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New pain block could help chest trauma patients breathe on their own sooner

NCT ID NCT05920109

Symptom relief Sponsor: University Hospital, Grenoble Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving a specific nerve block (ESP block) within 6 hours of a severe chest injury can reduce the number of days patients need a ventilator. The block numbs the chest wall to ease pain and improve breathing. 400 adults with at least 3 rib fractures will be randomly assigned to get the block plus standard care, or standard care alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ropivacaine
What this could lead to
If it works, this could reduce the number of days patients with severe chest injuries need a breathing machine, potentially speeding recovery.
What could go wrong
This is an early-stage trial with no prior large-scale evidence. The nerve block may not work as expected, and there are risks like catheter failure or rare complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Age \> 18 years Blunt chest trauma with 3 or more rib fractures on Thoracic CT scan With spontaneous breathing or under mechanical ventilation in the trauma bay Requiring an intensive (or intermediate) care unit admission Exclusion Criteria: Pre-hospital cardiac arrest Patient not expected to survive within the first 72 hours Uncontrolled haemodynamic instability despite initial resuscitation (systolic arterial blood pressure lower than 90 mmHg at the time of catheter insertion) Mechanical ventilation for severe traumatic brain injury (Abbreviated Injury Score, AIS, head \> 2) Spinal cord injury at the cervical or thoracic levels Hypovolaemia. Hypersensitivity to ropivacaine or other amide-bound local anaesthetics Subject in exclusion period of another interventional study Pregnant, breastfeeding women

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Conditions

The condition(s) this trial relates to.

agnosia Thoracic Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Severe chest trauma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    14 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CH Annecy Genevois

    RECRUITING

    Épagny, 74370, France

  • CHRU Hôpitaux De Tours

    RECRUITING

    Tours, 37000, France

  • CHU Bordeaux - Pellegrin

    RECRUITING

    Bordeaux, 33000, France

  • CHU Clermont-Ferrand

    RECRUITING

    Clermont-Ferrand, 63000, France

  • CHU Grenoble Alpes

    RECRUITING

    Grenoble, 38049, France

  • CHU de Lille

    RECRUITING

    Lille, 59000, France

  • Chu Toulouse - Hopital Purpan

    RECRUITING

    Toulouse, 69003, France

  • Chu Toulouse - Hopital Rangueil

    RECRUITING

    Toulouse, 31059, France

  • Hopital Beaujon - AP-HP

    RECRUITING

    Clichy, 92118, France

  • Hôpital Européen Georges Pompidou - AH-HP

    RECRUITING

    Paris, 75015, France

  • Hôpital Lyon Sud

    RECRUITING

    Pierre-Bénite, 69310, France

  • Hôpital Pitie Salpetriere - AP-HP

    RECRUITING

    Paris, 75013, France

  • Hôpital d'Instruction des Armées Sainte Anne

    RECRUITING

    Toulon, 83000, France

  • Hôpital d'instruction des armées Percy

    RECRUITING

    Clamart, 92140, France