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Tooth color may reveal risk of enamel loss in children with cheese molars

NCT ID NCT07727200

Knowledge-focused Sponsor: University of Basel Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This study looks at children with molar-incisor hypomineralisation (MIH), also called cheese molars, to see if the color of the defect can predict future enamel breakdown. Researchers will photograph and scan affected teeth over nine months and compare the scans to measure enamel loss. If a clear link exists, dentists could identify high-risk teeth early and take steps to prevent damage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If a link is found, dentists might predict enamel breakdown early and take steps to protect the teeth before damage occurs.
What could go wrong
This is a small observational study, so any link found may not apply to all children. It does not test a treatment, only a possible prediction tool.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Children screened by the school dental services of Basel-Stadt as well children attending the department of children and adolescents (KJZM) of the University Centre for Dental Medicine in Basel (UZB), diagnosed with MIH on one or more first permanent molars will receive a letter of information- invitation to be seen in the department of children and adolescents (KJZM). The control group will consist of fit and healthy children 5-8 years old, who attend the department of children and adolescents (KJZM-UZB) for their regular dental check-ups.

Ages

5 to 8 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

MIH Study Group Inclusion Criteria: * Children between 5 to 8 years with MIH molars with or without hypersensitivity according to the MIH-TN Index (Bekes et al 2016) * Children with first molars in occlusion * Children fit and healthy Exclusion Criteria: * MIH first permanent molars that have already received any kind of dental treatment * Children diagnosed with HSPM (hypomineralised second primary molars) * Children older than 8 years - Children younger than 5 years * Children with any cranio-facial and/or other developmental dental defects * Children diagnosed with parafunctions (attrition/ erosion) * Children and/or parents who did not consent to the study * Children with MIH teeth that show clinically visible enamel loss during the eruption * Children without the first molars in occlusion Non- MIH Control Group Inclusion Criteria: * Children between 5 to 8 years with no clinically affected molars- Page 4 of 5 * Children fit and healthy Exclusion Criteria: * Children who have already received any kind of dental treatment on their permanent or primary teeth * Children diagnosed with MIH or any other disease of the teeth * Children older than 8 years * Children younger than 5 years * Children with any cranio-facial and/or other developmental dental defects * Children diagnosed with parafunctions (attrition/ erosion) * Children and/or parents who did not consent to the study

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Conditions

The condition(s) this trial relates to.

color vision disorder Molar Hypomineralization

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colour of defect Enamel breakdown Molar incisor hypomineralisation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University Centre for Dental Medicine

    RECRUITING

    Basel, Canton of Basel-City, 4058, Switzerland

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