were split into two groups: one used a stress ball during contractions, the other received standard care. Researchers measured pain, comfort, and self-efficacy…

This study tested whether placing full-term newborns in a soft, supportive "nest" of pillows before, during, and after a heel prick blood test reduces their pain. 59 healthy newborns participated; 29 were nested and 30 received standard care. Pain was measured using the Neonatal …

This study looked at whether adding a low-dose ketamine infusion to standard pain medication can help people who just had knee replacement surgery. One hundred adults were randomly assigned to get either standard pain relief alone or standard relief plus ketamine through a patien…

This study tested whether a simple home-based thigh exercise can reduce knee pain in older adults with osteoarthritis. Fifty people aged 60 to 85 did daily 10-second thigh squeezes for 28 days, and some also used topical gels like CBD or arnica. The goal was to see if this low-co…

This study tested a special stitching technique during C-sections to see if it reduces pain and helps women get out of bed sooner. 60 women having their first C-section took part. The new method aims to put less tension on the tissue, which may lead to less pain and faster recove…

This study looked at 120 adults having gallbladder surgery to see if the position they are in when getting a nerve block (called an ESP block) affects pain after surgery. Patients were placed on their side, stomach, or sitting up during the block. The goal was to find which posit…

This study tested whether injecting the numbing drug bupivacaine into the vaginal cuff during vaginal hysterectomy reduces pain after surgery. Forty-eight women were randomly assigned to receive either the injection or standard care. Pain levels were measured over 24 hours using …

This study tested a medical device that automatically gives the pain drug remifentanil during surgery, based on heart rate, blood pressure, and a pain index. 52 adults having burn surgery took part. The goal was to see if the device could reduce the total amount of pain medicine …

This study tested whether a special nerve block called the erector spinae plane (ESP) block can improve pain control after flexible ureteroscopy, a common surgery for kidney stones. 70 adults were randomly assigned to receive either the ESP block plus standard pain care or standa…

This study looked at whether a computer algorithm could improve how a cochlear implant is set for people who have one implant and a hearing aid in the other ear. Nine adults with severe hearing loss took part. The goal was to see if the new settings helped them hear better in qui…

This study tested whether combining mild electrical brain stimulation (tRNS) with white noise can temporarily reduce tinnitus symptoms. 35 adults with chronic tinnitus received either the combined treatment or brain stimulation alone. Researchers measured changes in tinnitus loud…

This study looked at whether giving a low dose of ketamine continuously could lower the amount of strong painkillers (opioids) needed by people with serious injuries. The goal was to see at least a 25% reduction in opioid use over 48 hours while still controlling pain just as wel…

This study tested whether wearing eye masks and earplugs at night for three nights could help prevent confusion (delirium) and reduce pain in children aged 6-12 in the pediatric intensive care unit (PICU). 74 children were randomly assigned to either wear the sleep aids or receiv…

This study looked at whether working with a care manager (patient navigator) and using an online pain coping program can help people with chronic pain improve how they manage their pain and daily activities. The study included 32 adults who had daily pain for at least 3 months an…

This study tested whether people with tinnitus can tell if they are receiving real or fake ultrasound stimulation of the vagus nerve in the ear. Twenty adults with constant tinnitus for at least six months took part. The goal was to see how well the blinding worked and what side …

This study tested a new way to adjust cochlear implants for people who are deaf in one ear but have some hearing in the other. Researchers used an evolutionary algorithm to customize the frequency settings of the implant. The goal was to help participants understand speech better…

This study tested two different pain-relief mixtures given as a nerve block before hip surgery. One group received nalbuphine plus bupivacaine, the other dexamethasone plus bupivacaine. The goal was to see which combination provided longer pain relief and reduced the need for ext…

This study tested two methods of delivering a pain-blocking injection (TAP block) after laparoscopic upper abdominal surgery: one guided by ultrasound and the other by the surgical camera. Sixty adults aged 18-70 took part, and researchers measured their pain levels and need for …

This study tested whether applying scents (like lavender) during heel blood collection can reduce crying, pain, and stress in newborns. 120 healthy full-term babies were randomly assigned to receive a scent or not. Researchers measured crying time, heart rate, and a standard pain…

This study tested a new sound processor, the Osia 3, against the current Osia 2 model in 12 adults with hearing implants. Participants completed hearing tests and rated sound quality with both devices. The goal was to see if the new processor improves speech understanding in nois…

This pilot study tested whether prolonged exposure teletherapy can help adults with psychogenic nonepileptic seizures (PNES) and PTSD. Forty-four participants received either the teletherapy or standard education about PNES. The goal was to see if the therapy reduces seizure freq…

This study tested three different pain-blocking methods in 75 children aged 2 to 7 having hernia surgery. The goal was to see which method works best to keep kids comfortable after the operation. Researchers measured pain levels, how much extra pain medicine was needed, and any s…

This study tested whether mirror therapy—a technique using visual feedback from a mirror to trick the brain—works better than routine physical therapy for people with Complex Regional Pain Syndrome (CRPS), a chronic pain condition often after injury. Fifty-two adults aged 40-65 w…

This study tested whether applying ice packs over surgical incisions every 4 hours for up to 72 hours can improve patients' recovery after chest, abdomen, or groin surgery. 196 adults were randomly assigned to receive cryotherapy plus standard care or standard care alone. The mai…

This study looked at whether showing cartoons or playing music during tooth extractions can lower pain and anxiety in children aged 6 to 12. Sixty kids were randomly assigned to watch cartoons, listen to music, or receive standard care. Researchers measured heart rate, oxygen lev…

This study looked at whether chewing gum (with or without sugar) can help children aged 7 to 12 feel less pain and fear during a blood draw. A total of 144 kids were randomly assigned to chew sugared gum, sugar-free gum, or no gum at all. Researchers measured pain, fear, and cryi…

This study tested whether a new sound processor (Osia 3) helps adults with hearing loss or single-sided deafness hear better than the current model (Osia 2). Twenty-nine adults who already have a bone-anchored implant tried both processors. Researchers measured speech understandi…

This study looked at whether acupuncture can help manage pain for people visiting the emergency department with common painful conditions like back pain or abdominal pain. About 290 adults were split into two groups: one received acupuncture, the other got usual care. The goal wa…

This study tested a daily dietary supplement called ACEMg (Soundbites) in 64 adults with hearing loss or tinnitus. Participants took the supplement for 24 weeks and completed hearing tests and symptom surveys at home using a smartphone app. The goal was to see if the supplement c…

This study tested whether a non-invasive brain stimulation technique called rTMS, guided by MRI scans, could reduce severe hallucinations in people with schizophrenia who don't respond to medication. 85 participants received either MRI-guided or standard rTMS over 5 days. The goa…

This study tested whether medical hypnosis can reduce anxiety and pain in patients undergoing electroneuromyography (ENMG), a nerve test that can be uncomfortable. Six anxious adults were enrolled and received either hypnosis or standard care. Researchers measured pain and anxiet…

This study tested whether repetitive transcranial magnetic stimulation (rTMS) can help people with chronic, severe tinnitus (ringing in the ears). Sixty-four adults received either real or fake rTMS at different intensities. The goal was to see if the treatment reduces tinnitus l…

This study tested whether a nerve block called an erector spinae plane block can reduce pain and the need for painkillers after robotic-assisted partial kidney removal. Forty-six adults aged 18-70 were randomly assigned to receive either the nerve block or standard care. The goal…

This study tested whether changing the stimulation settings (called MAPs) in cochlear implants can improve how well adults with hearing loss understand speech, both in quiet and noisy environments. Twenty experienced cochlear implant users tried different low-power settings and e…

This study looked at adding tramadol, nefopam, or opioids to standard painkillers (paracetamol and ketoprofene) for adults recovering from shoulder surgery. 92 patients were enrolled, and their recovery quality was measured using a survey. The goal was to find the best oral pain …

This study tested a T-shirt printed with ceramic particles that claim to use body heat to emit far infrared radiation, potentially reducing inflammation and muscle pain. Fifty adults with chronic neck or lower back pain wore the shirt for 8 hours. Researchers measured changes in …

This study placed a humanoid robot in the homes of 10 children aged 8 to 12 who have cochlear implants. The robot can talk, listen, and interact via a touchscreen, aiming to make speech therapy practice more fun and accessible. The main goal was to see how often children would us…

This study compared two ways to manage pain after total hip replacement: a newer ultrasound-guided nerve block (PENG block) versus standard surgical infiltration. The goal was to see which method reduces the need for strong painkillers like morphine, especially in older patients …

This study tested two pain medicines, ketamine and dexmedetomidine, in 38 adults recovering from brain surgery in the ICU. Researchers measured pain levels using a special tool at 6, 12, and 24 hours after treatment. The goal was to see which drug provides better pain relief for …

This study tested the ALICE app, a smartphone tool designed to train listening and communication skills in people with hearing loss. 161 adults who already use hearing aids or cochlear implants used the app alongside their usual care. The goal was to see if the app could improve …

This completed study tested whether an ultrasound-guided nerve block called RIFP can reduce pain and the need for rescue painkillers after laparoscopic gallbladder removal. 77 patients were enrolled. The block targets nerves in the upper abdomen to provide pain relief. The main g…

This study tested a 6-week online pain management program for breast cancer survivors who still have bothersome pain after treatment. The program included education, exercises, and psychological strategies to cope with pain. Researchers wanted to see if it helps reduce pain's imp…

This study tested ozone therapy to treat painful mouth sores caused by radiation and chemotherapy in 58 head and neck cancer patients. Patients received professional ozone treatments at the dental clinic plus ozone-based toothpaste, mouthrinse, and gel to use at home for 15 days.…

This study tested whether using heat or cold packs during childbirth can lessen perineal pain after delivery. 115 women having their first vaginal birth took part. Researchers measured pain levels and healing. The goal was to find a simple, drug-free way to improve comfort after …

This study tested the RONDO 3, a new single-unit audio processor for people with cochlear implants. It includes features like beamforming and noise reduction to help users hear speech in noisy places. Twenty experienced users participated to see if these features improve hearing …

This study tested whether wearing virtual reality (VR) glasses during a leg artery procedure (angioplasty) can lower patients' pain and anxiety. 52 adults having elective angioplasty were randomly assigned to either use VR or standard care. Researchers measured pain and anxiety l…

This study tested whether virtual reality (VR) exposure therapy could reduce anxiety in people with epilepsy who worry about their seizures. Fourteen participants were split into two groups: one received VR therapy using 360-degree videos of social or public settings, and the oth…

This study tested a device that gently vibrates the left ear to stimulate the vagus nerve, aiming to reduce the bother of chronic tinnitus. Forty adults with moderate to severe tinnitus used either the active device or a sham (inactive) device during 8 weeks of online mindfulness…

This study tested a new device called Incremental Velocity Error (IVE) that uses a headband to help retrain the brain's balance system. It compared the device to standard eye and head exercises in 24 adults with dizziness from mild traumatic brain injury or inner-ear nerve damage…

This study tested whether using a virtual reality headset during cancer surgery under local anesthesia can reduce pain and anxiety. 42 adults with cancer were randomly assigned to receive either local anesthesia alone or local anesthesia plus VR. The VR used hypnosis and relaxati…

This study tested whether a small device called TENS, which sends mild electrical pulses to the skin, could reduce leg pain during walking in people with peripheral artery disease (PAD). It also looked at adding a patient education program to encourage more physical activity. The…

This study tested whether using a virtual reality headset is as good as standard equipment for improving balance in people with vertigo. 76 adults with vestibular disorders completed a 3-4 week rehabilitation program. The goal was to see if the cheaper, smaller VR device could ma…

This pilot study tested a virtual reality system called DizzyVR for rehabilitating people with dizziness from inner ear disorders. Ten adults used the system for eight weekly sessions. The goal was to see if it was easy to use, safe, and enjoyable, and to gather early data on whe…

This study looked at whether a special nerve block called PENG can reduce pain when positioning patients with hip fractures for spinal anesthesia. Sixty adults having hip fracture surgery were randomly assigned to receive the block or not. The main goal was to see if the block ma…

This study tested two online programs—cognitive behavioral therapy (CBT) and mindfulness—to help adults cope with the distress caused by tinnitus (ringing in the ears). 67 participants were randomly assigned to one of the two treatments or a waiting list. The goal was to see if t…

This study tested whether adding a nerve block to a standard hematoma block reduces pain better during wrist fracture realignment. 180 adults with displaced wrist fractures were randomly assigned to receive either a hematoma block alone or a hematoma block plus a median nerve blo…

This study looked at whether giving ketamine during anesthesia can reduce the need for morphine and lower pain after breast cancer surgery. About 230 adults having a mastectomy or lumpectomy took part. The goal was to see if ketamine helps avoid morphine's side effects.

This study tested whether using augmented virtual reality (AVR) during chemotherapy can help reduce pain, stress, and anxiety while boosting self-confidence. 150 adult cancer patients in the West Bank were split into two groups: one received standard care, and the other used AVR …

This study tested whether hypnosis or virtual reality can reduce pain during repeated medical procedures like wound dressing. 52 patients received standard pain care, standard care plus hypnosis, or standard care plus virtual reality in a random order. The goal was to see if thes…

This study tested a new virtual reality rehab program for adults with two cochlear implants who struggle to locate where sounds come from. Twelve participants completed 8 sessions over a month, using head movements and joystick feedback to practice sound localization. The goal wa…

This completed study tested an oral form of the painkiller nalbuphine, called PHN131, in 16 healthy adults. The goal was to see how the body absorbs and processes the pill compared to the injected version. Researchers also monitored safety by checking vital signs like blood press…

Researchers are following people with Leber congenital amaurosis caused by RPE65 gene mutations to see how their vision and retinas change over time. The study enrolls children and adults, ages 3 and older, who have this inherited retinal dystrophy. Participants undergo regular e…

Researchers want to know whether a specific brain wave, called mismatch negativity, can serve as a marker for problems locating sound. They will compare three groups: people with normal hearing, people with single-sided deafness, and people with a cochlear implant in one ear. Par…

This study looked at whether adding a brain wave monitor (pEEG) to standard sedation checks helps reduce delirium and time on a breathing machine in ICU patients. Researchers followed 150 adults on ventilators who needed sedation. They compared those who got both the brain monito…

This study follows 61 people who previously used the REVISYON SDS 100 device for mild-to-moderate cataract. Researchers will check for side effects and measure vision changes over about 20 months. No new treatment is given; the goal is to see if the device stays safe and works we…

This completed study followed 26 adults aged 55 and older with early age-related macular degeneration (AMD) or healthy eyes for up to 5 years. Researchers used eye exams, imaging, and vision tests to track changes in the retina and visual function. The goal was to better understa…

Researchers are analyzing records from about 180,000 people who received cochlear implants in China between 1995 and 2026. The study aims to map how severe hearing loss and implant use have changed over time, how age and gender patterns look, and how patients move between provinc…

This completed study looked at how well different eye tests can track changes in retinitis pigmentosa (RP), a group of blinding eye diseases. Researchers tested 49 people with RP and healthy volunteers using exams like vision tests, retinal imaging, and electrical signal recordin…

This study aims to find the genetic causes of hereditary hearing loss and balance disorders. Researchers will study families with these conditions, collecting medical history, blood or cheek swabs, hearing and balance tests, and sometimes scans. The goal is to identify genes and …

This study aims to find the genes that cause inherited hearing loss by analyzing DNA from 24,000 people in large Pakistani families. Researchers will compare affected and unaffected family members to identify new deafness genes. The goal is to improve genetic testing and counseli…

This study looked at how deaf children ages 18 to 60 months learn new words in American Sign Language (ASL). Researchers used eye-tracking and behavior tests to see if kids assume each object has only one sign (mutual exclusivity) or if bilingual deaf children expect two words—on…

This study surveys intensive care unit (ICU) doctors and nurses across Europe and Israel about their understanding of palliative care and local laws regarding end-of-life decisions. The goal is to measure how aware clinicians are of palliative care practices and the legal framewo…

This study surveys 500 adults with chronic tinnitus to understand their preferences about a future brain implant that could ease their symptoms. Participants answer questions about their willingness to undergo surgery, accept risks, and pay for such a device. The results will hel…

This study followed 57 people with age-related macular degeneration (AMD) for up to 5 years to see how their eyes adjust to darkness. Participants had yearly eye exams and dark adaptation tests, where they sat in a dark room and pressed a button when they saw a light. The goal wa…

This study looks at disability claims in Israel from 2018 to 2025 to see if hearing-related disabilities are becoming more common. Researchers will compare general disability claims with work-injury claims and describe the main diagnoses, such as hearing loss, tinnitus, and noise…

This study looks at X-linked juvenile retinoschisis (XLRS), a rare inherited eye disease that causes vision loss in young males. Researchers will examine 351 participants, including affected males and female carriers, using eye exams, retinal photos, and genetic tests. The goal i…

This study collects information from about 889 people with inherited retinal diseases (IRDs) to understand how vision changes over time. Participants have their eyesight and visual field tested regularly. The goal is to learn more about the natural course of these rare eye condit…

This study followed 20 adults aged 55 and older with geographic atrophy, an advanced form of age-related macular degeneration that causes central vision loss. Researchers measured how the damaged area in the eye changed over nearly 4 years using eye exams and photos. The goal was…

This study tested a new way to program cochlear implants in 47 children aged 4 to 12. Instead of the standard method, doctors used CT scans to see exactly where the implant's electrodes sit inside the ear, then turned off any poorly placed ones. The goal was to see if this person…

This observational study explores whether thigh muscle structure can predict pain relief after a genicular nerve block, an injection that blocks pain signals from the knee, in people with chronic knee osteoarthritis. Researchers will measure thigh muscle thickness, fiber length, …

This trial tests whether a specially designed audio-described education program can improve menopause knowledge and reduce symptom severity in visually impaired women. About 46 women aged 40-60 who are members of a blind association will be randomly assigned to receive the progra…

This study aims to measure how common glaucoma is among people aged 50 and older in the Bangkoknoi district of Bangkok, Thailand. Researchers will examine about 1,470 volunteers using standard eye tests and advanced imaging to detect signs of glaucoma and gather normal eye measur…

This study tests whether a 4-hour online training session can improve the self-efficacy of nurses who care for patients receiving palliative care. The training covers pain management strategies and is delivered via Zoom in four 50-minute blocks. Researchers will measure changes i…

This trial explores how the way pain relief options are presented affects what patients choose after wisdom tooth extraction. Adults planning to have one or more third molars removed will use a decision aid that offers either 2 options (non-opioid combo or opioid) or 3 options (n…

This study follows 103 adults with a genetic eye condition called retinitis pigmentosa caused by EYS mutations. Researchers will track changes in vision and eye structure over 4 years. The goal is to better understand how the disease progresses so that future clinical trials can …

This study tests a newer nerve block technique called the erector spinae plane (ESP) block, which involves injecting local anesthetic near the spine to numb the chest or abdominal wall. Healthy volunteers will receive the block with two different doses of lidocaine on separate vi…

This study tests whether a special technology tool can help deaf or hard-of-hearing children ages 3-10 improve their language skills. About 114 children will be randomly assigned to use the tool or continue their usual therapy. Researchers will measure changes in vocabulary, sent…

This trial compares game-based learning—using a digital escape room—to traditional education for teaching pain management to second-year nursing students. Researchers will measure students' knowledge, motivation, and satisfaction right after the lesson and again two weeks later. …

This study tested new ways of stimulating the hearing nerve in 19 adults who already have a cochlear implant. The goal was to see if these new methods could improve how well they hear sounds and understand speech. Researchers adjusted the device settings and measured hearing perf…

This completed study observed 572 patients with neovascular age-related macular degeneration or diabetic macular edema who were already receiving brolucizumab injections. Researchers collected routine medical data to see how well the drug resolved fluid in the eye and improved vi…

This study tests whether a special camera called the OcuMet Beacon can detect stressed cells in the retina of people with geographic atrophy, an advanced form of age-related macular degeneration. Researchers want to see if the patterns of stress match areas of damage seen on stan…

This study looks at immune cell patterns in people with three types of nephrotic syndrome—membranous nephropathy, minimal change disease, and focal segmental glomerulosclerosis. Researchers aim to see if certain immune cells can serve as biomarkers to track how well a patient res…

This study compared two different eye imaging machines (Clarus and Optos) to see how well they measure geographic atrophy, a form of vision loss from age-related macular degeneration. Researchers enrolled 62 patients and took images with each device, then compared the measurement…

This study looks at how a very low dose of LSD (13 micrograms) affects mood and behavior in 48 healthy adults. Some participants will be told exactly what they are getting (LSD or placebo), while others will not know. The goal is to understand whether people's expectations—not ju…

This study investigates whether a quick, painless electrical measurement called transimpedance matrix (TIM) can detect scar tissue (fibrosis) that sometimes forms inside the cochlea after cochlear implant surgery. Researchers will compare TIM results with CT scans in 180 adults w…

This study tests whether an 8-week program combining balance exercises, strength activities, and cognitive tasks (like counting and memory games) can improve how healthy 3- to 6-year-olds walk, balance, and control their impulses. Children are randomly assigned to either the prog…

This study looks at whether a person's expectations before a diagnostic nerve block influence how much pain relief they experience. Researchers will measure pain levels before and after the block and track changes over a week. The goal is to understand the role of expectations in…

This study tests an open-source speech-processing platform, called the Master Hearing Aid, as a wearable hearing aid for people with sensorineural hearing loss. Participants will wear the device in real-world settings and adjust it to their liking, then complete speech perception…

This study looks at what people with age-related macular degeneration (AMD) know about their disease and what they need to manage it better. Researchers will survey and interview 118 patients to understand their knowledge, daily challenges, and support needs. The goal is to use t…

This study aimed to understand why people with cochlear implants vary in how well they understand speech. Researchers measured electrical interactions between the implant's electrodes in 17 adults with hearing loss. They compared these measurements to each person's ability to rec…

This study tested whether virtual reality (VR) training could help deaf and hard-of-hearing students learn vocational skills better than traditional methods. 48 students aged 17-20 with profound hearing loss participated in a 6-week program using 360-degree VR simulations of hote…

This study is testing a new wearable device that uses focused ultrasound to stimulate nerves in the arms and legs. Researchers want to see if it's comfortable and easy to use in 15 healthy adults aged 20-40. Participants will complete nine sessions involving cold water and pressu…

This study looked at how patients view the routine pain checks they receive after planned surgery. Researchers surveyed and interviewed 312 adults to understand whether these checks feel supportive or stressful, and how that affects trust in nurses and willingness to report pain.…

This study looked at how ketorolac, a non-steroidal anti-inflammatory drug (NSAID) used for pain after cesarean delivery, affects platelet function and blood clotting. Researchers measured clotting in 40 women undergoing scheduled C-sections using special blood tests. The goal wa…

This study looked at how low doses of LSD change the way healthy adults make decisions based on what they see. Thirty participants completed computer tasks that tested their ability to predict and respond to visual patterns. The goal was to understand how LSD influences brain sig…

This small study tested whether adding exercise (stationary biking) to standard sensory training could improve sensation and reduce pain after nerve injuries in the arm or hand. Seven adults who had a nerve injury between 2010 and 2025 took part. The goal was to see if this appro…

This study looked at 183 parents of children with hearing impairments to understand how their psychological resilience relates to their disaster preparedness. Parents completed surveys measuring their resilience and how ready they feel for disasters. The goal is to find ways to b…

This study followed 516 older adults in France for 8 years to see how many develop age-related macular degeneration (AMD), a leading cause of blindness. Researchers used eye exams and imaging to track the disease and look for risk factors like genetics and lifestyle. The goal is …

This study looked at how nerve cells in the eye are lost in people with multiple sclerosis (MS) even when there is no active inflammation. Researchers followed 64 adults with relapsing-remitting MS who were already part of a larger study. By using special eye scans over time, the…

This study tested two different methods for programming cochlear implants in 17 adults with hearing loss. The goal was to see if a new, faster fitting method works as well as the standard one for understanding speech in quiet and noisy settings. Results will help improve how impl…

This study examined how vision loss progresses in people with geographic atrophy, an advanced form of dry age-related macular degeneration. Researchers analyzed past medical records and eye images from 60 patients to see which retinal changes are linked to faster vision decline. …

This completed study collected eye images from 1,000 people with intermediate age-related macular degeneration (AMD) to create a detailed database. Researchers will analyze these images to find signs that predict whether the disease will worsen to advanced stages. The goal is to …

This study looked at whether the muscle relaxant tizanidine affects the acoustic reflex, which is your ear's natural way of protecting itself from loud sounds. 48 adults who were already taking tizanidine had their hearing and reflex tested before and after one week of treatment.…

This study tested four different approaches to find and treat eye diseases like cataracts, glaucoma, and diabetic retinopathy in communities in Nepal. Over 87,000 people aged 50 and older took part. The goal was to see which method—comprehensive screening, cataract camps, communi…

This completed study used PET scans to examine brain changes in 20 people with asymmetric hearing loss who received a cochlear implant. Participants performed hearing and voice perception tests while their brain activity was measured. The goal was to understand how the central au…

This study looked at how to improve care for dizzy patients in the emergency department. Over 90,000 adults participated. The goal was to help doctors use proven tests and treatments for common causes of dizziness like BPPV. The study tested new training and tools to make sure pa…

This completed study looked at whether healthcare professionals in Saudi Arabia received and understood safety materials about the epilepsy drug Depakine (sodium valproate). Researchers surveyed 455 doctors, pharmacists, and gynecologists to measure their knowledge and behavior. …

This completed study tested three different intensities of gentle neck movements designed to stimulate the vagus nerve in 128 healthy adults. Researchers measured changes in heart rate, balance, pain sensitivity, and digestion (via stool samples). The goal was to find the best 'd…

This study tested a simple way for adult survivors of childhood cancer to get their hearing checked. Instead of going to a hospital, participants took a hearing test at a local hearing aid shop. The goal was to see if this approach could help more survivors find out if they have …

This study looked at whether hearing and vision loss are linked to delirium (sudden confusion) in older hospital patients. Over 1,500 participants answered screening questions and had their hearing and vision tested. In a smaller trial, researchers tested if posting communication…

This study tested a program designed to improve psychological hardiness (like resilience and commitment) in hard-of-hearing female students in Saudi Arabia. 25 students took part, with some receiving the program and others continuing their usual activities. The goal was to see if…

This study looked at 52 adults with dizziness and balance problems from a one-sided inner ear disorder. Researchers measured how well people functioned before and after a standard balance therapy program. The goal was to see if things like dizziness severity or personal factors c…

This study tested whether an audio-based educational program about puberty could improve self-concept and healthy behaviors in visually impaired teenage girls. Forty-six girls aged 12-18 from two schools in Egypt took part. The program used simple Arabic audio sessions and Braill…

This study collected walking data from 110 healthy children aged 3 to 15 to create a reference database for a new gait index called Ker-EGI Kids. Researchers placed 28 stickers on each child's legs to record muscle activity while they walked. The goal is to establish what normal …

This study looked at proteins in the eye fluid of 100 people with wet age-related macular degeneration (AMD). The goal was to measure certain growth factors that might explain why about 37% of patients do not respond well to standard anti-VEGF injections. Researchers collected a …

This study looked at whether functional MRI (fMRI) can help doctors diagnose Auditory Processing Disorder (APD) in children aged 7 to 18. APD makes it hard for kids to understand sounds even though their ears work normally. Researchers compared brain scans of children with APD, c…

This completed pilot study looked at 46 older adults with Alzheimer's disease to see if age-related hearing loss is linked to trouble finding words. Participants took a computer test to measure word-finding ability and answered a hearing questionnaire. The goal was to better unde…

This study tested French versions of three hearing and quality-of-life questionnaires (PEACH, SSQ-C, SSQ-P) in 101 children and teens aged 1 to 17. The goal was to see if these tools are reliable and accurate for measuring hearing performance and quality of life in French-speakin…

This study looked at why children with hereditary epidermolysis bullosa (a rare condition causing fragile skin and painful blisters) often do not take prescribed opioid painkillers before baths and bandage changes. Researchers interviewed 10 children and their parents to understa…

This study tested whether using real-ear measurements (REM) to fit hearing aids leads to better outcomes than using the manufacturer's default settings. 101 first-time hearing aid users participated. Researchers measured hearing ability, satisfaction, and cost-effectiveness to se…

This study looked at 77 people with Alzheimer's or frontotemporal dementia to understand why some lose awareness of their condition (anosognosia). Researchers used EEG and brain scans to measure how the brain responds to mistakes and emotional signals. The goal is to find brain m…

This study tested a mobile app called OASES that guides nurses and clinical officers in rural Uganda through emergency care steps for severe diarrhea, breathing problems, and seizures. About 15 clinicians used the app during simulated patient scenarios to see if it helped them fo…

This completed study looked at 150 children with severe to profound hearing loss to find how many have a specific genetic form called DFNB9. Researchers collected medical and genetic data from routine care. The goal was to better understand this condition and pave the way for fut…

This study looked at 91 people with a type of bleeding in the eye caused by age-related macular degeneration (AMD). It compared two treatments: surgery followed by anti-VEGF injections, or a gas injection followed by anti-VEGF injections. The goal was to see which approach helps …

This study tested a new method for programming cochlear implants called Focused Multipolar Stimulation (FMS). Researchers compared two ways to set up the implant: one using objective measurements and another based on the user's feedback. The goal was to see which approach helps a…

This study looked at 360,000 French patients who received eye injections for conditions like age-related macular degeneration. The goal was to find out how often a serious eye infection called endophthalmitis happens within 28 days after the injection. Researchers analyzed data f…

This study looked at how the COVID-19 lockdown changed the health habits and medical care of 1,343 people with chronic conditions like heart disease, multiple sclerosis, and hemophilia. Researchers used phone surveys to track medication use, lifestyle changes, and access to healt…

This study looked for early signs of epilepsy in children with autism and tested whether a structured exercise program could influence those signs. Fifty children aged 10-15 with autism, epilepsy, or both took part. Researchers analyzed blood, sleep, brain activity, and thinking …

This study looked at 30 patients with a type of age-related macular degeneration (AMD) to see how treatment affects the barrier between blood and eye fluid. Researchers measured protein levels in the eye fluid before and during anti-angiogenic therapy. The goal was to better unde…

This study collected information from nearly 1,000 people in France with inherited retinal diseases (IRDs) to better understand the genetics behind these conditions. Researchers looked at genetic test results and disease types to help build a national registry. The goal is to imp…

This completed study looked at 72 newborns who had seizures shortly after birth. Researchers measured inflammation markers in their blood and tracked whether they later developed epilepsy. The goal was to understand if inflammation plays a role in epilepsy risk after neonatal sei…

This study asked over 1,000 emergency doctors in Europe what they would prescribe for a patient with sudden belly pain. The patient's race was changed to see if it affected the doctor's choice to give morphine. The goal was to understand if racial bias plays a role in pain manage…

This study checked whether hot air balloon pilots, who are exposed to burner noise and air pressure changes, have more hearing, eustachian tube, or balance problems than other adults. About 105 pilots and non-pilots took part in safe, non-invasive hearing and balance tests. The g…

This study tested two different tablet forms of an experimental pain drug (LTG-001) in 14 healthy adults to see how well each is absorbed. Participants took single doses of each version, and researchers measured drug levels in the blood. The goal was to find which formulation wor…

This completed study looked at how the inner ear responds to sound during and after cochlear implant surgery in 88 participants. Researchers used a noninvasive test called electrocochleography to measure electrical activity in the cochlea. The goal was to see if these measurement…

This study tested a new mobile app feature that helps cochlear implant users measure how loud different sounds feel. Twenty adults with cochlear implants used the app at home and in the clinic. The goal was to see if the app could collect accurate loudness data, which could make …

This study looked at two ways of monitoring wet age-related macular degeneration (AMD) using eye scans: standard OCT B-scans and a newer technique called OCT angiography. The goal was to see if the newer scan could better detect when the disease is active, helping doctors decide …

This study looked at 50 older adults (65+) having major surgery to see if using a computer-controlled sedation method (target-controlled infusion, or TCI) helps protect thinking and memory after the operation. Participants were split into two groups: one received TCI and the othe…

This study looked at whether musical pitch training can improve music appreciation and hearing in people with cochlear implants. 120 teenage and adult implant users took part, with some receiving musical training and others visual training as a comparison. The goal was to underst…

This study tested a device called ANI that measures heart rate changes to assess comfort in patients who cannot speak, such as those in end-of-life care. Twenty non-communicating patients in a palliative care unit were monitored during a painful procedure. The device's readings w…

This study aims to create an algorithm that detects epileptic seizures by continuously analyzing the heart's electrical activity (ECG). Researchers will use data from 40 epilepsy patients who had seizures recorded during long-term video-EEG monitoring. The goal is to see how accu…

This completed study surveyed 250 adults with vestibular disorders (like vertigo) across Belgium, France, and the US. Participants filled out questionnaires about dizziness, anxiety, and thinking problems, while doctors provided routine test results. The goal is to link symptoms …

This study looked at how children aged 8 to 17 with two cochlear implants locate sounds in three-dimensional space. Using virtual reality and motion tracking, researchers measured pointing accuracy and head movements during sound tasks. The goal was to better understand spatial h…

This study aimed to better understand hearing loss by measuring electrical signals from the hearing nerve during brain surgery. Researchers studied 19 patients with normal hearing or hearing loss to see how nerve fibers respond to sound. The goal was to improve a computer model o…

This study looked at 49 adult cochlear implant users to see if electrical measurements from the inner ear can predict the best sound levels for each person. Researchers collected data during surgery and after months of implant use, then compared it to standard hearing tests. The …

This study looked at how the brain processes speech sounds in 25 people with language impairment or hearing loss. Researchers used e-learning games or hearing aids to see if these interventions change brain activity. The goal was to better understand the underlying problems and g…

This completed study looked at whether the sedative ketamine can cause seizure-like brain activity in people without epilepsy. Researchers monitored 300 adults undergoing a routine stomach scope procedure using EEG brain scans. They compared ketamine to two other common sedatives…

This study tested whether French versions of two standard hearing aid benefit questionnaires (IOI-HA and COSI) are accurate and reliable. Researchers enrolled 100 adults with hearing loss who use hearing aids. The goal was to confirm these questionnaires work well in French, so c…

This study tested a new questionnaire designed to measure how well babies (0-36 months old) with eye diseases can see, even before they can talk. The goal was to help doctors decide the best time for surgery. The study included 150 children with different eye conditions and check…

This study looked at whether thinning of the retina (the back part of the eye) can be a sign of Alzheimer's disease. Researchers compared eye scans from 55 people with Alzheimer's, Lewy body disease, and healthy volunteers. The goal was to see if measuring retinal layers could he…

This study tested a mobile app that lets adults with cochlear implants track their hearing difficulties in real-world situations, like noisy restaurants. The goal was to see if the app could collect useful data on how the implant performs outside the clinic. Fifty-one experienced…

This study looked at 10 people with rare genetic conditions that cause very low cholesterol and trouble absorbing vitamins. Researchers measured a protective pigment in the eye called macular pigment, which may be low in these patients and could explain why some still develop vis…

This study looked at 119 children who had platinum-based chemotherapy for certain cancers. Researchers wanted to find out if certain genes make some kids more likely to develop hearing loss from the treatment. By analyzing DNA from saliva samples, they hope to identify high-risk …

This pilot study looked at how distraction (like listening to something) changes walking patterns and pain in people with chronic low back pain. Sixteen participants walked on a treadmill at different speeds, with and without distraction. The goal was to see if distraction could …

This study followed 51 adults who received a wider bone-anchored hearing implant (BIA300) to see how well it stayed in place and worked after 10 years. Researchers measured implant stability and checked for any skin or tissue problems. The goal was to see if the wider design is a…

This study looked at how much lidocaine and ropivacaine stay in the blood when both are used for pain control during major abdominal surgery. It involved 51 adults having open abdominal surgery. The goal was to understand if combining these drugs is safe and how their levels chan…

This study looked at whether it's possible and acceptable to screen for hearing loss in the emergency department (ED). Researchers worked with 133 veterans who had mild hearing trouble to see if using a hearing device helped them communicate with doctors and understand discharge …

This study looked at new ways to measure and train eye movements in 21 people with macular degeneration, a condition that causes central vision loss. The goal was to see if training could help them use their remaining side vision more effectively. The research focused on understa…

This study looked at 470 people with age-related macular degeneration (AMD) to see if special eye scans (SDOCT) can predict vision loss and disease worsening. Participants were already in the AREDS 2 trial and had moderate to high risk of progression. Researchers tracked changes …

This study looked at how COVID-19 infection relates to tinnitus (ringing in the ears). Researchers in Brazil followed 233 people who had COVID-19 between 2020 and 2024, comparing those who developed new tinnitus, those who had it before, and those without it. The goal was to unde…

This study looked at whether telling healthy adults their genetic risk for age-related macular degeneration (AMD) encourages them to eat more carotenoid-rich foods, which are good for eye health. Eighty Caucasian participants aged 18 to 64 without AMD were given genetic risk info…

This study looked at how often people have vision problems after a stroke. Researchers followed 127 stroke patients for 3 months, testing their eyesight and comparing results with brain scans. The goal was to find out how common these issues are and whether a simple vision screen…

This completed study looked at 556 people to understand how night vision problems are connected to early age-related macular degeneration (AMD). Participants took vision tests and had detailed eye imaging. The goal was to find reliable markers that could help design future treatm…

This study looks at how disrupted sleep changes the way common drugs (like painkillers, stimulants, and sedatives) work in the body. Researchers will disturb the sleep of 148 healthy adults in a lab and then measure how their brains respond to these drugs, including pain relief a…

This study looked at whether a person's working memory should influence how hearing aids are set. Researchers tested 42 adults with hearing loss in a lab, adjusting two features: directional microphones and compression. Participants listened to sentences in noise from different d…

This study tested whether personalized risk profiling (including genetic testing) and coaching can motivate people with age-related macular degeneration (AMD) to change their lifestyle. 150 participants received standard lifestyle advice plus supplements, and some also got person…

This study tested a French version of a questionnaire that measures dizziness symptoms in children aged 7 to 17. Researchers asked 85 kids with and without balance issues to fill out the survey twice, two weeks apart. The goal was to see if the translated questionnaire is reliabl…

This study measured the hearing quality of life of 130 children aged 2 to 10 with hearing aids or cochlear implants. Parents filled out a questionnaire called PEACH to rate how well their child hears in quiet and noisy everyday situations. The goal was to understand how different…

This study examined 22 deaf infants under 10 months old to find factors linked to early signs of neurodevelopmental disorders like autism. Researchers filmed psychiatric consultations and used a special scoring system to assess the babies' interaction and movement skills. By comp…

This study followed 50 children who received cochlear implants, measuring their brain's electrical responses to sounds and comparing them with speech and language test results over three years. The goal was to see if certain brain wave patterns could predict how well a child deve…

This study looked at 150 adults who came to the emergency room with sudden low back spasms. Researchers compared those who got only standard pain medication to those who also received physiotherapy, including manual therapy and TENS. The goal was to see if adding physiotherapy im…

This study looked at 20 people with long-term balance problems caused by inner-ear damage. Researchers wanted to see if fast, unconscious eye movements called 'covert saccades' help them see clearly when moving their head. Participants had their eye movements measured during quic…

This study looked at how different channels in a cochlear implant interact and affect a person's ability to understand speech in noisy settings. Researchers tested 28 adults—some with normal hearing and some with cochlear implants—using speech tests and sound masking measurements…

This study tested a new, non-invasive eye scan called OCT angiography to see if it can better detect changes in abnormal blood vessels in people with wet age-related macular degeneration (AMD) who are being treated with Eylea. Researchers followed 49 patients to compare the new s…

This completed study tested whether a virtual reality training program could improve the ability to locate sounds in people with hearing loss. 79 participants performed sound localization tasks with and without visual feedback. The goal was to see if training could reduce pointin…