EYE DISEASES

This study tests an experimental drug called sepofarsen in people with a rare genetic eye disease (LCA10) that causes severe vision loss from childhood. The drug is injected into one eye, while the other eye gets a placebo, to see if it can improve vision safely. About 32 partici…

This study tests two different surgical techniques for people who need repeat eyelid surgery for trichiasis, a condition where eyelashes grow inward and scratch the eye. About 1,000 adults in Tanzania will receive either the standard procedure or a newer technique called B-RAP. T…

This study tests whether giving a laser treatment (transscleral cyclophotocoagulation) to lower eye pressure before a Boston keratoprosthesis (a plastic cornea implant) can prevent or slow glaucoma. Twenty adults who need the implant will receive one of two laser types 4-8 weeks …

This study tests whether dapagliflozin, a drug used for diabetes, can slow the progression of geographic atrophy—an advanced form of dry age-related macular degeneration that causes blind spots. About 70 adults aged 50 and older with non-foveal geographic atrophy will take the dr…

This study tests a new handheld device that automatically aligns to take detailed pictures of the back of the eye (retina) in adults and children. Researchers want to see if it can help detect eye diseases like glaucoma and retinal problems. About 50 volunteers and patients will …

This study compares a technology-enhanced eye screening to a standard eye exam for detecting three leading causes of blindness: glaucoma, diabetic retinopathy, and cataracts. About 900 adults from a health center will participate. The goal is to see if the faster telemedicine app…

This study tests whether TRYPTYR, an eye drop, can improve quality of life and work ability in adults with chronic dry eye who are not satisfied with their current treatment (Restasis). About 40 participants will use TRYPTYR for one month and complete questionnaires about their s…

This study tests whether adding a surgical procedure to standard anti-VEGF injections can help people with wet age-related macular degeneration who have a bleed under the retina see better. About 210 adults aged 50 and older will be randomly assigned to get either injections alon…

This study helps doctors at the National Eye Institute examine people with eye diseases to see if they can join other research studies. No treatment is offered. People of all ages with various eye conditions, including genetic disorders, may take part. Tests include eye exams, bl…

This study aims to identify the normal bacteria living on the surface of the eye and how they differ in people with certain eye conditions. Researchers will collect samples from 500 adults with healthy eyes, mild glaucoma, or non-infectious corneal disease. The goal is to build a…

This study tests a special imaging technique called adaptive optics to take super-detailed pictures of the retina. Researchers hope this can help find eye diseases earlier, before serious damage occurs. Up to 1,000 people aged 12 and older, with or without eye disease, will parti…

This study follows 45 adults with retinitis pigmentosa caused by EYS gene mutations to learn how the disease naturally changes over 4 years. Researchers will measure vision and eye function to find the best ways to track the disease in future treatment trials. The goal is to help…

This study tests a new widefield eye camera (WiSLO) designed to be more comfortable for children and infants. Researchers will compare WiSLO images and user satisfaction with a standard commercial camera in 42 participants, including healthy adults and children with or without ey…