Perceptual disorders

This trial tests whether the antiviral drug valganciclovir can improve hearing and language outcomes in infants who have hearing loss due to congenital cytomegalovirus (CMV) infection. Infants aged 1 to 12 months with confirmed sensorineural hearing loss will receive either valga…

This early-stage study tests the safety of an experimental drug called RO7669330, given as an injection into the eye, for people with geographic atrophy (GA) due to age-related macular degeneration (AMD). The study involves 27 participants and will monitor side effects and eye he…

This trial asks whether adding an oral statin to the usual steroid treatment can improve recovery from sudden sensorineural hearing loss, a condition where hearing drops rapidly in one ear. Adults diagnosed within 30 days of symptom onset will receive either a statin or a placebo…

This trial tested a computer-based therapy called AmblyoFix for treating lazy eye (amblyopia) in 40 people aged 8 to 19. Participants either used the therapy for 90 minutes daily or wore a standard eye patch. The study was stopped early, and only 4-week data is available, making …

This study tested a drug called vatiquinone in 68 people with mitochondrial disease and epilepsy that doesn't respond to standard treatments. Participants were randomly assigned to receive either vatiquinone or a placebo for 24 weeks to see if the drug could reduce the number of …

This study tested whether BHV-7000, taken alongside other medications, could reduce generalized tonic-clonic seizures in people with idiopathic generalized epilepsy. The trial was terminated early and enrolled only 27 adults aged 18-75. The main goal was to see how long it took f…

This study tested whether the epilepsy drug zonisamide could prevent hearing damage in police officers after shooting range training. Only 3 people enrolled before the study was stopped early. The goal was to see if the drug could reduce hearing loss measured by hearing tests and…

This study tested a single injection of a gene therapy called GT005 in 98 people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes vision loss. The goal was to see if the treatment could slow the growth of damaged areas in the eye and c…

This study tested a single injection of GT005, a gene therapy, in 255 people with geographic atrophy from dry age-related macular degeneration. The goal was to see if it could slow the growth of blind spots in the eye. The trial was terminated early, so we have less data than hop…

This early-stage trial tested a gene therapy called GT005 for dry age-related macular degeneration (AMD), a leading cause of vision loss. The therapy delivers a working gene to the retina via a single injection. The study enrolled 56 people and focused on safety and dosing, but w…

This study tested a gene therapy for retinitis pigmentosa, an inherited eye disease that causes gradual vision loss. The treatment involved injecting a corrected gene under the retina in one eye. The trial included 19 people aged 13 and older with a specific genetic defect. The m…

This study tested whether using a virtual reality headset for one-hour sessions could help regenerate damaged optic nerves and improve vision in people with glaucoma or other retinal diseases. The idea came from promising results in rodents. However, the trial was terminated earl…

This study looked at the long-term safety of an experimental drug called CVL-865 in adults whose focal seizures were not controlled by other medications. About 105 people who completed a previous trial took CVL-865 alongside their usual seizure drugs for up to 57 weeks. The study…

This study looked at whether laser eye surgery (PRK) could improve vision in children aged 2 to 17 with lazy eye (amblyopia) caused by large differences in prescription between eyes or very high nearsightedness, farsightedness, or astigmatism. These children had not improved afte…

This study tested the drug perampanel in adults whose seizures did not stop with standard treatments. The goal was to see if it could safely stop seizures and reduce time in the hospital. Only one person enrolled before the study was ended early, so no clear conclusions can be dr…

This study tested whether lorcaserin, when added to current medications, could reduce convulsive seizures in people with Dravet syndrome, a severe form of epilepsy. The trial planned to enroll about 22 participants aged 2 and older, but it was terminated early. The main goal was …

This Phase 2 study tested an oral drug called danicopan in 365 people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes blind spots. Participants took different doses of danicopan or a placebo for up to 104 weeks to see if it could slow…

This study tests whether a new tool, the VISIODOL® scale, can help people with visual impairment communicate pain. Researchers will compare pain ratings from this scale with those from a standard numerical scale during heat-induced pain. The study includes healthy volunteers with…

This study tested whether a virtual reality headset combined with machine learning can measure pupil reactions more reliably than the standard flashlight test for Relative Afferent Pupillary Defect (RAPD). About 71 adults with and without known RAPD took part. Researchers compare…

This study tested a device called EarGenie that uses light to measure brain activity in babies while they listen to sounds. The goal was to see if it could accurately detect whether infants can hear and tell sounds apart. The trial included 10 normal-hearing babies aged 1-24 mont…

This study aimed to create and validate a screening tool for auditory processing disorder (APD) in children aged 7 to 13. The tool combines a parent and teacher questionnaire with a short set of hearing tests. The goal was to see if it could accurately identify children who need …

This study tested a new device called the CochSyn test prototype, which measures brain responses to sound to detect a type of hidden hearing loss called cochlear synaptopathy. The goal was to see if it could identify hearing problems earlier than standard hearing tests. The study…

This study looked at whether eating corn rich in zeaxanthin (a natural pigment) could increase the density of the macular pigment in the eye, which may help prevent age-related macular degeneration (AMD), a leading cause of blindness. Nine healthy volunteers aged 20-35 ate a dail…

Paramedics in the Netherlands often treat severe pain after trauma with either fentanyl or esketamine, but no one knows if one works as well as the other or if a nasal spray works as well as an IV. The FORE-PAIN trial randomly assigns adults with acute traumatic pain to one of fo…

Researchers at the University of Missouri-Columbia are testing whether warming lidocaine to 98 F makes it work better than room-temperature lidocaine for numbing the eye before intravitreal injections. The study includes 100 people who receive these injections for various eye con…

This study tests whether shining bright blue light on adults with painful rib fractures can reduce pain and inflammation. 75 hospitalized patients will be randomly assigned to receive blue light, white light, or standard hospital lighting for 4 hours each morning for up to 3 days…

This study tested whether synthetic cannabidiol (CBD) could help people living with HIV who have a condition called alexithymia, which makes it hard to recognize and describe emotions. Participants took either CBD or a placebo for 4 weeks. The goal was to see if CBD could improve…

This study looked at whether adding guanfacine (a blood pressure medicine) to morphine could reduce pain sensitivity and tolerance in people with chronic neck or back pain. The study planned to enroll 137 adults who had not taken opioids recently. However, the study was terminate…

This study tests a new way for hearing aids to process soft sounds, aiming to make quiet speech clearer. Sixteen adults with hearing loss will try two different hearing aid settings in a lab and rate which one sounds more natural and understandable. The goal is to improve hearing…

This study looked at whether adding guanfacine to opioid painkillers could reverse the extra pain sensitivity that long-term opioid use can cause. It involved 8 adults with chronic neck or back pain who were already taking opioids. The study was terminated early, so results are l…

This study tested a nasal spray containing a strong painkiller (sufentanil) for adults with sickle cell disease experiencing a painful crisis. The goal was to see if it could provide faster relief than the standard gas mixture (EMONO) before giving morphine through an IV. The tri…

This study tested whether a combination of non-opioid medicines (ketamine, ketorolac, and acetaminophen) can control pain after robotic prostatectomy as well as standard opioid painkillers. Men aged 40-75 with prostate cancer were randomly assigned to receive either opioids or th…

This study looked at whether adding an iPACK nerve block to standard pain treatments (adductor canal block and local injections) helps people feel less pain and recover faster after total knee replacement. Only 10 people were enrolled before the study was stopped early. The goal …

This study looked at whether a special noise reduction feature in Phonak hearing aids helps adults with moderate hearing loss understand speech better in noisy settings. 21 participants tested the Phonak device and a competitor's device in a lab and a real cafe. They completed sp…

This study aimed to see if a combination of pain medicines (multimodal analgesia) works better than standard care for pain after lower back fusion surgery. It included 50 adults aged 18 to 70. The study was stopped early, so results are limited.

This study aimed to find the ideal dose of a spinal pain medicine (hydromorphone) for children undergoing back surgery for scoliosis. Researchers tested several doses in 31 patients to balance good pain control with fewer side effects. The trial was stopped early, so the results …

This study tested a device called CoolStat that is placed in the nose to cool down brain-injured patients with fever in the ICU. The goal was to see if it could safely and quickly bring their temperature to normal. Only 9 patients were enrolled before the study was stopped early,…

This study tested whether adding baclofen (a muscle relaxant) to buprenorphine (a painkiller) could improve pain relief in 19 healthy volunteers. Participants received either a placebo or baclofen alongside buprenorphine and then underwent heat-based pain tests. The trial was ter…

This study aimed to find the best amount of exercise needed to improve dizziness symptoms in people with balance disorders. Researchers used virtual reality (VR) to measure how much exercise helps and compared VR exercises to standard physical therapy. The study included people w…

This study tested whether low level laser therapy (LLLT) could reduce pain and improve hand function in people with hand osteoarthritis. About 83 military members and their families received either real or sham laser treatment weekly for six weeks. The trial was terminated early,…

This phase 2 trial tested whether adding MR-guided radiation to standard chemotherapy could reduce pain in people with metastatic pancreatic cancer. Only 9 participants were enrolled before the study was terminated early. The main goal was to track pain scores over time, but the …

This study looked at whether a single surgery to place a bone-anchored hearing implant is as safe as the usual two-step procedure in children aged 4 to 9. The main goal was to see how many implants were lost. The study was stopped early, so results are limited.

This study tested a system that combines virtual reality (VR) with brain training (neurofeedback) to help people manage chronic back pain without using opioid drugs. Eleven adults with severe back pain took part in up to 20 sessions. Researchers measured how well patients tolerat…

This study tested a cannabidiol (CBD) oral solution in children under 2 years old with tuberous sclerosis complex, Dravet syndrome, or Lennox-Gastaut syndrome who had uncontrolled seizures. The goal was to see if CBD is safe and can reduce seizures. However, the study was termina…

This study follows people with geographic atrophy, a severe form of age-related macular degeneration that causes blind spots, to see how their vision changes over time. Researchers will measure visual function, such as reading speed and sensitivity to light, and track the growth …

This study looked at people with cone disorders, a type of inherited eye disease that affects color vision and sharp sight. Researchers analyzed genetic changes of unknown significance to see if they cause disease. The goal was to improve genetic diagnosis, not to test a treatmen…

This study tested how well adults with a NeuroZti cochlear implant could hear and how satisfied they were with two different sound processors: the current Neu2 and a newer Nuc8. Four participants attended a single 3-hour visit to compare speech understanding at normal and soft vo…

This study tested a new, non-invasive eye imaging method called hyperspectral imaging. It takes pictures of the back of the eye using many different colors of light to find details not visible with standard cameras. About 679 adults with healthy eyes or eye diseases like diabetic…

This study looked at whether measuring a protein called S100B in the blood right after a first seizure could help predict if someone will have more seizures within a year. The researchers planned to follow 37 adults for one year, but the study was stopped early. The goal was to f…

This study followed 7 people with Mucolipidosis Type IV (MLIV) to learn how the disease naturally progresses. Researchers used tests like neuropsychological exams, blood and urine tests, and brain MRIs to find better ways to measure the disease. The goal was to improve future cli…

This small pilot study tested whether a wearable device called BioButton could help detect walking problems caused by multiple medications in nursing home residents. Only 17 people took part before the study was stopped early. The goal was to see if the device was safe and easy t…

This study looked at whether people born with cytomegalovirus (CMV) infection who have hearing loss or balance problems also have a condition called endolymphatic hydrops (fluid buildup in the inner ear). Researchers used a special MRI scan with a contrast dye to check for this f…

This study looked at over 100 people with inherited retinal dystrophies, a group of rare eye diseases that can cause vision loss. Researchers collected genetic and eye exam data to find links between specific gene mutations and symptoms. The goal was to better understand these di…

This study looked at why a common numbing shot for knee surgery works so well. Doctors used ultrasound to see if the medicine spreads to nerves behind the knee. The goal was to measure how often this spread happens in 30 adults having knee surgery. The study was stopped early, bu…

This study looked at whether a brain wave test called mismatch negativity (MMN) can measure how well adult cochlear implant users can tell apart similar sounds. Researchers compared the brain wave results to a standard hearing test using made-up words (logatoms). The goal was to …