EYE DISEASES

This early-stage study tested the safety of a new drug called VP-001, given as an injection into the eye, for people with a rare genetic eye disease (PRPF31 mutation) that causes vision loss. Six participants aged 12 and older received multiple doses. The main goal was to check f…

This phase 3 study tested the long-term safety of LNZ101 eye drops, a combination of aceclidine and brimonidine, in 362 adults aged 45-75 with presbyopia (age-related blurry near vision). Participants used the drops regularly and were monitored for side effects. The study is comp…

This study tested a new type of artificial lens (PODEYE TORIC) for people having cataract surgery who also have astigmatism, a condition where the eye is shaped like a football instead of a basketball. 261 adults received either the new lens or a standard lens to see if it safely…

This study tested whether a steroid eye drop (fluorometholone) given for four weeks after trachoma surgery could stop eyelashes from growing back and rubbing against the eye. Over 2,400 people aged 15 and older took part. The goal was to see if this simple, low-cost addition to s…

This study tested a new medicine called LASN01 in 41 adults with thyroid eye disease, a condition that causes eye bulging and discomfort. The goal was to see if LASN01 could safely reduce eye bulging compared to a placebo. Participants received either LASN01 or a dummy treatment …

This study tested whether a high-resolution eye scan called SD-OCT can diagnose glaucoma more accurately than standard methods. Researchers compared 109 people with and without glaucoma using the scan. The goal was to see if this technology could catch the disease earlier, before…

This study tested whether a nurse-assisted online eye screening app (Easee) is cost-effective for older adults receiving home healthcare. 234 participants aged 65+ used the app with a nurse's help to check their vision. The goal was to see if this approach reduces eye complaints …

This completed trial tested whether large language models (AI chatbots) can diagnose eye diseases like cataracts and glaucoma. Researchers compared the diagnostic accuracy of several AI models against real ophthalmologists using patient complaints and eye images from 2000 partici…

This study tested an eye drop called LNZ101 to help people with presbyopia (age-related trouble seeing up close) read without glasses. 469 adults aged 45-75 received the drops, and researchers measured how many gained clear near vision without losing distance vision on the first …

This Phase 3 trial tested LNZ101 eye drops in 229 people aged 45-75 with presbyopia, a condition that makes it hard to see up close. The drops combine aceclidine and brimonidine to temporarily improve near vision. The main goal was to see if participants could read three lines be…

This study used a special eye camera (adaptive optics) to look at blood vessel inflammation in the retina of 50 people with multiple sclerosis (MS) and healthy volunteers. The goal was to see if this inflammation differs between MS types and could serve as an early marker of dise…

This early-phase study at Stanford looked at how a nutritional supplement called alpha-ketoglutarate is absorbed into the eyes when taken orally. Seventeen adults with age-related eye diseases participated. The main goal was to measure changes in the supplement's level in eye flu…

This study looked at whether the amount of propofol (anesthesia medicine) in a child's breath matches the amount in their blood during eye surgery. 32 children took part, and the researchers compared breath measurements with blood samples and brain activity. The goal was to see i…

This study tested a new questionnaire designed to measure how well babies (0-36 months old) with eye diseases can see, even before they can talk. The goal was to help doctors decide the best time for surgery. The study included 150 children with different eye conditions and check…