Perceptual disorders

This early-phase trial tests a single injection of ASP2020, stem cells turned into retinal cells, placed under the retina in people with Stargardt disease or similar inherited macular dystrophies. The main goal is to check safety and tolerability, while also looking for signs tha…

This trial tests a gene therapy called SPVN20, given as a single injection into the eye, for people with advanced rod-cone dystrophy, a genetic condition that causes progressive vision loss. The study includes adults with a confirmed genetic diagnosis and some remaining cone cell…

This study tests a new gene therapy called DB-OTO for children with hearing loss caused by changes in the otoferlin gene. The treatment is injected into the inner ear to help restore hearing. Up to 30 children and infants will take part to check safety and how well it works.

This study tests an oral drug called STL303 for geographic atrophy, a form of dry age-related macular degeneration that causes a blind spot in central vision. About 300 adults aged 60 and older will receive either STL303 or a placebo pill for up to 2 years. The goal is to see if …

This study tests a refillable eye implant (Port Delivery System) that slowly releases the drug ranibizumab to treat wet age-related macular degeneration. The implant is refilled every 36 weeks, potentially reducing the need for frequent eye injections. About 250 participants who …

This study tests a single injection into the eye of a new drug (SAR446597) for people with geographic atrophy, a progressive form of age-related macular degeneration that causes vision loss. About 104 participants aged 60 and older will be followed for 2 years, with an optional 3…

This study tests a gene therapy called ATSN-201 in males aged 6 and older with X-linked retinoschisis, a genetic eye condition that leads to vision loss. The therapy delivers a working copy of the RS1 gene to the retina. The trial has three parts: first, finding the right dose; s…

This Phase 3 trial tests an oral drug called gildeuretinol acetate (ALK 001) in 230 people aged 8 to 45 with Stargardt disease, a genetic condition that causes progressive vision loss. Participants take the drug or a placebo daily for 24 months. The goal is to see if the drug can…

This trial tests whether adding a mild electrical brain stimulation to augmented reality-based vision therapy can improve vision in adults aged 18 to 35 with lazy eye (anisometropic amblyopia). Participants will use special augmented reality glasses that encourage both eyes to wo…

Researchers are testing a new treatment called PAL-222 for people with neovascular age-related macular degeneration (AMD) whose disease has not responded to existing therapies. The study will enroll up to 10 adults aged 18 to 85 with this condition. Each participant will have a s…

This study tests a new medicine called tiespectus (EYE201) for wet age-related macular degeneration, a leading cause of vision loss. About 960 people will receive either tiespectus or the standard treatment aflibercept via eye injections. The goal is to see if tiespectus can impr…

This phase 3 trial tests two injectable drugs, pozelimab and cemdisiran, alone or together, to slow the growth of geographic atrophy—an advanced form of dry age-related macular degeneration that causes central vision loss. About 975 participants will receive either the drugs or a…

This early-stage trial tests a new oral drug called OCT-980 for people with a specific inherited eye disease (autosomal dominant retinitis pigmentosa) that causes gradual vision loss and blindness. The study first gives a single dose to healthy volunteers to check safety, then mu…

This phase 3 trial tests whether a new drug called ABP 938 works as well as the approved treatment Eylea HD for wet age-related macular degeneration, a leading cause of vision loss. About 304 people aged 50 and older with untreated wet AMD will receive injections of either drug i…

About one in four children with seizures does not respond well to standard treatments. This study collects data from people whose doctors have prescribed the ketogenic diet, a high-fat, low-carbohydrate regimen, to see how it affects brain electrical activity and metabolism. Rese…

Researchers are testing a new eye drop called NT-101 in people with wet age-related macular degeneration, a condition where abnormal blood vessels leak fluid into the retina and damage central vision. The trial enrolls 66 adults aged 50 and older who have active leaking vessels u…

This study tests a gene therapy called ABBV-RGX-314 for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The goal is to see if a single treatment can reduce the need for frequent eye injections while keeping vision stable. About 561 adults a…

This study tests whether clemizole HCl (EPX-100) can safely reduce seizures when added to current treatments for Lennox-Gastaut syndrome, a severe form of epilepsy. About 260 children and adults aged 2 to 55 will receive either the drug or a placebo. The main goal is to measure c…

This study tests an experimental drug called EPX-100 (clemizole) in 150 children and adults with Dravet syndrome, a severe form of epilepsy. The goal is to see if adding EPX-100 to current treatments can safely reduce the number of motor seizures. Participants will be randomly as…

This study tests a cell therapy called OpRegen for people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes blind spots. About 60 participants will receive a one-time injection of retinal cells under the retina during eye surgery. The m…

This study follows people who already received an eye injection of JNJ-81201887 or a sham in earlier studies for geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. The goal is to check long-term safety, including side effects and eye …

This phase 3 trial tests whether adding surgery (vitrectomy, clot-busting drug, and gas bubble) to standard anti-VEGF injections can improve vision more than injections alone for people with a macular bleed from wet AMD. About 210 participants across Europe will be randomly assig…

This study tests an experimental drug called ONL1204, given as an eye injection, to see if it can slow the growth of blind spots in people with geographic atrophy, an advanced form of dry age-related macular degeneration. About 324 adults aged 55 and older will receive either the…

This Phase 2 trial tests FWY003, an experimental drug, in 272 people with geographic atrophy (a form of advanced age-related macular degeneration). The goal is to see if different doses can slow the growth of damaged areas in the eye and preserve vision. Participants receive eith…

This study follows 1,500 adults with focal-onset seizures who take eslicarbazepine as part of their normal care. Researchers track changes in seizure frequency, quality of life, and side effects over three months. Participants include people newly diagnosed and those switching fr…

This Phase 2 trial tests an experimental drug called EYE103 (Restoret) in 160 people with wet age-related macular degeneration or macular edema from a branch retinal vein occlusion. Participants receive three eye injections of either a low or high dose of EYE103, spaced four week…

This early-stage study tests a stem cell therapy called ASP7317 for people with geographic atrophy, the advanced form of dry age-related macular degeneration that causes central vision loss. The treatment involves injecting special cells under the retina to replace damaged ones. …

This study tests an experimental drug called ADX-038 in 240 people with geographic atrophy, a form of advanced age-related macular degeneration that causes blind spots. The drug is given as a shot under the skin and is compared to a placebo to see if it can slow the loss of a key…

This early-phase trial tests a new gene therapy called VG801 for Stargardt disease, a genetic condition that causes vision loss. Fifteen people aged 6 and older will receive a single injection under the retina. The main goal is to check safety, but researchers will also measure a…

This study will test a newer bone conduction implant, the Osia system, against an older one, the Baha Connect system, in 20 adults with mixed or conductive hearing loss. Participants already have a Baha implant and will switch to the Osia system. Researchers will measure speech u…

This phase 3 study tests whether an investigational drug called RAP-219 can safely reduce the number of focal seizures in adults with epilepsy. About 312 participants will take either a low or medium dose of RAP-219 or a placebo pill daily. The main goal is to see if the drug low…

This study tests whether photobiomodulation (PBM), a light-based therapy delivered by the Valeda system, can safely improve vision in people with dry age-related macular degeneration (AMD). Researchers will collect data from 500 participants in routine clinical practice across Eu…

This study is testing a refillable eye implant that delivers the drug ranibizumab to treat wet age-related macular degeneration (AMD). The main goal is to see if the implant affects the cells on the inner surface of the cornea. About 188 people with wet AMD will receive the impla…

This trial tests whether nursing home residents who become acutely ill can be safely assessed and treated at home by municipal acute care teams, with remote consultation from a senior hospital physician, instead of being sent to the hospital. Participating nursing homes are rando…

This study follows people with wet age-related macular degeneration who received an injection of SKG0106, an experimental gene therapy, in an earlier trial. Researchers will track their eye health, vision, and any side effects for up to 5 years after the injection. The goal is to…

This trial tests two standard steroid treatments for sudden sensorineural hearing loss, a condition where hearing drops quickly, often in one ear. One group takes methylprednisolone pills daily for two weeks, while the other receives dexamethasone injections into the middle ear e…

This study tests an experimental drug called RAP-219 in 333 adults with focal seizures (a type of epilepsy). The goal is to see if the drug safely reduces how often seizures happen compared to a placebo. Participants must be 18-75, have had focal epilepsy for at least 2 years, an…

This study is checking the long-term safety of a small implant placed in the eye that slowly releases medicine to treat wet age-related macular degeneration, a condition that can cause rapid vision loss. About 1,000 people who have already used the implant in earlier studies will…

This trial tests whether a structured home-based exercise and education program, added to standard care, can improve quality of life and reduce leg symptoms in adults with chronic venous insufficiency—a condition where leg veins struggle to return blood to the heart. Around 120 p…

This phase 1/2 trial tests SKG0106, a gene therapy injected into the eye, in people with wet age-related macular degeneration (nAMD). The treatment aims to help the eye produce proteins that block abnormal blood vessel growth, potentially reducing the need for frequent anti-VEGF …

This study looks at whether removing a brain tumor and the nearby area where seizures start can help people with tumor-related epilepsy. About 100 people aged 8 and older with brain tumors and seizures will have surgery and be followed for up to a year. The goal is to see if seiz…

This study tests an auditory brainstem implant in 20 children who are deaf because they are missing the inner ear or the nerve that carries sound to the brain. The device is surgically placed to stimulate the brainstem directly, bypassing the missing parts. Researchers will monit…

This early-stage trial tests a new gene therapy called SKY-GJB2 for children aged 9 months to 7 years with hearing loss caused by changes in the GJB2 gene. The therapy is given as a single injection into the inner ear using a special delivery device. The study will enroll 10 chil…

This program offers an experimental treatment called OCU400 to up to 75 adults with retinitis pigmentosa (RP) who cannot join the main Phase 3 study. Participants must be 18 or older, have a confirmed genetic diagnosis of RP (except a specific mutation), and have remaining light-…

This study tests a device that delivers tiny electrical pulses through the eyelid to the back of the eye. The goal is to see if it can safely slow vision loss or improve sight in people with intermediate to advanced dry age-related macular degeneration. One hundred participants w…

This study tests whether dapagliflozin, a drug used for diabetes, can slow the progression of geographic atrophy—an advanced form of dry age-related macular degeneration that causes blind spots. About 70 adults aged 50 and older with this condition will take the drug for 12 month…

This study tests whether the drug BHV-7000 can safely reduce seizures in adults with focal epilepsy that hasn't improved with other treatments. About 390 participants will receive either the drug or a placebo. The main goal is to see if the drug lowers the number of seizures per …

This study tests whether GAL-101 eye drops can slow the growth of geographic atrophy, a form of advanced age-related macular degeneration that causes blind spots. About 110 adults aged 55 and older with early-stage atrophy will use the drops or a placebo daily for up to two years…

This study tests a new treatment called OpCT-001 for people with inherited eye diseases that damage the retina, such as retinitis pigmentosa. The treatment involves injecting special photoreceptor cells, made from stem cells, into the back of the eye to replace lost cells. The tr…

This study tests a device called PRIMA, which is implanted under the retina to help people with inherited retinal diseases like Stargardt disease and retinitis pigmentosa see better. The trial will enroll 5 adults with severe central vision loss and measure improvements in visual…

This Phase 3 trial tests whether privosegtor, a neuroprotective drug, can improve vision recovery in people having their first episode of optic neuritis. About 210 adults aged 18 to 50 will receive either privosegtor or a placebo, both alongside standard steroid treatment. The ma…

This study tests a new gene therapy (VV-14295) given as an injection into the eye for people with geographic atrophy, a form of advanced dry age-related macular degeneration that causes blind spots. The goal is to see if it is safe and can slow the growth of these blind spots. Ab…

This study looks at two ways to treat Lennox-Gastaut syndrome (LGS), a severe form of childhood epilepsy: adding more anti-seizure medications or undergoing palliative surgery (like a vagus nerve stimulator or corpus callosotomy). Researchers will track thousands of children acro…

This study tests a new drug called tiespectus (MK-8748) against the current standard treatment, aflibercept, for people with wet age-related macular degeneration (AMD). About 960 participants will receive injections into the eye and be followed for a year to see if tiespectus can…

This study looks at what happens when people with epilepsy who have been seizure-free for at least two years stop one of their antiseizure medications. The goal is to see if coming off the drug improves quality of life and reduces side effects, without greatly increasing the risk…

This early-stage study tests an experimental drug called pozelimab, given as an injection into the eye, for people with geographic atrophy (GA) — a condition where parts of the retina stop working, leading to vision loss. The main goal is to check the drug's safety and tolerabili…

This study is testing a new type of cochlear implant that is completely hidden under the skin, with no visible parts outside the ear. It is for adults with severe hearing loss due to inner ear or nerve damage. The goal is to see if the implant helps people understand speech bette…

This early-stage trial tests whether adding the drug valproate to standard patching therapy can improve vision in children aged 8 to 17 with lazy eye (amblyopia). Participants will take valproate or a placebo daily for 8 weeks while patching the stronger eye. The study aims to se…

This study tests a gene therapy called AAVB-039 for Stargardt disease, an inherited condition that causes vision loss. About 75 adults with a specific gene mutation will receive a single injection under the retina. The main goal is to check safety, but researchers will also measu…

After a cardiac arrest, some patients develop seizures that do not respond to standard treatment. This trial tests whether putting the brain into a deeper state of electrical silence — called burst suppression — can stop those seizures better than the usual approach of only suppr…

This study tests if a device that delivers mild electrical pulses to the eye (transcorneal electrical stimulation) can safely slow the progression of geographic atrophy, an advanced form of age-related macular degeneration that causes vision loss. About 70 people aged 60 and olde…

This phase 4 trial will test the drug faricimab (Vabysmo) in 64 people with wet age-related macular degeneration (AMD). Participants will receive eye injections every 4 weeks for 4 doses, then a treat-and-extend schedule based on disease activity. The study also measures biomarke…

This phase 3 study tests a single injection of Ixo-vec gene therapy against standard aflibercept injections in 284 people with wet AMD. The goal is to see if Ixo-vec can maintain or improve vision while reducing the need for repeated eye injections. Participants must be at least …

This study tests a telemonitoring device called ANTALGEEK® that helps people manage acute pain at home after outpatient surgery. The device tracks pain levels and guides medication use, aiming to improve recovery and lower the risk of chronic pain. About 150 adults having surgery…

This study is testing an experimental device called a vestibular implant, which is surgically placed behind the ear to stimulate the balance nerve. The goal is to see if it can improve walking and balance in adults with long-term dizziness that hasn't improved with other treatmen…

This early-stage trial tests a new medicine called EYC-0305, given as an eye injection every 24 weeks, in 30 people aged 50 and older with wet age-related macular degeneration (AMD). The main goal is to check if the treatment is safe and tolerable. Researchers will also measure h…

This study tests whether programming a cochlear implant based on each person's unique inner ear structure improves hearing compared to the standard one-size-fits-all approach. Adults with severe to profound hearing loss who already have a MED-EL cochlear implant will receive both…

This study is checking the long-term safety of an implant called OTX-TKI (axitinib) for people with wet age-related macular degeneration (AMD). The implant is placed in the eye and slowly releases medicine to control the disease. About 850 people who already completed two years o…

This study tests whether injecting a person's own bone marrow stem cells into or near the eye can help treat various retinal and optic nerve diseases, including age-related macular degeneration, retinitis pigmentosa, and glaucoma. Participants receive stem cell injections via dif…

This study is testing whether a cochlear implant is safe and effective for infants and toddlers who are deaf in one ear. Sixty children will receive the implant and be followed until age 5. Researchers will compare their hearing abilities to children with normal hearing and to th…

This study looks at switching people with wet age-related macular degeneration (AMD) to a higher dose (8 mg) of the drug aflibercept. The goal is to see if it can extend the time between eye injections while still controlling the disease. Researchers will compare injection interv…

This phase 3 trial tests an experimental drug called sepofarsen in 32 people with Leber congenital amaurosis (LCA), a rare genetic condition that causes severe vision loss from birth. The drug is injected into one eye, while the other eye gets a placebo, to see if it safely impro…

This study looks at 100 people with wet age-related macular degeneration (AMD) who have been getting regular eye injections with older drugs. They will switch to a newer drug called faricimab. The goal is to see if faricimab can extend the time between injections, meaning fewer t…

This study tests a single injection of CTx001 gene therapy into the eye for people with geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. The trial involves 75 participants and will monitor safety and whether the treatment can slow d…

This study tests a gene therapy called ZVS203e for people with retinitis pigmentosa caused by a specific RHO gene mutation. The therapy is injected into the eye and uses a harmless virus to deliver a gene-editing tool. The trial includes 18 adults and will check safety and whethe…

This Phase 2 trial tests an experimental drug called KIO-301, injected into the eye, for people with late-stage retinitis pigmentosa who have little or no light perception. The study will give up to three doses over several weeks to 36 participants to see if it is safe and can im…

This trial tests an investigational drug called DX243 in people with mild to moderate age-related hearing loss. Participants receive daily injections of DX243 or a placebo for 29 days. The study checks whether the drug is safe and whether it improves hearing, using speech-in-nois…

This study tests a one-time injection of lab-grown nerve cells (NRTX-1001) into the brain for people with a specific type of epilepsy that doesn't respond to medication. The cells are designed to release a calming chemical called GABA to quiet overactive brain signals. Researcher…

This study tests a nurse-led program called BEST CARE ICTUS_HC for adults hospitalized with acute stroke in hospitals without specialized stroke units. The program includes staff training, swallowing tests, and environmental adaptations to help with attention and safety. Research…

This early-stage trial is testing a brain implant designed to create artificial vision in people who are blind. Five participants will have a wireless device surgically placed in the part of the brain that processes vision. The study will check if the device is safe and whether i…

This study tests an experimental device called the Tinnitus Implant System for adults with moderate to severe chronic tinnitus. The implant is placed behind the ear and sends electrical signals to the hearing nerve. Researchers will measure how much tinnitus loudness changes over…

This study tests an oral drug called sparsentan in 67 children with certain kidney diseases that cause protein to leak into urine. The goal is to see if the drug safely reduces protein levels over 108 weeks. Participants must have a certain level of kidney function to join.

This study tests whether a purine-rich diet can lower disease markers in people with AICA-ribosiduria, a rare genetic condition causing severe disability and epilepsy. Ten participants will follow a diet with 160 mg of purines per day. Early results in one patient showed promise,…

This pilot study is testing a brain implant that uses tiny electrodes to stimulate the visual cortex, aiming to create simple visual perceptions (phosphenes) in blind individuals. Five participants will undergo a small skull opening to receive the implant. The goal is to see if t…

This study tests whether a single injection of dexamethasone-loaded exosomes into the ear can improve hearing recovery better than standard steroid injections in adults with sudden sensorineural hearing loss. About 30 participants who did not improve with oral steroids will be ra…

This Phase 3 trial tests a single injection of 4D-150, a gene therapy, in 480 adults with wet age-related macular degeneration (AMD). The goal is to see if one treatment can maintain or improve vision and reduce the need for standard anti-VEGF injections like Eylea. Participants …

This early-stage trial tests a gene therapy called ZVS106e for Stargardt disease, a genetic condition that causes vision loss. Nine participants will receive a single injection of the drug under their retina. The main goal is to check safety over 52 weeks, not yet to prove it wor…

This early-stage trial tests a single injection of a gene therapy called RTx-021 in the eye of people with Stargardt disease, a genetic condition that causes vision loss. Up to 18 participants will receive different doses to check safety and tolerability. Researchers will monitor…

This early-stage trial tests the safety of a new drug called ZM-02, given as an injection into one eye, in 12 adults with retinitis pigmentosa—a genetic condition that causes gradual vision loss. The main goal is to check for side effects, not to cure the disease. Researchers wil…

This early-stage trial tests a gene therapy called OPGx-BEST1 for two rare inherited eye diseases that cause vision loss. About 10 adults will receive a single injection into one eye to see if it is safe and to find the best dose. The study will follow participants for 5 years to…

This Phase IIb trial tests a retinal implant (CPCB-RPE1) in 24 people with advanced dry age-related macular degeneration (geographic atrophy). Participants are randomly assigned to receive the implant or a sham procedure. The study measures changes in retinal sensitivity and visu…

This study tests a small telescope-like implant called SING IMT™ for people with advanced age-related macular degeneration (AMD) who have poor central vision in both eyes. The device is placed inside the eye during surgery, either replacing or sitting in front of the existing len…

This study tests whether wearing the right glasses can improve vision in adults with amblyopia (lazy eye). Researchers will measure how well participants see before, during, and after wearing custom spectacles. The goal is to see if the adult brain can still learn to see better w…

This study tests whether clemastine fumarate, a drug originally approved for allergies, can help repair nerve damage in people with acute optic neuritis (inflammation of the optic nerve). About 90 participants will receive either clemastine or a placebo for 9 months. Researchers …

This Phase 3 trial tests faricimab (Vabysmo) in 50 people with a type of age-related macular degeneration called polypoidal choroidal vasculopathy (PCV). The goal is to see if a personalized treat-and-extend schedule can keep the eye healthy while allowing longer breaks between i…

This study looks at how well a higher dose (8mg) of the drug Aflibercept (Eylea) works in the first two months for people with wet age-related macular degeneration, a leading cause of vision loss. Researchers will track fluid changes in the retina and vision improvements in 50 pa…

This study compares two common procedures—CSF shunting and dural venous sinus stenting—to see which better preserves vision in adults with idiopathic intracranial hypertension (IIH) who are at risk of permanent sight loss. About 80 participants will be randomly assigned to one of…

This study tests whether playing special video games or watching movies through a virtual reality headset can improve vision in children aged 8 to 12 with amblyopia (lazy eye). About 252 kids will be randomly assigned to use one of two VR treatments or just wear glasses. The main…

This study looks at the best way to treat lazy eye (amblyopia) in children aged 3 to under 13. Some children get glasses and an eye patch at the same time, while others start with glasses alone and add patching later if needed. The goal is to see if both approaches lead to simila…

This phase 3 trial tests whether brain tumor patients who have been seizure-free for 6 months on levetiracetam can safely stop the drug earlier than the standard 2-3 years. 604 adults with primary brain tumors and controlled seizures will be randomly assigned to stop levetiraceta…

This study tests whether watching specially designed movies through a virtual reality headset for 1 hour a day, 6 days a week, can improve vision in children with lazy eye (amblyopia) as effectively as the standard treatment of wearing an eye patch for 2 hours daily. The trial in…

This study follows 300 deaf patients of all ages who receive cochlear implants, tracking their hearing, speech, and quality of life over time. Researchers aim to see how different age groups and treatment types respond, to personalize rehabilitation. Participants must have severe…

This study tests whether an oral drug called dimethyl fumarate (Tecfidera) can safely slow the growth of geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. About 90 adults aged 55–85 with geographic atrophy will take the drug for 12 m…

This study tests whether high-dose atorvastatin (a statin drug) can improve vision in people with intermediate age-related macular degeneration (AMD). Researchers will measure how quickly participants' eyes adjust to darkness and track changes in fatty deposits (drusen) in the re…

This study tests whether using a real-time hearing monitoring technique called ECochG during cochlear implant surgery helps preserve natural hearing and inner ear structure better than standard surgery. About 102 adults with severe-to-profound hearing loss will be randomly assign…

This study tests whether taking krill oil capsules daily for 3 months can reduce drusen (fatty deposits) in the eyes of people with early or intermediate dry age-related macular degeneration (AMD). 24 adults will receive either krill oil or a placebo. The main goal is to see if t…

This study tests the long-term safety and effectiveness of a drug called SPN-817 in adults with focal onset seizures (a type of epilepsy). About 100 people who completed a previous SPN-817 study will take the drug for one year. Researchers will track side effects and measure chan…

This study tests whether faricimab (Vabysmo) injections given every 12-16 weeks can maintain stability in people with wet age-related macular degeneration (AMD) after an initial series of loading doses. The trial will enroll 40 adults over 50 with active wet AMD. The main goal is…

This pilot study is testing whether injections of a substance made from umbilical cord blood (called CB-PRP) can slow the progression of dry age-related macular degeneration (AMD), a common cause of vision loss in older adults. The study will enroll 36 people aged 65 and older wi…

This study tests whether injecting a special blood product from umbilical cords into the eye can slow vision loss in people with dry age-related macular degeneration (AMD). The trial will involve 36 participants aged 65 and older with bilateral dry AMD. One eye will receive the i…

This study is testing a small device that fits in the ear to detect seizures by measuring brain waves. Researchers will first test it on 5 healthy people, then on 10 people with epilepsy who are already scheduled for a standard scalp EEG. The goal is to see if the in-ear device i…

Researchers at Gødstrup Hospital are studying whether balance and dizziness problems in young children come from the inner ear's balance system. The study includes 30 children aged 6 months to 10 years who have delayed gross motor development or dizziness and balance issues. Chil…

Researchers are studying how often children with sensorineural hearing loss also have problems with their balance system. The study enrolls 48 children aged 3 to 10 with hearing loss in one or both ears. Children complete questionnaires and a series of balance and inner-ear tests…

This study evaluates PathFinder 1.0, a software that analyzes OCT images of the retina to detect macular abnormalities such as epiretinal membrane, dry age-related macular degeneration, and other retinal conditions. About 400 adults with and without macular issues will undergo st…

This study is testing a home-based eye-tracking system called AVIGA to see if it can detect when wet age-related macular degeneration (AMD) comes back. Sixty adults aged 50-99 who are being treated for wet AMD will use the AVIGA device at home, and its accuracy will be compared t…

This study looks at whether a new set of international criteria can accurately diagnose optic neuritis—a condition that causes sudden vision loss—in Chinese patients. Researchers will enroll 500 people with acute or subacute vision loss and compare the criteria's results against …

This study is testing a new device called TES HT100 that uses low-power electromagnetic waves to screen for brain injuries in adults coming to the emergency room with mild head trauma or certain neurological symptoms. The device is non-invasive, takes about 5 minutes, and gives a…

This study looks at whether a special brain wave monitor (EEG) can help doctors choose the right amount of sedation medicine for children who need a brain MRI. About 50 children under 5 years old (or older children who have trouble staying still) will receive a standard low dose …

This study compares a technology-enhanced eye exam to a standard optometric exam for detecting three leading causes of blindness: glaucoma, diabetic retinopathy, and cataracts. About 900 adults at a Federally Qualified Health Center will be randomly assigned to one of the two exa…

This study is testing a wearable device that sits on the ears and uses sensors to detect and predict seizures in people with epilepsy. The device records brain, muscle, and eye activity, along with heart rate and skin signals. It will be compared to standard hospital EEG monitori…

This study tests whether the seizure drug levetiracetam (Keppra) can prevent first-time seizures in people with brain metastases located in the motor cortex. About 150 adults who have never had a seizure will be randomly assigned to take the drug or receive standard care. The goa…

This phase 3 trial tests whether two different eye treatments can prevent vision loss in people who have had radiation therapy for a type of eye cancer called uveal melanoma. The study will compare faricimab injections given every 3 months, a fluocinolone acetonide implant placed…

This study tests whether using hearing aids and related support can help slow memory decline in adults aged 55-75 who have mild to moderate hearing loss and early signs of memory problems. Participants are randomly assigned to receive either a hearing intervention or a health edu…

After a cardiac arrest, many survivors develop seizures that can worsen brain injury. This trial tests whether giving the drug perampanel soon after resuscitation can prevent those seizures. About 52 adults who are comatose after a cardiac arrest will receive either perampanel or…

This study tests whether eating goji berries five days a week for six months can lower the risk of age-related macular degeneration (AMD) in people aged 65 to 95. Participants will eat 14 grams of goji berries or a fiber supplement and have their eye health, gut bacteria, and oth…

This trial tests whether a community-based screening program using advanced eye imaging (OCT, fundus photography, and pressure checks) can prevent vision loss from age-related macular degeneration, diabetic retinopathy, and glaucoma better than simple vision tests alone. About 60…

This study tests if the drug levetiracetam can prevent epileptic seizures in 120 adults over 40 with Down syndrome and Alzheimer's disease. Participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop seizures and possibly slow brai…

This study tests whether injecting a special gel (sodium thiosulfate) into the ear before each round of cisplatin chemotherapy can prevent hearing loss. About 100 adults with head and neck cancer will receive the gel in one ear only, so the treated ear can be compared to the untr…

Researchers at University Hospital, Toulouse are studying how adults with profound deafness in one ear and usable hearing in the other learn to understand speech after receiving a cochlear implant. The trial compares two training programs: listening with the implant alone versus …

This study tests whether adding dexmedetomidine or dexamethasone to a standard numbing medicine (bupivacaine) can improve pain control after thyroid removal. Sixty adults undergoing total thyroidectomy will receive one of the two combinations via an ultrasound-guided nerve block.…

Small fiber neuropathy damages tiny nerve fibers, causing severe pain that often resists standard painkillers. This trial tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive technique that sends magnetic pulses to specific brain regions, can reduce t…

This study tests whether a gentle, non-invasive ultrasound treatment can reduce or stop seizure activity in people with a severe type of ongoing seizure called status epilepticus that hasn't improved with standard medications. Ten participants in the ICU will receive a 10-minute …

This study tests a speech therapy called DTTC-Connect for children aged 3 to 12 with childhood apraxia of speech, a disorder that makes it hard to say words clearly. The therapy focuses on helping children move from saying single words to speaking in phrases. Sixty-eight children…

Researchers in Denmark are testing whether people with hearing aids can fine-tune them remotely using a smartphone app instead of visiting a clinic. The trial enrolls 120 adults with hearing loss who are comfortable using smartphones. Participants are randomly assigned to either …

Researchers are testing whether a home-based augmented reality therapy can improve vision in adults with anisometropic amblyopia, a type of lazy eye. Participants use a mixed-reality headset during daily activities, with the image to the stronger eye dimmed to encourage the weake…

Researchers are testing whether a multidisciplinary vision rehabilitation programme improves quality of life more than low vision training alone for adults with visual impairment. The trial enrolls 1,000 Cantonese-speaking adults in Hong Kong aged 18 to 80 who have a clinical dia…

Researchers test whether the location used to pull out the appendix (near the belly button versus the lower left abdomen) and numbing medicine injected into the small incisions change pain after laparoscopic appendectomy. Adults with acute appendicitis having emergency surgery jo…

This study tests three treatments—a nerve block (SPB), Botox, and capsaicin—to see which works best for chronic nerve pain after mastectomy. 123 women whose pain is not controlled by standard medicines will be randomly assigned to one of the three groups. The main goal is to meas…

This pilot study tests whether a device called IVS3 is tolerable and easy to use for arm recovery in people who had a stroke at least 6 months ago. The device uses mirrored video to create the illusion that the affected arm is moving. Researchers will track how many sessions part…

Researchers are testing whether adding a sacral submultifidus nerve block to a standard image-guided sacroiliac joint injection eases chronic low back pain better than the joint injection alone. The study enrolls 54 adults with long-lasting sacroiliac joint pain that has not resp…

This study looks at whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration (like macular degeneration or retinitis pigmentosa). Researchers believe it may calm overactive cells in the retina. The study involves …

This early study tests a device that uses low-intensity focused ultrasound to calm overactive brain areas in people with drug-resistant temporal lobe epilepsy. Eight adults will receive up to three 10-minute ultrasound sessions. Researchers will track side effects and check if se…

Researchers at Georgetown University are testing whether a mild electrical brain stimulation called transcranial random noise stimulation (tRNS) can boost the effects of visual training in people who have lost part of their vision from brain damage. The study includes 30 adults w…

This study compares two pain relief methods for people undergoing total knee replacement: injecting numbing medicine into the knee area versus blocking several nerves around the knee. The goal is to see which method reduces the need for strong painkillers like opioids in the firs…

Researchers are testing whether four weeks of intensive motor speech therapy can improve speech accuracy in children who have childhood apraxia of speech along with a rare genetic condition. The study enrolls up to 20 children aged 3 to 16. Each child receives 12 sessions of eith…

This study will test whether a 4-week daily music therapy app can reduce chronic pain and improve quality of life in 25 youth with sickle cell disease. Participants will either use the app or receive standard educational materials. Researchers will also look at changes in immune …

Researchers at the University of Rochester are testing a home-based computer program that trains people to detect visual stimuli in their blind field. The trial enrolls adults who have lost part of their vision because of damage to the brain's visual cortex, often from a stroke. …

Children having corrective heart surgery through a chest incision often need strong pain medicine. This trial compares two ultrasound-guided nerve blocks, a parasternal intercostal plane block and an erector spinae plane block, both using a mix of bupivacaine and lidocaine. All c…

Researchers are testing a device called the Pedal Pump, which pumps both feet for 10 minutes to mobilize the body and improve lymphatic flow. The trial enrolls 30 hospitalized patients with lower extremity edema caused by heart failure, chronic venous insufficiency, kidney diseas…

This study tests whether adding lidocaine, a numbing medicine, to standard pain treatment can lower the amount of strong opioids needed during severe sickle cell pain crises. About 104 adults with sickle cell disease who are in the intensive care unit for a pain crisis will take …

This study tests a device called SWAN that guides people through head movements to reduce motion sickness and improve balance. It is for adults with inner ear disorders, motion sickness, or those recovering from vestibular schwannoma surgery. Participants use the device at home f…

This study tests whether phentolamine eye drops can improve vision in low light for people who had laser eye surgery and now see glare, halos, or starbursts at night. About 200 adults will use the drops or a placebo every evening for two weeks. The main goal is to see if more peo…

This study compares two types of nerve blocks—coeliac plexus block and splanchnic nerve block—to see which one reduces pain better in adults with upper abdominal cancer. Forty-four participants will receive one of the procedures and be monitored for pain, opioid use, and quality …

This trial compares two injection sites for steroid shots in people with moderate-to-severe knee osteoarthritis. Participants get the injection on either the inside or outside of the knee, then report pain and function over 12 weeks. The goal is to see if one spot provides better…

This study compares opioid-free anesthesia to standard opioid anesthesia in 200 adults undergoing pancreatic surgery. The goal is to see if avoiding opioids during surgery can still control pain well and reduce the need for painkillers afterward. Participants will have their pain…

This study looks at whether over-the-counter hearing aids can improve communication for older adults with mild cognitive impairment and mild to moderate hearing loss. Fifty participants and their communication partners will be randomly assigned to try hearing aids first or receiv…

This study tests two types of nerve blocks—anterior iliopsoas space block and PENG block—to see which helps patients with hip fractures get into position for spinal anesthesia more easily and with less pain. About 90 adults undergoing hip surgery will receive one of the blocks be…

This study compares opioid-free anesthesia to standard opioid-based anesthesia for people having laparoscopic pancreatic surgery. The goal is to see if avoiding opioids leads to less pain and lower opioid use after surgery. Two hundred adults aged 18-80 will take part, and resear…

This study tests whether combining a gentle brain stimulation technique (tDCS) with repetitive arm and hand exercises can help people who have neglect after a stroke. Neglect means they have trouble paying attention to one side of their body or space. The study also aims to combi…

This study tests whether injecting a mix of hyaluronic acid and fibrinogen into the knee can reduce pain and improve function in people with knee osteoarthritis. About 31 adults aged 45 to 75 will receive the injection as part of routine care. Researchers will track changes in pa…

This study tests whether low-dose radiotherapy can reduce pain in people with knee osteoarthritis. 128 participants will receive either real radiation or a sham treatment three times a week for two weeks. Researchers will track pain scores and painkiller use for six months to see…

This study tests whether adding regional anesthesia, such as nerve blocks, to standard pain treatment can reduce opioid use and pain after pelvic or acetabular fracture surgery. Adults undergoing surgery for these fractures may receive ultrasound-guided nerve blocks with a long-a…

This study tests whether atorvastatin, a widely used cholesterol medication, can reduce hearing loss caused by cisplatin chemotherapy in people with head and neck cancer. About 224 adults will be randomly assigned to take atorvastatin or a placebo daily during and for three month…

This study is testing whether a low dose of ketamine, given alongside standard pain medicine, can better control severe pain from sickle cell disease in children and young adults aged 5 to 20. Participants will receive either ketamine or a placebo infusion, and researchers will m…

This study tests whether hearing aids can improve quality of life in cancer patients who develop hearing loss from platinum-based chemotherapy. Fifty-two adults currently on such chemotherapy and with confirmed hearing loss will be randomly assigned to receive a hearing aid or st…

This trial tests a personalized program called TIHA for adults with autism who find everyday sounds painfully loud, a condition known as loudness hyperacusis. The program combines counseling, safe sound management, and gradual exposure to therapeutic sounds. Researchers will rand…

This study tests a new nerve block called the External Oblique Intercostal Plane Block (EOIB) to see if it reduces pain and the need for opioids after major upper abdominal surgery. 78 adults having laparoscopic surgery on the stomach, liver, gallbladder, or pancreas will be rand…

This study tests whether wearing a virtual reality headset with calming scenes and hypnotic speech can lower pain and anxiety during minimally invasive leg artery surgery done under local anesthesia. About 90 adults with peripheral artery disease will take part. The main goal is …

This study looks at whether special posture exercises or a wearable sensor can help improve mild vision problems in university students with forward head posture. 72 participants will be split into three groups to compare different training methods. The goal is to see if correcti…

This trial asks whether adding morphine to spinal anesthesia or using an ultrasound-guided nerve block provides better pain control after hip surgery. Sixty-four adults having hip replacement or hip fracture surgery will be randomly assigned to one of the two methods. Researchers…

This trial tests whether a technique called neurofeedback can help people with bothersome tinnitus. Using real-time brain scans, participants learn to adjust the activity of brain networks linked to emotion and cognition, with the goal of reducing tinnitus-related distress. The s…

This study tests a new Bluetooth Low Energy Audio feature in Nucleus 8 and Kanso 3 sound processors for cochlear implants. Twenty experienced adult users will try wireless microphones at home and in the lab to see if they can hear speech better in noisy places like classrooms. Th…

This study tests a new cognitive behavioral therapy called ReACT for children aged 9-18 with psychogenic non-epileptic seizures (PNES) — episodes that look like seizures but have no physical cause. The therapy focuses on helping kids feel more in control and less afraid of their …

This study investigates whether listening to self-selected music during breast surgery can reduce the amount of propofol, an anesthesia drug, needed. Participants are randomly assigned to either listen to music through headphones during surgery and recovery or receive standard ca…

This study tests whether a special ultrasound-guided nerve block can lower the amount of strong painkillers (opioids) needed after breast reduction surgery. About 80 women will be randomly assigned to receive either standard pain treatment alone or standard treatment plus the ner…

This trial asks whether an intravenous dose of magnesium sulfate can relieve acute non-traumatic headaches—such as migraines, tension-type, or cluster headaches—more effectively than the standard painkiller paracetamol. Adults arriving at the emergency department with moderate to…

This trial compares two ultrasound-guided nerve block techniques for pain control after total hip replacement surgery. One technique, the QLESP block, uses a single injection to target two areas, while the other combines two blocks (PENG and LFCN) to target nerves around the hip …

This study tests whether a robotic baby seal named PARO can reduce pain and anxiety in children aged 1 to 7 during a common but stressful procedure: placing an IV line. About 120 children will either receive standard care alone or standard care plus the robot. Researchers will me…

This trial tests whether simple distractions—blowing a pinwheel, watching a 3D hologram of butterflies, or chewing sugar-free gum—can reduce pain and fear in children aged 5 to 10 during a blood draw. About 164 children will be randomly assigned to one of these three activities o…

This study looks at whether adding a Whole Health Coach to standard pain management teams helps veterans with chronic pain feel better and use opioids more safely. About 432 veterans will work with a coach to set personal health goals and learn self-management strategies. The mai…

This study tests the long-term safety of rimegepant, a migraine medication taken as a dissolving tablet, in children and adolescents aged 6 to 18. About 600 participants with a history of migraine will take the drug as needed for up to one year. The main goal is to check for side…

This study tests new speech-enhancement software in cochlear implants to help adults with hearing loss understand speech better in noisy places. About 150 adult cochlear implant users will compare the new algorithms to the standard ones. The goal is to see if the new software imp…

This study tests whether a small device that sends mild electrical pulses through the skin (TENS) can reduce pain during a prostate biopsy. About 140 men will get either a real TENS device or a fake one, along with standard numbing medicine. The goal is to see if TENS makes the p…

This clinical trial tests whether safinamide, an add-on medication, can reduce chronic pain in people with Parkinson's disease who also experience motor fluctuations. About 60 adults with Parkinson's and pain lasting over three months will receive either safinamide or a placebo f…

This study looks at two ways of giving the pain medicine ketorolac to children after heart surgery: as a steady drip or as shots every few hours. The goal is to see if the steady drip reduces the need for stronger opioid pain medicines. About 166 children aged 3 months to 5 years…

This study is testing whether a single dose of nicotine gum can reverse age-related hearing problems. Researchers will give 48 healthy non-smokers aged 18-85 either nicotine gum or a placebo and measure their hearing and brain responses. The goal is to see if nicotine can improve…

This early-stage study at Johns Hopkins is testing whether cannabidiol (CBD) can reduce stress and nicotine withdrawal symptoms in people who smoke. Ninety healthy smokers will receive CBD and then be exposed to stress while researchers measure their mood, heart rate, and stress …

This study compares two ways to control pain after a single-level lumbar microdiscectomy (a common back surgery). One group receives an ultrasound-guided nerve block (quadro-iliac plane block) with bupivacaine, while the other gets standard local infiltration of pain medicine at …

This study tests a coaching program called OPTIONS that helps veterans with chronic pain learn non-medication strategies. Around 296 veterans with musculoskeletal pain will work with a coach to align pain management with their personal values and goals. The main goal is to see if…

This study tests whether giving acetaminophen (Tylenol) and ketorolac (Toradol) to children on ventilators can better control pain and reduce the need for strong opioids. About 644 children aged 2 months to 17 years with acute respiratory failure will be randomly assigned to rece…

This study tests whether a non-invasive brain stimulation technique called tDCS can safely improve vision in 100 children aged 4-14 with lazy eye (amblyopia) that hasn't improved with standard patching. Children will receive either real or sham tDCS over three sessions, and their…

This trial tests a wearable-sensor system called MINDGAPS that tracks eye and body movements during balance exercises. Researchers want to see if it can improve dizziness and stability in older adults with vestibular hypofunction — a common cause of falls. The study also checks w…

This study investigates whether Manuka honey can help reduce pain after tonsillectomy (surgery to remove the tonsils). Adults undergoing the procedure will take either honey or a placebo syrup three times daily for 14 days, alongside standard pain medication. The goal is to see i…

This study tests whether a paracervical block (an injection near the cervix) containing ketorolac and lidocaine can reduce pain during placement of osmotic dilators, which are used to prepare the cervix for a second-trimester abortion. About 76 participants will be randomly assig…

This study investigates whether wearing a virtual reality headset during epidural injections can lower pain and anxiety in people with nerve root pain (radiculopathy). Participants receive two injections, each with the headset, and researchers measure anxiety levels and pain scor…

This trial tests whether giving the painkiller parecoxib before a CT-guided wire placement can reduce pain during lung nodule localization for surgery. About 150 adults with lung cancer scheduled for video-assisted thoracoscopic surgery will receive either parecoxib or a placebo …

This study tests whether motivational interviews led by midwives can lower stress and alexithymia (trouble identifying feelings) in pregnant women and their partners. About 140 couples will be split into two groups: one gets the motivational sessions, the other does not. Research…

This study compares a lighter 'ambulatory' epidural to a standard one during childbirth, measuring how satisfied women feel about their labor and delivery. About 126 women with healthy, full-term pregnancies will fill out a questionnaire 2 days and 4 weeks after giving birth. The…

This study tests whether sleeping with a weighted blanket (about 10% of your body weight) can help adults with chronic pain feel better. About 44 people will use the blanket every night for 5 weeks and report changes in pain, sleep, and daily activities. The goal is to see if thi…

This study tests if a safe, non-invasive nerve stimulation on the ear can lower pain and the need for strong painkillers after abdominal or urologic surgery. 174 adults will receive either real stimulation at different frequencies or a sham (fake) treatment before and after surge…

This study compares a new local anesthesia technique called PENG 360° to standard spinal anesthesia for people having hip replacement surgery after a fracture. The goal is to see if the new method controls pain just as well while allowing patients to move their leg sooner. One hu…

This study tests a new type of talk therapy called ReACT for adults with functional seizures (also called psychogenic non-epileptic seizures). The therapy aims to help people regain control over their body by changing thoughts and behaviors that trigger seizures. Fifty participan…

This study tests whether adding foot reflexology to standard physical therapy can reduce pain and improve sleep in women with fibromyalgia. Sixty women aged 18–65 will receive either standard therapy alone or standard therapy plus foot reflexology twice a week for six weeks. Rese…

This study looks at whether a visual rehabilitation program can ease anxiety and depression in people with advanced age-related macular degeneration (AMD). Twenty-two participants will attend five group sessions over 60 days, learning skills like coin recognition, using voice ass…

This study is testing two holistic, non-drug programs to help military members manage chronic musculoskeletal pain. About 608 participants will be randomly assigned to either a single-session class called Empowered Relief, a multi-session program called Move to Health, or usual c…

This study tests whether an Enhanced Recovery After Surgery (ERAS) protocol can reduce opioid prescriptions and pain after breast conserving surgery. 260 breast cancer patients will be randomly assigned to receive either the ERAS protocol or standard care. The ERAS protocol inclu…

This study compares a newer type of nerve block (serratus plane block) to standard local anesthesia for pain control during chest tube placement in intensive care patients. About 70 awake, non-intubated adults will be enrolled. The goal is to see if the nerve block reduces pain s…

This study tests whether using virtual reality for mindfulness therapy can help adults with long-term low back pain feel better and move easier. About 214 people aged 20-70 will either get 8 weeks of VR mindfulness sessions plus usual care, or just usual care. The goal is to see …

This study tests a training program for stroke survivors who have trouble paying attention to one side of their world, a condition called spatial neglect. The training teaches mental strategies to improve awareness and daily functioning. Researchers will enroll 45 people living i…

This study tests whether adding acupuncture to standard steroid treatment helps people recover hearing after sudden sensorineural hearing loss. 256 adults will receive either real or sham acupuncture three times a week for four weeks, along with oral steroids. The main goal is to…

This study tests whether personalized health coaching can reduce chronic muscle and joint pain in people aged 60 and older. 268 participants will either receive four face-to-face coaching sessions focused on exercise, diet, stress, sleep, social support, and avoiding risky substa…

This study tests three home-based programs for people with long-term muscle or joint pain (like back pain or arthritis) who also sleep poorly. Participants will be randomly assigned to 12 months of exercise, cognitive behavioural therapy for insomnia (CBT-I), or both. The goal is…

This study tests whether using a virtual reality (VR) headset showing calming nature videos can reduce pain and anxiety during a first-trimester procedural abortion. Seventy-two adults will either receive usual care (pain medication and local anesthetic) or usual care plus the VR…

This study tests whether an erector spinae plane block (ESPB) — an injection of the anesthetic ropivacaine into back muscles — can reduce pain and the need for pain medication in children undergoing posterior spinal fusion for scoliosis. About 42 children with adolescent idiopath…

This study tests whether a one-month treatment combining the allergy drug clemastine fumarate with engineered sound can improve the ability to hear speech in background noise for people aged 45-65 with age-related central auditory processing disorder (CAPD). About 344 participant…

This study tests a 30-microgram sublingual sufentanil tablet for treating moderate to severe pain from a single injury in the emergency department. 300 adults with pain scores of 4 or higher on a 0-10 scale will receive either the tablet or standard pain treatment. The goal is to…

This pilot study is testing whether CBD oil can help reduce pain and nerve damage in people with diabetic peripheral neuropathy (DPN). About 20 adults with mild to moderate DPN will receive either CBD or a placebo for 6 weeks. The goal is to see if CBD is safe and effective, and …

This study tests whether a single dose of methadone, a long-acting opioid, can control pain better than standard short-acting opioids (like fentanyl) in infants and young children after cleft palate repair. About 60 children aged 6 months to 4 years will participate. The goal is …

Many blast-exposed veterans struggle to hear in noisy places even though their standard hearing tests are normal. This study tests whether a new fitting method called speech-based audiometry (SBA) makes low-gain hearing aids more effective than the usual approach. Eighty veterans…

This study tests a new way to treat chronic tinnitus by pairing gentle electrical stimulation on the back of the head with a listening exercise. One hundred adults with constant ringing in the ears will be randomly assigned to receive real or fake stimulation combined with active…

This study tests if lip reading rehabilitation improves how well people with hearing aids can recognize spoken words by watching a speaker's mouth. Eight adults with moderate to severe hearing loss will participate. The goal is to see if this therapy helps them understand speech …

This study tests whether automatic sound processing in cochlear implants helps children with hearing loss understand speech in noisy environments. Twenty children aged 6 to 16 who use cochlear implants will compare three different sound settings. The goal is to see which setting …

This trial tests whether a set of three virtual-reality games, called BEARS, can improve hearing in noisy places for children aged 8 to 16 who have two cochlear implants. The games train the brain to pick out speech from background noise, locate where sounds come from, and enjoy …

This study tests a special speech therapy for minimally verbal children who have both autism and childhood apraxia of speech (a motor planning disorder). The therapy uses motor learning principles in a natural play-like setting. Researchers will enroll 20 children to see if this …

This study looks at whether walking on a treadmill can improve how stroke survivors move. Many people who have had a stroke walk unevenly and have different skin temperatures on their affected side. The researchers will measure changes in walking speed, endurance, and body heat p…

This study tests whether a special belt that vibrates can help people with balance disorders walk better and feel more steady. Researchers will enroll 90 adults aged 18-80 who have balance issues from conditions like inner ear problems or ataxia. Participants will use the belt an…

This study tests if watching relaxing virtual reality (VR) scenes before an egg retrieval procedure can lower pain. One hundred women having elective egg freezing will either get standard care or standard care plus a VR relaxation session. Pain levels are measured with a simple 0…

This study tests a new cognitive behavioral therapy called ReACT for teens aged 11-18 with psychogenic non-epileptic seizures (PNES) – episodes that look like seizures but are not caused by epilepsy. The therapy focuses on helping teens regain a sense of control over their body a…

This study tests a telehealth program called ENGAGE for people with stage IV breast, prostate, lung, or colorectal cancer. The program helps manage symptoms like pain, fatigue, and distress that interfere with daily life. About 190 participants will be randomly assigned to ENGAGE…

This study tests a new ultrasound-guided nerve block called the Quadro-Iliac Plane Block to manage pain after lumbar spine surgery. Researchers will enroll 80 adults undergoing elective back surgery to see if the block reduces opioid use and improves recovery quality. The goal is…

This study looks at whether using a stress ball during cataract surgery can lower patients' pain and fear and increase their satisfaction. About 60 adults having their first cataract surgery will be asked to squeeze a stress ball during the procedure. Researchers will measure pai…

This study tests whether a numbing injection (nerve block) given before facial fracture surgery can lower the amount of opioids patients need after surgery. 70 adults with facial fractures will be randomly assigned to receive either the nerve block or a placebo. The goal is to se…

This study tests if freezing the nerves around the knee (cryoneurolysis) one day before total knee replacement surgery can lower pain and help patients move better afterward. About 100 adults with knee arthritis will be randomly assigned to get the freezing procedure plus surgery…

This study in Ukraine compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by neuromas from combat injuries. Fifty adults with moderate to severe pain will be randomly assigned to one treatment. The go…

This study looks at whether numbing the upper and lower jaw nerves before surgery can lower pain and the need for extra pain medicine after jaw surgery. About 60 adults having planned jaw surgery will take part. The goal is to see if this nerve block helps control pain better tha…

This study looks at whether adding fluoxetine (a common antidepressant) to standard eye patching can improve and maintain vision in people over 10 with lazy eye (amblyopia). Researchers will use special eye scans and brain tests to measure changes. The goal is to find a new way t…

This study tests whether a new pain scale that considers both pain level and ability to move can better guide when to give extra painkillers after surgery. About 76 adults having scheduled surgery will be randomly assigned to receive rescue pain medication based on either the sta…

This study tests whether adding a special nerve block (BAP) to a standard abdominal wall block (TAP) can better control pain and reduce the need for strong painkillers after minimally invasive left-sided colorectal surgery. About 140 adults having elective laparoscopic surgery wi…

This study tests whether a mild electrical device called TENS can reduce pain during labor in first-time mothers. 132 women will receive both real TENS and a sham (inactive) device at different times to compare pain levels. The goal is to see if TENS offers a safe, non-drug optio…

This study tests a safe, low-dose electrical brain stimulation technique called tDCS to see if it can reduce the loudness and distress of tinnitus (ringing in the ears). Forty adults with tinnitus will receive multiple sessions, and researchers will measure changes in symptoms an…

This study tests two methods of giving epidural pain medicine during labor: continuous drip versus small, timed bursts. 60 women giving birth will be randomly assigned to one method, and researchers will measure pain levels, total medicine used, and satisfaction. The goal is to f…

This study tests two minimally invasive treatments for people with long-lasting hip pain (Greater Trochanteric Pain Syndrome). Participants will receive either a targeted artery treatment (TAME) or a platelet-rich plasma (PRP) injection. The goal is to see which one reduces pain …

This study looks at whether adding early nurse and psychologist support after a retinitis pigmentosa (RP) diagnosis helps patients feel better emotionally. RP is a rare, progressive eye disease, and the diagnosis can be upsetting. Eighty newly diagnosed adults will get either sta…

This study tests a virtual reality training program (KidTrain) designed to help children aged 7-17 with bilateral cochlear implants improve their ability to locate sounds and understand speech in noisy environments. The training uses immersive VR with varying background noise and…

This study compares two types of anesthesia—spinal and epidural—for people having liver surgery. The goal is to see if spinal anesthesia leads to better blood pressure control, less need for IV fluids, and similar pain relief with faster recovery. About 128 adults undergoing elec…

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat injuries. About 50 adults in Ukraine will be randomly assigned to one treatment, and researchers will measure pain levels, op…

This study compares an herbal extract called Aescin (Reparil®) to the common painkiller ibuprofen for managing pain, swelling, and jaw stiffness after wisdom tooth removal. About 100 adults aged 18-40 will take either Aescin or ibuprofen for five days after surgery. Researchers w…

This study tests if a home-based program of laughter and fun yoga can lower pain in children aged 2-10 with acute lymphoblastic leukemia who are receiving chemotherapy. Sixty participants will be randomly assigned to either the laughter and yoga program plus usual care, or usual …

This study tests whether a digital cognitive behavioral therapy (CBT) program, with or without a peer health coach, can reduce pain and opioid use in 470 teens and young adults (ages 16–30) with sickle cell disease and chronic pain. Participants use an app to track pain and mood,…

This study tests whether controlled breathing exercises can control pain during joint injections as well as local anesthesia. 136 participants will be randomly assigned to either receive lidocaine (standard care) or practice 5-minute breathing cycles. The goal is to see if the br…

This study compares two types of nerve blocks—M-TAPA and TAP block—for pain relief after open inguinal hernia repair. Sixty adults undergoing elective surgery will receive one of the two blocks with the same numbing medicine. Researchers will measure pain scores and patient satis…

This study tests whether a 5-week audio-proprio-phonatory training program can reduce the daily-life disability caused by chronic tinnitus. 56 adults with tinnitus will either receive the training or not, and researchers will use brain wave recordings (EEG) and questionnaires to …

This study is for children under 6 years old who need heart surgery. It tests a pain medicine called EXPAREL to see if it works well and is safe compared to a standard painkiller. The medicine is given near the surgery area to help with pain after the operation. About 48 children…

This study tests a new hearing aid, Audiocap, in 100 adults with mild-to-moderate hearing loss who have never used a hearing aid before. The goal is to see if it improves hearing better than a placebo device after one month of use. Participants will undergo standard hearing tests…

This study tests whether a nerve block called the erector spinae plane block can reduce abdominal pain in people with gastrointestinal cancer. Researchers will compare opioid use and hospital stay length between 25 patients who get the block and a matched group who received stand…

This study tests whether intravenous magnesium sulfate can quickly reduce severe period pain in women visiting the emergency room. Sixty women with acute dysmenorrhea will receive either magnesium or a standard painkiller (dexketoprofen). Pain levels are measured before and one h…

This study tests whether a personal sound amplifier, along with hearing training, can reduce troubling symptoms like agitation and distress in older adults with Alzheimer's or related dementias who also have hearing loss. Researchers will enroll 300 people aged 60-100 and their c…

This study tests whether adding a 6-week online telerehabilitation program to standard medical care can improve function and reduce pain in adults with chronic low back pain. Two hundred participants will either receive usual care alone or usual care plus the digital program, whi…

This study looks at whether giving Veterans who have trouble hearing a small personal amplifier in the emergency room can help them understand their discharge instructions better and lower their chances of coming back to the ER within 3 or 30 days. About 1,050 Veterans from six V…

This study tests whether giving a specific nerve block (ESP block) within 6 hours of a severe chest injury can reduce the number of days patients need a ventilator. The block numbs the chest wall to ease pain and improve breathing. 400 adults with at least 3 rib fractures will be…

This study tests a simpler way for paramedics to treat seizures in children. Instead of calculating doses, paramedics will use age-based, pre-set doses of a seizure-stopping medicine given as a shot or nasal spray. The goal is to see if this approach stops seizures before the chi…

This study tests whether a low dose of ketorolac, an NSAID, can safely reduce pain and the need for opiates in critically ill ICU patients. Thirty adults with pain will receive either ketorolac or a placebo for up to three days. The main goal is to see if this approach is feasibl…

This study compares telerehabilitation (remote training) to in-office care for adults with low vision who have received new magnification devices or assistive apps. Researchers will also use Bluetooth sensors to monitor if patients stop using their devices, aiming to provide time…

This study compares three routine pain control methods used during minimally invasive cancer surgery: a nerve block plus local anesthetic, nerve block alone, or local anesthetic alone. About 48 adults having surgery for various cancers will be randomly assigned to one of the thre…

This study compares two hands-on techniques—SNAG (a gentle spinal glide) and sciatic nerve mobilization exercises—for easing non-specific sciatica pain. Thirty adults with pain lasting over 12 weeks will try both methods in a crossover design, with each session separated by 10 da…

This study tests whether adding shiatsu—a gentle Japanese bodywork therapy—to standard medical care can improve quality of life for children aged 10 to 18 with chronic non-inflammatory pain. About 40 participants will receive one 30-minute shiatsu session per week for six weeks a…

This study tests whether a TENS pain-relief device, combined with video coaching sessions from a physiotherapist, can help people with leg pain from peripheral artery disease (PAD) become more active. Forty-eight participants will either get the TENS device plus coaching or usual…

This study screens children and adults aged 8 and older with known or suspected epilepsy, especially those whose seizures are not controlled by medication. Participants undergo tests like EEG, MRI, and PET scans to characterize their epilepsy. The goal is to find suitable candida…

This study is creating a large collection of health information and biological samples (like blood, saliva, and eye tissue) from people with and without retinal diseases. Researchers aim to use this database to better understand conditions like age-related macular degeneration an…

This study looks at how heart rate variability (a measure of stress response) relates to emotional control and parent-teen relationships in 74 adolescents with depression. Teens will wear a Fitbit while sleeping for a week and fill out questionnaires. The goal is to better unders…

This study aims to understand why some children develop sleep issues, anxiety, or aggression for up to two weeks after being sedated for medical procedures. Researchers will follow over 2,000 children aged 1-17 in emergency rooms and dental clinics. By identifying risk factors li…

This study follows 25 people aged 10 and older with Stargardt-like macular dystrophy (STDG3), a rare inherited eye disease that causes vision loss. Over three years, researchers will measure changes in the retina using eye exams, imaging, and vision tests. The goal is to understa…

This early-stage study is testing whether a contrast agent called mangafodipir can safely highlight areas where the blood-brain barrier is broken in people with drug-resistant epilepsy. Forty adults will undergo MRI scans with mangafodipir and gadolinium to see if these scans can…

This study aims to find out why 20-40% of people with wet age-related macular degeneration (AMD) don't respond well to standard anti-VEGF injections. Researchers will collect fluid from inside the eye of 117 patients and compare those who respond well to treatment with those who …

This study collects skin, hair, blood, urine, or saliva samples from people with certain eye diseases (like macular degeneration) and from healthy volunteers. Researchers will turn these samples into stem cells in the lab to study how the diseases develop and to test potential ne…

This study is the first time the experimental drug ARO-033 is being given to humans. Its main goal is to check the safety and tolerability of single and multiple doses in healthy adult volunteers. Researchers will also measure how the drug moves through the body. This is an early…

This observational study aims to understand why individuals perceive colours and visual rivalry differently. Researchers will test 128 adults using computer-based tasks to measure colour perception and binocular rivalry (when each eye sees a different image). They will also explo…

This global study follows people with POLG-related disorders, a group of rare mitochondrial conditions, to understand how the disease progresses over time. By observing clinical changes in up to 300 participants of all ages, researchers aim to identify key milestones that could s…

This study tests whether a home-based computer training program can improve vision in people who have lost part of their visual field due to stroke, traumatic brain injury, or brain tumor. Researchers will use brain scans to understand how the brain changes with training. The stu…

This study aims to understand why people with Turner syndrome often lose their hearing. Researchers will look at genetic and epigenetic markers in 150 adults aged 18-60. Participants will have hearing, balance, blood, and imaging tests. The goal is to find new ways to treat or de…

This study investigates repetitive behaviors—like repeating words or actions—in people with Alzheimer's disease. Researchers want to understand how common these behaviors are, what types occur, and whether they are linked to memory problems or lack of awareness of the condition. …

This study looks at how platinum-based chemotherapy can cause permanent hearing loss in cancer patients, and whether people from poorer backgrounds are more affected. Researchers will test hearing and thinking skills in 172 patients from North West England before and after treatm…

This study aims to learn more about the genetics and natural history of autoinflammatory diseases, which cause repeated fevers and inflammation. Researchers will study up to 5,000 people, including patients, their relatives, and healthy volunteers. Participants provide blood and …

This study follows 50 adults aged 18–85 with certain types of hearing loss who either use or could use an FDA-approved bone-anchored hearing device. Over 3 years, researchers will measure changes in memory, attention, and other thinking skills. The goal is to see if treating hear…

This study tests whether immune cells called monocytes from people with the atrophic form of age-related macular degeneration (AMD) survive longer on retinal cells than monocytes from healthy people. Researchers will collect blood samples from 80 participants, extract monocytes, …

This international study aims to collect genetic and health information from 1,500 people with rare inherited retinal diseases like retinitis pigmentosa. It has two parts: a registry to gather genetic and vision data, and a natural history study that follows participants over tim…

This study follows 500 people with neurocysticercosis, a brain infection caused by the pork tapeworm. Participants receive standard antiparasitic drugs and anti-inflammatories. Researchers will track their health over many years to understand what factors lead to better or worse …

This study observes 75 adults aged 55 and older with geographic atrophy (a late stage of age-related macular degeneration) to see how the condition progresses over a short time. Researchers will measure changes in eye structure and function, and explore links to genetics and life…

Researchers are investigating whether narrowing of the ophthalmic artery, which supplies blood to the eye, contributes to geographic atrophy, an advanced form of dry age-related macular degeneration. The study will use a noninvasive imaging technique called PC-CTA to measure arte…

This early-stage study is testing a new oral drug called SK-09 in 72 healthy adults to see if it is safe and how the body processes it. The study is split into two parts: one where participants get a single dose, and another where they get multiple doses. No one knows who gets th…

This study compares how well people with a genetic form of deafness (DFNB9) can hear and understand speech after receiving gene therapy versus a cochlear implant. Researchers will also include healthy participants for comparison. The goal is to see if gene therapy can match or ou…

This study is testing whether a simple vision screening program in general practice can help detect vision loss early in adults over 70 who have at least one chronic condition. Participants will have three vision tests done by their GP or nurse, then visit a collaborating opticia…

Researchers are using a brain imaging technique called fNIRS to track how deaf children's brains develop after receiving a cochlear implant. The study includes children aged 10-24 months and 3-7 years, comparing them with normally hearing peers over 18 months. During tasks that t…

This study looks at how well people with retinal diseases like retinitis pigmentosa and Stargardt's disease see in the dark. Researchers want to find out if measuring dark adaptation can help detect and track these conditions. Healthy volunteers and people with retinal disease ag…

This study aims to create a large collection of tissue samples from people with head and neck disorders, such as hearing loss, mouth diseases, and throat cancers. Researchers will use leftover surgical tissue and additional samples like blood, saliva, and cheek swabs to study the…

Researchers at Hannover Medical School are testing a new device called an auditory nerve implant (ANI) in five deaf adults. The implant stimulates the auditory nerve directly, and the study asks whether it can produce clear loudness and pitch percepts. Participants will have the …

This pilot study will test two new eye imaging devices (R1 and HighRes OCT) against a standard device in 97 adults with healthy eyes or eye diseases like macular degeneration and diabetic retinopathy. Researchers will compare image quality and how well key eye structures are seen…

This study looks at how the brain changes after a stroke that causes vision loss. Researchers will use MRI scans to see which brain areas are damaged and how they respond to visual training. The goal is to better understand how the brain can adapt and restore some vision. About 1…

This study tests a teaching method called 'shape coding' to help deaf and hard of hearing middle schoolers improve their written English. Researchers will work with 30 students in grades 5-8 who use both spoken English and American Sign Language. The goal is to see if using visua…

This study follows 90 children and adults with Stargardt disease or similar inherited eye conditions to see how their vision changes over 2 years. Participants will have regular eye exams and imaging every 6 months. No treatment is given—the goal is to better understand the natur…

This study investigates whether specialized visual function tests can detect early changes in people with early or intermediate age-related macular degeneration (AMD). Researchers will follow 120 adults with good visual acuity but early signs of AMD, using tests like microperimet…

This study tests a software tool called OTOGUIDE that helps surgeons monitor the placement of a cochlear implant electrode during surgery. Currently, surgeons lack real-time feedback on where the electrode is inside the cochlea, which can affect hearing outcomes. The trial will c…

This trial explores whether physical activity, specifically walking in different visual environments, can improve the sense of self in people with schizophrenia, borderline personality disorder, or vestibular syndromes. Participants will complete walking sessions in three environ…

This study looks at whether a nerve block called the serratus anterior plane block (SAPB) can improve outcomes for adults with multiple rib fractures on one side. Researchers will compare patients who receive this block within 24 hours of injury to those who get standard opioid p…

This study looks at whether people treated with radiation (with or without chemotherapy) for head and neck cancer develop tinnitus (ringing in the ears) and hearing loss together. Researchers will follow about 140 patients for three months after treatment, measuring hearing and a…

This study asks children aged 6-16, their parents, and clinicians to vote on the most important research topics in pediatric anesthesia and perioperative medicine. Over 1,000 participants in Switzerland will complete online surveys to create a ranked list of the top 10 priorities…

This study is building a large online registry of US adults who experience sinus, ear, dizziness, and headache symptoms, with or without a migraine diagnosis. Participants answer questions about their symptoms, how these affect daily life, and which treatments they have tried. Th…

This study looks at whether measuring the stapedius reflex (a tiny ear muscle reflex) can help program cochlear implants in children aged 0 to 7. Currently, programming relies on behavioral responses, which can be hard to get from very young kids. The researchers will test the re…

This study looks at children with molar-incisor hypomineralisation (MIH), also called cheese molars, to see if the color of the defect can predict future enamel breakdown. Researchers will photograph and scan affected teeth over nine months and compare the scans to measure enamel…

This study looks at how the brain naturally reduces pain signals and whether that ability affects how well a lumbar medial branch block (a common injection for back pain) works. Researchers will test 40 adults with chronic low back pain using heat, pressure, and other sensations …

This study investigates why pain from chronic pancreatitis persists even after treating the pancreas. Researchers will use brain scans and psychological tests to see if the brain itself becomes sensitized to pain. By comparing patients with painful chronic pancreatitis to those w…

This study aims to improve how pain is assessed and managed in premature babies in the neonatal intensive care unit (NICU). Researchers are using machine learning to analyze video, brain activity, heart rate, and breathing patterns to better distinguish between painful and non-pa…

This study tracks eye pressure in 100 people receiving a larger-volume injection of Aflibercept (0.07mL) for macular diseases like age-related macular degeneration. Researchers measure pressure right after the injection and at several time points, then check for any nerve damage …

This observational study investigates why some people develop epilepsy after a stroke, while others do not. Researchers will compare first-time stroke patients with healthy volunteers using brain imaging (MRI), electrical brain recordings (EEG), and overnight sleep studies. The g…

This study follows 19 adults with hearing loss who already received a cochlear implant that releases a steroid to reduce inflammation. Researchers will check how well the implant works over 5 years by measuring electrical signals and tracking any side effects. The goal is to see …

This study investigates whether older adults with age-related hearing loss (presbycusis) can still hear and enjoy the sound of a crunchy biscuit while eating. Researchers will compare a crunchy biscuit with a soft one in 100 seniors aged 65 and older, asking them if they hear the…

This study is following 1,500 adults aged 55 and older to learn how early age-related macular degeneration (AMD) turns into the advanced form that can cause vision loss. Researchers will use eye imaging, genetic tests, and other measurements to find clues that predict progression…

This study watches how vision changes over two years in 50 people aged 65-90 with geographic atrophy (a form of dry age-related macular degeneration) who are already taking the drug pegcetacoplan. Researchers will use a special vision test that maps light sensitivity near damaged…

This study looks at three drugs (bevacizumab, ranibizumab, and aflibercept) used to treat age-related macular degeneration (AMD), a leading cause of blindness in older adults. Researchers will analyze costs and quality of life for 600 patients in France to see which treatment off…

This study is for people with rare kidney diseases like Minimal Change Disease, Focal Segmental Glomerulosclerosis, and Membranous Nephropathy. Researchers will collect health information and biological samples from 1,200 participants over many years. The goal is to better unders…

This study looks at whether listening to music with a steady beat can improve how older adults with age-related hearing loss process sentences. Researchers will have 55 participants aged 70 or older listen to regular or irregular rhythm music, then judge if sentences are grammati…

This study helps people with certain kidney diseases (like nephrotic syndrome and FSGS) find clinical trials that match their specific disease profile. Researchers analyze participants' molecular data to recommend targeted therapies in ongoing trials. The goal is to improve treat…

This study is following 5,000 adults aged 65 and older to learn how eye diseases develop and progress over time. Researchers will collect detailed health information, eye exams, and biological samples to build a comprehensive database. The goal is to create a personalized risk pr…

This study aims to create a North American registry of sudden unexplained death in epilepsy (SUDEP) cases. Researchers will interview family members and review medical records of people with epilepsy who died suddenly. By comparing these cases with living epilepsy patients, they …

This study will follow 5,000 children and teens with hearing loss and normal hearing over time. Researchers will measure changes in hearing, speech, language, and brain scans to see how different treatments—like hearing aids, cochlear implants, or gene therapy—affect development.…

This study follows 180 children up to age 16 who have hearing loss caused by mutations in the GJB2 or OTOF genes. Researchers will regularly measure their hearing using standard tests and questionnaires to see how it changes over time. The goal is to better understand the natural…

This study looks at a condition called alloknesia, where light touch—like from clothing or a breeze—triggers itching. Researchers want to find out how common this is in people with atopic dermatitis (eczema) and how it affects their daily lives. About 160 adults with eczema will …

This study collects fluid and blood samples from 260 people with age-related macular degeneration, diabetic retinopathy, or retinal detachment, plus healthy controls. Researchers will analyze proteins in these samples to identify markers that could help diagnose or track these ey…

This study observes 60 children with severe hearing loss who received cochlear implants before age 2. Researchers will track their speech therapy sessions and language skills over time to see which therapy approaches and how much therapy lead to better language development. The g…

This registry collects information from people with inherited retinal diseases, like retinitis pigmentosa and Stargardt disease. Participants share their symptoms, family history, and genetic test results online. The goal is to help researchers understand these rare diseases and …

This study looks at whether the Figure-of-8 Walk Test is a valid and reliable way to measure walking and balance in older adults with motoric cognitive risk syndrome (MCRS). MCRS combines slow walking speed with memory complaints and may signal future dementia. Researchers will t…

This early-stage study tests two ways to give fentanyl without needles: a face mask and a nasal spray. Twenty healthy volunteers will receive small doses to see how well the drug enters the body. The goal is to find a faster, easier way to manage pain in emergency rooms without n…

This study explores whether a special MRI technique can help people who have had a stroke improve their reading. Participants will practice controlling their own brain activity using real-time feedback from the MRI scanner. The goal is to retrain the brain's language areas to wor…

This study looks at adults aged 30 to 55 who have hearing loss that started after age 16 and carry a mutation in the GJB2 gene. Researchers will track how their hearing changes over time using hearing tests and genetic analysis. The goal is to better understand this form of heari…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life-support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals, then work with patients, families, and staff to design a safer sedat…

This study tests whether a computer model can predict which reading treatment works best for people who developed dyslexia after a stroke. Twelve participants will each try two different therapies—phonomotor treatment and semantic feature analysis—for 60 hours each. The goal is t…

This study uses a special camera called an adaptive optics scanning laser ophthalmoscope to take incredibly detailed pictures of the retina, the light-sensitive layer at the back of the eye. Researchers will compare images from healthy people and those with eye diseases like Star…

This study looks at people with retinitis pigmentosa and similar eye diseases who already use a device called OkuStim® that sends mild electrical pulses to the eye. Many patients report temporary improvements in vision right after treatment, but these haven't been measured in a s…

This study at Mayo Clinic looks at two different types of Progressive Apraxia of Speech, a condition that makes it hard to speak clearly. Researchers will use brain scans, speech assessments, and thinking tests in 47 adults to better tell these types apart. The goal is to improve…

This study is collecting medical information and biological samples (like blood, urine, and kidney tissue) from 300 people with FSGS or MCD who have had or will have a kidney transplant. The goal is to build a research biobank called RESOLVE to help scientists study why these dis…

This study tests two advanced eye imaging techniques—central microperimetry and radial OCT—to see if they can more accurately measure the progression of geographic atrophy, a severe form of age-related macular degeneration that can lead to blindness. Researchers will follow 80 ad…

This study follows 45 adults with retinitis pigmentosa caused by EYS gene mutations to understand how the disease progresses over 48 months. Researchers will measure vision changes using eye exams and genetic testing. The goal is to identify reliable ways to track the disease, wh…

This study compares two new ultrawide field cameras (Clarus and Optos) to the standard Spectralis camera for taking pictures of the back of the eye in people with inherited retinal diseases. Fifty adults will have their eyes dilated and photographed with all three cameras. The go…

This study is looking at whether people with benign paroxysmal positional vertigo (BPPV) have differences in their autonomic nervous system compared to healthy people. Researchers will measure heart rate variability (HRV) in 104 participants (52 with BPPV and 52 matched controls)…

This study aims to uncover genetic and biological differences between people with Menière's disease, those with vestibular migraine, and healthy individuals. Researchers will analyze blood samples from 250 participants to look for specific gene variations and biohumoral factors. …

This study is testing new eye exams to see if they can better track early age-related macular degeneration (AMD). Researchers will measure how quickly the eye adapts to darkness in 150 healthy volunteers and people with early AMD. The goal is to find reliable ways to measure dise…

This study tests a virtual reality (VR) game to measure hand-eye coordination in children aged 7 to 17 with and without chronic balance (vestibular) disorders. Researchers want to see if the VR tasks are reliable and fun for kids, and how balance problems affect coordination. The…

This study enrolls 25 people with severe retinal diseases like retinitis pigmentosa and Stargardt disease to test new ways of measuring visual function. Researchers will evaluate how well participants can perform various vision tests, such as navigating obstacles or detecting lig…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and respond to moderate exercise. Participants will do strength and aerobic exercises while their pain tolerance and sensitivity are measured. The goal is to understan…

This study looks at whether adjusting the difficulty of online listening exercises can help adults with hearing problems learn better. Researchers will have 120 participants do 30 minutes of training per day for two weeks. The goal is to understand how task difficulty affects lis…

This study looks at how people with hearing aids perceive the timbre (quality) of sounds and understand complex sound scenes, like music or crowded rooms. Researchers will compare 75 adults aged 60-75 with and without hearing loss. Participants will listen to sounds and rate how …

This study looks at how two common anesthesia drugs, propofol and alfentanil, change brain activity during a procedure called ERCP (a scope exam of the bile ducts). Researchers will monitor 20 patients' brain waves and pain signals to better understand how these drugs work togeth…

This study looks at how common central sensitization (a condition where the nervous system is overly sensitive to pain) is in adults with autism who do not have intellectual disabilities. Researchers will ask 100 participants to fill out a questionnaire about pain and sensitivity…

This study looks at how blind people use a white cane to sense the world around them, not just to move. Researchers will test how well users can feel where a touch happens on the cane and measure brain activity during these tasks. The goal is to understand how the cane becomes an…

This study tests whether a tiny device placed under the scalp can predict seizures in people with epilepsy that doesn't respond to medication. Twelve adults with focal epilepsy will wear the device and a smartwatch to track brain activity and other signals. The goal is to see if …

This study looks at a new compound called DDH-LSD, which is similar to LSD but is expected to wear off faster. Researchers will give 24 healthy adults DDH-LSD, LSD, or a placebo in random order to compare how long each lasts, how the body processes them, and what effects people f…

This observational study seeks to define a new concept called 'visual frailty' in people aged 60 and older with advanced age-related macular degeneration (AMD). Researchers will measure vision, reading ability, mental health, and daily function in 20 participants to develop a vis…

This study is a global registry for people with Castleman disease, a rare lymph node disorder. Researchers will collect medical records, lab results, and patient surveys from up to 1,000 participants to better understand symptoms, treatments, and outcomes. No experimental drug or…

This study looks at whether people who have their first seizure after age 50 should be checked for stroke risk factors like high blood pressure, diabetes, and high cholesterol. Researchers will screen 420 participants and track whether starting medications for these risks improve…

This nationwide study aims to understand how hearing loss affects thinking, language, reading, and emotional wellbeing in 256 deaf or hard-of-hearing adolescents. Researchers will use tests and questionnaires to measure speech perception, cognitive skills, and school burnout. No …

This study is gathering information from 100 children and adults who use MED-EL hearing devices, including implants and non-implantable devices. Researchers will collect data on hearing ability, speech understanding, and quality of life through tests and questionnaires. The goal …

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …

This study tests whether the CONOX monitor, which measures brain waves, can detect pain in 120 adults undergoing urological procedures like cystoscopy under sedation. Researchers will compare the monitor's readings to traditional signs like heart rate and blood pressure. The goal…

This study looks at whether oxytocin, a natural hormone, can change how nerves react to light touch and painful pressure after a small area of skin is heated. Sixty healthy adults will receive either oxytocin or a placebo through an IV, and a tiny needle will record nerve signals…

This study looks at eye problems in people with craniosynostosis, a condition where skull bones close too early. Researchers will check for issues like crossed eyes, lazy eye, and pressure inside the head. The goal is to better understand these eye problems to help improve care.

This study looks at whether special vision training can improve how people with central vision loss from macular degeneration see and move their eyes. Researchers will train 60 adults aged 18 to 89 with severe vision loss to better detect and discriminate visual patterns. The goa…

This study aims to establish normal scores for four paper-and-pencil tests that detect spatial neglect, a common attention problem after stroke. Researchers will test 210 healthy French-speaking adults aged 20 to 89, divided by age and sex. The results will help doctors know what…

This study looks at how pain and the ability to walk change in the first days after a limb amputation. Researchers will review medical records of 150 adults to see how pain levels and recovery are linked to patient details and treatments. The goal is to find patterns that could h…

This study looks at whether trouble processing sounds (called central auditory processing disorder, or CAPD) causes poor sleep in children and teens with autism. Researchers will compare two groups of 100 kids with autism—those with CAPD and those without—using parent surveys and…

This study looks at how short periods of high oxygen affect blood flow in the brains of ICU patients on breathing machines. Researchers will briefly increase the oxygen given through the ventilator and use ultrasound to monitor brain artery blood flow. The goal is to understand t…

This study investigates how attention influences the brain's ability to inhibit or stop actions. Researchers will test 120 participants, including healthy volunteers and people with conditions like ADHD or stroke-related neglect, using computer-based tasks that measure eye and ha…

This study aims to understand what causes Visual Snow Syndrome (VSS), a condition where people see constant flickering dots across their vision. Researchers will use brain scans and visual tests to find which brain pathways are involved. About 100 adults with VSS, migraine, or he…

This study is a registry that collects health information from people in Switzerland who have neuromuscular disorders like SMA, DMD, BMD, and others. It aims to track symptoms, treatments, and outcomes over time to help researchers and doctors improve care. No new treatments are …

This study collects information from 450 newborns who fail their initial hearing screening. Doctors will test them for congenital CMV, a common infection that can cause hearing loss and other problems. The goal is to see how often CMV is found and to improve follow-up care for af…

This pilot study will measure the normal range of binocular single vision—the ability to use both eyes together as one—in 30 healthy Asian adults aged 21 to 59 in Singapore. Current standards are based on a small 1974 study of Caucasians, which may not apply to today's Singaporea…

This study uses MRI scans to look at how the brain's visual networks change in people with inherited retinal diseases. Researchers will scan 200 patients before and after they receive treatments like retinal implants or optogenetics. The goal is to understand how the brain adapts…

This observational study looks at different ways to manage pain and sedation for adults with broken bones or dislocations in the emergency department. Researchers will compare standard care with various sedation and pain relief methods to see which one patients prefer and which p…

This study reviews medical records of 2,450 women who had C-sections at a French hospital to find out why some still feel pain despite spinal anesthesia. Researchers aim to identify risk factors and improve pain management. No new treatments are tested—just learning from past cas…

This study explores whether a brain-scanning technique called fNIRS can measure how well hearing aids help young children with hearing loss. Researchers will compare brain activity in 40 infants (3-18 months old) with normal hearing and those using hearing aids. If fNIRS proves r…

This study looks at whether sleep disorders make vertigo worse for people with Ménière's disease, a condition that causes hearing loss, ringing in the ears, and dizziness. Researchers will track 100 adults to see if those with more severe vertigo also have more sleep problems. Th…

This study follows 60 infants at high risk for Cerebral Visual Impairment (CVI), a brain-based vision problem often missed until later childhood. Researchers will collect data from clinical exams, brain scans, and vision tests up to 24 months of age. The goal is to create a model…

This study looks at whether sinusitis (sinus infection) is common in people with wet age-related macular degeneration (AMD) who need many eye injections. Researchers will screen 200 participants for sinusitis and treat it if found. They will then check if sinusitis treatment redu…

This study looks at how color vision changes over time in people with inherited retinal diseases (IRDs). Researchers will study 200 participants, including those with IRDs and healthy volunteers, to see how color vision loss relates to changes in the retina's structure. They are …

This study watches 90 adults having open heart surgery to compare three standard pain relief methods: IV drugs, an epidural, or a nerve block. The main goal is to see which method best prevents chronic pain 3 months later. Researchers will also track pain levels, recovery speed, …

This study is testing a new virtual reality (VR) test called VisionumVR to see if it can reliably measure how well people with low vision improve during rehabilitation. About 60 participants who are starting or already in orthoptic low vision therapy will take a 20-minute VR task…

This observational study looks at how bacteria in the gut and mouth are linked to epilepsy and whether they affect how well seizure medicines work. Researchers will collect stool, saliva, and blood samples from 1,500 people with newly diagnosed epilepsy and healthy controls. By a…

This phase 3 trial is testing whether a person's genetic makeup influences how well they respond to two standard drugs for wet age-related macular degeneration: ranibizumab and bevacizumab. About 630 patients will receive one of the two drugs and be followed for three years. The …

This study is for people with diabetic macular edema, a condition that causes vision loss. Researchers want to see if certain substances in the blood and patterns on eye scans can predict how well a patient will respond to two common treatments: anti-VEGF injections or a dexameth…

This study aims to see if a one-time health assessment and advice session can improve the overall vascular health of 1,000 adults living in Innsbruck, Austria. Participants will have their heart and blood vessel health measured using a standard score called Life's Essential 8, wh…

This study tests a high-resolution imaging system to see tiny structures in the eye that routine tools cannot detect. Researchers will scan 1,200 people with various eye conditions and healthy volunteers. The goal is to better understand diseases like glaucoma, diabetes, and reti…

This study looks at how having control over a virtual environment changes how people feel pain and anxiety. Twenty healthy adults will experience mild pain and anxiety in different virtual settings—some they can control, some they cannot. The goal is to understand how the brain a…

This study tests a new, ultracompact handheld eye scanner to take detailed pictures of the retina in children up to 8 years old with inherited retinal diseases. The goal is to see if this device can detect early signs of vision loss and help doctors monitor the disease over time.…

This study looks at how often pain occurs in intensive care unit (ICU) patients who are on mechanical ventilators (breathing machines). Researchers will observe 370 adults, using special pain scales to measure pain on the second day of ventilation and when they first wake up. The…

This observational study will follow 75 people aged 12 to 65 with Stargardt disease type 1, a genetic eye condition that causes vision loss. Researchers will use eye exams and imaging to track how the disease changes over time. The goal is to better understand the disease's progr…

This registry is gathering health information and biological samples from 500 people with focal segmental glomerulosclerosis (FSGS) or minimal change disease (MCD), two rare kidney conditions. Researchers will track participants over 10 years to understand how these diseases prog…

This study compares cognitive function in 180 adults aged 45-64 with severe hearing loss to those with normal hearing. Participants take memory, attention, and thinking tests. The goal is to see if hearing loss is linked to mild cognitive impairment earlier in life.

This study tests whether a small recording device called LENA can help speech therapists guide parents to improve their child's language environment. Thirty children with profound congenital deafness who received a cochlear implant before 18 months old will wear the recorder at h…

This study is collecting blood and joint fluid samples from 300 children and young adults with juvenile idiopathic arthritis (JIA) to see if certain markers can predict how severe the disease will become. Researchers will track participants' symptoms, treatments, and joint damage…

This study tests whether measuring a tiny ear muscle reflex (the stapedial reflex) can help doctors set the right volume levels on cochlear implants for children. Currently, kids must describe how loud sounds feel, which can be tricky. The researchers will compare reflex measurem…

This study looks at brain activity in 50 people with epilepsy who already need brain electrodes as part of their care. Researchers add tiny extra electrodes to record signals from single brain cells and brain waves. The goal is to understand what happens in the brain just before,…