New surgery trial aims to restore vision after macular bleeding
NCT ID NCT04663750
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase 3 trial tests whether adding surgery (vitrectomy, clot-busting drug, and gas bubble) to standard anti-VEGF injections can improve vision more than injections alone for people with a macular bleed from wet AMD. About 210 participants across Europe will be randomly assigned to one of the two treatments. The main goal is to see if more patients gain at least 10 letters on an eye chart after 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
aflibercept (anti-VEGF injection) and alteplase (tissue plasminogen activator)
What this could lead to
If successful, this could offer a new treatment option that improves vision recovery after a macular bleed in wet AMD.
What could go wrong
This is a surgical trial with added risks from the procedure, and it is still recruiting. The benefit over standard injections alone is not yet proven.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for EYE DISEASES are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Augenzentrum am St. Franziskus-Hospital Münster
RECRUITINGMünster, Germany
Contact
-
Barts Health NHST trust - Whipps Cross University Hospital
RECRUITINGLondon, E11 1NR, United Kingdom
Contact
-
Belfast Health and Social Care Trust
RECRUITINGBelfast, BT9 7AB, United Kingdom
Contact
-
Bristol Eye Hospital
RECRUITINGBristol, BS1 2LX, United Kingdom
Contact
-
Gartnavel General Hospital
WITHDRAWNGlasgow, United Kingdom
-
Hull Royal Infirmary
RECRUITINGHull, Yorkshire, HU3 2JZ, United Kingdom
Contact
-
Imperial College Healthcare NHS Foundation Trust (The Western Eye Hospital)
RECRUITINGLondon, NW1 5QH, United Kingdom
Contact
-
James Cook University Hospital, (South Tees NHSFT)
RECRUITINGMiddlesbrough, United Kingdom
Contact
-
Kent & Canterbury Hospital (East Kent University)
RECRUITINGCanterbury, Kent, CT1 3 NG, United Kingdom
Contact
-
King's College Hospital NHS Foundation Trust
RECRUITINGLondon, London, SE5 9RS, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-••••
Contact
-
Knappschaft Kliniken Saar GmbH, Sulzbach
RECRUITINGSulzbach, Germany
Contact
-
Leicester Royal Infirmary
RECRUITINGLeicester, United Kingdom
Contact
-
Ludwig Maximilians-University München
RECRUITINGMünchen, Germany
Contact
-
Maidstone and Tunbridge Wells NHS Trust
RECRUITINGMaidstone, ME16 9QQ, United Kingdom
Contact
-
Manchester Royal Eye Hospital
RECRUITINGManchester, United Kingdom
Contact
-
Mid and South Essex NHS Foundation Trust
RECRUITINGChelmsford, Essex, CM1 7ET, United Kingdom
Contact
-
Moorfields Eye Hospital
RECRUITINGLondon, EC1V 2PD, United Kingdom
Contact
-
New Cross Hosp, Royal Wolverhampton NHST
RECRUITINGWolverhampton, United Kingdom
Contact
-
Nottingham University Hospitals
RECRUITINGNottingham, United Kingdom
Contact
-
Ophthalmology Clinic Jasne Błonia
RECRUITINGLodz, Poland
Contact
-
Oxford University Hospitals NHS Foundation Trust
RECRUITINGOxford, OX3 9DU, United Kingdom
Contact
-
Royal Devon and Exeter Hospital
RECRUITINGExeter, United Kingdom
Contact
-
Royal Liverpool University Hospital
RECRUITINGLiverpool, L7 8 XP, United Kingdom
Contact
-
Royal Victoria Infirmary
RECRUITINGNewcastle upon Tyne, NE1 4LP, United Kingdom
Contact
-
Sunderland Eye Infimary
RECRUITINGSunderland, Tyne and Wear, SR2 9HP, United Kingdom
Contact
-
The Institute of Eye Surgery
RECRUITINGWaterford, Ireland
Contact
-
The Princess Alexandra Eye Pavilion
RECRUITINGEdinburgh, Scotlan, EH3 9HA, United Kingdom
Contact
-
Torbay and South Devon NHS
RECRUITINGTorquay, TQ2 7AA, United Kingdom
Contact
-
Ulm University Hospital
RECRUITINGUlm, Germany
Contact
-
University Hospital Bern
RECRUITINGBern, Switzerland
Contact
-
University Hospital Southampton NHS foundation Trust
RECRUITINGSouthampton, SO16 6YD, United Kingdom
Contact
-
University Hospitals Plymouth NHST
RECRUITINGPlymouth, United Kingdom
Contact
-
University Hospitals Sussex NHS Trust
WITHDRAWNBrighton, United Kingdom
-
University Medical Center Hamburg Eppendorf
RECRUITINGHamburg, Germany
Contact
-
University hospital of Würzburg
RECRUITINGWürzburg, Germany
Contact
-
University of Bonn
RECRUITINGBonn, Germany
Contact