EYE DISEASES

This study tests whether a laser treatment given before a Boston keratoprosthesis (a special plastic cornea implant) can help control eye pressure and prevent glaucoma damage. Twenty adults who need the cornea implant will receive one of two types of laser treatment 4 to 8 weeks …

This study tests two different surgical techniques for people who need repeat eyelid surgery for trichiasis, a condition where eyelashes grow inward and scratch the eye. Researchers will enroll 1,000 participants in Tanzania and compare a newer method (B-RAP) with the standard on…

This study tests an investigational drug called sepofarsen in people with Leber congenital amaurosis (LCA), a rare genetic eye disease that causes severe vision loss from birth. The trial includes 32 participants aged 6 and older who have a specific mutation in the CEP290 gene. E…

This study tests whether dapagliflozin, a drug used for diabetes, can slow the progression of geographic atrophy—an advanced form of dry age-related macular degeneration that causes blind spots. About 70 adults aged 50 and older with non-foveal geographic atrophy will take the dr…

This study is testing a new handheld device that automatically aligns to take detailed pictures of the back of the eye (retina) in adults and children. Researchers want to see if it can help detect eye diseases like glaucoma and retinal problems. About 50 volunteers and patients …

This study compares a technology-enhanced eye exam done remotely (telemedicine) with a standard in-person eye exam to see which detects three leading causes of blindness—glaucoma, diabetic retinopathy, and cataracts—more effectively. About 900 adults who speak English, Spanish, A…

This study tests whether adding a surgical procedure to standard anti-VEGF injections can help people with wet age-related macular degeneration who have a bleed under the retina see better. About 210 adults aged 50 and older will be randomly assigned to get either injections alon…

This study tests whether a treatment called TRYPTYR can improve quality of life and work performance in adults with chronic dry eye. Participants have had dry eye for at least 6 months, currently use Restasis but are unhappy with its results, and have symptoms that affect their d…

This study follows 45 adults with retinitis pigmentosa caused by EYS gene mutations to understand how their vision changes over four years. Researchers will measure things like visual field and retinal function to find the best tests for future treatment trials. Participants must…

This study tests a special camera called adaptive optics to take detailed pictures of the retina, the light-sensitive part at the back of the eye. Researchers want to see if this method can find eye diseases earlier than standard exams. About 1,000 people aged 12 and older, inclu…

This study aims to identify the normal bacteria living on the eye's surface and how they change in people with eye diseases like glaucoma or dry eye. Researchers will collect samples from 500 adults in Tennessee, including those with healthy eyes and those with specific eye condi…

This study helps doctors at the National Eye Institute examine people with eye diseases to see if they can join other research studies. No treatment is given here. People of all ages with various eye conditions may take part. Tests include eye exams, blood tests, and imaging to e…

This study tests a new, more comfortable eye camera (WiSLO) for children and adults with or without eye disease. Researchers want to see if it takes better pictures and is more comfortable than current cameras. About 42 participants will have their eyes imaged with both the new a…