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Can a gentle brain zap help adults with lazy eye see better?

NCT ID NCT07752433

Disease control Sponsor: Polytechnic Institute of Porto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 07, 2026 · Last updated Sep 18, 2026 · Updated 3 times

Summary

This trial tests whether adding a mild electrical brain stimulation to augmented reality-based vision therapy can improve vision in adults aged 18 to 35 with lazy eye (anisometropic amblyopia). Participants will use special augmented reality glasses that encourage both eyes to work together, and some will also receive a gentle current applied to the scalp. The study compares those who get real stimulation with those who get a sham version to see if the combination boosts visual acuity and depth perception more than therapy alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Active high-definition transcranial direct current stimulation (HD-tDCS) combined with augmented reality-based dichoptic therapy
What this could lead to
If it works, this could offer a new way to improve vision and depth perception in adults with lazy eye, a condition often considered hard to treat after childhood.
What could go wrong
This is an early-stage trial with a modest number of participants, and the added benefit of brain stimulation over therapy alone is unproven. The stimulation is generally mild, but any electrical brain stimulation carries some risk of discomfort or unexpected effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Apr 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 40 years. * Diagnosis of anisometropic amblyopia. * Unilateral amblyopia with an interocular difference of at least 2 lines in best-corrected visual acuity, with visual acuity worse than 20/32 in the worse-seeing eye. Exclusion Criteria: * Any type of amblyopia other than anisometropic amblyopia. * Bilateral amblyopia. * Ophthalmological or neuro-ophthalmological disease other than amblyopia. * Neurological disease. * Chronic pharmacological treatment. * Presence of an implanted medical device. * Any ocular surgery or treatment within the previous year. * Significant ocular media opacities. * Previous treatment with transcranial direct current stimulation or another non-invasive brain stimulation technique. * Pregnancy or planning to become pregnant during the study period. * Inability to provide informed consent. * History of head trauma, seizures, or frequent headaches. * Electrical or electronic implants, such as a cardiac pacemaker. * Metallic objects or implants in the head, except dental implants.

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Conditions

The condition(s) this trial relates to.

amblyopia ametropic amblyopia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amblyopia Anisometropic amblyopia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra

    RECRUITING

    Coimbra, Coimbra District, 3000-548, Portugal

  • RISE-Health, Center for Translational Health and Medical Biotechnology Research (TBIO), School of Health, Polytechnic of Porto

    RECRUITING

    Porto, Porto District, 4200-072, Portugal

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