EYE DISEASES

This study is testing if a daily pill called dapagliflozin, already used for diabetes, can slow the progression of an advanced form of age-related macular degeneration (AMD) called geographic atrophy (GA). About 70 adults with GA will take either the drug or a placebo for one yea…

This study is for people with a severe eye bleed caused by wet age-related macular degeneration (AMD). It compares the current standard treatment (eye injections) against the same injections plus a surgical procedure. The surgery aims to physically remove the blood clot from the …

This study is testing whether regular eye injections of an experimental drug called sepofarsen can improve vision in people with a specific genetic form of Leber congenital amaurosis (LCA), which causes severe vision loss from childhood. In this carefully designed trial, each par…

This study is testing whether a telemedicine approach can detect serious eye diseases as effectively as traditional in-person eye exams. Researchers will compare detection rates for glaucoma, diabetic retinopathy, and cataracts in 900 patients at community health centers. The goa…

This study is testing a new handheld eye scanner designed to be more comfortable, especially for children and babies, than current devices. Researchers will compare images from the new scanner to a standard camera in about 42 participants, including both healthy volunteers and pe…

This study is testing a new, easier-to-use version of a handheld eye scanner. The goal is to see if its automatic alignment feature can take clear pictures of the back of the eye (retina) in both adults and children. Researchers will enroll 50 volunteers and patients to see how w…

This study is testing whether a recently approved eye drop called TRYPTYR can improve the quality of life and ability to work for adults with chronic dry eye disease. It will enroll 40 participants whose dry eye symptoms significantly interfere with their work. The main goal is t…

This study aims to create a map of the normal bacteria and other microbes that live on the surface of the eye. Researchers will enroll 500 adults, including people with healthy eyes and those with common eye conditions like glaucoma and macular degeneration. By comparing samples,…

This study aims to understand how vision declines over time in adults with a specific genetic form of retinitis pigmentosa (RP) caused by mutations in the EYS gene. Researchers will follow 45 participants for four years, using detailed eye exams to measure changes in their vision…

This study is testing a new, very detailed camera system called adaptive optics to take pictures of the retina at the back of the eye. Researchers want to see if these super-clear images can help doctors find and understand eye diseases much earlier than is currently possible. Th…

This National Eye Institute study screens people with various eye conditions to determine if they qualify for other research studies. Participants undergo eye exams, vision tests, and other evaluations, but receive no treatment through this study. The goal is to match people with…