RETINAL DEGENERATION

This study tests whether metformin, a pill used for diabetes, can safely slow vision loss in people with ABCA4 retinopathy (including Stargardt disease). About 56 participants aged 12 and older will take metformin daily for 24 months. Researchers will measure changes in the retin…

This study tests a new treatment called OpCT-001 for people with inherited eye diseases like retinitis pigmentosa and Usher syndrome, which cause vision loss. The treatment involves injecting special cells into the eye to replace damaged light-sensing cells. The study has two par…

This study tests an investigational drug called VP-001, given as an eye injection, for people with a rare genetic form of retinitis pigmentosa caused by PRPF31 mutations. The goal is to see if it is safe and can help slow vision loss. The trial involves 16 adults who have already…

This study tests whether dapagliflozin, a drug used for diabetes, can slow the progression of geographic atrophy—an advanced form of dry age-related macular degeneration that causes blind spots. About 70 adults aged 50 and older with non-foveal geographic atrophy will take the dr…

This study looks at how well people see in the dark to learn more about retinal diseases like retinitis pigmentosa and Stargardt's disease. Researchers will compare healthy volunteers and people with retinal disease to see if dark adaptation tests can detect and track disease sev…

This study collects skin, hair, blood, saliva, or urine samples from people with certain eye diseases (like macular degeneration) and healthy volunteers. Researchers will turn these cells into stem cells in the lab to study how the diseases develop and to test potential new drugs…

This study uses special high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures that regular eye exams miss, which could help doctors better understand eye diseases. About 1,200 people with various eye conditions or healthy …