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Bone injection could ease dental pain for children with MIH

NCT ID NCT07457450

Symptom relief Sponsor: University of Zagreb Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two numbing methods for children aged 6–14 with molar incisor hypomineralization (MIH), a condition that makes teeth sensitive and hard to treat. Each child will receive both an intraosseous injection (into the jawbone) and a standard gum injection on different molars. The goal is to see which method provides better pain relief during dental fillings and reduces anxiety.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Intraosseous anesthesia (local anesthetic injected into the bone)
What this could lead to
If it works, dentists may have a better way to numb painful MIH teeth in children, making dental visits less stressful.
What could go wrong
This is a small, early-stage study with only 50 children. The technique may not work for everyone and could cause discomfort during injection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 14 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of molar-incisor hypomineralization (MIH) * At least two first permanent molars affected by MIH * No prior dental procedures on those molars * Mentally and physically healthy * Cooperative behavior (Frankl score 3 or 4) * No use of analgesics in the 48 hours prior to treatment Exclusion Criteria: * Periodontal changes (e.g., periodontal pockets, tooth mobility) * Radiographic bone loss, furcation involvement, or periapical radiolucency

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Conditions

The condition(s) this trial relates to.

Molar Hypomineralization

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Molar incisor hypomineralisation

Contacts and locations

Locations

  • School of Dental Medicine University of Zagreb

    Zagreb, 10 000, Croatia

More trials for these conditions

Other studies related to the condition(s) this trial covers.