New surgery trial aims to restore vision after macular bleeding

NCT ID NCT04663750

Recruiting now Disease control Sponsor: King's College Hospital NHS Trust Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase 3 trial tests whether adding surgery (vitrectomy, clot-busting drug, and gas bubble) to standard anti-VEGF injections can improve vision more than injections alone for people with a macular bleed from wet AMD. About 210 participants across Europe will be randomly assigned to one of the two treatments. The main goal is to see if more patients gain at least 10 letters on an eye chart after 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: aflibercept (anti-VEGF injection) and alteplase (tissue plasminogen activator)
What this could lead to: If successful, this could offer a new treatment option that improves vision recovery after a macular bleed in wet AMD.
What could go wrong: This is a surgical trial with added risks from the procedure, and it is still recruiting. The benefit over standard injections alone is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

eye disorder wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EYE DISEASES MACULAR DEGENERATION, WET SUB-MACULAR HEMORRHAGE

Contacts and locations

Locations

Augenzentrum am St. Franziskus-Hospital Münster
RECRUITING

Münster, Germany
Barts Health NHST trust - Whipps Cross University Hospital
RECRUITING

London, E11 1NR, United Kingdom
Belfast Health and Social Care Trust
RECRUITING

Belfast, BT9 7AB, United Kingdom
Bristol Eye Hospital
RECRUITING

Bristol, BS1 2LX, United Kingdom
Gartnavel General Hospital
WITHDRAWN

Glasgow, United Kingdom
Hull Royal Infirmary
RECRUITING

Hull, Yorkshire, HU3 2JZ, United Kingdom
Imperial College Healthcare NHS Foundation Trust (The Western Eye Hospital)
RECRUITING

London, NW1 5QH, United Kingdom
James Cook University Hospital, (South Tees NHSFT)
RECRUITING

Middlesbrough, United Kingdom
Kent & Canterbury Hospital (East Kent University)
RECRUITING

Canterbury, Kent, CT1 3 NG, United Kingdom
King's College Hospital NHS Foundation Trust
RECRUITING

London, London, SE5 9RS, United Kingdom
Knappschaft Kliniken Saar GmbH, Sulzbach
RECRUITING

Sulzbach, Germany
Leicester Royal Infirmary
RECRUITING

Leicester, United Kingdom
Ludwig Maximilians-University München
RECRUITING

München, Germany
Maidstone and Tunbridge Wells NHS Trust
RECRUITING

Maidstone, ME16 9QQ, United Kingdom
Manchester Royal Eye Hospital
RECRUITING

Manchester, United Kingdom
Mid and South Essex NHS Foundation Trust
RECRUITING

Chelmsford, Essex, CM1 7ET, United Kingdom
Moorfields Eye Hospital
RECRUITING

London, EC1V 2PD, United Kingdom
New Cross Hosp, Royal Wolverhampton NHST
RECRUITING

Wolverhampton, United Kingdom
Nottingham University Hospitals
RECRUITING

Nottingham, United Kingdom
Ophthalmology Clinic Jasne Błonia
RECRUITING

Lodz, Poland
Oxford University Hospitals NHS Foundation Trust
RECRUITING

Oxford, OX3 9DU, United Kingdom
Royal Devon and Exeter Hospital
RECRUITING

Exeter, United Kingdom
Royal Liverpool University Hospital
RECRUITING

Liverpool, L7 8 XP, United Kingdom
Royal Victoria Infirmary
RECRUITING

Newcastle upon Tyne, NE1 4LP, United Kingdom
Sunderland Eye Infimary
RECRUITING

Sunderland, Tyne and Wear, SR2 9HP, United Kingdom
The Institute of Eye Surgery
RECRUITING

Waterford, Ireland
The Princess Alexandra Eye Pavilion
RECRUITING

Edinburgh, Scotlan, EH3 9HA, United Kingdom
Torbay and South Devon NHS
RECRUITING

Torquay, TQ2 7AA, United Kingdom
Ulm University Hospital
RECRUITING

Ulm, Germany
University Hospital Bern
RECRUITING

Bern, Switzerland
University Hospital Southampton NHS foundation Trust
RECRUITING

Southampton, SO16 6YD, United Kingdom
University Hospitals Plymouth NHST
RECRUITING

Plymouth, United Kingdom
University Hospitals Sussex NHS Trust
WITHDRAWN

Brighton, United Kingdom
University Medical Center Hamburg Eppendorf
RECRUITING

Hamburg, Germany
University hospital of Würzburg
RECRUITING

Würzburg, Germany
University of Bonn
RECRUITING

Bonn, Germany

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