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Gene therapy trial for dry AMD halted early

NCT ID NCT03846193

First seen Feb 02, 2026 · Last updated Jun 18, 2026 · Updated 15 times

Summary

This study tested a single injection of GT005 gene therapy in 56 people with dry age-related macular degeneration (AMD), a leading cause of vision loss. The goal was to check safety and whether it could slow disease progression. The trial was terminated early, so results are limited, but it aimed to control the disease rather than cure it.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Bristol Eye Hospital

    Bristol, United Kingdom

  • Cincinnati Eye Institute

    Cincinnati, Ohio, 45242, United States

  • Manchester Eye Hospital

    Manchester, United Kingdom

  • Mid-Atlantic Retina

    Philadelphia, Pennsylvania, 19107, United States

  • Midwest Eye Institute

    Indianapolis, Indiana, 46290, United States

  • Moorfields Eye Hospital

    London, United Kingdom

  • Ophthalamic Consultants of Boston (OCB)

    Boston, Massachusetts, 02114, United States

  • Oxford University Hospital

    Oxford, United Kingdom

  • Pepose Vision Institute

    Chesterfield, Missouri, 63017, United States

  • Retina Clinic London

    London, W1G 7LA, United Kingdom

  • Sierra Eye Associates

    Reno, Nevada, 89502, United States

  • Sunderland Eye Infirmary

    Sunderland, United Kingdom

  • Wolfe Eye Clinic

    West Des Moines, Iowa, 50266, United States

Conditions

The condition(s) this trial relates to.

age-related macular degeneration dry age related macular degeneration eye disorder Geographic Atrophy macular degeneration primary anetoderma retinal degeneration retinal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.